Charles Zorumski

Professor of Psychiatry, Director of the Taylor Family Institute for Innovative Psychiatric Research, Professor of Neuroscience, Samuel B. Guze Professor of Psychiatry

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    Available to Mentor:

    PhD/MSTP Students

    • 12477
    1981 …2023

    Research activity per year

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    Research interests

    Glutamate and GABA are the major excitatory and inhibitory neurotransmitters in the mammalian central nervous system, playing roles in a variety of physiological and pathological processes. On the one hand these agents function in normal synaptic transmission; yet alterations in these systems can have profound consequences leading to seizures and neuronal damage.

    Our laboratory is interested in the physiology and pharmacology of amino acid neurotransmitters with emphasis on the regulation of fast excitatory and inhibitory synaptic function. In our studies, we use whole cell voltage clamp and isolated patch recording techniques to examine modulation of the N-methyl-D-aspartate (NMDA) and non-NMDA (kainate/AMPA) classes of glutamate receptors on postnatal rat hippocampal neurons and hippocampal slices. Other studies in the lab are examining factors contributing to short- and long-term forms of synaptic plasticity in the hippocampus and the effects of neuroactive steroids and oxysterols on GABA and glutamate channels.

    Clinical interests

    Electroconvulsive therapy, brain stimulation methods, electrophysiology, exitotoxic neuronal damage and neuropsychiatric disorders

    Available to Mentor:

    • PhD/MSTP Students


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