Charles Zorumski

Samuel B. Guze Professor of Psychiatry, Head of the Department of Psychiatry, Professor of Neuroscience

    • 14553 Citations
    1981 …2020

    Research output per year

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    Personal profile

    Research interests

    Glutamate and GABA are the major excitatory and inhibitory neurotransmitters in the mammalian central nervous system, playing roles in a variety of physiological and pathological processes. On the one hand these agents function in normal synaptic transmission; yet alterations in these systems can have profound consequences leading to seizures and neuronal damage. Our laboratory is interested in the physiology and pharmacology of amino acid neurotransmitters with emphasis on the regulation of fast excitatory and inhibitory synaptic function. In our studies, we use whole cell voltage clamp and isolated patch recording techniques to examine modulation of the N-methyl-D-aspartate (NMDA) and non-NMDA (kainate/AMPA) classes of glutamate receptors on postnatal rat hippocampal neurons and hippocampal slices. Other studies in the lab are examining factors contributing to short- and long-term forms of synaptic plasticity in the hippocampus and the effects of neuroactive steroids and oxysterols on GABA and glutamate channels.

    Areas of Clinical Interest

    Electroconvulsive therapy, brain stimulation methods, electrophysiology, exitotoxic neuronal damage and neuropsychiatric disorders

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    Research Output

    Academic Psychiatry Department Names: Reflections on Research, Practice, and Education

    Zagoloff, A., Hong, B. A., Freese, R., Palmer, B., Zorumski, C. F., Vinogradov, S. & Robiner, W. N., 2020, (Accepted/In press) In : Academic Psychiatry.

    Research output: Contribution to journalArticle

  • Open Access
  • JAMA Psychiatry: Best of 2019

    Zorumski, C. F., Feb 2020, In : JAMA psychiatry. 77, 2, p. 117-118 2 p.

    Research output: Contribution to journalReview article

  • Ketamine and nitrous oxide: The evolution of NMDA receptor antagonists as antidepressant agents

    Kalmoe, M. C., Janski, A. M., Zorumski, C. F., Nagele, P., Palanca, B. J. & Conway, C. R., May 15 2020, In : Journal of the Neurological Sciences. 412, 116778.

    Research output: Contribution to journalReview article

  • 2 Scopus citations
    Open Access