Charles Gu

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Charles Gu

Associate Professor of Biostatistics, Associate Professor of Genetics

 https://orcid.org/0000-0002-8527-8145

    Willing to Mentor

    Available to Mentor:

    PhD/MSTP Students

    • 5565
      Citations
    1993 …2023

    Research activity per year

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    Search results

    • 2023

      Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis

      NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Apr 1 2023, In: Nature. 616, 7958, p. 755-763 9 p.

      Research output: Contribution to journal › Article › peer-review

      6 Scopus citations

    • Activation of Endothelial Large Conductance Potassium Channels Protects against TNF-α-Induced Inflammation

      Zyrianova, T., Zou, K., Lopez, B., Liao, A., Gu, C., Olcese, R. & Schwingshackl, A., Feb 2023, In: International journal of molecular sciences. 24, 4, 4087.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • Activation of TREK-1 (K2P2.1) potassium channels protects against influenza A-induced lung injury

      Zyrianova, T., Lopez, B., Zou, K., Gu, C., Pham, D., Talapaneni, S., Waters, C. M., Olcese, R. & Schwingshackl, A., Jan 2023, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 324, 1, p. L64-L75

      Research output: Contribution to journal › Article › peer-review

      3 Scopus citations

    • Author Correction: Clonal haematopoiesis and risk of chronic liver disease (Nature, (2023), 616, 7958, (747-754), 10.1038/s41586-023-05857-4)

      NHLBI TOPMed Hematology Working Group, Jul 20 2023, In: Nature. 619, 7970, p. E47

      Research output: Contribution to journal › Comment/debate

      Open Access

    • Clonal haematopoiesis and risk of chronic liver disease

      NHLBI TOPMed Hematology Working Group, Apr 27 2023, In: Nature. 616, 7958, p. 747-754 8 p.

      Research output: Contribution to journal › Article › peer-review

      15 Scopus citations

    • Epigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma

      NHLBI Trans-Omics in Precision Medicine (TOPMed) Consortium, Sep 2023, In: EBioMedicine. 95, 104758.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups

      Kurniansyah, N., Goodman, M. O., Khan, A. T., Wang, J., Feofanova, E., Bis, J. C., Wiggins, K. L., Huffman, J. E., Kelly, T., Elfassy, T., Guo, X., Palmas, W., Lin, H. J., Hwang, S. J., Gao, Y., Young, K., Kinney, G. L., Smith, J. A., Yu, B., Liu, S., & 23 othersWassertheil-Smoller, S., Manson, J. A. E., Zhu, X., Chen, Y. D. I., Lee, I. T., Gu, C. C., Lloyd-Jones, D. M., Zöllner, S., Fornage, M., Kooperberg, C., Correa, A., Psaty, B. M., Arnett, D. K., Isasi, C. R., Rich, S. S., Kaplan, R. C., Redline, S., Mitchell, B. D., Franceschini, N., Levy, D., Rotter, J. I., Morrison, A. C. & Sofer, T., Dec 2023, In: Nature communications. 14, 1, 3202.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • The genetic determinants of recurrent somatic mutations in 43,693 blood genomes

      NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Apr 2023, In: Science Advances. 9, 17, eabm4945.

      Research output: Contribution to journal › Review article › peer-review

      Open Access
      1 Scopus citations
    • 2022

      Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

      TOPMed Anthropometry Working Group & NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Mar 2022, In: Nature Genetics. 54, 3, p. 263-273 11 p.

      Research output: Contribution to journal › Article › peer-review

      82 Scopus citations

    • Gene-lifestyle interactions in the genomics of human complex traits

      the CHARGE Gene-Lifestyle Interactions Working Group, Jun 2022, In: European Journal of Human Genetics. 30, 6, p. 730-739 10 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      4 Scopus citations

    • Genetic diversity fuels gene discovery for tobacco and alcohol use

      23andMe Research Team, the BioBank Japan Project, Gu, C. C., Rice, J. P., Saccone, N. L. & Bierut, L. J., Dec 22 2022, In: Nature. 612, 7941, p. 720-724 5 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      35 Scopus citations

    • Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential

      The Samoan Obesity, Lifestyle and Genetic Adaptations Study (OLaGA) Group & NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Apr 2022, In: Science Advances. 8, 14, eabl6579.

      Research output: Contribution to journal › Article › peer-review

      24 Scopus citations

    • Multi-omics insights into the biological mechanisms underlying statistical gene-by-lifestyle interactions with smoking and alcohol consumption

      on behalf of the CHARGE Gene-Lifestyle Interactions Working Group, Dec 5 2022, In: Frontiers in Genetics. 13, 954713.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      1 Scopus citations

    • Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies

      NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Lipids Working Group, 2022, (Accepted/In press) In: Nature Genetics.

      Research output: Contribution to journal › Article › peer-review

      4 Scopus citations

    • Whole genome sequence analysis of blood lipid levels in >66,000 individuals

      NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Dec 2022, In: Nature communications. 13, 1, 5995.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      11 Scopus citations
    • 2021

      A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response

      NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Oct 2021, In: Nature Genetics. 53, 10, p. 1504-1516 13 p.

      Research output: Contribution to journal › Article › peer-review

      37 Scopus citations

    • Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes (Nature, (2020), 586, 7831, (763-768), 10.1038/s41586-020-2819-2)

      NHLBI Trans-Omics for Precision Medicine Consortium, Mar 25 2021, In: Nature. 591, 7851, p. E27

      Research output: Contribution to journal › Comment/debate

      Open Access
      4 Scopus citations

    • Author Correction: A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response (Nature Genetics, (2021), 53, 10, (1504-1516), 10.1038/s41588-021-00935-7)

      NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Dec 2021, In: Nature Genetics. 53, 12, p. 1722 1 p.

      Research output: Contribution to journal › Comment/debate

      Open Access
      1 Scopus citations

    • Bk channels regulate LPS-induced CCL-2 release from human pulmonary endothelial cells

      Zyrianova, T., Lopez, B., Liao, A., Gu, C., Wong, L., Ottolia, M., Olcese, R. & Schwingshackl, A., 2021, In: American Journal of Respiratory Cell and Molecular Biology. 64, 2, p. 224-234 11 p.

      Research output: Contribution to journal › Article › peer-review

      10 Scopus citations

    • Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

      NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium & FinnGen, Dec 1 2021, In: Nature communications. 12, 1, 2182.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      11 Scopus citations

    • Donor-specific phenotypic variation in hiPSC cardiomyocyte-derived exosomes impacts endothelial cell function

      Turner, A., Aggarwal, P., Matter, A., Olson, B., Charles Gu, C., Hunt, S. C., Lewis, C. E., Arnett, D. K., Lorier, R. & Broeckel, U., 2021, In: American Journal of Physiology - Heart and Circulatory Physiology. 320, 3, p. H954-H968

      Research output: Contribution to journal › Article › peer-review

      7 Scopus citations

    • Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

      Lifelines Cohort Study, Jun 2021, In: Molecular Psychiatry. 26, 6, p. 2111-2125 15 p.

      Research output: Contribution to journal › Article › peer-review

      13 Scopus citations

    • Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium

      NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), Dec 2021, In: Genome medicine. 13, 1, 66.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      19 Scopus citations

    • Genome sequencing unveils a regulatory landscape of platelet reactivity

      NHLBI Trans-Omics for Precision (TOPMed) Consortium, Dec 1 2021, In: Nature communications. 12, 1, 3626.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      20 Scopus citations

    • Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits

      Lifelines Cohort Study, Jan 14 2021, In: Human Genetics and Genomics Advances. 2, 1, 100013.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      2 Scopus citations

    • Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

      NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Feb 11 2021, In: Nature. 590, 7845, p. 290-299 10 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      607 Scopus citations

    • Three genetic–environmental networks for human personality

      Zwir, I., Del-Val, C., Arnedo, J., Pulkki-Råback, L., Konte, B., Yang, S. S., Romero-Zaliz, R., Hintsanen, M., Cloninger, K. M., Garcia, D., Svrakic, D. M., Lester, N., Rozsa, S., Mesa, A., Lyytikäinen, L. P., Giegling, I., Kähönen, M., Martinez, M., Seppälä, I., Raitoharju, E., & 10 othersde Erausquin, G. A., Mamah, D., Raitakari, O., Rujescu, D., Postolache, T. T., Gu, C. C., Sung, J., Lehtimäki, T., Keltikangas-Järvinen, L. & Cloninger, C. R., Aug 2021, In: Molecular Psychiatry. 26, 8, p. 3858-3875 18 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      49 Scopus citations

    • Variant-specific inflation factors for assessing population stratification at the phenotypic variance level

      NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Dec 1 2021, In: Nature communications. 12, 1, 3506.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      1 Scopus citations

    • Whole-Exome Sequencing and hiPSC Cardiomyocyte Models Identify MYRIP, TRAPPC11, and SLC27A6 of Potential Importance to Left Ventricular Hypertrophy in an African Ancestry Population

      Irvin, M. R., Aggarwal, P., Claas, S. A., de las Fuentes, L., Do, A. N., Gu, C. C., Matter, A., Olson, B. S., Patki, A., Schwander, K., Smith, J. D., Srinivasasainagendra, V., Tiwari, H. K., Turner, A. J., Nickerson, D. A., Rao, D. C., Broeckel, U. & Arnett, D. K., Feb 19 2021, In: Frontiers in Genetics. 12, 588452.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      5 Scopus citations

    • Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program

      TOPMed Sleep Working Group & NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Dec 2021, In: Genome medicine. 13, 1, 136.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      11 Scopus citations
    • 2020

      ATRAID regulates the action of nitrogen-containing bisphosphonates on bone

      Surface, L. E., Burrow, D. T., Li, J., Park, J., Kumar, S., Lyu, C., Song, N., Yu, Z., Rajagopal, A., Bae, Y., Lee, B. H., Mumm, S., Gu, C. C., Baker, J. C., Mohseni, M., Sum, M., Huskey, M., Duan, S., Bijanki, V. N., Civitelli, R., & 18 othersGardner, M. J., McAndrew, C. M., Ricci, W. M., Gurnett, C. A., Diemer, K., Wan, F., Costantino, C. L., Shannon, K. M., Raje, N., Dodson, T. B., Haber, D. A., Carette, J. E., Varadarajan, M., Brummelkamp, T. R., Birsoy, K., Sabatini, D. M., Haller, G. & Peterson, T. R., May 20 2020, In: Science translational medicine. 12, 544, eaav9166.

      Research output: Contribution to journal › Article › peer-review

      11 Scopus citations

    • Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale

      NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium & TOPMed Lipids Working Group, Sep 1 2020, In: Nature Genetics. 52, 9, p. 969-983 15 p.

      Research output: Contribution to journal › Article › peer-review

      84 Scopus citations

    • Inherited causes of clonal haematopoiesis in 97,691 whole genomes

      NHLBI Trans-Omics for Precision Medicine Consortium, Oct 29 2020, In: Nature. 586, 7831, p. 763-768 6 p.

      Research output: Contribution to journal › Article › peer-review

      270 Scopus citations

    • Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries (Nature Communications, (2018), 9, 1, (2606), 10.1038/s41467-018-04668-w)

      NHLBI TOPMed Lipids Working Group, Dec 1 2020, In: Nature communications. 11, 1, 1715.

      Research output: Contribution to journal › Comment/debate

      Open Access
      2 Scopus citations

    • Uncovering the complex genetics of human personality: response from authors on the PGMRA Model

      Zwir, I., Mishra, P., Del-Val, C., Gu, C. C., de Erausquin, G. A., Lehtimäki, T. & Cloninger, C. R., Oct 1 2020, In: Molecular Psychiatry. 25, 10, p. 2210-2213 4 p.

      Research output: Contribution to journal › Letter › peer-review

      Open Access
      11 Scopus citations
    • 2019

      A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

      Sung, Y. J., De Las Fuentes, L., Winkler, T. W., Chasman, D. I., Bentley, A. R., Kraja, A. T., Ntalla, I., Warren, H. R., Guo, X., Schwander, K., Manning, A. K., Brown, M. R., Aschard, H., Feitosa, M. F., Franceschini, N., Lu, Y., Cheng, C. Y., Sim, X., Vojinovic, D., Marten, J., & 261 othersMusani, S. K., Kilpeläinen, T. O., Richard, M. A., Aslibekyan, S., Bartz, T. M., Dorajoo, R., Li, C., Liu, Y., Rankinen, T., Smith, A. V., Tajuddin, S. M., Tayo, B. O., Zhao, W., Zhou, Y., Matoba, N., Sofer, T., Alver, M., Amini, M., Boissel, M., Chai, J. F., Chen, X., Divers, J., Gandin, I., Gao, C., Giulianini, F., Goel, A., Harris, S. E., Hartwig, F. P., He, M., Horimoto, A. R. V. R., Hsu, F. C., Jackson, A. U., Kammerer, C. M., Kasturiratne, A., Komulainen, P., Kühnel, B., Leander, K., Lee, W. J., Lin, K. H., Luan, J., Lyytikäinen, L. P., McKenzie, C. A., Nelson, C. P., Noordam, R., Scott, R. A., Sheu, W. H. H., Stančáková, A., Takeuchi, F., Van Der Most, P. J., Varga, T. V., Waken, R. J., Wang, H., Wang, Y., Ware, E. B., Weiss, S., Wen, W., Yanek, L. R., Zhang, W., Zhao, J. H., Afaq, S., Alfred, T., Amin, N., Arking, D. E., Aung, T., Barr, R. G., Bielak, L. F., Boerwinkle, E., Bottinger, E. P., Braund, P. S., Brody, J. A., Broeckel, U., Cade, B., Campbell, A., Canouil, M., Chakravarti, A., Cocca, M., Collins, F. S., Connell, J. M., De Mutsert, R., De Silva, H. J., Dörr, M., Duan, Q., Eaton, C. B., Ehret, G., Evangelou, E., Faul, J. D., Forouhi, N. G., Franco, O. H., Friedlander, Y., Gao, H., Gigante, B., Gu, C. C., Gupta, P., Hagenaars, S. P., Harris, T. B., He, J., Heikkinen, S., Heng, C. K., Hofman, A., Howard, B. V., Hunt, S. C., Irvin, M. R., Jia, Y., Katsuya, T., Kaufman, J., Kerrison, N. D., Khor, C. C., Koh, W. P., Koistinen, H. A., Kooperberg, C. B., Krieger, J. E., Kubo, M., Kutalik, Z., Kuusisto, J., Lakka, T. A., Langefeld, C. D., Langenberg, C., Launer, L. J., Lee, J. H., Lehne, B., Levy, D., Lewis, C. E., Li, Y., Lim, S. H., Liu, C. T., Liu, J., Liu, J., Liu, Y., Loh, M., Lohman, K. K., Louie, T., Mägi, R., Matsuda, K., Meitinger, T., Metspalu, A., Milani, L., Momozawa, Y., Thomas, T. H., Nalls, M. A., Nasri, U., O'Connell, J. R., Ogunniyi, A., Palmas, W. R., Palmer, N. D., Pankow, J. S., Pedersen, N. L., Peters, A., Peyser, P. A., Polasek, O., Porteous, D., Raitakari, O. T., Renström, F., Rice, T. K., Ridker, P. M., Robino, A., Robinson, J. G., Rose, L. M., Rudan, I., Sabanayagam, C., Salako, B. L., Sandow, K., Schmidt, C. O., Schreiner, P. J., Scott, W. R., Sever, P., Sims, M., Sitlani, C. M., Smith, B. H., Smith, J. A., Snieder, H., Starr, J. M., Strauch, K., Tang, H., Taylor, K. D., Teo, Y. Y., Tham, Y. C., Uitterlinden, A. G., Waldenberger, M., Wang, L., Wang, Y. X., Wei, W. B., Wilson, G., Wojczynski, M. K., Xiang, Y. B., Yao, J., Yuan, J. M., Zonderman, A. B., Becker, D. M., Boehnke, M., Bowden, D. W., Chambers, J. C., Chen, Y. D. I., Weir, D. R., De Faire, U., Deary, I. J., Esko, T., Farrall, M., Forrester, T., Freedman, B. I., Froguel, P., Gasparini, P., Gieger, C., Horta, B. L., Hung, Y. J., Jonas, J. B., Kato, N., Kooner, J. S., Laakso, M., Lehtimäki, T., Liang, K. W., Magnusson, P. K. E., Oldehinkel, A. J., Pereira, A. C., Perls, T., Rauramaa, R., Redline, S., Rettig, R., Samani, N. J., Scott, J., Shu, X. O., Van Der Harst, P., Wagenknecht, L. E., Wareham, N. J., Watkins, H., Wickremasinghe, A. R., Wu, T., Kamatani, Y., Laurie, C. C., Bouchard, C., Cooper, R. S., Evans, M. K., Gudnason, V., Hixson, J., Kardia, S. L. R., Kritchevsky, S. B., Psaty, B. M., Van Dam, R. M., Arnett, D. K., Mook-Kanamori, D. O., Fornage, M., Fox, E. R., Hayward, C., Van Duijn, C. M., Tai, E. S., Wong, T. Y., Loos, R. J. F., Reiner, A. P., Rotimi, C. N., Bierut, L. J., Zhu, X., Cupples, L. A., Province, M. A., Rotter, J. I., Franks, P. W., Rice, K., Elliott, P., Caulfield, M. J., Gauderman, W. J., Munroe, P. B., Rao, D. C. & Morrison, A. C., Aug 1 2019, In: Human molecular genetics. 28, 15, p. 2615-2633 19 p.

      Research output: Contribution to journal › Article › peer-review

      22 Scopus citations

    • Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

      Kraja, A. T., Liu, C., Fetterman, J. L., Graff, M., Have, C. T., Gu, C., Yanek, L. R., Feitosa, M. F., Arking, D. E., Chasman, D. I., Young, K., Ligthart, S., Hill, W. D., Weiss, S., Luan, J., Giulianini, F., Li-Gao, R., Hartwig, F. P., Lin, S. J., Wang, L., & 132 othersRichardson, T. G., Yao, J., Fernandez, E. P., Ghanbari, M., Wojczynski, M. K., Lee, W. J., Argos, M., Armasu, S. M., Barve, R. A., Ryan, K. A., An, P., Baranski, T. J., Bielinski, S. J., Bowden, D. W., Broeckel, U., Christensen, K., Chu, A. Y., Corley, J., Cox, S. R., Uitterlinden, A. G., Rivadeneira, F., Cropp, C. D., Daw, E. W., van Heemst, D., de las Fuentes, L., Gao, H., Tzoulaki, I., Ahluwalia, T. S., de Mutsert, R., Emery, L. S., Erzurumluoglu, A. M., Perry, J. A., Fu, M., Forouhi, N. G., Gu, Z., Hai, Y., Harris, S. E., Hemani, G., Hunt, S. C., Irvin, M. R., Jonsson, A. E., Justice, A. E., Kerrison, N. D., Larson, N. B., Lin, K. H., Love-Gregory, L. D., Mathias, R. A., Lee, J. H., Nauck, M., Noordam, R., Ong, K. K., Pankow, J., Patki, A., Pattie, A., Petersmann, A., Qi, Q., Ribel-Madsen, R., Rohde, R., Sandow, K., Schnurr, T. M., Sofer, T., Starr, J. M., Taylor, A. M., Teumer, A., Timpson, N. J., de Haan, H. G., Wang, Y., Weeke, P. E., Williams, C., Wu, H., Yang, W., Zeng, D., Witte, D. R., Weir, B. S., Wareham, N. J., Vestergaard, H., Turner, S. T., Torp-Pedersen, C., Stergiakouli, E., Sheu, W. H. H., Rosendaal, F. R., Ikram, M. A., Franco, O. H., Ridker, P. M., Perls, T. T., Pedersen, O., Nohr, E. A., Newman, A. B., Linneberg, A., Langenberg, C., Kilpeläinen, T. O., Kardia, S. L. R., Jørgensen, M. E., Jørgensen, T., Sørensen, T. I. A., Homuth, G., Hansen, T., Goodarzi, M. O., Deary, I. J., Christensen, C., Chen, Y. D. I., Chakravarti, A., Brandslund, I., Bonnelykke, K., Taylor, K. D., Wilson, J. G., Rodriguez, S., Davies, G., Horta, B. L., Thyagarajan, B., Rao, D. C., Grarup, N., Davila-Roman, V. G., Hudson, G., Guo, X., Arnett, D. K., Hayward, C., Vaidya, D., Mook-Kanamori, D. O., Tiwari, H. K., Levy, D., Loos, R. J. F., Dehghan, A., Elliott, P., Malik, A. N., Scott, R. A., Becker, D. M., de Andrade, M., Province, M. A., Meigs, J. B., Rotter, J. I. & North, K. E., Jan 3 2019, In: American journal of human genetics. 104, 1, p. 112-138 27 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      65 Scopus citations

    • Combined linkage and association analysis identifies rare and low frequency variants for blood pressure at 1q31

      Wang, H., Nandakumar, P., Tekola-Ayele, F., Tayo, B. O., Ware, E. B., Gu, C. C., Lu, Y., Yao, J., Zhao, W., Smith, J. A., Hellwege, J. N., Guo, X., Edwards, T. L., Loos, R. J. F., Arnett, D. K., Fornage, M., Rotimi, C., Kardia, S. L. R., Cooper, R. S., Rao, D. C., & 3 othersEhret, G., Chakravarti, A. & Zhu, X., Feb 1 2019, In: European Journal of Human Genetics. 27, 2, p. 269-277 9 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      5 Scopus citations

    • Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

      De Vries, P. S., Brown, M. R., Bentley, A. R., Sung, Y. J., Winkler, T. W., Ntalla, I., Schwander, K., Kraja, A. T., Guo, X., Franceschini, N., Cheng, C. Y., Sim, X., Vojinovic, D., Huffman, J. E., Musani, S. K., Li, C., Feitosa, M. F., Richard, M. A., Noordam, R., Aschard, H., & 246 othersBartz, T. M., Bielak, L. F., Deng, X., Dorajoo, R., Lohman, K. K., Manning, A. K., Rankinen, T., Smith, A. V., Tajuddin, S. M., Evangelou, E., Graff, M., Alver, M., Boissel, M., Chai, J. F., Chen, X., Divers, J., Gandin, I., Gao, C., Goel, A., Hagemeijer, Y., Harris, S. E., Hartwig, F. P., He, M., Horimoto, A. R. V. R., Hsu, F. C., Jackson, A. U., Kasturiratne, A., Komulainen, P., Kühnel, B., Laguzzi, F., Lee, J. H., Luan, JA., Lyytikäinen, L. P., Matoba, N., Nolte, I. M., Pietzner, M., Riaz, M., Said, M. A., Scott, R. A., Sofer, T., Stančáková, A., Takeuchi, F., Tayo, B. O., Van Der Most, P. J., Varga, T. V., Wang, Y., Ware, E. B., Wen, W., Yanek, L. R., Zhang, W., Zhao, J. H., Afaq, S., Amin, N., Amini, M., Arking, D. E., Aung, T., Ballantyne, C., Boerwinkle, E., Broeckel, U., Campbell, A., Canouil, M., Charumathi, S., Chen, Y. D. I., Connell, J. M., De Faire, U., De Las Fuentes, L., De Mutsert, R., De Silva, H. J., Ding, J., Dominiczak, A. F., Duan, Q., Eaton, C. B., Eppinga, R. N., Faul, J. D., Fisher, V., Forrester, T., Franco, O. H., Friedlander, Y., Ghanbari, M., Giulianini, F., Grabe, H. J., Grove, M. L., Gu, C. C., Harris, T. B., Heikkinen, S., Heng, C. K., Hirata, M., Hixson, J. E., Howard, B. V., Ikram, M. A., Jacobs, D. R., Johnson, C., Jonas, J. B., Kammerer, C. M., Katsuya, T., Khor, C. C., Kilpeläinen, T. O., Koh, W. P., Koistinen, H. A., Kolcic, I., Kooperberg, C., Krieger, J. E., Kritchevsky, S. B., Kubo, M., Kuusisto, J., Lakka, T. A., Langefeld, C. D., Langenberg, C., Launer, L. J., Lehne, B., Lemaitre, R. N., Li, Y., Liang, J., Liu, J., Liu, K., Loh, M., Louie, T., Mägi, R., Manichaikul, A. W., McKenzie, C. A., Meitinger, T., Metspalu, A., Milaneschi, Y., Milani, L., Mohlke, K. L., Mosley, T. H., Mukamal, K. J., Nalls, M. A., Nauck, M., Nelson, C. P., Sotoodehnia, N., O'Connell, J. R., Palmer, N. D., Pazoki, R., Pedersen, N. L., Peters, A., Peyser, P. A., Polasek, O., Poulter, N., Raffel, L. J., Raitakari, O. T., Reiner, A. P., Rice, T. K., Rich, S. S., Robino, A., Robinson, J. G., Rose, L. M., Rudan, I., Schmidt, C. O., Schreiner, P. J., Scott, W. R., Sever, P., Shi, Y., Sidney, S., Sims, M., Smith, B. H., Smith, J. A., Snieder, H., Starr, J. M., Strauch, K., Tan, N., Taylor, K. D., Teo, Y. Y., Tham, Y. C., Uitterlinden, A. G., Van Heemst, D., Vuckovic, D., Waldenberger, M., Wang, L., Wang, Y., Wang, Z., Wei, W. B., Williams, C., Wilson, G., Wojczynski, M. K., Yao, J., Yu, B., Yu, C., Yuan, J. M., Zhao, W., Zonderman, A. B., Becker, D. M., Boehnke, M., Bowden, D. W., Chambers, J. C., Deary, I. J., Esko, T., Farrall, M., Franks, P. W., Freedman, B. I., Froguel, P., Gasparini, P., Gieger, C., Horta, B. L., Kamatani, Y., Kato, N., Kooner, J. S., Laakso, M., Leander, K., Lehtimäki, T., Magnusson, P. K. E., Penninx, B., Pereira, A. C., Rauramaa, R., Samani, N. J., Scott, J., Shu, X. O., Van Der Harst, P., Wagenknecht, L. E., Wang, Y. X., Wareham, N. J., Watkins, H., Weir, D. R., Wickremasinghe, A. R., Zheng, W., Elliott, P., North, K. E., Bouchard, C., Evans, M. K., Gudnason, V., Liu, C. T., Liu, Y., Psaty, B. M., Ridker, P. M., Van Dam, R. M., Kardia, S. L. R., Zhu, X., Rotimi, C. N., Mook-Kanamori, D. O., Fornage, M., Kelly, T. N., Fox, E. R., Hayward, C., Van Duijn, C. M., Tai, E. S., Wong, T. Y., Liu, J., Rotter, J. I., Gauderman, W. J., Province, M. A., Munroe, P. B., Rice, K., Chasman, D. I., Cupples, L. A., Rao, D. C. & Morrison, A. C., Jun 1 2019, In: American journal of epidemiology. 188, 6, p. 1033-1054 22 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      58 Scopus citations

    • Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

      Understanding Society Scientific group, Lifelines Cohort, COGENT-Kidney Consortium & EPIC-InterAct Consortium, Apr 1 2019, In: Nature Genetics. 51, 4, p. 636-648 13 p.

      Research output: Contribution to journal › Article › peer-review

      70 Scopus citations

    • Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

      Lifelines Cohort Study, Dec 1 2019, In: Nature communications. 10, 1, 376.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      50 Scopus citations

    • Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma

      National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Consortium, Dec 1 2019, In: CHEST. 156, 6, p. 1068-1079 12 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      5 Scopus citations
    • 2018

      A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

      The CHARGE Neurology Working Group, The COGENT-Kidney Consortium, The GIANT Consortium & Lifelines Cohort Study, Mar 1 2018, In: American journal of human genetics. 102, 3, p. 375-400 26 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      86 Scopus citations

    • Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

      NHLBI TOPMed Lipids Working Group, Dec 1 2018, In: Nature communications. 9, 1, 3391.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      113 Scopus citations

    • Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

      Zekavat, S. M., Ruotsalainen, S., Handsaker, R. E., Alver, M., Bloom, J., Poterba, T., Seed, C., Ernst, J., Chaffin, M., Engreitz, J., Peloso, G. M., Manichaikul, A., Yang, C., Ryan, K. A., Fu, M., Johnson, W. C., Tsai, M., Budoff, M., Ramachandran, V. S., Cupples, L. A., & 323 othersRotter, J. I., Rich, S. S., Post, W., Mitchell, B. D., Correa, A., Metspalu, A., Wilson, J. G., Salomaa, V., Kellis, M., Daly, M. J., Neale, B. M., McCarroll, S., Surakka, I., Esko, T., Ganna, A., Ripatti, S., Kathiresan, S., Natarajan, P., Abe, N., Abecasis, G., Albert, C., Allred, N. P., Almasy, L., Alonso, A., Ament, S., Anderson, P., Anugu, P., Applebaum-Bowden, D., Arking, D., Arnett, D. K., Ashley-Koch, A., Aslibekyan, S., Assimes, T., Auer, P., Avramopoulos, D., Barnard, J., Barnes, K., Barr, R. G., Barron-Casella, E., Beaty, T., Becker, D., Becker, L., Beer, R., Begum, F., Beitelshees, A., Benjamin, E., Bezerra, M., Bielak, L., Bis, J., Blackwell, T., Blangero, J., Boerwinkle, E., Borecki, I., Bowler, R., Brody, J., Broeckel, U., Broome, J., Bunting, K., Burchard, E., Cardwell, J., Carty, C., Casaburi, R., Casella, J., Chang, C., Chasman, D., Chavan, S., Chen, B. J., Chen, W. M., Chen, Y. D. I., Cho, M., Choi, S. H., Chuang, L. M., Chung, M., Cornell, E., Crandall, C., Crapo, J., Curran, J., Curtis, J., Custer, B., Damcott, C., Darbar, D., Das, S., David, S., Davis, C., Daya, M., Andrade, M. D., Debaun, M., Deka, R., Demeo, D., Devine, S., Do, R., Duan, Q., Duggirala, R., Durda, P., Dutcher, S., Eaton, C., Ekunwe, L., Ellinor, P., Emery, L., Farber, C., Farnam, L., Fingerlin, T., Flickinger, M., Fornage, M., Franceschini, N., Fullerton, S. M., Fulton, L., Gabriel, S., Gan, W., Gao, Y., Gass, M., Gelb, B., Geng, X., Germer, S., Gignoux, C., Gladwin, M., Glahn, D., Gogarten, S., Gong, D. W., Goring, H., Gu, C. C., Guan, Y., Guo, X., Haessler, J., Hall, M., Harris, D., Hawley, N., He, J., Heavner, B., Heckbert, S., Hernandez, R., Herrington, D., Hersh, C., Hidalgo, B., Hixson, J., Hokanson, J., Hong, E., Hoth, K., Hsiung, C., Huston, H., Hwu, C. M., Irvin, M. R., Jackson, R., Jain, D., Jaquish, C., Jhun, M. A., Johnsen, J., Johnson, A., Johnston, R., Jones, K., Kang, H. M., Kaplan, R., Kardia, S., Kaufman, L., Kelly, S., Kenny, E., Kessler, M., Khan, A., Kinney, G., Konkle, B., Kooperberg, C., Kramer, H., Krauter, S., Lange, C., Lange, E., Lange, L., Laurie, C., Laurie, C., Leboff, M., Lee, S. S., Lee, W. J., Lefaive, J., Levine, D., Levy, D., Lewis, J., Li, Y., Lin, H., Lin, K. H., Liu, S., Liu, Y., Loos, R., Lubitz, S., Lunetta, K., Luo, J., Mahaney, M., Make, B., Manson, J. A., Margolin, L., Martin, L., Mathai, S., Mathias, R., McArdle, P., McDonald, M. L., McFarland, S., McGarvey, S., Mei, H., Meyers, D. A., Mikulla, J., Min, N., Minear, M., Minster, R. L., Montasser, M. E., Musani, S., Mwasongwe, S., Mychaleckyj, J. C., Nadkarni, G., Naik, R., Nekhai, S., Nickerson, D., North, K., O'connell, J., O'connor, T., Ochs-Balcom, H., Pankow, J., Papanicolaou, G., Parker, M., Parsa, A., Penchev, S., Peralta, J. M., Perez, M., Perry, J., Peters, U., Peyser, P., Phillips, L., Phillips, S., Pollin, T., Becker, J. P., Boorgula, M. P., Preuss, M., Prokopenko, D., Psaty, B., Qasba, P., Qiao, D., Qin, Z., Rafaels, N., Raffield, L., Rao, D. C., Rasmussen-Torvik, L., Ratan, A., Redline, S., Reed, R., Regan, E., Reiner, A., Rice, K., Roden, D., Roselli, C., Ruczinski, I., Russell, P., Ruuska, S., Sakornsakolpat, P., Salimi, S., Salzberg, S., Sandow, K., Sankaran, V., Scheller, C., Schmidt, E., Schwander, K., Schwartz, D., Sciurba, F., Seidman, C., Sheehan, V., Shetty, A., Shetty, A., Sheu, W. H. H., Shoemaker, M. B., Silver, B., Silverman, E., Smith, J., Smith, J., Smith, N., Smith, T., Smoller, S., Snively, B., Sofer, T., Sotoodehnia, N., Stilp, A., Streeten, E., Sung, Y. J., Sylvia, J., Szpiro, A., Sztalryd, C., Taliun, D., Tang, H., Taub, M., Taylor, K., Taylor, S., Telen, M., Thornton, T. A., Tinker, L., Tirschwell, D., Tiwari, H., Tracy, R., Vaidya, D., Vandehaar, P., Vrieze, S., Walker, T., Wallace, R., Walts, A., Wan, E., Wang, F. F., Watson, K., Weeks, D. E., Weir, B., Weiss, S., Weng, L. C., Willer, C., Williams, K., Williams, L. K., Wilson, C., Wong, Q., Xu, H., Yanek, L., Yang, I., Yang, R., Zaghloul, N., Zhang, Y., Zhao, S. X., Zhao, W., Zheng, X., Zhi, D., Zhou, X., Zody, M. & Zoellner, S., Dec 1 2018, In: Nature communications. 9, 1, 2606.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      65 Scopus citations

    • Erratum to: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries (Nature Communications, (2018), 9, 1, (2606), 10.1038/s41467-018-04668-w)

      NHLBI TOPMed Lipids Working Group, Dec 1 2018, In: Nature communications. 9, 1, 3493.

      Research output: Contribution to journal › Comment/debate

      Open Access
      1 Scopus citations

    • Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

      Feitosa, M. F., Kraja, A. T., Chasman, D. I., Sung, Y. J., Winkler, T. W., Ntalla, I., Guo, X., Franceschini, N., Cheng, C. Y., Sim, X., Vojinovic, D., Marten, J., Musani, S. K., Li, C., Bentley, A. R., Brown, M. R., Schwander, K., Richard, M. A., Noordam, R., Aschard, H., & 252 othersBartz, T. M., Bielak, L. F., Dorajoo, R., Fisher, V., Hartwig, F. P., Horimoto, A. R. V. R., Lohman, K. K., Manning, A. K., Rankinen, T., Smith, A. V., Tajuddin, S. M., Wojczynski, M. K., Alver, M., Boissel, M., Cai, Q., Campbell, A., Chai, J. F., Chen, X., Divers, J., Gao, C., Goel, A., Hagemeijer, Y., Harris, S. E., He, M., Hsu, F. C., Jackson, A. U., Kähönen, M., Kasturiratne, A., Komulainen, P., Kühnel, B., Laguzzi, F., Luan, JA., Matoba, N., Nolte, I. M., Padmanabhan, S., Riaz, M., Rueedi, R., Robino, A., Said, M. A., Scott, R. A., Sofer, T., Stančáková, A., Takeuchi, F., Tayo, B. O., Van Der Most, P. J., Varga, T. V., Vitart, V., Wang, Y., Ware, E. B., Warren, H. R., Weiss, S., Wen, W., Yanek, L. R., Zhang, W., Zhao, J. H., Afaq, S., Amin, N., Amini, M., Arking, D. E., Aung, T., Boerwinkle, E., Borecki, I., Broeckel, U., Brown, M., Brumat, M., Burke, G. L., Canouil, M., Chakravarti, A., Charumathi, S., Chen, Y. D. I., Connell, J. M., Correa, A., De Las Fuentes, L., De Mutsert, R., De Silva, H. J., Deng, X., Ding, J., Duan, Q., Eaton, C. B., Ehret, G., Eppinga, R. N., Evangelou, E., Faul, J. D., Felix, S. B., Forouhi, N. G., Forrester, T., Franco, O. H., Friedlander, Y., Gandin, I., Gao, H., Ghanbari, M., Gigante, B., Gu, C. C., Gu, D., Hagenaars, S. P., Hallmans, G., Harris, T. B., He, J., Heikkinen, S., Heng, C. K., Hirata, M., Howard, B. V., Ikram, M. A., John, U., Katsuya, T., Khor, C. C., Kilpeläinen, T. O., Koh, W. P., Krieger, J. E., Kritchevsky, S. B., Kubo, M., Kuusisto, J., Lakka, T. A., Langefeld, C. D., Langenberg, C., Launer, L. J., Lehne, B., Lewis, C. E., Li, Y., Lin, S., Liu, J., Liu, J., Loh, M., Louie, T., Mägi, R., McKenzie, C. A., Meitinger, T., Metspalu, A., Milaneschi, Y., Milani, L., Mohlke, K. L., Momozawa, Y., Nalls, M. A., Nelson, C. P., Sotoodehnia, N., Norris, J. M., O'Connell, J. R., Palmer, N. D., Perls, T., Pedersen, N. L., Peters, A., Peyser, P. A., Poulter, N., Raffel, L. J., Raitakari, O. T., Roll, K., Rose, L. M., Rosendaal, F. R., Rotter, J. I., Schmidt, C. O., Schreiner, P. J., Schupf, N., Scott, W. R., Sever, P. S., Shi, Y., Sidney, S., Sims, M., Sitlani, C. M., Smith, J. A., Snieder, H., Starr, J. M., Strauch, K., Stringham, H. M., Tan, N. Y. Q., Tang, H., Taylor, K. D., Teo, Y. Y., Tham, Y. C., Turner, S. T., Uitterlinden, A. G., Vollenweider, P., Waldenberger, M., Wang, L., Wang, Y. X., Wei, W. B., Williams, C., Yao, J., Yu, C., Yuan, J. M., Zhao, W., Zonderman, A. B., Becker, D. M., Boehnke, M., Bowden, D. W., Chambers, J. C., Deary, I. J., Esko, T., Farrall, M., Franks, P. W., Freedman, B. I., Froguel, P., Gasparini, P., Gieger, C., Jonas, J. B., Kamatani, Y., Kato, N., Kooner, J. S., Kutalik, Z., Laakso, M., Laurie, C. C., Leander, K., Lehtimäki, T., Magnusson, P. K. E., Oldehinkel, A. J., Penninx, B. W. J. H., Polasek, O., Porteous, D. J., Rauramaa, R., Samani, N. J., Scott, J., Shu, X. O., Van Der Harst, P., Wagenknecht, L. E., Wareham, N. J., Watkins, H., Weir, D. R., Wickremasinghe, A. R., Wu, T., Zheng, W., Bouchard, C., Christensen, K., Evans, M. K., Gudnason, V., Horta, B. L., Kardia, S. L. R., Liu, Y., Pereira, A. C., Psaty, B. M., Ridker, P. M., Van Dam, R. M., Gauderman, W. J., Zhu, X., Mook-Kanamori, D. O., Fornage, M., Rotimi, C. N., Cupples, L. A., Kelly, T. N., Fox, E. R., Hayward, C., Van Duijn, C. M., Tai, E. S., Wong, T. Y., Kooperberg, C., Palmas, W., Rice, K., Morrison, A. C., Elliott, P., Caulfield, M. J., Munroe, P. B., Rao, D. C., Province, M. A. & Levy, D., Jun 2018, In: PloS one. 13, 6, e0198166.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      58 Scopus citations

    • Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI

      Gong, J., Nishimura, K. K., Fernandez-Rhodes, L., Haessler, J., Bien, S., Graff, M., Lim, U., Lu, Y., Gross, M., Fornage, M., Yoneyama, S., Isasi, C. R., Buzkova, P., Daviglus, M., Lin, D. Y., Tao, R., Goodloe, R., Bush, W. S., Farber-Eger, E., Boston, J., & 28 othersDilks, H. H., Ehret, G., Gu, C. C., Lewis, C. E., Nguyen, K. D. H., Cooper, R., Leppert, M., Irvin, M. R., Bottinger, E. P., Wilkens, L. R., Haiman, C. A., Park, L., Monroe, K. R., Cheng, I., Stram, D. O., Carlson, C. S., Jackson, R., Kuller, L., Houston, D., Kooperberg, C., Buyske, S., Hindorff, L. A., Crawford, D. C., Loos, R. J. F., Le Marchand, L., Matise, T. C., North, K. E. & Peters, U., Mar 1 2018, In: International Journal of Obesity. 42, 3, p. 384-390 7 p.

      Research output: Contribution to journal › Article › peer-review

      10 Scopus citations
    • 2017

      Associations between genetic variants of NADPH oxidase-related genes and blood pressure responses to dietary sodium intervention: The GenSalt study

      Han, X., Hu, Z., Chen, J., Huang, J., Huang, C., Liu, F., Gu, C., Yang, X., Hixson, J. E., Lu, X., Wang, L., Liu, D. P., He, J., Chen, S. & Gu, D., Apr 1 2017, In: American Journal of Hypertension. 30, 4, p. 427-434 8 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      12 Scopus citations

    • Blood pressure genetic risk score predicts blood pressure responses to dietary sodium and potassium the GenSalt Study (Genetic epidemiology network of salt sensitivity)

      Nierenberg, J. L., Li, C., He, J., Gu, D., Chen, J., Lu, X., Li, J., Wu, X., Gu, C. C., Hixson, J. E., Rao, D. C. & Kelly, T. N., 2017, In: Hypertension. 70, 6, p. 1106-1112 7 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      25 Scopus citations