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Charles Gu

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Charles Gu

Associate Professor of Biostatistics, Associate Professor of Genetics

 https://orcid.org/0000-0002-8527-8145

    Willing to Mentor

    Available to Mentor:

    PhD Students

    • 8918
      Citations
    1993 …2026

    Research activity per year

    Personal profile

    Research interests

    My current research focuses on two areas of genetic epidemiology and statistical human genetics. The first is the development and application of new statistical methods and bioinformatic tools to deal with high-dimensional data in genetic studies of complex human traits. Interests include machine learning techniques and fast and reliable discovery of important gene-gene and gene-environment interactions in high-throughput genetic studies of complex diseases. The second area is conducting real-world genetic studies on common human disease using the latest biotechnologies and most advanced analytical designs. Specific disease areas of interest include hypertension, hypertensive heart disease and cardiovascular diseases in general, obesity and metabolic syndrome, and kidney diseases.

    Available to Mentor:

    • PhD Students

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    • cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions

      NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Feb 2026, In: Nature Methods. 23, 2, p. 338-349 12 p.

      Research output: Contribution to journal › Article › peer-review

      1   Link opens in a new tab Scopus citations

    • Genome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants

      Noordam, R., Wang, W., Nagarajan, P., Wang, H., Brown, M. R., Bentley, A. R., Hui, Q., Kraja, A. T., Morrison, J. L., O'Connel, J. R., Lee, S., Schwander, K., Bartz, T. M., de las Fuentes, L., Feitosa, M. F., Guo, X., Hanfei, X., Harris, S. E., Huang, Z. & Kals, M. & 129 others, Lefevre, C., Mangino, M., Milaneschi, Y., van der Most, P. J., Pacheco, N. L., Palmer, N. D., Rao, V., Rauramaa, R., Sun, Q., Tabara, Y., Vojinovic, D., Wang, Y., Weiss, S., Yang, Q., Zhao, W., Zhu, W., Ansari, M. A. Y., Aschard, H., Anugu, P., Assimes, T. L., Attia, J., Baker, L. D., Ballantyne, C., Bazzano, L., Boerwinkle, E., Cade, B., Chen, H. H., Chen, W., Ida Chen, Y. D., Chen, Z., Cho, K., De Anda-Duran, I., Dimitrov, L., Do, A., Edwards, T., Faquih, T., Hingorani, A., Fisher-Hoch, S. P., Gaziano, J. M., Gharib, S. A., Giri, A., Ghanbari, M., Grabe, H. J., Graff, M., Gu, C., He, J., Heikkinen, S., Hixson, J., Ho, Y. L., Hood, M. M., Houghton, S. C., Karvonen-Gutierrez, C. A., Kawaguchi, T., Kilpeläinen, T. O., Komulainen, P., Lin, H. J., Linchangco, G. V., Luik, A. I., Ma, J., Meigs, J. B., McCormick, J. B., Menni, C., Nolte, I. M., Norris, J. M., Petty, L. E., Polikowsky, H. G., Raffield, L. M., Rich, S. S., Riha, R. L., Russ, T. C., Ruiz-Narvaez, E. A., Sitlani, C. M., Smith, J. A., Snieder, H., Sofer, T., Shen, B., Tang, J., Taylor, K. D., Teder-Laving, M., Triatin, R., Tsai, M. Y., Völzke, H., Westerman, K. E., Xia, R., Yao, J., Young, K. L., Zhang, R., Zonderman, A. B., Zhu, X., Below, J. E., Cox, S. R., Evans, M., Fornage, M., Fox, E. R., Franceschini, N., Harlow, S. D., Holliday, E., Ikram, M. A., Kelly, T., Lakka, T. A., Lawlor, D. A., Li, C., Liu, C. T., Mägi, R., Manning, A. K., Matsuda, F., Morrison, A. C., Nauck, M., North, K. E., Penninx, B. W. J. H., Province, M. A., Psaty, B. M., Rotter, J. I., Spector, T. D., Wagenknecht, L. E., van Dijk, K. W., Jaquish, C. E., Wilson, P. W. F., Peyser, P. A., Munroe, P. B., de Vries, P. S., Gauderman, W. J., Sun, Y. V., Chen, H., Miller, C. L., Winkler, T. W., Rao, D. C., Redline, S. & van Heemst, D., Jan 2026, In: Atherosclerosis. 412, 120603.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      1   Link opens in a new tab Scopus citations

    • Large-scale blood pressure GWAS accounting for gene-depression interactions in 564,680 individuals from diverse populations

      Lee, S., Miller, C. L., Bentley, A. R., Brown, M. R., Nagarajan, P., Noordam, R., Morrison, J. L., Schwander, K., Westerman, K., Kho, M., Kraja, A. T., de Vries, P. S., Ammous, F., Aschard, H., Bartz, T. M., Do, A., Dupont, C. T., Feitosa, M. F., Gudmundsdottir, V. & Guo, X. & 129 others, Harris, S. E., Hikino, K., Huang, Z., Lefevre, C., Lyytikäinen, L. P., Milaneschi, Y., Nardone, G. G., Santin, A., Schmidt, H., Shen, B., Sofer, T., Sun, Q., Tan, Y. A., Tang, J., Thériault, S., van der Most, P. J., Ware, E. B., Weiss, S., Xing, W. Y., Yu, C., Zhao, W., Ansari, M. A. Y., Anugu, P., Attia, J. R., Bazzano, L. A., Bis, J. C., Breyer, M., Cade, B., Chen, G., Collins, S., Corley, J., Davies, G., Dörr, M., Du, J., Edwards, T. L., Faquih, T., Faul, J. D., Fohner, A. E., Fretts, A. M., Gangireddy, S., Gepner, A., Graff, M. E., Hofer, E., Homuth, G., Hood, M. M., Jie, X., Kähönen, M., Kardia, S. L. R., Karvonen-Gutierrez, C. A., Launer, L. J., Levy, D., Maheshwari, M., Martin, L. W., Matsuda, K., McNeil, J. J., Nolte, I. M., Okochi, T., Raffield, L. M., Raitakari, O. T., Risch, L., Risch, M., Roux, A. D., Ruiz-Narvaez, E. A., Russ, T. C., Saito, T., Schreiner, P. J., Scott, R. J., Shikany, J., Smith, J. A., Snieder, H., Spedicati, B., Tai, E. S., Taylor, A. M., Taylor, K. D., Tesolin, P., van Dam, R. M., Wang, R., Wenbin, W., Xie, T., Yao, J., Young, K. L., Zhang, R., Zonderman, A. B., Concas, M. P., Conen, D., Cox, S. R., Evans, M. K., Fox, E. R., de las Fuentes, L., Giri, A., Girotto, G., Grabe, H. J., Gu, C., Gudnason, V., Harlow, S. D., Holliday, E., Jost, J. B., Lacaze, P., Lee, S., Lehtimäki, T., Li, C., Liu, C. T., Morrison, A. C., North, K. E., Penninx, B. W. J. H., Peyser, P. A., Province, M. M., Psaty, B. M., Redline, S., Rosendaal, F. R., Rotimi, C. N., Rotter, J. I., Schmidt, R., Sim, X., Terao, C., Weir, D. R., Zhu, X., Franceschini, N., O’Connell, J. R., Jaquish, C. E., Wang, H., Manning, A., Munroe, P. B., Rao, D. C., Chen, H., Gauderman, W. J., Bierut, L. J., Winkler, T. W. & Fornage, M., Apr 9 2026, In: Human Genetics and Genomics Advances. 7, 2, 100566.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • Mosaic loss of Y chromosome associates with lung function, emphysema, and epigenetic aging

      NHLBI Trans-Omics for Precision Medicine Consortium, Jul 2026, In: American journal of respiratory and critical care medicine. 212, 7, p. 1483-1494 12 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      1   Link opens in a new tab Scopus citations

    • A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations

      Million Veteran Program, Nagarajan, P., Winkler, T. W., Bentley, A. R., Miller, C. L., Kraja, A. T., Schwander, K., Lee, S., Wang, W., Brown, M. R., Morrison, J. L., Giri, A., O’Connell, J. R., Bartz, T. M., de las Fuentes, L., Gudmundsdottir, V., Guo, X., Harris, S. E., Huang, Z. & Kals, M. & 181 others, Kho, M., Lefevre, C., Luan, J., Lyytikäinen, L. P., Mangino, M., Milaneschi, Y., Palmer, N. D., Rao, V., Rauramaa, R., Shen, B., Stadler, S., Sun, Q., Tang, J., Thériault, S., van der Graaf, A., van der Most, P. J., Wang, Y., Weiss, S., Westerman, K. E., Yang, Q., Yasuharu, T., Zhao, W., Zhu, W., Altschul, D., Ansari, M. A. Y., Anugu, P., Argoty-Pantoja, A. D., Arzt, M., Aschard, H., Attia, J. R., Bazzanno, L., Breyer, M. A., Brody, J. A., Cade, B. E., Chen, H. H., Chen, Y. D. I., Chen, Z., de Vries, P. S., Dimitrov, L. M., Do, A., Du, J., Dupont, C. T., Edwards, T. L., Evans, M. K., Faquih, T., Felix, S. B., Fisher-Hoch, S. P., Floyd, J. S., Graff, M., Gu, C., Gu, D., Hairston, K. G., Hanley, A. J., Heid, I. M., Heikkinen, S., Highland, H. M., Hood, M. M., Kähönen, M., Karvonen-Gutierrez, C. A., Kawaguchi, T., Kazuya, S., Kelly, T. N., Komulainen, P., Levy, D., Lin, H. J., Liu, P. Y., Marques-Vidal, P., McCormick, J. B., Mei, H., Meigs, J. B., Menni, C., Nam, K., Nolte, I. M., Pacheco, N. L., Petty, L. E., Polikowsky, H. G., Province, M. A., Psaty, B. M., Raffield, L. M., Raitakari, O. T., Rich, S. S., Riha, R. L., Risch, L., Risch, M., Ruiz-Narvaez, E. A., Scott, R. J., Sitlani, C. M., Smith, J. A., Sofer, T., Teder-Laving, M., Völker, U., Vollenweider, P., Wang, G., Willems van Dijk, K., Wilson, O. D., Xia, R., Yao, J., Young, K. L., Zhang, R., Zhu, X., Below, J. E., Böger, C. A., Conen, D., Cox, S. R., Dörr, M., Feitosa, M. F., Fox, E. R., Franceschini, N., Gharib, S. A., Gudnason, V., Harlow, S. D., He, J., Holliday, E. G., Kutalik, Z., Lakka, T. A., Lawlor, D. A., Lee, S., Lehtimäki, T., Li, C., Liu, C. T., Mägi, R., Matsuda, F., Morrison, A. C., Penninx, B. W. J. H., Peyser, P. A., Rotter, J. I., Snieder, H., Spector, T. D., Wagenknecht, L. E., Wareham, N. J., Zonderman, A. B., North, K. E., Fornage, M., Yen, A. W., Yeh, S. S., Xu, J., Wilson, P., Whooley, M., Whittle, J., Wells, J., Walsh, J., Villareal, G., Tandon, N., Strollo, P., Sriram, P., Smith, R., Sharma, S., Servatius, R., Rai, A. S., Rauchman, M., Potter, E., Poon, S., Petrakis, I., Oursler, K. A., Ong, M. K., Okusaga, O., Norton, J., Naik, E., Murdoch, M., Morgan, T., Morales, P., Moorman, J., Meyer, P., Mattocks, K., Mastorides, S., Marrache, R., Mahan, C. S., Lo, T. S., Lichy, J., Liangpunsakul, S., Liang, P., Landry, M., Kinlay, S., Jhala, D., Jacono, F., Iruvanti, P., Hurley, R., Hogan, D. J., Hamner, M., Harley, J. & Rao, D. C., Aug 2025, In: Molecular Psychiatry. 30, 8, p. 3660-3672 13 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      2   Link opens in a new tab Scopus citations
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