Charles Gu

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Charles Gu

Associate Professor of Biostatistics, Associate Professor of Genetics

 https://orcid.org/0000-0002-8527-8145

    Willing to Mentor

    Available to Mentor:

    PhD Students

    • 8148
      Citations
    1993 …2025

    Research activity per year

    Personal profile

    Research interests

    My current research focuses on two areas of genetic epidemiology and statistical human genetics. The first is the development and application of new statistical methods and bioinformatic tools to deal with high-dimensional data in genetic studies of complex human traits. Interests include machine learning techniques and fast and reliable discovery of important gene-gene and gene-environment interactions in high-throughput genetic studies of complex diseases. The second area is conducting real-world genetic studies on common human disease using the latest biotechnologies and most advanced analytical designs. Specific disease areas of interest include hypertension, hypertensive heart disease and cardiovascular diseases in general, obesity and metabolic syndrome, and kidney diseases.

    Available to Mentor:

    • PhD Students

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    Collaborations and top research areas from the last five years

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    • A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations

      Million Veteran Program, Nagarajan, P., Winkler, T. W., Bentley, A. R., Miller, C. L., Kraja, A. T., Schwander, K., Lee, S., Wang, W., Brown, M. R., Morrison, J. L., Giri, A., O’Connell, J. R., Bartz, T. M., de las Fuentes, L., Gudmundsdottir, V., Guo, X., Harris, S. E., Huang, Z. & Kals, M. & 181 others, Kho, M., Lefevre, C., Luan, J., Lyytikäinen, L. P., Mangino, M., Milaneschi, Y., Palmer, N. D., Rao, V., Rauramaa, R., Shen, B., Stadler, S., Sun, Q., Tang, J., Thériault, S., van der Graaf, A., van der Most, P. J., Wang, Y., Weiss, S., Westerman, K. E., Yang, Q., Yasuharu, T., Zhao, W., Zhu, W., Altschul, D., Ansari, M. A. Y., Anugu, P., Argoty-Pantoja, A. D., Arzt, M., Aschard, H., Attia, J. R., Bazzanno, L., Breyer, M. A., Brody, J. A., Cade, B. E., Chen, H. H., Chen, Y. D. I., Chen, Z., de Vries, P. S., Dimitrov, L. M., Do, A., Du, J., Dupont, C. T., Edwards, T. L., Evans, M. K., Faquih, T., Felix, S. B., Fisher-Hoch, S. P., Floyd, J. S., Graff, M., Gu, C., Gu, D., Hairston, K. G., Hanley, A. J., Heid, I. M., Heikkinen, S., Highland, H. M., Hood, M. M., Kähönen, M., Karvonen-Gutierrez, C. A., Kawaguchi, T., Kazuya, S., Kelly, T. N., Komulainen, P., Levy, D., Lin, H. J., Liu, P. Y., Marques-Vidal, P., McCormick, J. B., Mei, H., Meigs, J. B., Menni, C., Nam, K., Nolte, I. M., Pacheco, N. L., Petty, L. E., Polikowsky, H. G., Province, M. A., Psaty, B. M., Raffield, L. M., Raitakari, O. T., Rich, S. S., Riha, R. L., Risch, L., Risch, M., Ruiz-Narvaez, E. A., Scott, R. J., Sitlani, C. M., Smith, J. A., Sofer, T., Teder-Laving, M., Völker, U., Vollenweider, P., Wang, G., Willems van Dijk, K., Wilson, O. D., Xia, R., Yao, J., Young, K. L., Zhang, R., Zhu, X., Below, J. E., Böger, C. A., Conen, D., Cox, S. R., Dörr, M., Feitosa, M. F., Fox, E. R., Franceschini, N., Gharib, S. A., Gudnason, V., Harlow, S. D., He, J., Holliday, E. G., Kutalik, Z., Lakka, T. A., Lawlor, D. A., Lee, S., Lehtimäki, T., Li, C., Liu, C. T., Mägi, R., Matsuda, F., Morrison, A. C., Penninx, B. W. J. H., Peyser, P. A., Rotter, J. I., Snieder, H., Spector, T. D., Wagenknecht, L. E., Wareham, N. J., Zonderman, A. B., North, K. E., Fornage, M., Yen, A. W., Yeh, S. S., Xu, J., Wilson, P., Whooley, M., Whittle, J., Wells, J., Walsh, J., Villareal, G., Tandon, N., Strollo, P., Sriram, P., Smith, R., Sharma, S., Servatius, R., Rai, A. S., Rauchman, M., Potter, E., Poon, S., Petrakis, I., Oursler, K. A., Ong, M. K., Okusaga, O., Norton, J., Naik, E., Murdoch, M., Morgan, T., Morales, P., Moorman, J., Meyer, P., Mattocks, K., Mastorides, S., Marrache, R., Mahan, C. S., Lo, T. S., Lichy, J., Liangpunsakul, S., Liang, P., Landry, M., Kinlay, S., Jhala, D., Jacono, F., Iruvanti, P., Hurley, R., Hogan, D. J., Hamner, M., Harley, J. & Rao, D. C., Aug 2025, In: Molecular Psychiatry. 30, 8, p. 3660-3672 13 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies

      NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Li, X., Chen, H., Selvaraj, M. S., Van Buren, E., Zhou, H., Wang, Y., Sun, R., McCaw, Z. R., Yu, Z., Jiang, M. Z., DiCorpo, D., Gaynor, S. M., Dey, R., Arnett, D. K., Benjamin, E. J., Bis, J. C., Blangero, J., Boerwinkle, E. & Bowden, D. W. & 181 others, Brody, J. A., Cade, B. E., Carson, A. P., Carlson, J. C., Chami, N., Chen, Y. D. I., Curran, J. E., de Vries, P. S., Fornage, M., Franceschini, N., Freedman, B. I., Gu, C., Heard-Costa, N. L., He, J., Hou, L., Hung, Y. J., Irvin, M. R., Kaplan, R. C., Kardia, S. L. R., Kelly, T. N., Konigsberg, I., Kooperberg, C., Kral, B. G., Li, C., Li, Y., Lin, H., Liu, C. T., Loos, R. J. F., Mahaney, M. C., Martin, L. W., Mathias, R. A., Mitchell, B. D., Montasser, M. E., Morrison, A. C., Naseri, T., North, K. E., Palmer, N. D., Peyser, P. A., Psaty, B. M., Redline, S., Reiner, A. P., Rich, S. S., Sitlani, C. M., Smith, J. A., Taylor, K. D., Tiwari, H. K., Vasan, R. S., Viali, S., Wang, Z., Wessel, J., Yanek, L. R., Yu, B., de las Fuentes, L., de Andrade, M., Zoellner, S., Zody, M., Ziv, E., Zhu, X., Zhao, W., Zhao, S. X., Zhang, Y., Zekavat, S. M., Yu, K., Yang, I., Xu, H., Wu, J., Wu, B., Wong, Q., Winterkorn, L., Wilson, J., Wilson, C., Williams, S., Williams, L. K., Williams, K., Willer, C., Weng, L. C., Weiss, S. T., Weir, B., Weinstock, J., Weeks, D. E., Watt, J., Watson, K., Wang, J., Wang, H., Wang, F. F., Walts, A., Wallace, R., Walker, T., Vrieze, S., VandeHaar, P., Van Den Berg, D., Vaidya, D., Tsai, M., Tracy, R., Tong, C., Tishkoff, S., Tirschwell, D., Tinker, L., Threlkeld, M., Thornton, T. A., Telen, M., Taylor, S., Taylor, M., Taub, M., Tang, H., Taliun, D., Sériès, F., Szpiro, A., Sylvia, J., Sung, Y. J., Su, J. L., Streeten, E., Storm, G., Stilp, A. M., Sotoodehnia, N., Sofer, T., Snyder, M., Snively, B., Smoller, S., Smith, T., Smith, N., Smith, J., Smith, A. V., Skomro, R., Silverman, E., Silver, B., Shoemaker, M. B., Sheu, W. H. H., Shetty, A., Shetty, A., Sherman, S. L., Sheehan, V., Seidman, J., Seidman, C., Sciurba, F., Schwartz, D., Schwander, K., Santibanez, J., Sankaran, V. G., Sandow, K., Salzberg, S., Salvi, S., Salimi, S., Saleheen, D., Sabino, E. C., Ryan, K., Ruuska, S., Russell, P., Runnels, A., Ruczinski, I., Roselli, C., Dan Roden, R., Robine, N., Robillard, R., Sefuiva Reupena, M., Regan, E., Reeves, C., Reed, R., Ratan, A., Rasmussen-Torvik, L., Rao, D. C., Rajendran, M., Rafaels, N., Qin, Z., Qiao, D., Qasba, P., Preuss, M., Boorgula, M. P., Becker, J. P., Post, W., Pollin, T., Pleiness, J., Phillips, L. S., Peters, U., Perry, J., Perez, M., Peralta, J. M., Parker, C., Papanicolaou, G., Fulton, L. & Dutcher, S. K., Feb 2025, In: Nature Computational Science. 5, 2, p. 125-143 19 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      3 Scopus citations

    • Genetic determinants and genomic consequences of non-leukemogenic somatic point mutations

      Weinstock, J. S., Chaudhry, S. A., Ioannou, M., Viskadourou, M., Reventun, P., Jakubek, Y. A., Liggett, L. A., Laurie, C., Broome, J. G., Khan, A., Taylor, K. D., Guo, X., Peyser, P. A., Boerwinkle, E., Chami, N., Kenny, E. E., Loos, R. J., Psaty, B. M., Tracy, R. P. & Brody, J. A. & 34 others, Yun, J. H., Cho, M. H., Vasan, R. S., Kardia, S. L., Smith, J. A., Raffield, L. M., Bidulescu, A., O’Brien, E. C., de Andrade, M., Rotter, J. I., Rich, S. S., Chen, Y. D. I., Gu, C. C., Hsiung, C. A., Kooperberg, C., Haring, B., Nassir, R., Mathias, R., Reiner, A., Sankaran, V. G., Lowenstein, C. J., Blackwell, T. W., Abecasis, G. R., Smith, A. V., Kang, H. M., Natarajan, P., Jaiswal, S., Bick, A., Post, W. S., Scheet, P., Auer, P., Karantanos, T., Battle, A. & Arvanitis, M., Dec 2025, In: Nature communications. 16, 1, 9194.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • Refinement of a Published Gene-Physical Activity Interaction Impacting HDL-Cholesterol: Role of Sex and Lipoprotein Subfractions

      the CHARGE Gene-Lifestyle Interactions Working Group, Westerman, K. E., Kilpeläinen, T. O., Sevilla-Gonzalez, M., Connelly, M. A., Wood, A. C., Tsai, M. Y., Taylor, K. D., Rich, S. S., Rotter, J. I., Otvos, J. D., Bentley, A. R., Mora, S., Aschard, H., Rao, D. C., Gu, C., Chasman, D. I. & Manning, A. K., Jan 2025, In: Genetic Epidemiology. 49, 1, e22607.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk

      Regeneron Genetics Center, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Choi, S. H., Jurgens, S. J., Xiao, L., Hill, M. C., Haggerty, C. M., Sveinbjörnsson, G., Morrill, V. N., Marston, N. A., Weng, L. C., Pirruccello, J. P., Arnar, D. O., Gudbjartsson, D. F., Mantineo, H., von Falkenhausen, A. S., Natale, A., Tveit, A., Geelhoed, B. & Roselli, C. & 182 others, Van Wagoner, D. R., Darbar, D., Haase, D., Soliman, E. Z., Davogustto, G. E., Jun, G., Calkins, H., Anderson, J. L., Brody, J. A., Halford, J. L., Barnard, J., Hokanson, J. E., Smith, J. D., Bis, J. C., Young, K., Johnson, L. S. B., Risch, L., Gula, L. J., Kwee, L. C., Chaffin, M. D., Kühne, M., Preuss, M., Gupta, N., Nafissi, N. A., Smith, N. L., Nilsson, P. M., van der Harst, P., Wells, Q. S., Judy, R. L., Schnabel, R. B., Johnson, R., Smit, R. A. J., Gabriel, S., Knight, S., Furukawa, T., Blackwell, T. W., Nauffal, V., Wang, X., Min, Y. I., Yoneda, Z. T., Laksman, Z. W. M., Bezzina, C. R., Alonso, A., Psaty, B. M., Albert, C. M., Arking, D. E., Roden, D. M., Chasman, D. I., Rader, D. J., Conen, D., McManus, D. D., Fatkin, D., Benjamin, E. J., Boerwinkle, E., Marcus, G. M., Christophersen, I. E., Smith, J. G., Roberts, J. D., Raffield, L. M., Shoemaker, M. B., Cho, M. H., Cutler, M. J., Rienstra, M., Chung, M. K., S. Olesen, M., Sinner, M. F., Sotoodehnia, N., Kirchhof, P., Loos, R. J. F., Nazarian, S., Mohanty, S., Damrauer, S. M., Kaab, S., Heckbert, S. R., Redline, S., Shah, S. H., Tanaka, T., Ebana, Y., Wolf, S. E., Widom, L., Verweij, N., Ulloa, R. H., Staples, J. C., Siminovitch, K., Shuldiner, A., Schleicher, T. D., Salerno, W., Reid, J. G., Rasool, A., Pradhan, M., Polanco, T., Panea, R., Padilla, M. S., Overton, J. D., Orelus, M., O’Keeffe, S., Nielsen, J., Nafde, M., Mitnaul, L. J., Mighty, J., Maxwell, E. K., Mansfield, A. J., Manoochehri, K., Lotta, L. A., Lopez, A., Li, D., Lattari, M., Lanche, R., Krasheninina, O., Khalid, S., Karalis, K., Jones, M. B., Hawes, A., Habegger, L., Gu, Z., Fuller, E. D., Forsythe, C., Ferreira, M. A. R., Eom, G., Economides, A., Deubler, A., De, T., Coppola, G., Cantor, M., Boutkov, B., Beechert, C., Baras, A., Balasubramanian, S., Bai, X., Abecasis, G., Zoellner, S., Zody, M., Zhu, X., Zhao, W., Zhao, S. X., Zhang, Y., Zekavat, S. M., Yu, K., Yang, I., Yanek, L., Xu, H., Wu, J., Wong, Q., Winterkorn, L., Wilson, J., Wilson, C., Williams, L. K., Williams, K., Willer, C., Wessel, J., Weiss, S. T., Weir, B., Weinstock, J., Weeks, D. E., Watt, J., Watson, K., Wang, J., Wang, H., Wang, F. F., Walts, A., Wallace, R., Walker, T., Vrieze, S., VandeHaar, P., Van Den Berg, D., Vaidya, D., Tsai, M., Tracy, R., Tong, C., Tiwari, H., Tishkoff, S., Tirschwell, D., Tinker, L., Threlkeld, M., Thornton, T. A., Telen, M., Sung, Y. J., Rao, D. C., Gu, C. C., Fulton, L., Dutcher, S. K. & de las Fuentes, L., Mar 2025, In: Nature Genetics. 57, 3, p. 548-562 15 p., e020163.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      11 Scopus citations
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