Personal profile

Research interests

My current research focuses on two areas of genetic epidemiology and statistical human genetics. The first is the development and application of new statistical methods and bioinformatic tools to deal with high-dimensional data in genetic studies of complex human traits. Interests include machine learning techniques and fast and reliable discovery of important gene-gene and gene-environment interactions in high-throughput genetic studies of complex diseases. The second area is conducting real-world genetic studies on common human disease using the latest biotechnologies and most advanced analytical designs. Specific disease areas of interest include hypertension, hypertensive heart disease and cardiovascular diseases in general, obesity and metabolic syndrome, and kidney diseases.

Available to Mentor:

  • PhD/MSTP Students

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Collaborations and top research areas from the last five years

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  • A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels

    Trans-Omics for Precision Medicine (TOPMed) program, The INVENT Consortium, de Vries, P. S., Reventun, P., Brown, M. R., Heath, A. S., Huffman, J. E., Le, N. Q., Bebo, A., Brody, J. A., Temprano-Sagrera, G., Raffield, L. M., Ozel, A. B., Thibord, F., Jain, D., Lewis, J. P., Rodriguez, B. A. T., Pankratz, N., Taylor, K. D. & Polasek, O. & 182 others, Chen, M. H., Yanek, L. R., Carrasquilla, G. D., Marioni, R. E., Kleber, M. E., Trégouët, D. A., Yao, J., Li-Gao, R., Joshi, P. K., Trompet, S., Martinez-Perez, A., Ghanbari, M., Howard, T. E., Reiner, A. P., Arvanitis, M., Ryan, K. A., Bartz, T. M., Rudan, I., Faraday, N., Linneberg, A., Ekunwe, L., Davies, G., Delgado, G. E., Suchon, P., Guo, X., Rosendaal, F. R., Klaric, L., Noordam, R., van Rooij, F., Curran, J. E., Wheeler, M. M., Osburn, W. O., O'Connell, J. R., Boerwinkle, E., Beswick, A., Psaty, B. M., Kolcic, I., Souto, J. C., Becker, L. C., Hansen, T., Doyle, M. F., Harris, S. E., Moissl, A. P., Deleuze, J. F., Rich, S. S., van Hylckama Vlieg, A., Campbell, H., Stott, D. J., Soria, J. M., de Maat, M. P. M., Almasy, L., Brody, L. C., Auer, P. L., Abe, N., Abecasis, G., Aguet, F., Albert, C., Alonso, A., Ament, S., Anderson, P., Anugu, P., Applebaum-Bowden, D., Ardlie, K., Arking, D., Arnett, D. K., Ashley-Koch, A., Aslibekyan, S., Assimes, T., Auer, P., Avramopoulos, D., Ayas, N., Balasubramanian, A., Barnard, J., Barnes, K., Barr, R. G., Barron-Casella, E., Barwick, L., Beaty, T., Beck, G., Becker, D., Becker, L., Beer, R., Beitelshees, A., Benjamin, E., Benos, T., Bezerra, M., Bielak, L., Bis, J., Blackwell, T., Blangero, J., Blue, N., Bowden, D. W., Bowler, R., Brody, J., Broeckel, U., Broome, J., Brown, D., Bunting, K., Burchard, E., Bustamante, C., Buth, E., Cade, B., Cardwell, J., Carey, V., Carrier, J., Carson, A. P., Carty, C., Casaburi, R., Casas Romero, J. P., Casella, J., Castaldi, P., Chaffin, M., Chang, C., Chang, Y. C., Chasman, D., Chavan, S., Chen, B. J., Chen, W. M., Ida Chen, Y. D., Cho, M., Choi, S. H., Chuang, L. M., Chung, M., Chung, R. H., Clish, C., Comhair, S., Conomos, M., Cornell, E., Correa, A., Crandall, C., Crapo, J., Cupples, L. A., Curran, J., Curtis, J., Custer, B., Damcott, C., Darbar, D., David, S., Davis, C., Daya, M., de Andrade, M., de las Fuentes, L., de Vries, P., DeBaun, M., Deka, R., DeMeo, D., Devine, S., Dinh, H., Doddapaneni, H., Duan, Q., Dugan-Perez, S., Duggirala, R., Durda, J. P., Dutcher, S. K., Eaton, C., El Boueiz, A., Ellinor, P., Emery, L., Erzurum, S., Farber, C., Farek, J., Fingerlin, T., Flickinger, M., Fornage, M., Franceschini, N., Frazar, C., Fu, M., Fullerton, S. M., Fulton, L., Gabriel, S., Gan, W., Gao, S., Gao, Y., Gass, M., Geiger, H., Gelb, B., Geraci, M., Germer, S., Gerszten, R., Gu, C. C., Rao, D. C. & Sung, Y. J., May 2 2024, In: Blood. 143, 18, p. 1845-1855 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    3 Scopus citations
  • Epigenetic and proteomic signatures associate with clonal hematopoiesis expansion rate

    Mack, T. M., Raddatz, M. A., Pershad, Y., Nachun, D. C., Taylor, K. D., Guo, X., Shuldiner, A. R., O’Connell, J. R., Kenny, E. E., Loos, R. J. F., Redline, S., Cade, B. E., Psaty, B. M., Bis, J. C., Brody, J. A., Silverman, E. K., Yun, J. H., Cho, M. H., DeMeo, D. L. & Levy, D. & 25 others, Johnson, A. D., Mathias, R. A., Yanek, L. R., Heckbert, S. R., Smith, N. L., Wiggins, K. L., Raffield, L. M., Carson, A. P., Rotter, J. I., Rich, S. S., Manichaikul, A. W., Gu, C. C., Chen, Y. D. I., Lee, W. J., Shoemaker, M. B., Roden, D. M., Kooperberg, C., Auer, P. L., Desai, P., Blackwell, T. W., Smith, A. V., Reiner, A. P., Jaiswal, S., Weinstock, J. S. & Bick, A. G., Aug 2024, In: Nature Aging. 4, 8, p. 1043-1052 10 p.

    Research output: Contribution to journalLetterpeer-review

    2 Scopus citations
  • Machine learning models for predicting blood pressure phenotypes by combining multiple polygenic risk scores

    Hrytsenko, Y., Shea, B., Elgart, M., Kurniansyah, N., Lyons, G., Morrison, A. C., Carson, A. P., Haring, B., Mitchell, B. D., Psaty, B. M., Jaeger, B. C., Gu, C. C., Kooperberg, C., Levy, D., Lloyd-Jones, D., Choi, E., Brody, J. A., Smith, J. A., Rotter, J. I. & Moll, M. & 17 others, Fornage, M., Simon, N., Castaldi, P., Casanova, R., Chung, R. H., Kaplan, R., Loos, R. J. F., Kardia, S. L. R., Rich, S. S., Redline, S., Kelly, T., O’Connor, T., Zhao, W., Kim, W., Guo, X., Ida Chen, Y. D. & Sofer, T., Dec 2024, In: Scientific reports. 14, 1, 12436.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    1 Scopus citations
  • Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis

    NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Apr 27 2023, In: Nature. 616, 7958, p. 755-763 9 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    36 Scopus citations
  • Activation of Endothelial Large Conductance Potassium Channels Protects against TNF-α-Induced Inflammation

    Zyrianova, T., Zou, K., Lopez, B., Liao, A., Gu, C., Olcese, R. & Schwingshackl, A., Feb 2023, In: International journal of molecular sciences. 24, 4, 4087.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    3 Scopus citations