• 3981 Citations
1993 …2020

Research output per year

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Personal profile

Research interests

My current research focuses on two areas of genetic epidemiology and statistical human genetics. The first is the development and application of new statistical methods and bioinformatic tools to deal with high-dimensional data in genetic studies of complex human traits. Interests include machine learning techniques and fast and reliable discovery of important gene-gene and gene-environment interactions in high-throughput genetic studies of complex diseases. The second area is conducting real-world genetic studies on common human disease using the latest biotechnologies and most advanced analytical designs. Specific disease areas of interest include hypertension, hypertensive heart disease and cardiovascular diseases in general, obesity and metabolic syndrome, and kidney diseases.

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Research Output

ATRAID regulates the action of nitrogen-containing bisphosphonates on bone

Surface, L. E., Burrow, D. T., Li, J., Park, J., Kumar, S., Lyu, C., Song, N., Yu, Z., Rajagopal, A., Bae, Y., Lee, B. H., Mumm, S., Gu, C. C., Baker, J. C., Mohseni, M., Sum, M., Huskey, M., Duan, S., Bijanki, V. N., Civitelli, R. & 18 others, Gardner, M. J., McAndrew, C. M., Ricci, W. M., Gurnett, C. A., Diemer, K., Wan, F., Costantino, C. L., Shannon, K. M., Raje, N., Dodson, T. B., Haber, D. A., Carette, J. E., Varadarajan, M., Brummelkamp, T. R., Birsoy, K., Sabatini, D. M., Haller, G. & Peterson, T. R., May 20 2020, In : Science translational medicine. 12, 544, eaav9166.

Research output: Contribution to journalArticle

  • 2 Scopus citations

    Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale

    TOPMed Lipids Working Group & NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Sep 1 2020, In : Nature Genetics. 52, 9, p. 969-983 15 p.

    Research output: Contribution to journalArticle

  • Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

    Lifelines Cohort Study, 2020, (Accepted/In press) In : Molecular Psychiatry.

    Research output: Contribution to journalArticle

  • 1 Scopus citations
    Open Access
  • Uncovering the complex genetics of human personality: response from authors on the PGMRA Model

    Zwir, I., Mishra, P., Del-Val, C., Gu, C. C., de Erausquin, G. A., Lehtimäki, T. & Cloninger, C. R., Oct 1 2020, In : Molecular Psychiatry. 25, 10, p. 2210-2213 4 p.

    Research output: Contribution to journalLetter

    Open Access
    3 Scopus citations