Research output per year
Research output per year
Personal profile
Research interests
We are interested in developing novel optical imaging technologies for biomedical applications, especially in developing optical coherence tomography (OCT) and microscopy (OCM) technologies to perform "optical biopsy" and generate 3D in situ images of tissue morphology, function and pathological status in real-time without the need to remove and process specimens.
We are also interested in applying these technologies to a variety of biological and clinical applications, including cancer research, neuroscience, developmental biology and tissue engineering.
Projects include:
- Space-division multiplexing optical coherence tomography (SDM-OCT)
- Molecular-targeted OCT and OCM for cancer detection
- OCT and OCM Imaging in Developmental Biology
- 3D OCT imaging of Brain Functions
- OCT (OCM) combined with deep learning
- Optogenetic pacing in Drosophila melanogaster using integrated OCM imaging and red light stimulation system.
Available to Mentor:
- PhD/MSTP Students
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Collaborations and top research areas from the last five years
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Attention LSTM U-Net model for Drosophila melanogaster heart tube segmentation in optical coherence microscopy images
Ouyang, X., Matt, A., Wang, F., Gracheva, E., Migunova, E., Rajamani, S., Dubrovsky, E. B. & Zhou, C., Jun 1 2024, In: Biomedical Optics Express. 15, 6, p. 3639-3653 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Drosophila melanogaster heart tube segmentation in optical coherence tomography through an attention LSTM U-Net model
Ouyang, X., Matt, A., Wang, F., Gracheva, E. & Zhou, C., 2024, Diagnostic and Therapeutic Applications of Light in Cardiology 2024. Marcu, L., van Soest, G. & Bourantas, C. (eds.). SPIE, 128190W. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 12819).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review
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Dynamic contrast optical coherence tomography (DyC-OCT) for label-free live cell imaging
Ren, C., Hao, S., Wang, F., Matt, A., Amaral, M. M., Yang, D., Wang, L. & Zhou, C., Dec 2024, In: Communications Biology. 7, 1, 278.Research output: Contribution to journal › Short survey › peer-review
Open Access1 Scopus citations -
3D-cultured blastoids model human embryogenesis from pre-implantation to early gastrulation stages
Karvas, R. M., Zemke, J. E., Ali, S. S., Upton, E., Sane, E., Fischer, L. A., Dong, C., Park, K. M., Wang, F., Park, K., Hao, S., Chew, B., Meyer, B., Zhou, C., Dietmann, S. & Theunissen, T. W., Sep 7 2023, In: Cell Stem Cell. 30, 9, p. 1148-1165.e7Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
3D motion tracking using optical coherence tomography based on circular scan patterns
Hao, S., Amaral, M. M. & Zhou, C., 2023, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII. Izatt, J. A. & Fujimoto, J. G. (eds.). SPIE, 1236717. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 12367).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review