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Research interests

Tau dysfunction is implicated in many neurodegenerative diseases, including Alzheimer’s disease, frontotemporal dementia, progressive supranuclear palsy, corticobasal degeneration, and Pick’s disease. Most of these diseases are characterized by tau protein aggregation and are termed tauopathies. In these diseases, tau is affected at the molecular (splicing), protein (hyperphosphorylation, cleavage, aggregation), and cellular (secretion) levels. Thus, defining the molecular mechanisms underlying tauopathies require unraveling the complexities of the MAPT gene that encodes the tau protein, tau protein dysfunction within the cell, and the cell-cell interactions that produce pathology in the human brain. We use traditional immortalize and human induced pluripotent stem cell-derived neuron and astrocytes to define the molecular and cellular mechanisms underlying tauopathies.

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Research Output

Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer's Disease

Dominantly Inherited Alzheimer Network (DIAN) & PREVENT-AD Research Group, 2020, (Accepted/In press) In : Biological Psychiatry.

Research output: Contribution to journalArticle

  • 1 Scopus citations

    A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease

    the Dominantly Inherited Alzheimer Network, Mar 1 2020, In : Nature medicine. 26, 3, p. 398-407 10 p.

    Research output: Contribution to journalArticle

  • 18 Scopus citations

    Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN)

    Dominantly Inherited Alzheimer Network, Jan 1 2020, In : Alzheimer's and Dementia. 16, 1, p. 219-228 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models

    Gregory, J. A., Hoelzli, E., Abdelaal, R., Braine, C., Cuevas, M., Halpern, M., Barretto, N., Schrode, N., Akbalik, G., Kang, K., Cheng, E., Bowles, K., Lotz, S., Goderie, S., Karch, C. M., Temple, S., Goate, A., Brennand, K. J. & Phatnani, H., Jun 5 2020, In : Cells. 9, 6

    Research output: Contribution to journalArticle

    Open Access
  • Heavy metals contaminating the environment of a progressive supranuclear palsy cluster induce tau accumulation and cell death in cultured neurons

    Alquezar, C., Felix, J. B., McCandlish, E., Buckley, B. T., Caparros-Lefebvre, D., Karch, C. M., Golbe, L. I. & Kao, A. W., Dec 1 2020, In : Scientific reports. 10, 1, 569.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations