• 819 Citations

Research output per year

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Personal profile

Research interests

Our lab's overall focus is to understand how mutations in extracellular matrix genes lead to abnormal vascular development and disease. Similar to humans with cutis laxa caused by mutations in the extracellular matrix gene Fibulin-4; mice carrying mutations in Fibulin-4 develop aortic aneurysms and arterial tortuosity thought to be related to abnormal elastic fiber formation. Examination of the vasculature in this model showed surprising and previously unrecognized differences in the development of large conduit arteries versus small resistance arteries where elastic fibers of large conduit arteries were fragmented and disorganized, while those of small arteries muscular arteries were intact, suggesting that the process of elastic fiber assembly differs along the vascular tree. The aims of our lab are to understand the mechanisms by which mutations in Fibulin-4 lead to aneurysm development and to investigate differences in the development of small versus large arteries.

Areas of Clinical Interest

Diagnosis and management of congenital anomalies of the kidney and urinary tract, chronic kidney disease, hypertension, kidney stones, urinary tract infections, glomerular diseases including nephrotic and nephritic syndromes, and electrolyte disorders

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Research Output

  • 819 Citations
  • 19 Article
  • 1 Chapter
  • 1 Comment/debate
  • 1 Review article

Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by KATP channel overactivity

McClenaghan, C., Huang, Y., Yan, Z., Harter, T. M., Halabi, C. M., Chalk, R., Kovacs, A., Van Haaften, G., Remedi, M. S. & Nichols, C. G., Mar 2 2020, In : Journal of Clinical Investigation. 130, 3, p. 1116-1121 6 p.

Research output: Contribution to journalArticle

Open Access
  • 4 Scopus citations

    Vascular elastic fiber heterogeneity in health and disease

    Halabi, C. M. & Kozel, B. A., May 1 2020, In : Current opinion in hematology. 27, 3, p. 190-196 7 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations
    Open Access
  • Sodium-activated potassium channels moderate excitability in vascular smooth muscle

    Li, P., Halabi, C. M., Stewart, R., Butler, A., Brown, B., Xia, X., Santi, C., England, S., Ferreira, J., Mecham, R. P. & Salkoff, L., Oct 1 2019, In : Journal of Physiology. 597, 20, p. 5093-5108 16 p.

    Research output: Contribution to journalArticle

  • Cardiovascular consequences of KATP overactivity in Cantu syndrome

    Huang, Y., McClenaghan, C., Harter, T. M., Hinman, K., Halabi, C. M., Matkovich, S. J., Zhang, H., Brown, G. S., Mecham, R. P., England, S. K., Kovacs, A., Remedi, M. S. & Nichols, C. G., Aug 9 2018, In : JCI Insight. 3, 15

    Research output: Contribution to journalArticle

  • 12 Scopus citations