Carlos Cruchaga

2024

A genetic and proteomic comparison of key AD biomarkers across tissues

Dominantly Inherited Alzheimer Network, 2024, (Accepted/In press) In: Alzheimer's and Dementia.

Research output: Contribution to journal › Article › peer-review

Open Access

Alzheimer's polygenic risk scores are associated with cognitive phenotypes in Down syndrome

Gorijala, P., Aslam, M. M., Dang, L. H. T., Xicota, L., Fernandez, M. V., Sung, Y. J., Fan, K. H., Feingold, E., Surace, E. I., Chhatwal, J. P., Hom, C. L., Hartley, S. L., Hassenstab, J., Perrin, R. J., Mapstone, M., Zaman, S. H., Ances, B. M., Kamboh, M. I., Lee, J. H. & Cruchaga, C., Feb 2024, In: Alzheimer's and Dementia. 20, 2, p. 1038-1049 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

An interpretable machine learning-based cerebrospinal fluid proteomics clock for predicting age reveals novel insights into brain aging

Melendez, J., Sung, Y. J., Orr, M., Yoo, A., Schindler, S., Cruchaga, C. & Bateman, R., 2024, (Accepted/In press) In: Aging Cell.

Research output: Contribution to journal › Article › peer-review

Open Access

Apolipoprotein E in Alzheimer’s disease trajectories and the next-generation clinical care pathway

Narasimhan, S., Holtzman, D. M., Apostolova, L. G., Cruchaga, C., Masters, C. L., Hardy, J., Villemagne, V. L., Bell, J., Cho, M. & Hampel, H., Jul 2024, In: Nature neuroscience. 27, 7, p. 1236-1252 17 p.

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Baseline levels and longitudinal changes in plasma Aβ42/40 among Black and white individuals

Xiong, C., Luo, J., Wolk, D. A., Shaw, L. M., Roberson, E. D., Murchison, C. F., Henson, R. L., Benzinger, T. L. S., Bui, Q., Agboola, F., Grant, E., Gremminger, E. N., Moulder, K. L., Geldmacher, D. S., Clay, O. J., Babulal, G., Cruchaga, C., Holtzman, D. M., Bateman, R. J. & Morris, J. C. & 1 others, Schindler, S. E., Dec 2024, In: Nature communications. 15, 1, 5539.

Research output: Contribution to journal › Article › peer-review

Open Access

Biobank-wide association scan identifies risk factors for late-onset Alzheimer's disease and endophenotypes

Alzheimer's Disease Genetics Consortium (ADGC), May 24 2024, In: eLife. 12

Research output: Contribution to journal › Article › peer-review

Open Access

Blood-Based Proteomics for Adult-Onset Focal Dystonias

Timsina, J., Dinasarapu, A., Kilic-Berkmen, G., Budde, J., Sung, Y. J., Klein, A. M., Cruchaga, C. & Jinnah, H. A., Jul 2024, In: Annals of neurology. 96, 1, p. 110-120 11 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Comparison of cerebrospinal fluid, plasma and neuroimaging biomarker utility in Alzheimer’s disease

Meeker, K. L., Luckett, P. H., Barthélemy, N. R., Hobbs, D. A., Chen, C., Bollinger, J., Ovod, V., Flores, S., Keefe, S., Henson, R. L., Herries, E. M., McDade, E., Hassenstab, J. J., Xiong, C., Cruchaga, C., Benzinger, T. L. S., Holtzman, D. M., Schindler, S. E., Bateman, R. J. & Morris, J. C. & 2 others, Gordon, B. A. & Ances, B. M., 2024, In: Brain Communications. 6, 2

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study

Alzheimer's Biomarker Consortium–Down Syndrome & Dominantly Inherited Alzheimer Network, May 2024, In: The Lancet Neurology. 23, 5, p. 500-510 11 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson’s disease

Rutledge, J., Lehallier, B., Zarifkar, P., Losada, P. M., Shahid-Besanti, M., Western, D., Gorijala, P., Ryman, S., Yutsis, M., Deutsch, G. K., Mormino, E., Trelle, A., Wagner, A. D., Kerchner, G. A., Tian, L., Cruchaga, C., Henderson, V. W., Montine, T. J., Borghammer, P. & Wyss-Coray, T. & 1 others, Poston, K. L., Jun 2024, In: Acta Neuropathologica. 147, 1, 52.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

CSF biomarkers of immune activation and Alzheimer’s disease for predicting cognitive impairment risk in the elderly

Shue, F., White, L. J., Hendrix, R. D., Ulrich, J., Henson, R. L., Knight, W., Martens, Y. A., Wang, N., Roy, B., Starling, S. C., Ren, Y., Xiong, C., Asmann, Y. W., Syrjanen, J. A., Vassilaki, M., Mielke, M. M., Timsina, J., Sung, Y. J., Cruchaga, C. & Holtzman, D. M. & 4 others, Bu, G., Petersen, R. C., Heckman, M. G. & Kanekiyo, T., Apr 2024, In: Science Advances. 10, 14, eadk3674.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Deconstructing pathological tau by biological process in early stages of Alzheimer disease: a method for quantifying tau spatial spread in neuroimaging

the Dominantly Inherited Alzheimer Network (DIAN) Investigators, May 2024, In: EBioMedicine. 103, 105080.

Research output: Contribution to journal › Article › peer-review

Open Access

Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease: The DIAN-TU-001 Randomized Clinical Trial

Wagemann, O., Liu, H., Wang, G., Shi, X., Bittner, T., Scelsi, M. A., Farlow, M. R., Clifford, D. B., Supnet-Bell, C., Santacruz, A. M., Aschenbrenner, A. J., Hassenstab, J. J., Benzinger, T. L. S., Gordon, B. A., Coalier, K. A., Cruchaga, C., Ibanez, L., Perrin, R. J., Xiong, C. & Li, Y. & 30 others, Morris, J. C., Lah, J. J., Berman, S. B., Roberson, E. D., Van Dyck, C. H., Galasko, D., Gauthier, S., Hsiung, G. Y. R., Brooks, W. S., Pariente, J., Mummery, C. J., Day, G. S., Ringman, J. M., Mendez, P. C., St. George-Hyslop, P., Fox, N. C., Suzuki, K., Okhravi, H. R., Chhatwal, J., Levin, J., Jucker, M., Sims, J. R., Holdridge, K. C., Proctor, N. K., Yaari, R., Andersen, S. W., Mancini, M., Llibre-Guerra, J., Bateman, R. J. & McDade, E., Jun 10 2024, In: JAMA Neurology. 81, 6, p. 582-593 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Epistatic Features and Machine Learning Improve Alzheimer’s Disease Risk Prediction Over Polygenic Risk Scores

the Alzheimer's Disease Neuroimaging Initiative, Jun 11 2024, In: Journal of Alzheimer's Disease. 99, 4, p. 1425-1440 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Genetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center

Fernandez, M. V., Liu, M., Beric, A., Johnson, M., Cetin, A., Patel, M., Budde, J., Kohlfeld, P., Bergmann, K., Lowery, J., Flynn, A., Brock, W., Sanchez Montejo, B., Gentsch, J., Sykora, N., Norton, J., Gentsch, J., Valdez, O., Gorijala, P. & Sanford, J. & 24 others, Sun, Y., Wang, C., Western, D., Timsina, J., Mangetti Goncalves, T., Do, A. N., Sung, Y. J., Zhao, G., Morris, J. C., Moulder, K., Holtzman, D. M., Bateman, R. J., Karch, C., Hassenstab, J., Xiong, C., Schindler, S. E., Balls-Berry, J., Benzinger, T. L. S., Perrin, R. J., Denny, A., Snider, B. J., Stark, S. L., Ibanez, L. & Cruchaga, C., Dec 2024, In: Scientific data. 11, 1, 768.

Research output: Contribution to journal › Article › peer-review

Open Access

Genetic Complexities of Cerebral Small Vessel Disease, Blood Pressure, and Dementia

Sargurupremraj, M., Soumaré, A., Bis, J. C., Surakka, I., Jürgenson, T., Joly, P., Knol, M. J., Wang, R., Yang, Q., Satizabal, C. L., Gudjonsson, A., Mishra, A., Bouteloup, V., Phuah, C. L., Van Duijn, C. M., Cruchaga, C., Dufouil, C., Chêne, G., Lopez, O. L. & Psaty, B. M. & 14 others, Tzourio, C., Amouyel, P., Adams, H. H., Jacqmin-Gadda, H., Ikram, M. A., Gudnason, V., Milani, L., Winsvold, B. S., Hveem, K., Matthews, P. M., Longstreth, W. T., Seshadri, S., Launer, L. J. & Debette, S., May 22 2024, In: JAMA Network Open. 7, 5, e2412824.

Research output: Contribution to journal › Article › peer-review

Open Access

Genome and clonal hematopoiesis stability contrasts with immune, cfDNA, mitochondrial, and telomere length changes during short duration spaceflight

Garcia-Medina, J. S., Sienkiewicz, K., Narayanan, S. A., Overbey, E. G., Grigorev, K., Ryon, K. A., Burke, M., Proszynski, J., Tierney, B., Schmidt, C. M., Mencia-Trinchant, N., Klotz, R., Ortiz, V., Foox, J., Chin, C., Najjar, D., Matei, I., Chan, I., Cruchaga, C. & Kleinman, A. & 23 others, Kim, J. K., Lucaci, A., Loy, C., Mzava, O., De Vlaminck, I., Singaraju, A., Taylor, L. E., Schmidt, J. C., Schmidt, M. A., Blease, K., Moreno, J., Boddicker, A., Zhao, J., Lajoie, B., Altomare, A., Kruglyak, S., Levy, S., Yu, M., Hassane, D. C., Bailey, S. M., Bolton, K., Mateus, J. & Mason, C. E., Mar 1 2024, In: Precision Clinical Medicine. 7, 1, pbae007.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Harmonization of CSF and imaging biomarkers in Alzheimer's disease: Need and practical applications for genetics studies and preclinical classification

Timsina, J., Ali, M., Do, A., Wang, L., Western, D., Sung, Y. J. & Cruchaga, C., Jan 2024, In: Neurobiology of Disease. 190, 106373.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Human whole-exome genotype data for Alzheimer’s disease

Leung, Y. Y., Naj, A. C., Chou, Y. F., Valladares, O., Schmidt, M., Hamilton-Nelson, K., Wheeler, N., Lin, H., Gangadharan, P., Qu, L., Clark, K., Kuzma, A. B., Lee, W. P., Cantwell, L., Nicaretta, H., van der Lee, S., English, A., Kalra, D., Muzny, D. & Skinner, E. & 121 others, Doddapeneni, H., Dinh, H., Hu, J., Santibanez, J., Jayaseelan, J., Worley, K., Gibbs, R. A., Lee, S., Dugan-Perez, S., Korchina, V., Nasser, W., Liu, X., Han, Y., Zhu, Y., Liu, Y., Khan, Z., Zhu, C., Sun, F. J., Jun, G. R., Chung, J., Farrell, J., Zhang, X., Banks, E., Gupta, N., Gabriel, S., Butkiewicz, M., Benchek, P., Smieszek, S., Song, Y., Vardarajan, B., Reitz, C., Reyes-Dumeyer, D., Tosto, G., De Jager, P. L., Barral, S., Ma, Y., Beiser, A., Liu, C. T., Dupuis, J., Lunetta, K., Cupples, L. A., Choi, S. H., Chen, Y., Mez, J., Vanderspek, A., Ikram, M. A., Ahmad, S., Faber, K., Foroud, T., Mlynarski, E., Schmidt, H., Schmidt, R., Kunkle, B., Rajabli, F., Beecham, G., Vance, J. M., Adams, L. D., Cuccaro, M., Mena, P., Booth, B. M., Renton, A., Goate, A., Marcora, E., Stine, A., Feolo, M., Launer, L. J., Koboldt, D. C., Wilson, R. K., van Duijn, C., Amin, N., Kapoor, M., Salerno, W., Bennett, D. A., Xia, L. C., Malamon, J., Mosley, T. H., Satizabal, C., Jan Bressler, B., Jian, X., Nato, A. Q., Horimoto, A. R., Wang, B., Psaty, B., Witten, D., Tsuang, D., Blue, E., Wijsman, E., Sohi, H., Nguyen, H., Bis, J. C., Rice, K., Brown, L., Dorschner, M., Saad, M., Navas, P., Nafikov, R., Thornton, T., Day, T., Haut, J., Sha, J., Zhang, N., Iqbal, T., Zhao, Y., Below, J. E., Larson, D. E., Appelbaum, E., Waligorski, J., Antonacci-Fulton, L., Fulton, R. S., Haines, J., Farrer, L., Seshadri, S., Brkanac, Z., Cruchaga, C., Pericak-Vance, M., Mayeux, R. P., Bush, W. S., Destefano, A., Martin, E., Schellenberg, G. D. & Wang, L. S., Dec 2024, In: Nature communications. 15, 1, 684.

Research output: Contribution to journal › Article › peer-review

Open Access

Investigating White Matter Neuroinflammation in Alzheimer Disease Using Diffusion-Based Neuroinflammation Imaging

Wang, Q., Schindler, S. E., Chen, G., Mckay, N. S., McCullough, A., Flores, S., Liu, J., Sun, Z., Wang, S., Wang, W., Hassenstab, J., Cruchaga, C., Perrin, R. J., Niven, A., Morris, J. C., Wang, Y. & Benzinger, T. L. S., Feb 1 2024, In: Neurology. 102, 4, p. e208013

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Investigation of sex differences in mutation carriers of the Dominantly Inherited Alzheimer Network

Wagemann, O., Li, Y., Hassenstab, J., Aschenbrenner, A. J., McKay, N. S., Gordon, B. A., Benzinger, T. L. S., Xiong, C., Cruchaga, C., Renton, A. E., Perrin, R. J., Berman, S. B., Chhatwal, J. P., Farlow, M. R., Day, G. S., Ikeuchi, T., Jucker, M., Lopera, F., Mori, H. & Noble, J. M. & 8 others, Sánchez-Valle, R., Schofield, P. R., Morris, J. C., Daniels, A., Levin, J., Bateman, R. J., McDade, E. & Llibre-Guerra, J. J., Jan 2024, In: Alzheimer's and Dementia. 20, 1, p. 47-62 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease

Kim, J. J., Vitale, D., Otani, D. V., Lian, M. M., Heilbron, K., Aslibekyan, S., Auton, A., Babalola, E., Bell, R. K., Bielenberg, J., Bryc, K., Bullis, E., Cannon, P., Coker, D., Partida, G. C., Dhamija, D., Das, S., Elson, S. L., Eriksson, N. & Filshtein, T. & 279 others, Fitch, A., Fletez-Brant, K., Fontanillas, P., Freyman, W., Granka, J. M., Hernandez, A., Hicks, B., Hinds, D. A., Jewett, E. M., Jiang, Y., Kukar, K., Kwong, A., Lin, K. H., Llamas, B. A., Lowe, M., McCreight, J. C., McIntyre, M. H., Micheletti, S. J., Moreno, M. E., Nandakumar, P., Nguyen, D. T., Noblin, E. S., O’Connell, J., Petrakovitz, A. A., Poznik, G. D., Reynoso, A., Schloetter, M., Schumacher, M., Shastri, A. J., Shelton, J. F., Shi, J., Shringarpure, S., Su, Q. J., Tat, S. A., Tchakouté, C. T., Tran, V., Tung, J. Y., Wang, X., Wang, W., Weldon, C. H., Wilton, P., Wong, C. D., Iwaki, H., Lake, J., Solsberg, C. W., Leonard, H., Makarious, M. B., Tan, E. K., Singleton, A. B., Bandres-Ciga, S., Noyce, A. J., Gatto, E. M., Kauffman, M., Khachatryan, S., Tavadyan, Z., Shepherd, C. E., Hunter, J., Kumar, K., Ellis, M., Rentería, M. E., Koks, S., Zimprich, A., Schumacher-Schuh, A. F., Rieder, C., Awad, P. S., Tumas, V., Camargos, S., Fon, E. A., Monchi, O., Fon, T., Galleguillos, B. P., Miranda, M., Bustamante, M. L., Olguin, P., Chana, P., Tang, B., Shang, H., Guo, J., Chan, P., Luo, W., Arboleda, G., Orozc, J., del Rio, M. J., Hernandez, A., Salama, M., Kamel, W. A., Zewde, Y. Z., Brice, A., Corvol, J. C., Westenberger, A., Illarionova, A., Mollenhauer, B., Klein, C., Vollstedt, E. J., Hopfner, F., Höglinger, G., Madoev, H., Trinh, J., Junker, J., Lohmann, K., Lange, L. M., Sharma, M., Groppa, S., Gasser, T., Fang, Z. H., Akpalu, A., Xiromerisiou, G., Hadjigorgiou, G., Dagklis, I., Tarnanas, I., Stefanis, L., Stamelou, M., Dadiotis, E., Medina, A., Chan, G. H. F., Ip, N., Cheung, N. Y. F., Chan, P., Zhou, X., Kishore, A., Divya, K. P., Pal, P., Kukkle, P. L., Rajan, R., Borgohain, R., Salari, M., Quattrone, A., Valente, E. M., Parnetti, L., Avenali, M., Schirinzi, T., Funayama, M., Hattori, N., Shiraishi, T., Karimova, A., Kaishibayeva, G., Shambetova, C., Krüger, R., Tan, A. H., Ahmad-Annuar, A., Norlinah, M. I., Murad, N. A. A., Azmin, S., Lim, S. Y., Mohamed, W., Tay, Y. W., Martinez-Ramirez, D., Rodriguez-Violante, M., Reyes-Pérez, P., Tserensodnom, B., Ojha, R., Anderson, T. J., Pitcher, T. L., Sanyaolu, A., Okubadejo, N., Ojo, O., Aasly, J. O., Pihlstrøm, L., Tan, M., Ur-Rehman, S., Veliz-Otani, D., Cornejo-Olivas, M., Doquenia, M. L., Rosales, R., Vinuela, A., Iakovenko, E., Mubarak, B. A., Umair, M., Amod, F., Carr, J., Bardien, S., Jeon, B., Kim, Y. J., Cubo, E., Alvarez, I., Hoenicka, J., Beyer, K., Periñan, M. T., Pastor, P., El-Sadig, S., Brolin, K., Zweier, C., Tinkhauser, G., Krack, P., Lin, C. H., Wu, H. C., Kung, P. J., Wu, R. M., Wu, Y., Amouri, R., Sassi, S. B., Başak, A. N., Genc, G., Çakmak, Ö. Ö., Ertan, S., Martínez-Carrasco, A., Schrag, A., Schapira, A., Carroll, C., Bale, C., Grosset, D., Stafford, E. J., Houlden, H., Morris, H. R., Hardy, J., Mok, K. Y., Rizig, M., Wood, N., Williams, N., Okunoye, O., Lewis, P. A., Kaiyrzhanov, R., Weil, R., Love, S., Stott, S., Jasaityte, S., Dey, S., Obese, V., Espay, A., O’Grady, A., Sobering, A. K., Siddiqi, B., Casey, B., Fiske, B., Jonas, C., Cruchaga, C., Pantazis, C. B., Comart, C., Wegel, C., Hall, D., Hernandez, D., Shiamim, E., Riley, E., Faghri, F., Serrano, G. E., Chen, H., Mata, I. F., Sarmiento, I. J. K., Williamson, J., Jankovic, J., Shulman, J., Solle, J. C., Murphy, K., Nuytemans, K., Kieburtz, K., Markopoulou, K., Marek, K., Levine, K. S., Chahine, L. M., Ibanez, L., Screven, L., Ruffrage, L., Shulman, L., Marsili, L., Kuhl, M., Dean, M., Koretsky, M., Puckelwartz, M. J., Inca-Martinez, M., Louie, N., Mencacci, N. E., Albin, R., Alcalay, R., Walker, R., Chowdhury, S., Dumanis, S., Lubbe, S., Xie, T., Foroud, T., Beach, T., Sherer, T., Song, Y., Nguyen, D., Nguyen, T., Atadzhanov, M., Blauwendraat, C., Nalls, M. A., Foo, J. N. & Mata, I., Jan 2024, In: Nature Genetics. 56, 1, p. 27-36 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Naturalistic assessment of reaction time variability in older adults at risk for Alzheimer's disease

Welhaf, M. S., Wilks, H., Aschenbrenner, A. J., Balota, D. A., Schindler, S. E., Benzinger, T. L. S., Gordon, B. A., Cruchaga, C., Xiong, C., Morris, J. C. & Hassenstab, J., Jun 29 2024, In: Journal of the International Neuropsychological Society. 30, 5, p. 428-438 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Pick a PACC: Comparing Domain-Specific and General Cognitive Composites in Alzheimer Disease Research

McKay, N. S., Millar, P. R., Nicosia, J., Aschenbrenner, A. J., Gordon, B. A., Benzinger, T. L. S., Cruchaga, C. C., Schindler, S. E., Morris, J. C. & Hassenstab, J., Apr 11 2024, In: Neuropsychology. 38, 5, p. 443-464 22 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Post-GWAS multiomic functional investigation of the TNIP1 locus in Alzheimer's disease highlights a potential role for GPX3

Panyard, D. J., Reus, L. M., Ali, M., Liu, J., Deming, Y. K., Lu, Q., Kollmorgen, G., Carboni, M., Wild, N., Visser, P. J., Bertram, L., Zetterberg, H., Blennow, K., Gobom, J., Western, D., Sung, Y. J., Carlsson, C. M., Johnson, S. C., Asthana, S. & Cruchaga, C. & 3 others, Tijms, B. M., Engelman, C. D. & Snyder, M. P., Jul 2024, In: Alzheimer's and Dementia. 20, 7, p. 5044-5053 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Predicting cognitive decline: Which is more useful, baseline amyloid levels or longitudinal change?

Chen, G., McKay, N. S., Gordon, B. A., Liu, J., Joseph-Mathurin, N., Schindler, S. E., Hassenstab, J., Aschenbrenner, A. J., Wang, Q., Schultz, S. A., Su, Y., LaMontagne, P. J., Keefe, S. J., Massoumzadeh, P., Cruchaga, C., Xiong, C., Morris, J. C. & Benzinger, T. L. S., Jan 2024, In: NeuroImage: Clinical. 41, 103551.

Research output: Contribution to journal › Article › peer-review

Open Access

Predictors and outcomes of fluctuations in the clinical dementia rating scale

Wilks, H., Benzinger, T. L. S., Schindler, S. E., Cruchaga, C., Morris, J. C. & Hassenstab, J., Mar 2024, In: Alzheimer's and Dementia. 20, 3, p. 2080-2088 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Presenilin-1 mutation position influences amyloidosis, small vessel disease, and dementia with disease stage

Joseph-Mathurin, N., Feldman, R. L., Lu, R., Shirzadi, Z., Toomer, C., Saint Clair, J. R., Ma, Y., McKay, N. S., Strain, J. F., Kilgore, C., Friedrichsen, K. A., Chen, C. D., Gordon, B. A., Chen, G., Hornbeck, R. C., Massoumzadeh, P., McCullough, A. A., Wang, Q., Li, Y. & Wang, G. & 38 others, Keefe, S. J., Schultz, S. A., Cruchaga, C., Preboske, G. M., Jack, C. R., Llibre-Guerra, J. J., Allegri, R. F., Ances, B. M., Berman, S. B., Brooks, W. S., Cash, D. M., Day, G. S., Fox, N. C., Fulham, M., Ghetti, B., Johnson, K. A., Jucker, M., Klunk, W. E., la Fougère, C., Levin, J., Niimi, Y., Oh, H., Perrin, R. J., Reischl, G., Ringman, J. M., Saykin, A. J., Schofield, P. R., Su, Y., Supnet-Bell, C., Vöglein, J., Yakushev, I., Brickman, A. M., Morris, J. C., McDade, E., Xiong, C., Bateman, R. J., Chhatwal, J. P. & Benzinger, T. L. S., Apr 2024, In: Alzheimer's and Dementia. 20, 4, p. 2680-2697 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer’s disease

Wang, L., Nykänen, N. P., Western, D., Gorijala, P., Timsina, J., Li, F., Wang, Z., Ali, M., Yang, C., Liu, M., Brock, W., Marquié, M., Boada, M., Alvarez, I., Aguilar, M., Pastor, P., Ruiz, A., Puerta, R., Orellana, A. & Rutledge, J. & 13 others, Oh, H., Greicius, M. D., Le Guen, Y., Perrin, R. J., Wyss-Coray, T., Jefferson, A., Hohman, T. J., Graff-Radford, N., Mori, H., Goate, A., Levin, J., Sung, Y. J. & Cruchaga, C., Dec 2024, In: Molecular neurodegeneration. 19, 1, 1.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Proteomic analysis of Alzheimer’s disease cerebrospinal fluid reveals alterations associated with APOE ε4 and atomoxetine treatment

Dammer, E. B., Shantaraman, A., Ping, L., Duong, D. M., Gerasimov, E. S., Ravindran, S. P., Gudmundsdottir, V., Frick, E. A., Gomez, G. T., Walker, K. A., Emilsson, V., Jennings, L. L., Gudnason, V., Western, D., Cruchaga, C., Lah, J. J., Wingo, T. S., Wingo, A. P., Seyfried, N. T. & Levey, A. I. & 1 others, Johnson, E. C. B., 2024, In: Science translational medicine. 16, 753, eadn3504.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease

Vance, J. M., Farrer, L. A., Huang, Y., Cruchaga, C., Hyman, B. T., Pericak-Vance, M. A., Goate, A. M., Greicius, M. D., Griswold, A. J., Haines, J. L., Tcw, J., Schellenberg, G. D., Tsai, L. H., Herz, J. & Holtzman, D. M., Apr 2024, In: Annals of neurology. 95, 4, p. 625-634 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

3 Scopus citations

RETHINKING THE POWER OF GRAPH CANONIZATION IN GRAPH REPRESENTATION LEARNING WITH STABILITY

Dong, Z., Zhang, M., Payne, P. R. O., Province, M. A., Cruchaga, C., Zhao, T., Li, F. & Chen, Y., 2024.

Research output: Contribution to conference › Paper › peer-review

1 Scopus citations

Sex-specific genetic architecture of late-life memory performance

Eissman, J. M., Archer, D. B., Mukherjee, S., Lee, M. L., Choi, S. E., Scollard, P., Trittschuh, E. H., Mez, J. B., Bush, W. S., Kunkle, B. W., Naj, A. C., Gifford, K. A., Cuccaro, M. L., Cruchaga, C., Pericak-Vance, M. A., Farrer, L. A., Wang, L. S., Schellenberg, G. D., Mayeux, R. P. & Haines, J. L. & 12 others, Jefferson, A. L., Kukull, W. A., Keene, C. D., Saykin, A. J., Thompson, P. M., Martin, E. R., Bennett, D. A., Barnes, L. L., Schneider, J. A., Crane, P. K., Hohman, T. J. & Dumitrescu, L., Feb 2024, In: Alzheimer's and Dementia. 20, 2, p. 1250-1267 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

TOPMed imputed genomics enhances genomic atlas of the human proteome in brain, cerebrospinal fluid, and plasma

Yi, H., Yang, Q., Repaci, C., Lee, C. M., Heo, G., Timsina, J., Gorijala, P., Yang, C., Budde, J., Wang, L., Cruchaga, C. & Sung, Y. J., Dec 2024, In: Scientific data. 11, 1, 387.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden

Dominantly Inherited Alzheimer Network, Jun 2024, In: Alzheimer's and Dementia. 20, 6, p. 4351-4365 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2023

Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease

Millar, P. R., Gordon, B. A., Wisch, J. K., Schultz, S. A., Benzinger, T. L., Cruchaga, C., Hassenstab, J. J., Ibanez, L., Karch, C., Llibre-Guerra, J. J., Morris, J. C., Perrin, R. J., Supnet-Bell, C., Xiong, C., Allegri, R. F., Berman, S. B., Chhatwal, J. P., Chrem Mendez, P. A., Day, G. S. & Hofmann, A. & 13 others, Ikeuchi, T., Jucker, M., Lee, J. H., Levin, J., Lopera, F., Niimi, Y., Sánchez-González, V. J., Schofield, P. R., Sosa-Ortiz, A. L., Vöglein, J., Bateman, R. J., Ances, B. M. & McDade, E. M., Dec 2023, In: Molecular neurodegeneration. 18, 1, 98.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

A flexible modeling approach for biomarker-based computation of absolute risk of Alzheimer's disease dementia

Hartz, S. M., Mozersky, J., Schindler, S., Linnenbringer, E., Wang, J., Gordon, B., Raji, C. A., Moulder, K. L., West, T., Benzinger, T. L. S., Cruchaga, C., Hassenstab, J. J., Bierut, L. J., Xiong, C. & Morris, J., Apr 2023, In: Alzheimer's and Dementia. 19, 4, p. 1452-1465 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Alzheimer’s disease genetic risk and cognitive reserve in relationship to long-term cognitive trajectories among cognitively normal individuals

Pettigrew, C., Nazarovs, J., Soldan, A., Singh, V., Wang, J., Hohman, T., Dumitrescu, L., Libby, J., Kunkle, B., Gross, A. L., Johnson, S., Lu, Q., Engelman, C., Masters, C. L., Maruff, P., Laws, S. M., Morris, J. C., Hassenstab, J., Cruchaga, C. & Resnick, S. M. & 3 others, Kitner-Triolo, M. H., An, Y. & Albert, M., Dec 2023, In: Alzheimer's Research and Therapy. 15, 1, 66.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Associations between age, sex, APOE genotype, and regional vascular physiology in typically aging adults

Damestani, N. L., Jacoby, J., Yadav, S. M., Lovely, A. E., Michael, A., Terpstra, M., Eshghi, M., Rashid, B., Cruchaga, C., Salat, D. H. & Juttukonda, M. R., Jul 15 2023, In: NeuroImage. 275, 120167.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Associations of Sex, Race, and Apolipoprotein e Alleles with Multiple Domains of Cognition among Older Adults

Walters, S., Contreras, A. G., Eissman, J. M., Mukherjee, S., Lee, M. L., Choi, S. E., Scollard, P., Trittschuh, E. H., Mez, J. B., Bush, W. S., Kunkle, B. W., Naj, A. C., Peterson, A., Gifford, K. A., Cuccaro, M. L., Cruchaga, C., Pericak-Vance, M. A., Farrer, L. A., Wang, L. S. & Haines, J. L. & 12 others, Jefferson, A. L., Kukull, W. A., Keene, C. D., Saykin, A. J., Thompson, P. M., Martin, E. R., Bennett, D. A., Barnes, L. L., Schneider, J. A., Crane, P. K., Hohman, T. J. & Dumitrescu, L., Sep 11 2023, In: JAMA Neurology. 80, 9, p. 929-939 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Author Correction: Elucidating causative gene variants in hereditary Parkinson’s disease in the Global Parkinson’s Genetics Program (GP2) (npj Parkinson's Disease, (2023), 9, 1, (100), 10.1038/s41531-023-00526-9)

the Global Parkinson’s Genetic Program (GP2) & Cruchaga, C., Dec 2023, In: npj Parkinson's Disease. 9, 1, 133.

Research output: Contribution to journal › Comment/debate

Open Access

Biomarker clustering in autosomal dominant Alzheimer's disease

for the Dominantly Inherited Alzheimer Network (DIAN), Jan 2023, In: Alzheimer's and Dementia. 19, 1, p. 274-284 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Brain network decoupling with increased serum neurofilament and reduced cognitive function in Alzheimer’s disease

Dominantly Inherited Alzheimer Network, Jul 1 2023, In: Brain. 146, 7, p. 2928-2943 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Cell-free RNA signatures predict Alzheimer's disease

Cisterna-García, A., Beric, A., Ali, M., Pardo, J. A., Chen, H. H., Fernandez, M. V., Norton, J., Gentsch, J., Bergmann, K., Budde, J., Perlmutter, J. S., Morris, J. C., Cruchaga, C., Botia, J. A. & Ibanez, L., Dec 15 2023, In: iScience. 26, 12, 108534.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease

the Dominantly Inherited Alzheimer Network, Aug 2023, In: Nature medicine. 29, 8, p. 1979-1988 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study

Alzheimer's Biomarker Consortium-Down Syndrome, Dominantly Inherited Alzheimer Network, Boerwinkle, A. H., Gordon, B. A., Wisch, J., Flores, S., Henson, R. L., Butt, O. H., McKay, N., Chen, C. D., Benzinger, T. L. S., Fagan, A. M., Cruchaga, C., Perrin, R. J., Xiong, C., Hassenstab, J., McDade, E., Bateman, R. J., Ances, B. M. & Barthelemy, N. & 8 others, Buckles, V., Day, G., Joseph-Mathurin, N., Holtzman, D., Karch, C., Li, Y., Wang, Q. & Xu, J., Jan 2023, In: The Lancet Neurology. 22, 1, p. 55-65 11 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Cross-sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle-aged individuals with a parental history of either autosomal dominant or late-onset Alzheimer's disease

and Dominantly Inherited Alzheimer Network (DIAN), Xiong, C., McCue, L. M., Buckles, V., Grant, E., Agboola, F., Coble, D., Bateman, R. J., Fagan, A. M., Benzinger, T. L. S., Hassenstab, J., Schindler, S. E., McDade, E., Moulder, K., Gordon, B. A., Cruchaga, C., Day, G. S., Ikeuchi, T., Suzuki, K. & Allegri, R. F. & 3 others, Vöglein, J., Levin, J. & Morris, J. C., Jul 2023, In: Alzheimer's and Dementia. 19, 7, p. 2923-2932 10 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

Towns, C., Richer, M., Jasaityte, S., Stafford, E. J., Joubert, J., Antar, T., Martinez-Carrasco, A., Makarious, M. B., Casey, B., Vitale, D., Levine, K., Leonard, H., Pantazis, C. B., Screven, L. A., Hernandez, D. G., Wegel, C. E., Solle, J., Nalls, M. A., Blauwendraat, C. & Singleton, A. B. & 224 others, Tan, M. M. X., Iwaki, H., Morris, H. R., Gatto, E. M., Kauffman, M., Khachatryan, S., Tavadyan, Z., Shepherd, C. E., Hunter, J., Kumar, K., Ellis, M., Rentería, M. E., Koks, S., Zimprich, A., Schumacher-Schuh, A. F., Rieder, C., Awad, P. S., Tumas, V., Camargos, S., Fon, E. A., Monchi, O., Fon, T., Galleguillos, B. P., Miranda, M., Bustamante, M. L., Olguin, P., Chana, P., Tang, B., Shang, H., Guo, J., Chan, P., Luo, W., Arboleda, G., Orozco, J., del Rio, M. J., Hernandez, A., Salama, M., Kamel, W. A., Zewde, Y. Z., Brice, A., Corvol, J. C., Westenberger, A., Illarionova, A., Mollenhauer, B., Klein, C., Vollstedt, E. J., Hopfner, F., Höglinger, G., Madoev, H., Trinh, J., Junker, J., Lohmann, K., Lange, L. M., Sharma, M., Groppa, S., Gasser, T., Fang, Z. H., Akpalu, A., Xiromerisiou, G., Hadjigorgiou, G., Dagklis, I., Tarnanas, I., Stefanis, L., Stamelou, M., Dadiotis, E., Medina, A., Chan, G. H. F., Ip, N., Cheung, N. Y. F., Chan, P., Zhou, X., Kishore, A., Kp, D., Pal, P., Kukkle, P. L., Rajan, R., Borgohain, R., Salari, M., Quattrone, A., Valente, E. M., Parnetti, L., Avenali, M., Schirinzi, T., Funayama, M., Hattori, N., Shiraishi, T., Karimova, A., Kaishibayeva, G., Shambetova, C., Krüger, R., Tan, A. H., Ahmad-Annuar, A., Norlinah, M. I., Murad, N. A. A., Azmin, S., Lim, S. Y., Mohamed, W., Tay, Y. W., Martinez-Ramirez, D., Rodriguez-Violante, M., Reyes-Pérez, P., Tserensodnom, B., Ojha, R., Anderson, T. J., Pitcher, T. L., Sanyaolu, A., Okubadejo, N., Ojo, O., Aasly, J. O., Pihlstrøm, L., Tan, M., Ur-Rehman, S., Cornejo-Olivas, M., Doquenia, M. L., Rosales, R., Vinuela, A., Iakovenko, E., Mubarak, B. A., Umair, M., Tan, E. K., Foo, J. N., Amod, F., Carr, J., Bardien, S., Jeon, B., Kim, Y. J., Cubo, E., Alvarez, I., Hoenicka, J., Beyer, K., Periñan, M. T., Pastor, P., El-Sadig, S., Zweier, C., Krack, P., Lin, C. H., Wu, H. C., Kung, P. J., Wu, R. M., Wu, Y., Amouri, R., Sassi, S. B., Başak, A. N., Genc, G., Çakmak, Ö. Ö., Ertan, S., Noyce, A., Schrag, A., Schapira, A., Carroll, C., Bale, C., Grosset, D., Houlden, H., Hardy, J., Mok, K. Y., Rizig, M., Wood, N., Williams, N., Okunoye, O., Lewis, P. A., Kaiyrzhanov, R., Weil, R., Love, S., Stott, S., Jasaitye, S., Dey, S., Obese, V., Espay, A., O’Grady, A., Sobering, A. K., Siddiqi, B., Fiske, B., Jonas, C., Cruchaga, C., Comart, C., Wegel, C., Hall, D., Hernandez, D., Shiamim, E., Riley, E., Faghri, F., Serrano, G. E., Chen, H., Mata, I. F., Sarmiento, I. J. K., Williamson, J., Kim, J. J., Jankovic, J., Shulman, J., Solle, J. C., Murphy, K., Nuytemans, K., Kieburtz, K., Markopoulou, K., Marek, K., Levine, K. S., Chahine, L. M., Ibanez, L., Screven, L., Ruffrage, L., Shulman, L., Marsili, L., Kuhl, M., Dean, M., Koretsky, M., Puckelwartz, M. J., Inca-Martinez, M., Louie, N., Mencacci, N. E., Albin, R., Alcalay, R., Walker, R., Bandres-Ciga, S., Chowdhury, S., Dumanis, S., Lubbe, S., Xie, T., Foroud, T., Beach, T., Sherer, T., Song, Y., Nguyen, D., Nguyen, T. & Atadzhanov, M., Dec 2023, In: npj Parkinson's Disease. 9, 1, 131.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Editorial: Molecular and cellular mechanisms of synaptopathies: emerging synaptic aging-related molecular pathways in neurological disorders

Quintá, H. R., Ibanez, L., Cruchaga, C. & Maschi, D., 2023, In: Frontiers in Aging Neuroscience. 15, 1267033.

Research output: Contribution to journal › Editorial

Open Access

Erratum: Comparative Analysis of Alzheimer's Disease Cerebrospinal Fluid Biomarkers Measurement by Multiplex SOMAscan Platform and Immunoassay-Based Approach (Journal of Alzheimer's Disease (2022) 89 (193–207) DOI: 10.3233/JAD-220399)

Timsina, J., Gomez-Fonseca, D., Wang, L., Do, A., Western, D., Alvarez, I., Aguilar, M., Pastor, P., Henson, R. L., Herries, E., Xiong, C., Schindler, S., Fagan, A. M., Bateman, R. J., Farlow, M., Morris, J., Perrin, R. J., Moulder, K., Hassenstab, J. & Voglein, J. & 4 others, Chhatwal, J., Mori, H., Ju Sung, Y. & Cruchaga, C., 2023, In: Journal of Alzheimer's Disease. 91, 2, p. 911 1 p.

Research output: Contribution to journal › Comment/debate

Open Access

Carlos Cruchaga

Research output

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