Personal profile
Research interests
The goal of my lab is to understand the biology of neurodegenerative diseases (i.e: Alzheimer, Parkinson, Frontotemporal dementia), identify risk and protective genes and pathways, create prediction models and identify druggable targets, by generating and analyzing human multi-tissue multi-omic data (genetic, genomics, proteomics, epigenomics, and lipidomics) from large and well characterized cohorts.
In the lab we use classic human statistical genetics approaches such as association studies using GWAS, or Whole Genome Sequencing (WGS) in unrelated or familial cases, as well as novel and powerful genomic approaches such as QTL mapping, colocalization, Mendelian Randomization or Machine Learning to identify causal genes.
In summary, the mission of our lab is a human-data driven using molecular profiling where omics and functional genomics studies in neurodegeneration and diseases of the CNS are translated into improvements in human health through better understanding of the molecular underpinnings of disease.
Mentoring
My lab regularly takes graduate students, postdocs, undergraduates, as well as summer students. I am a faculty member in the Division of Biology and Biomedical Sciences (DBBS) on the Human and Statistical Genetics, Neurosciences, Biomedical Informatics and Data Science Program and Molecular Genetics and Genomics Program.
Keywords
- COVID-19
Available to Mentor:
- Undergraduate Students
- Post-Baccalaureate Students
- PhD Students
- Postdocs
- Residents and Fellows
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Collaborations and top research areas from the last five years
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Analyses of plasma multi-omic data across ancestries identify novel pathways implicated in Alzheimer's disease
Yang, C., Timsina, J., Liu, M., Budde, J., Kohlfeld, P., Brock, W., Morris, J. C., Holtzman, D. M., Sung, Y. J. & Cruchaga, C., Feb 2026, In: Alzheimer's and Dementia. 22, 2, e71164.Research output: Contribution to journal › Article › peer-review
Open Access -
APOE-stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease
Li, F., Chen, Y., Western, D., Ali, M., Liu, M., Gong, K., Xu, Y., Lowery, J., Holtzman, D. M., Robins, C., Eicher, J. D., Huang, Y. N., Liu, S. W., Park, T., Saykin, A. J., Nho, K., Moqri, M., Mohs, R. C., Farinas, A. & Moran-Losada, P. & 3 others, , Apr 13 2026, In: Advanced Science. 13, 21, e13872.Research output: Contribution to journal › Article › peer-review
Open Access -
Association of LRRK2 p.A419V with Parkinson’s Disease in East Asians and analysis of age at onset
the Global Parkinson’s Genetics Program (GP2), Dec 2026, In: npj Parkinson's Disease. 12, 1, 51.Research output: Contribution to journal › Article › peer-review
Open Access -
Brain volume trajectories in Down syndrome and autosomal dominant Alzheimer's disease
the Alzheimer's Brain Consortium – Down Syndrome, and the Dominantly Inherited Alzheimer's Network, Jan 2026, In: Alzheimer's and Dementia. 22, 1, e71103.Research output: Contribution to journal › Article › peer-review
Open Access -
CDK4/6 inhibition mitigates chemotherapy-induced expansion of TP53-mutant clonal hematopoiesis
Chan, I. C. C., Zhang, P., Pan, X., Castro, C., Fox, N., Lewis, A. M., Weis, K., Cuibus, A., Tittley, S., Petrone, G., Beeler, J. S., Tran, D., Mustion, G., Fronick, C., Stopsack, K. H., Cruchaga, C., Abdel-Wahab, O. & Bolton, K. L., Mar 2026, In: Nature Genetics. 58, 3, p. 582-592 11 p.Research output: Contribution to journal › Article › peer-review
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