My research involves combining techniques to uncover aspects about neurodegenerative disease processes. I am primarily focused on the factors influencing brain Aß dynamics in mouse models of AD, particularly in relation to synaptic activity. Our long-term goal is to understand the pathways and risk factors involved in Aß generation and accumulation in the brain, with the hope of identifying effective therapeutic targets. I am also Co-Director of the Animal Behavior Core at Washington University where I am involved in helping investigators design and interpret behavioral function in many animal models of disease. My research interests involve behavioral phenotyping of new genetic models, as well as evaluating functional effects of specific treatment strategies on diverse models of neurological disorders.

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