Research output per year
Research output per year
Personal profile
Research interests
We work on apoE proteins. ApoE4 is the major risk factor for late-onset Alzheimer's Disease A second project involves proteins of the bacterial system called curli that lead to biofilm formation in vivo
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Apolipoprotein E4 has extensive conformational heterogeneity in lipid-free and lipid-bound forms
Stuchell-Brereton, M. D., Zimmerman, M. I., Miller, J. J., Mallimadugula, U. L., Incicco, J. J., Roy, D., Smith, L. G., Cubuk, J., Baban, B., DeKoster, G. T., Frieden, C., Bowman, G. R. & Soranno, A., Feb 14 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 7, e2215371120.Research output: Contribution to journal › Article › peer-review
Open Access -
Single-molecule spectroscopy of Apolipoprotein E reveals a complex conformational ensemble
Stuchell-Brereton, M. D., Zimmerman, M. I., Miller, J. J., Mallimadugula, U. L., Incicco, J. J., Roy, D., Smith, L. G., Cubuk, J., Baban, B., DeKoster, G. T., Frieden, C., Bowman, G. & Soranno, A., Feb 10 2023, In: Biophysical Journal. 122, 3S1, p. 329aResearch output: Contribution to journal › Article › peer-review
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APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia
Liu, C. C., Murray, M. E., Li, X., Zhao, N., Wang, N., Heckman, M. G., Shue, F., Martens, Y., Li, Y., Raulin, A. C., Rosenberg, C. L., Doss, S. V., Zhao, J., Wren, M. C., Jia, L., Ren, Y., Ikezu, T. C., Lu, W., Fu, Y., Caulfield, T., & 27 others, Sep 29 2021, In: Science translational medicine. 13, 613, eabc9375.Research output: Contribution to journal › Article › peer-review
22 Scopus citations -
Bioorthogonal Chemistry Enables Single-Molecule FRET Measurements of Catalytically Active Protein Disulfide Isomerase
Chinnaraj, M., Barrios, D. A., Frieden, C., Heyduk, T., Flaumenhaft, R. & Pozzi, N., Jan 5 2021, In: ChemBioChem. 22, 1, p. 134-138 5 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Functional insights from biophysical study of TREM2 interactions with apoE and Aβ1-42
Kober, D. L., Stuchell-Brereton, M. D., Kluender, C. E., Dean, H. B., Strickland, M. R., Steinberg, D. F., Nelson, S. S., Baban, B., Holtzman, D. M., Frieden, C., Alexander-Brett, J., Roberson, E. D., Song, Y. & Brett, T. J., Mar 2021, In: Alzheimer's and Dementia. 17, 3, p. 475-488 14 p.Research output: Contribution to journal › Article › peer-review
25 Scopus citations