• 11167 Citations
1954 …2020

Research output per year

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Personal profile

Research interests

We work on apoE proteins. ApoE4 is the major risk factor for late-onset Alzheimer's Disease A second project involves proteins of the bacterial system called curli that lead to biofilm formation in vivo

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Research Output

19F NMR reveals the conformational properties of free thrombin and its zymogen precursor prethrombin-2

Ruben, E. A., Gandhi, P. S., Chen, Z., Koester, S. K., DeKoster, G. T., Frieden, C. & Di Cera, E., Jun 12 2020, In : The Journal of biological chemistry. 295, 24, p. 8227-8235 9 p.

Research output: Contribution to journalArticle

Open Access
  • Bioorthogonal Chemistry Enables Single-Molecule FRET Measurements of Catalytically Active Protein Disulfide Isomerase

    Chinnaraj, M., Barrios, D. A., Frieden, C., Heyduk, T., Flaumenhaft, R. & Pozzi, N., 2020, (Accepted/In press) In : ChemBioChem.

    Research output: Contribution to journalArticle

  • Charge Reduction of Membrane Proteins in Native Mass Spectrometry Using Alkali Metal Acetate Salts

    Petroff, J. T., Tong, A., Chen, L. J., Dekoster, G. T., Khan, F., Abramson, J., Frieden, C. & Cheng, W. W. L., May 5 2020, In : Analytical Chemistry. 92, 9, p. 6622-6630 9 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Native Mass Spectrometry, Ion Mobility, Electron-Capture Dissociation, and Modeling Provide Structural Information for Gas-Phase Apolipoprotein E Oligomers

    Wang, H., Eschweiler, J., Cui, W., Zhang, H., Frieden, C., Ruotolo, B. T. & Gross, M. L., May 16 2019, In : Journal of the American Society for Mass Spectrometry. 30, 5, p. 876-885 10 p.

    Research output: Contribution to journalArticle

  • 5 Scopus citations

    Protein oligomerization as a metabolic control mechanism: Application to apoE

    Frieden, C., Apr 2019, In : Protein Science. 28, 4, p. 837-842 6 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations