Research output per year
Research output per year
Personal profile
Research interests
We work on apoE proteins. ApoE4 is the major risk factor for late-onset Alzheimer's Disease A second project involves proteins of the bacterial system called curli that lead to biofilm formation in vivo
Available to Mentor:
- PhD/MSTP Students
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Collaborations and top research areas from the last five years
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Apolipoprotein E4 has extensive conformational heterogeneity in lipid-free and lipid-bound forms
Stuchell-Brereton, M. D., Zimmerman, M. I., Miller, J. J., Mallimadugula, U. L., Incicco, J. J., Roy, D., Smith, L. G., Cubuk, J., Baban, B., DeKoster, G. T., Frieden, C., Bowman, G. R. & Soranno, A., Feb 14 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 7, e2215371120.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia
Liu, C. C., Murray, M. E., Li, X., Zhao, N., Wang, N., Heckman, M. G., Shue, F., Martens, Y., Li, Y., Raulin, A. C., Rosenberg, C. L., Doss, S. V., Zhao, J., Wren, M. C., Jia, L., Ren, Y., Ikezu, T. C., Lu, W., Fu, Y. & Caulfield, T. & 27 others, , Sep 29 2021, In: Science translational medicine. 13, 613, eabc9375.Research output: Contribution to journal › Article › peer-review
Open Access55 Scopus citations -
Bioorthogonal Chemistry Enables Single-Molecule FRET Measurements of Catalytically Active Protein Disulfide Isomerase
Chinnaraj, M., Barrios, D. A., Frieden, C., Heyduk, T., Flaumenhaft, R. & Pozzi, N., Jan 5 2021, In: ChemBioChem. 22, 1, p. 134-138 5 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
Functional insights from biophysical study of TREM2 interactions with apoE and Aβ1-42
Kober, D. L., Stuchell-Brereton, M. D., Kluender, C. E., Dean, H. B., Strickland, M. R., Steinberg, D. F., Nelson, S. S., Baban, B., Holtzman, D. M., Frieden, C., Alexander-Brett, J., Roberson, E. D., Song, Y. & Brett, T. J., Mar 2021, In: Alzheimer's and Dementia. 17, 3, p. 475-488 14 p.Research output: Contribution to journal › Article › peer-review
Open Access44 Scopus citations -
19F NMR reveals the conformational properties of free thrombin and its zymogen precursor prethrombin-2
Ruben, E. A., Gandhi, P. S., Chen, Z., Koester, S. K., DeKoster, G. T., Frieden, C. & Di Cera, E., Jun 12 2020, In: Journal of Biological Chemistry. 295, 24, p. 8227-8235 9 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations