C. William Balke

2019

Regional differences in the expression of tetrodotoxin-sensitive inward Ca²⁺ and outward Cs⁺/K⁺ currents in mouse and human ventricles

Wang, W., Mellor, R. L., Nerbonne, J. M. & Balke, C. W., Jan 1 2019, In: Channels. 13, 1, p. 72-87 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2015

National institutes of health career development awards for cardiovascular physician-scientists recent trends and strategies for success

Lindman, B. R., Tong, C. W., Carlson, D. E., Balke, C. W., Jackson, E. A., Madhur, M. S., Barac, A., Abdalla, M., Brittain, E. L., Desai, N., Kates, A. M., Freeman, A. M. & Mann, D. L., Oct 20 2015, In: Journal of the American College of Cardiology. 66, 16, p. 1816-1827 12 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

12 Scopus citations

2012

Augmented phosphorylation of cardiac troponin I in hypertensive heart failure

Dong, X., Sumandea, C. A., Chen, Y. C., Garcia-Cazarin, M. L., Zhang, J., Balke, C. W., Sumandea, M. P. & Ge, Y., Jan 6 2012, In: Journal of Biological Chemistry. 287, 2, p. 848-857 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

85 Scopus citations

2011

Age-associated disruption of molecular clock expression in skeletal muscle of the spontaneously hypertensive rat

Miyazaki, M., Schroder, E., Edelmann, S. E., Hughes, M. E., Kornacker, K., Balke, C. W. & Esser, K. A., Nov 4 2011, In: PloS one. 6, 11, e27168.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

Arrhythmia triggers in heart failure: The smoking gun of [Ca ²⁺]_i dysregulation

Aistrup, G. L., Balke, C. W. & Wasserstrom, J. A., Nov 2011, In: Heart rhythm. 8, 11, p. 1804-1808 5 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Cardiac troponin T, a sarcomeric AKAP, tethers protein kinase a at the myofilaments

Sumandea, C. A., Garcia-Cazarin, M. L., Bozio, C. H., Sievert, G. A., Balke, C. W. & Sumandea, M. P., Jan 7 2011, In: Journal of Biological Chemistry. 286, 1, p. 530-541 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

38 Scopus citations

Commentary: Improving participant recruitment in clinical and translational research

Nasser, N., Grady, D. & Balke, C. W., Nov 2011, In: Academic Medicine. 86, 11, p. 1334-1335 2 p.

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Crossing the chasm: Information technology to biomedical informatics

Fahy, B. G., William Balke, C., Umberger, G. H., Talbert, J., Canales, D. N., Steltenkamp, C. L. & Conigliaro, J., Jun 2011, In: Journal of Investigative Medicine. 59, 5, p. 768-779 12 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

2010

Cardiomyopathy-causing deletion K210 in cardiac troponin T alters phosphorylation propensity of sarcomeric proteins

Sfichi-Duke, L., Garcia-Cazarin, M. L., Sumandea, C. A., Sievert, G. A., Balke, C. W., Zhan, D. Y., Morimoto, S. & Sumandea, M. P., May 2010, In: Journal of Molecular and Cellular Cardiology. 48, 5, p. 934-942 9 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Early development of intracellular calcium cycling defects in intact hearts of spontaneously hypertensive rats

Kapur, S., Aistrup, G. L., Sharma, R., Kelly, J. E., Arora, R., Zheng, J., Veramasuneni, M., Kadish, A. H., Balke, C. W. & Wasserstrom, J. A., Dec 2010, In: American Journal of Physiology - Heart and Circulatory Physiology. 299, 6, p. H1843-H1853

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

"Oh, the Places You'll Go"1: Transformation of the Nation's Biomedical Research Enterprise in the 21st Century

Balke, C. W., Umberger, G. H. & Mattacola, C. G., Nov 2010, In: Journal of Sport Rehabilitation. 19, 4, p. 359-368 10 p.

Research output: Contribution to journal › Article › peer-review

2009

Funding opportunities for investigators in the early stages of career development

Sumandea, C. A. & Balke, C. W., Mar 10 2009, In: Circulation. 119, 9, p. 1320-1327 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Multiple defects in intracellular calcium cycling in whole failing rat heart

Wasserstrom, J. A., Sharma, R., Kapur, S., Kelly, J. E., Kadish, A. H., Balke, C. W. & Aistrup, G. L., May 2009, In: Circulation: Heart Failure. 2, 3, p. 223-232 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

2008

Calcium handling in human embryonic stem cell-derived cardiomyocytes

Satin, J., Itzhaki, I., Rapoport, S., Schroder, E. A., Izu, L., Arbel, G., Beyar, R., Balke, C. W., Schiller, J. & Gepstein, L., Aug 2008, In: STEM CELLS. 26, 8, p. 1961-1972 12 p.

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Left ventricular dysfunction and associated cellular injury in rats exposed to chronic intermittent hypoxia

Chen, L., Zhang, J., Gan, T. X., Chen-Izu, Y., Hasday, J. D., Karmazyn, M., Balke, C. W. & Scharf, S. M., Jan 2008, In: Journal of Applied Physiology. 104, 1, p. 218-223 6 p.

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Transformation of adult rat cardiac myocytes in primary culture

Banyasz, T., Lozinskiy, I., Payne, C. E., Edelmann, S., Norton, B., Chen, B., Chen-Izu, Y., Izu, L. T. & Balke, C. W., Mar 2008, In: Experimental Physiology. 93, 3, p. 370-382 13 p.

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Tyrosine phosphorylation modifies protein kinase C δ-dependent phosphorylation of cardiac troponin I

Sumandea, M. P., Rybin, V. O., Hinken, A. C., Wang, C., Kobayashi, T., Harleton, E., Sievert, G., Balke, C. W., Feinmark, S. J., Solaro, R. J. & Steinberg, S. F., Aug 15 2008, In: Journal of Biological Chemistry. 283, 33, p. 22680-22689 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

54 Scopus citations

2007

A new approach to the detection and statistical classification of Ca ²⁺ sparks

Bányász, T., Chen-Izu, Y., Balke, C. W. & Izu, L. T., Jun 2007, In: Biophysical Journal. 92, 12, p. 4458-4465 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Application of blebbistatin as an excitation-contraction uncoupler for electrophysiologic study of rat and rabbit hearts

Fedorov, V. V., Lozinsky, I. T., Sosunov, E. A., Anyukhovsky, E. P., Rosen, M. R., Balke, C. W. & Efimov, I. R., May 2007, In: Heart rhythm. 4, 5, p. 619-626 8 p.

Research output: Contribution to journal › Article › peer-review

268 Scopus citations

Cellular and molecular determinants of altered Ca²⁺ handling in the failing rabbit heart: Primary defects in SR Ca²⁺ uptake and release mechanisms

Armoundas, A. A., Rose, J., Aggarwal, R., Stuyvers, B. D., O'Rourke, B., Kass, D. A., Marbán, E., Shorofsky, S. R., Tomaselli, G. F. & Balke, C. W., Mar 2007, In: American Journal of Physiology - Heart and Circulatory Physiology. 292, 3, p. H1607-H1618

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Eavesdropping on the social lives of Ca²⁺ sparks

Izu, L. T., Bányász, T., Balke, C. W. & Chen-Izu, Y., Nov 2007, In: Biophysical Journal. 93, 10, p. 3408-3420 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Hypertension-induced remodeling of cardiac excitation-contraction coupling in ventricular myocytes occurs prior to hypertrophy development

Chen-Izu, Y., Chen, L., Bányász, T., McCulle, S. L., Norton, B., Scharf, S. M., Agarwal, A., Patwardhan, A., Izu, L. T. & Balke, C. W., Dec 2007, In: American Journal of Physiology - Heart and Circulatory Physiology. 293, 6, p. H3301-H3310

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Phosphorylation of RyR₂ and shortening of RyR₂ cluster spacing in spontaneously hypertensive rat with heart failure

Chen-Izu, Y., Ward, C. W., Stark, W., Banyasz, T., Sumandea, M. P., Balke, C. W., Izu, L. T. & Wehrens, X. H. T., Oct 2007, In: American Journal of Physiology - Heart and Circulatory Physiology. 293, 4, p. H2409-H2417

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Robust gene expression with amplified RNA from biopsy-sized human heart tissue

Barrows, B. R., Azimzadeh, A. M., McCulle, S. L., Vives-Rodriguez, G., Stark, W. N., Ambulos, N., Yin, J., Chen, H., Balke, C. W., Moravec, C. S., Pierson, R. N., Gottlieb, S. S., Bond, M. & Johnson, F. L., Jan 2007, In: Journal of Molecular and Cellular Cardiology. 42, 1, p. 260-264 5 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2006

Interplay of ryanodine receptor distribution and calcium dynamics

Izu, L. T., Means, S. A., Shadid, J. N., Chen-Izu, Y. & Balke, C. W., 2006, In: Biophysical Journal. 91, 1, p. 95-112 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

83 Scopus citations

Mitochondrial buffering of calcium in the heart: Potential mechanism for linking cyclic energetic cost with energy supply?

Sullivan, P. G., Balke, C. W. & Esser, K. A., Jul 2006, In: Circulation research. 99, 2, p. 109-110 2 p.

Research output: Contribution to journal › Editorial

Open Access

7 Scopus citations

Orphaned ryanodine receptors in the failing heart

Song, L. S., Sobie, E. A., McCulle, S., Lederer, W. J., Balke, C. W. & Cheng, H., Mar 14 2006, In: Proceedings of the National Academy of Sciences of the United States of America. 103, 11, p. 4305-4310 6 p.

Research output: Contribution to journal › Article › peer-review

357 Scopus citations

Progress in the development of a unifying hypothesis on the mechanisms underlying the electrical and mechanical abnormalities of the failing heart: One step backward but two steps forward

Chen-Izu, Y. & William Balke, C., Sep 2006, In: Journal of Molecular and Cellular Cardiology. 41, 3, p. 424-425 2 p.

Research output: Contribution to journal › Editorial

Three-dimensional distribution of ryanodine receptor clusters in cardiac myocytes

Chen-Izu, Y., McCulle, S. L., Ward, C. W., Soeller, C., Allen, B. M., Rabang, C., Cannell, M. B., Balke, C. W. & Izu, L. T., 2006, In: Biophysical Journal. 91, 1, p. 1-13 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

2005

Erratum: How to become a cardiovascular investigator (Journal of the American College of Cardiology (October 4, 2005) SUPPL. A))

Mendelsohn, M. E., Balke, C. W., Bonow, R. O., Fuster, V., Grant, A. O., Mark, D. B., Peterson, E. D., Antman, E. M., Krumholz, H. M., Balaban, R. S., Prystowsky, E. N., Ferguson, J. J., Al-Sheikh, T. O., Berk, B. C., Vatner, S. F., Zipes, D. P., Holmes, D. R., Seidman, C. E., Nabel, E. G. & Zoghbi, W. A., Dec 6 2005, In: Journal of the American College of Cardiology. 46, 11, p. 2151-2152 2 p.

Research output: Contribution to journal › Comment/debate

Open Access

Oxidative stress and left ventricular function with chronic intermittent hypoxia in rats

Chen, L., Einbinder, E., Zhang, Q., Hasday, J., Balke, C. W. & Scharf, S. M., Oct 1 2005, In: American journal of respiratory and critical care medicine. 172, 7, p. 915-920 6 p.

Research output: Contribution to journal › Article › peer-review

205 Scopus citations

Redox mechanisms of muscle dysfunction in inflammatory disease

Reid, M. B., Andrade, F. H., Balke, C. W. & Esser, K. A., Nov 2005, In: Physical Medicine and Rehabilitation Clinics of North America. 16, 4, p. 925-949 25 p.

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Sodium pump α2 subunits control myogenic tone and blood pressure in mice

Zhang, J., Lee, M. Y., Cavalli, M., Chen, L., Berra-Romani, R., Balke, C. W., Bianchi, G., Ferrari, P., Hamlyn, J. M., Iwamoto, T., Lingrel, J. B., Matteson, D. R., Wier, W. G. & Blaustein, M. P., Nov 15 2005, In: Journal of Physiology. 569, 1, p. 243-256 14 p.

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

2004

Na⁺/Ca²⁺ exchange linking β₂- adrenergic G_i signaling to heart failure: Associated defect of adrenergic contractile support

Xiao, R. P. & Balke, C. W., Jan 2004, In: Journal of Molecular and Cellular Cardiology. 36, 1, p. 7-11 5 p.

Research output: Contribution to journal › Editorial

13 Scopus citations

2003

An antisense oligonucleotide against H1 inhibits the classical sodium current but not I_Ca(TTX) in rat ventricular cells

Sha, Q., Robinson, S. W., McCulle, S. L., Shorofsky, S. R., Welling, P. A., Goldman, L. & Balke, C. W., Mar 1 2003, In: Journal of Physiology. 547, 2, p. 435-440 6 p.

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Enhanced G_i signaling selectively negates β ₂-adrenergic receptor (AR)- but not β₁-AR-mediated positive inotropic effect in myocytes from failing rat hearts

Xiao, R. P., Zhang, S. J., Chakir, K., Avdonin, P., Zhu, W., Bond, R. A., Balke, C. W., Lakatta, E. G. & Cheng, H., Sep 30 2003, In: Circulation. 108, 13, p. 1633-1639 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

109 Scopus citations

Excitation contraction coupling in cardiac muscle: Is there a purely voltage-dependent component?

Balke, C. W. & Goldman, L., May 1 2003, In: Journal of General Physiology. 121, 5, p. 349-352 4 p.

Research output: Contribution to journal › Comment/debate

Open Access

1 Scopus citations

Role of the transverse-axial tubule system in generating calcium sparks and calcium transients in rat atrial myocytes

Kirk, M. M., Izu, L. T., Chen-Izu, Y., McCulle, S. L., Gil Wier, W., Balke, C. W. & Shorofsky, S. R., Mar 1 2003, In: Journal of Physiology. 547, 2, p. 441-451 11 p.

Research output: Contribution to journal › Review article › peer-review

47 Scopus citations

Sex, digitalis, and the sodium pump.

Blaustein, M. P., Robinson, S. W., Gottlieb, S. S., Balke, C. W. & Hamlyn, J. M., Mar 2003, In: Molecular interventions. 3, 2, p. 68-72, 50

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

2002

Do defects in the late sodium current in human ventricular cells cause heart failure?

Goldman, L. & Balke, C. W., Nov 1 2002, In: Journal of Molecular and Cellular Cardiology. 34, 11, p. 1473-1476 4 p.

Research output: Contribution to journal › Editorial

7 Scopus citations

The Ca²⁺ synapse redo: A matter of location, location, location

Izu, L. T. & William Balke, C., Aug 23 2002, In: Circulation research. 91, 4, p. 276-277 2 p.

Research output: Contribution to journal › Editorial

Open Access

2001

Adrenergic stimulation of rat resistance arteries affects Ca²⁺ sparks, Ca²⁺ waves, and Ca²⁺ oscillations

Mauban, J. R. H., Lamont, C., Balke, C. W. & Wier, W. G., May 2001, In: American Journal of Physiology - Heart and Circulatory Physiology. 280, 5 49-5, p. H2399-H2405

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Calcium currents and arrhythmias: Insights from molecular biology

Shorofsky, S. R. & Balke, C. W., Feb 1 2001, In: American Journal of Medicine. 110, 2, p. 127-140 14 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Evolution of cardiac calcium waves from stochastic calcium sparks

Izu, L. T., Wier, W. G. & Balke, C. W., 2001, In: Biophysical Journal. 80, 1, p. 103-120 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

90 Scopus citations

Graded α₁-adrenoceptor activation of arteries involves recruitment of smooth muscle cells to produce 'all or none' Ca²⁺ signals

Zang, W. J., Balke, C. W. & Wier, W. G., 2001, In: Cell Calcium. 29, 5, p. 327-334 8 p.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

I_Ca(TTX) channels are distinct from those generating the classical cardiac Na⁺ current

Chen-Izu, Y., Sha, Q., Shorofsky, S. R., Robinson, S. W., Wier, W. G., Goldman, L. & Balke, C. W., 2001, In: Biophysical Journal. 81, 5, p. 2647-2659 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access