Dr. Rosa’s research is focused on the bioinformatic analysis of high-throughput omics datasets. His research has focused on the study of parasitic helminths, which infect almost a third of the world’s population (primarily in tropical regions) and cause widespread disease, disability and even death. Through the analysis of omics data, he has contributed to studies on a range of parasitic nematodes and trematodes, including comprehensive studies spanning the phyla, identifying novel drug targets and drugs, analyzing molecular pathways associated with host interactions and anthelmintic responses, and other types of statistical analyses. All of this work will contribute to the broader goals of identifying more effective treatment and prevention strategies.

In addition to his parasitic helminth work, Dr. Rosa is involved in collaborative projects studying conserved host immune responses to tuberculosis (spanning humans, macaques and mice), human immune responses to malaria before and after treatment, and strain differences during HIV infection.