Brad Warner

Jessie L. Ternberg, M.D., PhD. Distinguished Professor of Pediatric Surgery in Surgery, Professor of Pediatrics

    • 6279 Citations
    1986 …2021

    Research output per year

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    Personal profile

    Research interests

    The major thrust of work in my laboratory is to gain a more comprehensive understanding of the adaptation process in response to massive small bowel resection. As a surgeon/scientist, I have directed a productive research program focused in this area for the past 20 years. This has been possible through a unique, collaborative team comprised of myself, a PhD molecular biologist, and a PhD cell biologist. In addition, this laboratory has been the training ground for over 40 graduate and post-graduate fellows – the majority of whom have progressed to academic positions throughout the country. Our laboratory has pioneered a murine model for small bowel resection and has made many seminal contributions toward understanding the pathogenesis of adaptation. We have used this unique surgical model to establish a critical role for epidermal growth factor receptor signaling as a major regulator of the magnitude of adaptation responses. We have also identified specific genes that are fundamental for the induction of enterocyte proliferation (p21) as well as a key gene necessary for enterocyte apoptosis (Bax). Employing indirect calorimetry and nuclear magnetic resonance, we have extended our studies to include an understanding of metabolic responses and body compositional changes in association with massive intestinal loss. Since moving from the University of Cincinnati in 2007, I have been able to embrace the outstanding research environment of the Washington University School of Medicine. This move has enabled the development of multiple key collaborations which have significantly enhanced our research program.

    Areas of Clinical Interest

    Appendicitis,inguinal hernia, necrotizing enterocolitis, omphalocele, umbilical hernia, biliary atresea, Hirschsprung’s disease, imperforate anus, intussusception, malrotation/volvulus, cystic hygroma, duodenal atresia, gastroschisis, hiatal hernia (pediatric), pyloric stenosis, and esophageal atresia.

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    Research Output

    Small Bowel Resection Increases Paracellular Gut Barrier Permeability via Alterations of Tight Junction Complexes Mediated by Intestinal TLR4

    Courtney, C. M., Onufer, E. J., McDonald, K. G., Steinberger, A. E., Sescleifer, A. M., Seiler, K. M., Tecos, M. E., Newberry, R. D. & Warner, B., Feb 2021, In : Journal of Surgical Research. 258, p. 73-81 9 p.

    Research output: Contribution to journalArticle

  • Adaptation of extracellular matrix to massive small bowel resection in mice

    Seiler, K. M., Goo, W. H., Zhang, Q., Courtney, C., Bajinting, A., Guo, J. & Warner, B. W., Jan 1 2020, (Accepted/In press) In : Journal of Pediatric Surgery.

    Research output: Contribution to journalArticle

  • Alterations in pancreatic islet cell function in response to small bowel resection

    Courtney, C. M., Shyr, Z. A., Yan, Z., Onufer, E. J., Steinberger, A. E., Tecos, M. E., Barron, L. K., Guo, J., Remedi, M. S. & Warner, B. W., Jul 1 2020, In : American journal of physiology. Gastrointestinal and liver physiology. 319, 1, p. G36-G42

    Research output: Contribution to journalArticle

  • Changing the Paradigm for Management of Pediatric Primary Spontaneous Pneumothorax: A Simple Aspiration Test Predicts Need for Operation

    on behalf of the Midwest Pediatric Surgery Consortium MWPSC, Jan 2020, In : Journal of Pediatric Surgery. 55, 1, p. 169-175 7 p.

    Research output: Contribution to journalReview article

    Open Access
  • 4 Scopus citations

    Comparative outcomes of right versus left congenital diaphragmatic hernia: A multicenter analysis

    Abramov, A., Fan, W., Hernan, R., Zenilman, A. L., Wynn, J., Aspelund, G., Khlevner, J., Krishnan, U., Lim, F. Y., Mychaliska, G. B., Warner, B. W., Cusick, R., Crombleholme, T., Chung, D., Danko, M. E., Wagner, A. J., Azarow, K., Schindel, D., Potoka, D., Soffer, S. & 5 others, Fisher, J., McCulley, D., Farkouh-Karoleski, C., Chung, W. K. & Duron, V., Jan 2020, In : Journal of Pediatric Surgery. 55, 1, p. 33-38 6 p.

    Research output: Contribution to journalArticle