Personal profile
Research interests
Our lab employs cutting-edge molecular biology techniques to investigate the genetic, epigenetic, and cellular alterations driving the initiation, progression, and therapeutic resistance of skull base brain tumors. By elucidating the molecular pathways involved, we aim to identify novel biomarkers for early detection, prognostication, and personalized treatment strategies.
Clinical interests
Brain metastases, Chordoma, chondrosarcoma and other clival tumors, Chondrosarcoma, Craniofacial and sinonasal tumors, Glioblastomas and other gliomas, Hydrocephalus, Meningiomas, Skull base and pituitary tumors, Vestibular schwannomas
Available to Mentor:
- PhD Students
- Health Professions (Medical, OT, PT, Dental, Audiology, etc.) Students
- Postdocs
- Residents and Fellows
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Collaborations and top research areas from the last five years
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Single-cell multi-omic techniques highlight the diverse composition and intercellular interactions of the vestibular schwannoma tumor microenvironment
Pari, S. S., Pugazenthi, S., Kim, A. H. & Patel, B., Mar 1 2026, In: Neuro-Oncology Advances. 8, p. i36-i42Research output: Contribution to journal › Article › peer-review
Open Access -
NF2 loss-of-function and hypoxia drive radiation resistance in grade 2 meningiomas
Patel, B., Pugazenthi, S., English, C. W., Nitturi, V., Pari, S. S., Mahlokozera, T., Leidig, W. A., Lu, H. C., Yang, A., Roberts, K., Desouza, P., Mcgeehan, K. P., Mao, D. D., Sinha, N., Ippolito, J. E., Dahiya, S., Petti, A., Yano, H., Klisch, T. J. & Harmanci, A. S. & 2 others, , Jun 1 2025, In: Journal of the National Cancer Institute. 117, 6, p. 1175-1187 13 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Scopus citations -
Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics
Ritter, M., Blume, C., Tang, Y., Patel, A., Patel, B., Berghaus, N., Kada Benotmane, J., Kueckelhaus, J., Yabo, Y., Zhang, J., Grabis, E., Villa, G., Zimmer, D. N., Khriesh, A., Sievers, P., Seferbekova, Z., Hinz, F., Ravi, V. M., Seiz-Rosenhagen, M. & Ratliff, M. & 8 others, , Feb 2025, In: Nature Cancer. 6, 2, p. 292-306 15 p., 4122.Research output: Contribution to journal › Article › peer-review
Open Access19 Link opens in a new tab Scopus citations -
The evolution and application of multi-omic analysis for pituitary neuroendocrine tumors
Pugazenthi, S., Pari, S. S., Zhang, Z., Silverstein, J., Kim, A. H. & Patel, B., 2025, In: Frontiers in Medicine. 12, 1629621.Research output: Contribution to journal › Review article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Anterolateral keyhole transorbital routes to the skull base: a comparative anatomical study
Karampouga, M., Terrarosa, A. K., Patel, B., Affolter, K., Wang, E. W., Choby, G. W., Fu, R., Bonhomme, G. R., Stefko, S. T., McDowell, M. M., Snyderman, C. H., Gardner, P. A. & Zenonos, G. A., 2024, In: Neurosurgical focus. 56, 4, E3.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Scopus citations