Personal profile
Research interests
Clinical interest is in identifying the underlying pathogenesis of necrotizing enterocolitis (NEC) in infants, specifically, evaluating the role of epidermal growth factor (EGF) in NEC prevention. We are studying EGF metabolism using stable isotope infusions and mass spectrometry analysis to identify phenotypic variation in EGF expression. This phenotype will be correlated with results from studies of EGF/EGF receptor genotypes in a population of preterm infants, and ultimately to risk of NEC. We are also evaluating the preterm infant’s intestinal microbial and inflammatory environment, and its contribution to NEC development. Ultimately we would evaluate the impact of exogenous EGF administration to the intestinal milieu. Our work translates basic science research on epidermal growth factor (EGF) to clinical application in preterm infants, ultimately to be used as the basis for clinical trials to prevent NEC.
Clinical interests
Neonatology, Fetal Care
Keywords
- COVID-19
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Collaborations and top research areas from the last five years
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Neonatal Brain Volumes and Early Parenting Behavior as Mediators in Associations Between Prenatal Social Disadvantage and Socioemotional Problems in Toddlers
Leverett, S. D., Poolos, O., Brady, R. G., Tillman, R., Lean, R. E., Gerstein, E. D., Anaya, B., Triplett, R. L., Alexopoulos, D., Warner, B., Luby, J. L., Smyser, C. D., Rogers, C. E. & Barch, D. M., Mar 1 2026, In: Biological Psychiatry. 99, 5, p. 387-397 11 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Prenatal Adversity and Neonatal Brain Connectivity Relate to Emerging Executive Function at Age 2 Years
Lean, R. E., Kenley, J. K., Latham, A. R., Smyser, T. A., Neil, J. J., Nielsen, A. N., Sylvester, C. M., Miller, J. P., Shimony, J. J., Luby, J. L., Barch, D. M., Warner, B. B., Smyser, C. D. & Rogers, C. E., Apr 2026, In: Journal of the American Academy of Child and Adolescent Psychiatry. 65, 4, p. 564-576 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Associations between Parenting and Cognitive and Language Abilities at 2 Years of Age Depend on Prenatal Exposure to Disadvantage
Leverett, S. D., Brady, R. G., Tooley, U. A., Lean, R. E., Tillman, R., Wilson, J., Ruscitti, M., Triplett, R. L., Alexopoulos, D., Gerstein, E. D., Smyser, T. A., Warner, B., Luby, J. L., Smyser, C. D., Rogers, C. E. & Barch, D. M., Jan 2025, In: Journal of Pediatrics. 276, 114289.Research output: Contribution to journal › Article › peer-review
Open Access8 Link opens in a new tab Scopus citations -
Associations between prenatal inflammation and dimensions of depressive symptoms across the perinatal period
Redic, M. M., Miller, J. P., Kimmel, M., Luby, J., Smyser, T., Rogers, C. E., Warner, B. B., Smyser, C. D., Barch, D. M., Miller, G. E. & Chen, E., Dec 2025, In: Psychoneuroendocrinology. 182, 107648.Research output: Contribution to journal › Article › peer-review
Open Access -
A survey of long-term NICU developmental follow-up practices in gastroschisis patients
Rundell, M. R., Miller, L. E., Warner, B. B. & Wagner, A. J., Aug 2025, In: Journal of Perinatology. 45, 8, p. 1114-1118 5 p.Research output: Contribution to journal › Article › peer-review