Research output per year
Research output per year
Personal profile
Research interests
Clinical interest is in identifying the underlying pathogenesis of necrotizing enterocolitis (NEC) in infants, specifically, evaluating the role of epidermal growth factor (EGF) in NEC prevention. We are studying EGF metabolism using stable isotope infusions and mass spectrometry analysis to identify phenotypic variation in EGF expression. This phenotype will be correlated with results from studies of EGF/EGF receptor genotypes in a population of preterm infants, and ultimately to risk of NEC. We are also evaluating the preterm infant’s intestinal microbial and inflammatory environment, and its contribution to NEC development. Ultimately we would evaluate the impact of exogenous EGF administration to the intestinal milieu. Our work translates basic science research on epidermal growth factor (EGF) to clinical application in preterm infants, ultimately to be used as the basis for clinical trials to prevent NEC.
Clinical interests
Newborn medicine
Keywords
- COVID-19
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Association of Prenatal Exposure to Early-Life Adversity with Neonatal Brain Volumes at Birth
Triplett, R. L., Lean, R. E., Parikh, A., Miller, J. P., Alexopoulos, D., Kaplan, S., Meyer, D., Adamson, C., Smyser, T. A., Rogers, C. E., Barch, D. M., Warner, B., Luby, J. L. & Smyser, C. D., 2022, (Accepted/In press) In: JAMA Network Open. p. E227045Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Longitudinal gut virome analysis identifies specific viral signatures that precede necrotizing enterocolitis onset in preterm infants
Kaelin, E. A., Rodriguez, C., Hall-Moore, C., Hoffmann, J. A., Linneman, L. A., Ndao, I. M., Warner, B. B., Tarr, P. I., Holtz, L. R. & Lim, E. S., May 2022, In: Nature microbiology. 7, 5, p. 653-662 10 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Neonatal Intensive Care Unit Network Neurobehavioral Scale Profiles in Full-Term Infants: Associations with Maternal Adversity, Medical Risk, and Neonatal Outcomes
Parikh, A. N., Triplett, R. L., Wu, T. J., Arora, J., Lukas, K., Smyser, T. A., Miller, J. P., Luby, J. L., Rogers, C. E., Barch, D. M., Warner, B. B. & Smyser, C. D., Jul 2022, In: Journal of Pediatrics. 246, p. 71-79.e3Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Neurodevelopmental patterns of early postnatal white matter maturation represent distinct underlying microstructure and histology
Nazeri, A., Krsnik, Ž., Kostović, I., Ha, S. M., Kopić, J., Alexopoulos, D., Kaplan, S., Meyer, D., Luby, J. L., Warner, B. B., Rogers, C. E., Barch, D. M., Shimony, J. S., McKinstry, R. C., Neil, J. J., Smyser, C. D. & Sotiras, A., Dec 7 2022, In: Neuron. 110, 23, p. 4015-4030.e4Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Prenatal exposure to maternal social disadvantage and psychosocial stress and neonatal white matter connectivity at birth
Lean, R. E., Smyser, C. D., Brady, R. G., Triplett, R. L., Kaplan, S., Kenley, J. K., Shimony, J. S., Smyser, T. A., Miller, J. P., Barch, D. M., Luby, J. L., Warner, B. B. & Rogers, C., Oct 18 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 42, e2204135119.Research output: Contribution to journal › Article › peer-review
Open Access