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Personal profile

Research interests

Clinical interest is in identifying the underlying pathogenesis of necrotizing enterocolitis (NEC) in infants, specifically, evaluating the role of epidermal growth factor (EGF) in NEC prevention. We are studying EGF metabolism using stable isotope infusions and mass spectrometry analysis to identify phenotypic variation in EGF expression. This phenotype will be correlated with results from studies of EGF/EGF receptor genotypes in a population of preterm infants, and ultimately to risk of NEC. We are also evaluating the preterm infant’s intestinal microbial and inflammatory environment, and its contribution to NEC development. Ultimately we would evaluate the impact of exogenous EGF administration to the intestinal milieu. Our work translates basic science research on epidermal growth factor (EGF) to clinical application in preterm infants, ultimately to be used as the basis for clinical trials to prevent NEC.

Areas of Clinical Interest

Newborn medicine

Keywords

  • COVID-19

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Research Output

Maternal activation of the EGFR prevents translocation of gut-residing pathogenic Escherichia coli in a model of late-onset neonatal sepsis

Knoop, K. A., Coughlin, P. E., Floyd, A. N., Malick Ndao, I., Hall-Moore, C., Shaikh, N., Gasparrini, A. J., Rusconi, B., Escobedo, M., Good, M., Warner, B. B., Tarr, P. I. & Newberry, R. D., Apr 7 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 14, p. 7941-7949 9 p.

Research output: Contribution to journalArticle

Open Access
  • 1 Scopus citations

    Neutrophil extracellular trap inhibition increases inflammation, bacteraemia and mortality in murine necrotizing enterocolitis

    Chaaban, H., Burge, K., Eckert, J., Keshari, R. S., Silasi, R., Lupu, C., Warner, B., Escobedo, M., Caplan, M. & Lupu, F., 2020, (Accepted/In press) In : Journal of Cellular and Molecular Medicine.

    Research output: Contribution to journalArticle

    Open Access
  • Postmenstrual age at discharge in premature infants with and without ventilatory pattern instability

    Hoover, J., Wambach, J., Vachharajani, A., Warner, B., Carroll, J. L. & Kemp, J. S., Jan 1 2020, In : Journal of Perinatology. 40, 1, p. 157-162 6 p.

    Research output: Contribution to journalArticle

  • Prenatal food insecurity post Hurricane Maria is associated with decreased Veillonella in the infant gut

    Wang, L., de Ángel Solá, D., Acevedo Flores, M., Schriefer, A., Wang, L., Gerónimo López, K., Chang, A., Warner, B., Shan, L., Holtz, L. R. & Rosario Matos, N., 2020, (Accepted/In press) In : Pediatric research.

    Research output: Contribution to journalArticle

  • Synchronization of mothers and offspring promotes tolerance and limits allergy

    Knoop, K. A., McDonald, K. G., Coughlin, P. E., Kulkarni, D. H., Gustafsson, J. K., Rusconi, B., John, V., Malick Ndao, I., Beigelman, A., Good, M., Warner, B. B., Elson, C. O., Hsieh, C. S., Hogan, S. P., Tarr, P. I. & Newberry, R. D., Aug 6 2020, In : JCI Insight. 5, 15, e137943.

    Research output: Contribution to journalArticle

    Open Access