Balraj Doray

2023

A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs

Dey, D., Qing, E., He, Y., Chen, Y., Jennings, B., Cohn, W., Singh, S., Gakhar, L., Schnicker, N. J., Pierce, B. G., Whitelegge, J. P., Doray, B., Orban, J., Gallagher, T. & Hasan, S. S., Dec 2023, In: Nature communications. 14, 1, 8358.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2022

Antigen glycosylation regulates efficacy of CAR T cells targeting CD19

Heard, A., Landmann, J. H., Hansen, A. R., Papadopolou, A., Hsu, Y. S., Selli, M. E., Warrington, J. M., Lattin, J., Chang, J., Ha, H., Haug-Kroeper, M., Doray, B., Gill, S., Ruella, M., Hayer, K. E., Weitzman, M. D., Green, A. M., Fluhrer, R. & Singh, N., Dec 2022, In: Nature communications. 13, 1, 3367.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Structure of the human GlcNAc-1-phosphotransferase αβ subunits reveals regulatory mechanism for lysosomal enzyme glycan phosphorylation

Li, H., Lee, W. S., Feng, X., Bai, L., Jennings, B. C., Liu, L., Doray, B., Canfield, W. M., Kornfeld, S. & Li, H., Apr 2022, In: Nature Structural and Molecular Biology. 29, 4, p. 348-356 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2021

A weak COPI binding motif in the cytoplasmic tail of SARS-CoV-2 spike glycoprotein is necessary for its cleavage, glycosylation, and localization

Jennings, B. C., Kornfeld, S. & Doray, B., Jul 2021, In: FEBS Letters. 595, 13, p. 1758-1767 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Elevated mRNA expression and defective processing of cathepsin D in HeLa cells lacking the mannose 6-phosphate pathway

Liu, L. & Doray, B., Jun 2021, In: FEBS Open Bio. 11, 6, p. 1695-1703 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Inactivation of the three GGA genes in HeLa cells partially compromises lysosomal enzyme sorting

Doray, B., Liu, L., Lee, W. S., Jennings, B. C. & Kornfeld, S., Feb 2021, In: FEBS Open Bio. 11, 2, p. 367-374 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2020

Disease-causing missense mutations within the N-terminal transmembrane domain of GlcNAc-1-phosphotransferase impair endoplasmic reticulum translocation or Golgi retention

Lee, W. S., Jennings, B. C., Doray, B. & Kornfeld, S., Jul 1 2020, In: Human mutation. 41, 7, p. 1321-1328 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2018

Recycling of Golgi glycosyltransferases requires direct binding to coatomer

Liu, L., Doray, B. & Kornfeld, S., Sep 4 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 36, p. 8984-8989 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

58 Scopus citations

2017

Engineering of GlcNAc-1-Phosphotransferase for Production of Highly Phosphorylated Lysosomal Enzymes for Enzyme Replacement Therapy

Liu, L., Lee, W. S., Doray, B. & Kornfeld, S., Jun 16 2017, In: Molecular Therapy - Methods and Clinical Development. 5, p. 59-65 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

Role of spacer-1 in the maturation and function of GlcNAc-1-phosphotransferase

Liu, L., Lee, W. S., Doray, B. & Kornfeld, S., Jan 1 2017, In: FEBS Letters. 591, 1, p. 47-55 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

2016

Multiple domains of GlcNAc-1-phosphotransferase mediate recognition of lysosomal enzymes

Van Meel, E., Lee, W. S., Liu, L., Qian, Y., Doray, B. & Kornfeld, S., Apr 8 2016, In: Journal of Biological Chemistry. 291, 15, p. 8295-8307 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

2014

A clathrin coat assembly role for the muniscin protein central linker revealed by TALEN-mediated gene editing

Umasankar, P. K., Ma, L., Thieman, J. R., Jha, A., Doray, B., Watkins, S. C. & Traub, L. M., Oct 10 2014, In: eLife. 3, e04137.

Research output: Contribution to journal › Article › peer-review

Open Access

45 Scopus citations

Impact of genetic background on neonatal lethality of Gga2 gene-trap mice

Doray, B., Govero, J. & Kornfeld, S., 2014, In: G3: Genes, Genomes, Genetics. 4, 5, p. 885-890 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2012

Analysis of Gga null mice demonstrates a non-redundant role for mammalian GGA2 during development

Govero, J., Doray, B., Bai, H. & Kornfeld, S., Jan 26 2012, In: PloS one. 7, 1, e30184.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Do gga adaptors bind internal dxxll motifs?

Doray, B., Misra, S., Qian, Y., Brett, T. J. & Kornfeld, S., Oct 2012, In: Traffic. 13, 10, p. 1315-1325 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

2009

Clathrin regulates the association of PIPKIγ661 with the AP-2 adaptor β2 Appendage

Thieman, J. R., Mishra, S. K., Ling, K., Doray, B., Anderson, R. A. & Traub, L. M., May 15 2009, In: Journal of Biological Chemistry. 284, 20, p. 13924-13939 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

2008

Binding of cargo sorting signals to AP-1 enhances its association with ADP ribosylation factor 1-GTP

Lee, I., Doray, B., Govero, J. & Kornfeld, S., Feb 11 2008, In: Journal of Cell Biology. 180, 3, p. 467-472 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

Identification of acidic dileucine signals in LRP9 that interact with both GGAs and AP-1/AP-2

Doray, B., Knisely, J. M., Wartman, L., Bu, G. & Kornfeld, S., 2008, In: Traffic. 9, 9, p. 1551-1562 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

2007

The γ/σ1 and α/σ2 hemicomplexes of clathrin adaptors AP-1 and AP-2 Harbor the dileucine recognition site

Doray, B., Lee, I., Knisely, J., Bu, G. & Kornfeld, S., May 2007, In: Molecular biology of the cell. 18, 5, p. 1887-1896 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

142 Scopus citations

2004

Discovery of estrogen receptor alpha target genes and response elements in breast tumor cells.

Lin, C. Y., Ström, A., Vega, V. B., Kong, S. L., Yeo, A. L., Thomsen, J. S., Chan, W. C., Doray, B., Bangarusamy, D. K., Ramasamy, A., Vergara, L. A., Tang, S., Chong, A., Bajic, V. B., Miller, L. D., Gustafsson, J. A. & Liu, E. T., 2004, In: Genome biology. 5, 9, p. R66

Research output: Contribution to journal › Article › peer-review

250 Scopus citations

GGA1 Interacts with the Adaptor Protein AP-1 through a WNSF Sequence in Its Hinge Region

Bai, H., Doray, B. & Kornfeld, S., Apr 23 2004, In: Journal of Biological Chemistry. 279, 17, p. 17411-17417 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

2002

Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif

Doray, B., Bruns, K., Ghosh, P. & Kornfeld, S. A., Jun 11 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, 12, p. 8072-8077 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

73 Scopus citations

Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network

Doray, B., Ghosh, P., Griffith, J., Geuze, H. J. & Kornfeld, S., Sep 6 2002, In: Science. 297, 5587, p. 1700-1703 4 p.

Research output: Contribution to journal › Article › peer-review

213 Scopus citations

Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins

Doray, B., Bruns, K., Ghosh, P. & Kornfeld, S., May 24 2002, In: Journal of Biological Chemistry. 277, 21, p. 18477-18482 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

58 Scopus citations

2001

Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor

Zhu, Y., Doray, B., Poussu, A., Lehto, V. P. & Kornfeld, S., Jun 1 2001, In: Science. 292, 5522, p. 1716-1718 3 p.

Research output: Contribution to journal › Article › peer-review

241 Scopus citations

N-terminal deletions and His-tag fusions dramatically affect expression of cytochrome P450 2C2 in bacteria

Doray, B., Chen, C. D. & Kemper, B., 2001, In: Archives of Biochemistry and Biophysics. 393, 1, p. 143-153 11 p., 92473.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

γ Subunit of the AP-1 adaptor complex binds clathrin: Implications for cooperative binding in coated vesicle assembly

Doray, B. & Kornfeld, S., 2001, In: Molecular biology of the cell. 12, 7, p. 1925-1935 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

61 Scopus citations

1999

Substitutions in the C-terminal portion of the catalytic domain partially reverse assembly defects introduced by mutations in the N-terminal linker sequence of cytochrome P450 2C2

Doray, B., Chen, C. D. & Kemper, B., Sep 14 1999, In: Biochemistry. 38, 37, p. 12180-12186 7 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

1998

A conserved proline-rich sequence between the N-terminal signal-anchor and catalytic domains is required for assembly of functional cytochrome P450 2C2

Chen, C. D., Doray, B. & Kemper, B., Feb 15 1998, In: Archives of Biochemistry and Biophysics. 350, 2, p. 233-238 6 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

1997

Efficient assembly of functional cytochrome P450 2C2 requires a spacer sequence between the N-terminal signal anchor and catalytic domains

Chen, C. D., Doray, B. & Kemper, B., Sep 5 1997, In: Journal of Biological Chemistry. 272, 36, p. 22891-22897 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Functional analysis of the linker region of P450 2C2

Oioli, G. P., Doray, B. & Kemper, B., Dec 1 1997, In: FASEB Journal. 11, 9, p. A794

Research output: Contribution to journal › Article › peer-review

1995

Retardation of RNA electrophoretic mobility due to a palindromic region

Dante, M., Michalik, S. S., Mathew, Z., Doray, B., Ho, L. L., Wise, K. J. & Christianson, T. W., Mar 1995, In: Analytical Biochemistry. 225, 2, p. 348-351 4 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

The cytoplasmic and N-terminal transmembrane domains of cytochrome P450 contain independent signals for retention in the endoplasmic reticulum

Szczesna-Skorupa, E., Ahn, K., Chen, C. D., Doray, B. & Kemper, B., Oct 13 1995, In: Journal of Biological Chemistry. 270, 41, p. 24327-24333 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

65 Scopus citations

Balraj Doray

Research output

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