Bahaa Eldien Elgendy

2024

2,5-Diketopiperazines (DKPs): Promising Scaffolds for Anticancer Agents

Goher, S. S., Abdrabo, W. S., Veerakanellore, G. B. & Elgendy, B., 2024, In: Current Pharmaceutical Design. 30, 8, p. 597-623 27 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

A Synthetic ERR Agonist Alleviates Metabolic Syndrome

Billon, C., Schoepke, E., Avdagic, A., Chatterjee, A., Butler, A. A., Elgendy, B., Walker, J. K. & Burris, T. P., Feb 1 2024, In: Journal of Pharmacology and Experimental Therapeutics. 388, 2, p. 232-240 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Tailoring FXR Modulators for Intestinal Specificity: Recent Progress and Insights

Morrison, A. & Elgendy, B., May 2024, In: Molecules. 29, 9, 2022.

Research output: Contribution to journal › Review article › peer-review

Open Access

2023

4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments

Ragab, M. A., Eldehna, W. M., Nocentini, A., Bonardi, A., Okda, H. E., Elgendy, B., Ibrahim, T. S., Abd-Alhaseeb, M. M., Gratteri, P., Supuran, C. T., Al-Karmalawy, A. A. & Elagawany, M., Mar 15 2023, In: European Journal of Medicinal Chemistry. 250, 115180.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney

Wang, X. X., Myakala, K., Libby, A. E., Krawczyk, E., Panov, J., Jones, B. A., Bhasin, K., Shults, N., Qi, Y., Krausz, K. W., Zerfas, P. M., Takahashi, S., Daneshpajouhnejad, P., Titievsky, A., Taranenko, E., Billon, C., Chatterjee, A., Elgendy, B., Walker, J. K. & Albanese, C. & 7 others, Kopp, J. B., Rosenberg, A. Z., Gonzalez, F. J., Guha, U., Brodsky, L., Burris, T. P. & Levi, M., Dec 2023, In: American Journal of Pathology. 193, 12, p. 1969-1987 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights

Badawi, W. A., Rashed, M., Nocentini, A., Bonardi, A., Abd-Alhaseeb, M. M., Al-Rashood, S. T., Veerakanellore, G. B., Majrashi, T. A., Elkaeed, E. B., Elgendy, B., Gratteri, P., Supuran, C. T., Eldehna, W. M. & Elagawany, M., 2023, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 38, 1, 2201407.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily—Update 2023

Burris, T. P., de Vera, I. M. S., Cote, I., Flaveny, C. A., Wanninayake, U. S., Chatterjee, A., Walker, J. K., Steinauer, N., Zhang, J., Coons, L. A., Korach, K. S., Cain, D. W., Hollenberg, A. N., Webb, P., Forrest, D., Jetten, A. M., Edwards, D. P., Grimm, S. L., Hartig, S. & Lange, C. A. & 16 others, Richer, J. K., Sartorius, C. A., Tetel, M., Billon, C., Elgendy, B., Hegazy, L., Griffett, K., Peinetti, N., Burnstein, K. L., Hughes, T. S., Sitaula, S., Stayrook, K. R., Culver, A., Murray, M. H., Finck, B. N. & Cidlowski, J. A., Nov 1 2023, In: Pharmacological Reviews. 75, 6, p. 1233-1318 86 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

REV-ERB activation as a novel pharmacological approach for treating inflammatory pain

Makhija, S., Griffett, J. D., Veerakanellore, G. B., Burris, T. P., Elgendy, B. & Griffett, K., 2023, In: Frontiers in Pharmacology. 14, 1171931.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Synthesis of 3-Aminoquinazolinones via a SnCl₂-Mediated ANRORC-like Reductive Rearrangement of 1,3,4-Oxadiazoles

Elagawany, M., Maram, L. & Elgendy, B., Dec 15 2023, In: Journal of Organic Chemistry. 88, 24, p. 17062-17068 7 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity

Billon, C., Sitaula, S., Banerjee, S., Welch, R., Elgendy, B., Hegazy, L., Oh, T. G., Kazantzis, M., Chatterjee, A., Chrivia, J., Hayes, M. E., Xu, W., Hamilton, A., Huss, J. M., Zhang, L., Walker, J. K., Downes, M., Evans, R. M. & Burris, T. P., Apr 21 2023, In: ACS Chemical Biology. 18, 4, p. 756-771 16 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

2022

Antihyperlipidemic Activity of Gut-Restricted LXR Inverse Agonists

Griffett, K., Hayes, M., Bedia-Diaz, G., Appourchaux, K., Sanders, R., Boeckman, M. P., Koelblen, T., Zhang, J., Schulman, I. G., Elgendy, B. & Burris, T. P., May 20 2022, In: ACS Chemical Biology. 17, 5, p. 1143-1154 12 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Design, Synthesis and Antitumor Activity of Novel Dispiro[oxindole-cyclohexanone]-pyrrolidines

Gouda, M., Bawazeer, M., Hegazy, L., Azab, M., Elagawany, M., Rateb, M., Yaseen, M. & Elgendy, B., 2022, In: Current Pharmaceutical Design. 28, 3, p. 198-207 10 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH

Welch, R. D., Billon, C., Losby, M., Bedia‐diaz, G., Fang, Y., Avdagic, A., Elgendy, B., Burris, T. P. & Griffett, K., Mar 2022, In: Metabolites. 12, 3, 238.

Research output: Contribution to journal › Review article › peer-review

Open Access

13 Scopus citations

Identification of Novel Mitochondrial Pyruvate Carrier Inhibitors by Homology Modeling and Pharmacophore-Based Virtual Screening

Hegazy, L., Gill, L. E., Pyles, K. D., Kaiho, C., Kchouk, S., Finck, B. N., McCommis, K. & Elgendy, B., Feb 2022, In: Biomedicines. 10, 2, 365.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Ligand-based design, synthesis, computational insights, and in vitro studies of novel N-(5-Nitrothiazol-2-yl)-carboxamido derivatives as potent inhibitors of SARS-CoV-2 main protease

Elagawany, M., Elmaaty, A. A., Mostafa, A., Abo Shama, N. M., Santali, E. Y., Elgendy, B. & Al-Karmalawy, A. A., 2022, In: Journal of Enzyme Inhibition and Medicinal Chemistry. 37, 1, p. 2112-2132 21 p.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

Metal coordinating inhibitors of Rift Valley fever virus replication

Geerling, E., Murphy, V., Mai, M. C., Stone, E. T., Casals, A. G., Hassert, M., O'Dea, A. T., Cao, F., Donlin, M. J., Elagawany, M., Elgendy, B., Pardali, V., Giannakopoulou, E., Zoidis, G., Schiavone, D. V., Berkowitz, A. J., Agyemang, N. B., Murelli, R. P., Tavis, J. E. & Pinto, A. K. & 1 others, Brien, J. D., Sep 2022, In: PloS one. 17, 9 Septamber, e0274266.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice

Hodges, W. T., Jarasvaraparn, C., Ferguson, D., Griffett, K., Gill, L. E., Chen, Y., Ilagan, M. X. G., Hegazy, L., Elgendy, B., Cho, K., Patti, G. J., McCommis, K. & Finck, B. N., Feb 1 2022, In: Journal of Biological Chemistry. 298, 2, 101554.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB

Murray, M. H., Valfort, A. C., Koelblen, T., Ronin, C., Ciesielski, F., Chatterjee, A., Veerakanellore, G. B., Elgendy, B., Walker, J. K., Hegazy, L. & Burris, T. P., Dec 2022, In: Nature communications. 13, 1, 7131.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Structure-based design and synthesis of conformationally constrained derivatives of methyl-piperidinopyrazole (MPP) with estrogen receptor (ER) antagonist activity

Ragab, M. A., Elagawany, M., Daabees, H., Ahmed, A. S. F., Awad, E. M., Billon, C., Elgendy, B., Abouzid, K. A. M. & Kassab, S. E., Feb 2022, In: Bioorganic Chemistry. 119, 105554.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Synthesis and structure activity relationship of the first class of LXR inverse agonists

Elgendy, B., Griffett, K., Hegazy, L., Di Fruscia, P., Sample, K., Schoepke, E., Kamenecka, T. M. & Burris, T. P., Feb 2022, In: Bioorganic Chemistry. 119, 105540.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

2021

Enhancement for the fluorescent properties of new synthesized GFPs chromophore

Elgendy, B., Azab, M. M., Gamil, M. & El-Feky, H. H., Jul 2021, In: Egyptian Journal of Chemistry. 64, 7, p. 3717-3727 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Novel synthesis of benzotriazolyl alkyl esters: an unprecedented CH₂insertion

Elagawany, M., Maram, L. & Elgendy, B., Feb 17 2021, In: RSC Advances. 11, 13, p. 7564-7569 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Potent antiplasmodial alkaloids from the rhizobacterium Pantoea agglomerans as hemozoin modulators

Thissera, B., Hallyburton, I., Ngwa, C. J., Cherif-Silini, H., Hassane, A. S. I., Anderson, M., Campbell, L. A., Mutter, N., Eshelli, M., Abdelmohsen, U. R., Yaseen, M., Pradel, G., Belbahri, L., Elgendy, B., Hegazy, L. & Rateb, M. E., Oct 2021, In: Bioorganic Chemistry. 115, 105215.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Recent Advances in the Medicinal Chemistry of Farnesoid X Receptor

Fang, Y., Hegazy, L., Finck, B. N. & Elgendy, B., Dec 23 2021, In: Journal of Medicinal Chemistry. 64, 24, p. 17545-17571 27 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Structure-based design of estrogen-related receptors modulators

Goher, S. S. & Elgendy, B., Sep 28 2021, Nuclear Receptors: The Art and Science of Modulator Design and Discovery. Springer International Publishing, p. 79-109 31 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

2020

Catalyst-and organic solvent-free synthesis, structural, and theoretical studies of 1-arylidenamino-2,4-disubstituted-2-imidazoline-5-ones

Saaed, W., Elagawany, M., Azab, M. M., Amin, A. S., Rath, N. P., Hegazy, L. & Elgendy, B., Jan 2020, In: Results in Chemistry. 2, 100042.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on bumetanide scaffold

Ibrahim, T. S., Salem, I. M., Mostafa, S. M., El-Sabbagh, O. I., ElKhamisi, M. K. M., Hegazy, L. & Elgendy, B., Jul 2020, In: Bioorganic Chemistry. 100, 103878.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Design and synthesis of novel pyrazolo[3,4-d]pyrimidin-4-one bearing quinoline scaffold as potent dual PDE5 inhibitors and apoptotic inducers for cancer therapy

Ibrahim, T. S., Hawwas, M. M., Taher, E. S., Alhakamy, N. A., Alfaleh, M. A., Elagawany, M., Elgendy, B., Zayed, G. M., Mohamed, M. F. A., Abdel-Samii, Z. K. & Elshaier, Y. A. M. M., Dec 2020, In: Bioorganic Chemistry. 105, 104352.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Expanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases

Elzahhar, P. A., Abd El Wahab, S. M., Elagawany, M., Daabees, H., Belal, A. S. F., EL-Yazbi, A. F., Eid, A. H., Alaaeddine, R., Hegazy, R. R., Allam, R. M., Helmy, M. W., Bahaa Elgendy, E., Angeli, A., El-Hawash, S. A. & Supuran, C. T., Aug 15 2020, In: European Journal of Medicinal Chemistry. 200, 112439.

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Modulation of estrogen-related receptors subtype selectivity: Conversion of an ERRβ/γ selective agonist to ERRα/β/γ pan agonists

Shahien, M., Elagawany, M., Sitaula, S., Goher, S. S., Burris, S. L., Sanders, R., Avdagic, A., Billon, C., Hegazy, L., Burris, T. P. & Elgendy, B., Sep 2020, In: Bioorganic Chemistry. 102, 104079.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

REV-ERB agonism improves liver pathology in a mouse model of NASH

Griffett, K., Bedia-Diaz, G., Elgendy, B. & Burris, T. P., Oct 2020, In: PloS one. 15, 10 October, e0236000.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Synthesis, assessment and corrosion protection investigations of some novel peptidomimetic cationic surfactants: Empirical and theoretical insights

Abdrabo, W. S., Elgendy, B., Soliman, K. A., Abd El-Lateef, H. M. & Tantawy, A. H., Oct 1 2020, In: Journal of Molecular Liquids. 315, 113672.

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

2019

Baclofen impurities: Facile synthesis and novel environmentally benign chromatographic method for their simultaneous determination in baclofen

Elagawany, M., Farid, N. F., Elgendy, B., Abdelmomen, E. H. & Abdelwahab, N. S., Sep 2019, In: Biomedical Chromatography. 33, 9, e4579.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Catalyst- and organic solvent-free synthesis of thioacids in water

Elagawany, M., Hegazy, L. & Elgendy, B., Jul 25 2019, In: Tetrahedron Letters. 60, 30, p. 2018-2021 4 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Development of novel liver X receptor modulators based on a 1,2,4-triazole scaffold

Goher, S. S., Griffett, K., Hegazy, L., Elagawany, M., Arief, M. M. H., Avdagic, A., Banerjee, S., Burris, T. P. & Elgendy, B., Feb 1 2019, In: Bioorganic and Medicinal Chemistry Letters. 29, 3, p. 449-453 5 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

2018

Identification of 4-isopropyl-thiotropolone as a novel anti-microbial: Regioselective synthesis, NMR characterization, and biological evaluation

Elagawany, M., Hegazy, L., Cao, F., Donlin, M. J., Rath, N., Tavis, J. & Elgendy, B., 2018, In: RSC Advances. 8, 52, p. 29967-29975 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Identification of novel small molecule inhibitors against the NS3/4A protease of hepatitis C virus genotype 4a

El-Sayed, S. M., Ali, M. A. M., El-Gendy, B. E. D. M., Dandash, S. S., Issac, Y., Saad, R., Azab, M. M. & Mohamed, M. R., 2018, In: Current Pharmaceutical Design. 24, 37, p. 4484-4491 8 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Recent Advances in the Medicinal Chemistry of Liver X Receptors

El-Gendy, B. E. D. M., Goher, S. S., Hegazy, L. S., Arief, M. M. H. & Burris, T. P., Dec 27 2018, In: Journal of Medicinal Chemistry. 61, 24, p. 10935-10956 22 p.

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Synthesis and Evaluation of Troponoids as a New Class of Antibiotics

Cao, F., Orth, C., Donlin, M. J., Adegboyega, P., Meyers, M. J., Murelli, R. P., Elagawany, M., Elgendy, B. & Tavis, J. E., Nov 8 2018, In: ACS Omega. 3, 11, p. 15125-15133 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

2016

P450 3A-Catalyzed O-Dealkylation of Lapatinib Induces Mitochondrial Stress and Activates Nrf2

Eno, M. R., El-Gendy, B. E. D. M. & Cameron, M. D., May 16 2016, In: Chemical Research in Toxicology. 29, 5, p. 784-796 13 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Stereoselective Synthesis, Structural and Spectroscopic Study of 4,5,11-Triazatricyclo[6.2.1.02,6]Undec-5-ene

Mabied, A. F., Girgis, A. S., Shalaby, E. S. M., George, R. F., El-Gendy, B. E. D. M. & Baselious, F. N., Jul 2016, In: Journal of Heterocyclic Chemistry. 53, 4, p. 1074-1080 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

2015

Antibacterial activity of diketopiperazines isolated from a marine fungus using t-butoxycarbonyl group as a simple tool for purification

El-Gendy, B. E. D. M. & Rateb, M. E., Jul 3 2015, In: Bioorganic and Medicinal Chemistry Letters. 25, 16, p. 3125-3128 4 p., 22800.

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis

Flaveny, C. A., Griffett, K., El-Gendy, B. E. D. M., Kazantzis, M., Sengupta, M., Amelio, A. L., Chatterjee, A., Walker, J., Solt, L. A., Kamenecka, T. M. & Burris, T. P., Jul 13 2015, In: Cancer Cell. 28, 1, p. 42-56 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

158 Scopus citations

Investigation of adsorption and inhibition effects of some novel anil compounds towards mild steel in H₂SO₄ solution: Electrochemical and theoretical quantum studies

Abd El-Lateef, H. M., Abu-Dief, A. M. & El-Gendy, B. E. D. M., Dec 1 2015, In: Journal of Electroanalytical Chemistry. 758, p. 135-147 13 p.

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

2014

Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour

Banerjee, S., Wang, Y., Solt, L. A., Griffett, K., Kazantzis, M., Amador, A., El-Gendy, B. M., Huitron-Resendiz, S., Roberts, A. J., Shin, Y., Kamenecka, T. M. & Burris, T. P., Dec 23 2014, In: Nature communications. 5, 5759.

Research output: Contribution to journal › Article › peer-review

Open Access

100 Scopus citations

Pyrrolizines: Promising scaffolds for anticancer drugs

Belal, A. & El-Gendy, B. E. D. M., Jan 1 2014, In: Bioorganic and Medicinal Chemistry. 22, 1, p. 46-53 8 p.

Research output: Contribution to journal › Review article › peer-review

50 Scopus citations

Regioselective synthesis, stereochemical structure, spectroscopic characterization and geometry optimization of dispiro[3H-indole-3,2′-pyrrolidine-3′,3″-piperidines]

Shalaby, E. M., Girgis, A. S., Moustafa, A. M., Elshaabiny, A. M., El-Gendy, B. E. D. M., Mabied, A. F. & Ahmed Farag, I. S., 2014, In: Journal of Molecular Structure. 1075, p. 327-334 8 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

2013

A liver-selective LXR inverse agonist that suppresses hepatic steatosis

Griffett, K., Solt, L. A., El-Gendy, B. E. D. M., Kamenecka, T. M. & Burris, T. P., Mar 15 2013, In: ACS Chemical Biology. 8, 3, p. 559-567 9 p.

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Small molecule amides as potent ROR-γ selective modulators

Khan, P. M., El-Gendy, B. E. D. M., Kumar, N., Garcia-Ordonez, R., Lin, L., Ruiz, C. H., Cameron, M. D., Griffin, P. R. & Kamenecka, T. M., Jan 15 2013, In: Bioorganic and Medicinal Chemistry Letters. 23, 2, p. 532-536 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

α-Substitution effects on the ease of S → N-Acyl transfer in aminothioesters

El-Gendy, B. E. D. M., Ghazvini Zadeh, E. H., Sotuyo, A. C., Pillai, G. G. & Katritzky, A. R., May 2013, In: Chemical Biology and Drug Design. 81, 5, p. 577-582 6 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Bahaa Eldien Elgendy

Research output

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