• 10938 Citations

Research output per year

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Personal profile

Research interests

Atherosclerosis is a chronic and insidious process wherein the arterial lining is compromised by lipid and cellular infiltration. Atherosclerotic plaque progression is the underlying cause of the majority of cardiovascular diseases including myocardial infarction and strokes leading to tremendous morbidity and mortality worldwide. Understanding the pathophysiology of plaque formation and progression remains an important area of investigation both scientifically and clinically, serving as the basis for future therapeutics. Inflammatory cells, especially macrophages, play a central role in atherosclerosis. Elucidation of cellular processes that are affected in plaque macrophages has led to our understanding that among other things, aberrant lipid homeostasis and inflammation are critical to plaque progression. Recent work on the autophagy-lysosomal system, or the process by which cells turn over long-lived organelles and proteins, has revealed that atherosclerotic macrophages manifest features of autophagy-lysosomal dysfunction with profound pathogenic consequences. Studying this system in animal models and translating findings to patients with cardiovascular diseases is a major thrust of my research.

Areas of Clinical Interest

Clinical cardiology, preventive cardiology, echocardiography.

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Research Output

Autophagy is critical for group 2 innate lymphoid cell metabolic homeostasis and effector function

Galle-Treger, L., Hurrell, B. P., Lewis, G., Howard, E., Jahani, P. S., Banie, H., Razani, B., Soroosh, P. & Akbari, O., Feb 2020, In : Journal of Allergy and Clinical Immunology. 145, 2, p. 502-517.e5

Research output: Contribution to journalArticle

Open Access
  • 4 Scopus citations

    High-protein diets increase cardiovascular risk by activating macrophage mTOR to suppress mitophagy

    Zhang, X., Sergin, I., Evans, T. D., Jeong, S. J., Rodriguez-Velez, A., Kapoor, D., Chen, S., Song, E., Holloway, K. B., Crowley, J. R., Epelman, S., Weihl, C. C., Diwan, A., Fan, D., Mittendorfer, B., Stitziel, N. O., Schilling, J. D., Lodhi, I. J. & Razani, B., Jan 1 2020, In : Nature Metabolism. 2, 1, p. 110-125 16 p.

    Research output: Contribution to journalArticle

  • 5 Scopus citations

    Assessment of Copper Nanoclusters for Accurate in Vivo Tumor Imaging and Potential for Translation

    Heo, G. S., Zhao, Y., Sultan, D., Zhang, X., Detering, L., Luehmann, H. P., Zhang, X., Li, R., Choksi, A., Sharp, S., Levingston, S., Primeau, T., Reichert, D. E., Sun, G., Razani, B., Li, S., Weilbaecher, K. N., Dehdashti, F., Wooley, K. L. & Liu, Y., Jun 5 2019, In : ACS Applied Materials and Interfaces. 11, 22, p. 19669-19678 10 p.

    Research output: Contribution to journalArticle

  • 11 Scopus citations

    Frontline Science: Acyl-CoA synthetase 1 exacerbates lipotoxic inflammasome activation in primary macrophages

    Kalugotla, G., He, L., Weber, K. J., Daemen, S., Reller, A., Razani, B. & Schilling, J. D., Oct 1 2019, In : Journal of Leukocyte Biology. 106, 4, p. 803-814 12 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Functional Characterization of LIPA (Lysosomal Acid Lipase) Variants Associated with Coronary Artery Disease

    Evans, T. D., Zhang, X., Clark, R. E., Alisio, A., Song, E., Zhang, H., Reilly, M. P., Stitziel, N. O. & Razani, B., Dec 1 2019, In : Arteriosclerosis, thrombosis, and vascular biology. 39, 12, p. 2480-2491 12 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations