Research output per year
Research output per year
- 1 - 50 out of 57 results
Search results
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2025
MicroRNA-181a/b-1 enhances chondroprogenitor anabolism and downregulates aquaporin-9
Bell-Hensley, A., Brito, V. G. B., Cai, L., Liu, J., Feeney, K., Zheng, H. & McAlinden, A., Mar 2025, In: Osteoarthritis and Cartilage Open. 7, 1, 100550.Research output: Contribution to journal › Article › peer-review
Open Access -
2024
Skeletal abnormalities in mice with Dnmt3a missense mutations
Bell-Hensley, A., Beard, D. C., Feeney, K., Zheng, H., Jiang, Y., Zhang, X., Liu, J., Gabel, H. & McAlinden, A., Jun 2024, In: Bone. 183, 117085.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Distinct disease mutations in DNMT3A result in a spectrum of behavioral, epigenetic, and transcriptional deficits
Beard, D. C., Zhang, X., Wu, D. Y., Martin, J. R., Erickson, A., Boua, J. V., Hamagami, N., Swift, R. G., McCullough, K. B., Ge, X., Bell-Hensley, A., Zheng, H., Palmer, C. W., Fuhler, N. A., Lawrence, A. B., Hill, C. A., Papouin, T., Noguchi, K. K., McAlinden, A. & Garbow, J. R. & 3 others, , Nov 28 2023, In: Cell Reports. 42, 11, 113411.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
MicroRNA-138: an emerging regulator of skeletal development, homeostasis, and disease
Brito, V. G. B., Bell-Hensley, A. & McAlinden, A., 2023, In: American Journal of Physiology - Cell Physiology. 325, 6, p. C1387-C1400Research output: Contribution to journal › Review article › peer-review
5 Scopus citations -
Modulation of MicroRNA Expression During In Vitro Chondrogenesis
Bell-Hensley, A., Zheng, H. & McAlinden, A., 2023, Methods in Molecular Biology. Humana Press Inc., p. 197-215 19 p. (Methods in Molecular Biology; vol. 2598).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
1 Scopus citations -
The miR-181 family: Wide-ranging pathophysiological effects on cell fate and function
Bell-Hensley, A., Das, S. & McAlinden, A., Apr 2023, In: Journal of Cellular Physiology. 238, 4, p. 698-713 16 p.Research output: Contribution to journal › Review article › peer-review
14 Scopus citations -
2021
Ablation of Proliferating Osteoblast Lineage Cells After Fracture Leads to Atrophic Nonunion in a Mouse Model
Hixon, K. R., McKenzie, J. A., Sykes, D. A. W., Yoneda, S., Hensley, A., Buettmann, E. G., Zheng, H., Skouteris, D., McAlinden, A., Miller, A. N. & Silva, M. J., Nov 2021, In: Journal of Bone and Mineral Research. 36, 11, p. 2243-2257 15 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Biochemical and immuno-histochemical localization of type IIA procollagen in annulus fibrosus of mature bovine intervertebral disc
McAlinden, A., Hudson, D. M., Fernandes, A. A., Ravindran, S. & Fernandes, R. J., Dec 2021, In: Matrix Biology Plus. 12, 100077.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Delineation of the 1q24.3 microdeletion syndrome provides further evidence for the potential role of non-coding RNAs in regulating the skeletal phenotype
Shepherdson, J. L., Zheng, H., Amarillo, I. E., McAlinden, A. & Shinawi, M., Jan 2021, In: Bone. 142, 115705.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Expression profiling of mitochondria-associated microRNAs during osteogenic differentiation of human MSCs
Zheng, H., Liu, J., Yu, J. & McAlinden, A., Oct 2021, In: Bone. 151, 116058.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
Gasdermin D deficiency attenuates arthritis induced by traumatic injury but not autoantibody-assembled immune complexes
Yang, T., Sun, K., Wang, C., Swarnkar, G., Quan, S., Kress, D., Xiao, J., Alippe, Y., Zheng, H., Brophy, R. H., Hao, D., McAlinden, A., Abu-Amer, Y., Shen, J. & Mbalaviele, G., Dec 2021, In: Arthritis Research and Therapy. 23, 1, 286.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Response to Letter to the Editor
McAlinden, A., Mar 2021, In: Bone. 144, 115823.Research output: Contribution to journal › Letter › peer-review
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RNA Isolation from Articular Cartilage Tissue
Zheng, H. & McAlinden, A., 2021, Methods in Molecular Biology. Humana Press Inc., p. 121-133 13 p. (Methods in Molecular Biology; vol. 2245).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
7 Scopus citations -
The role of microRNAs in bone development
Hensley, A. P. & McAlinden, A., Feb 2021, In: Bone. 143, 115760.Research output: Contribution to journal › Article › peer-review
56 Scopus citations -
2020
Long non-coding rna graslnd enhances chondrogenesis via suppression of interferon type II signaling pathway
Huynh, N. P. T., Gloss, C. C., Lorentz, J., Tang, R., Brunger, J. M., McAlinden, A., Zhang, B. & Guilak, F., Mar 2020, In: eLife. 9, e49558.Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
2019
Inhibition of 4-aminobutyrate aminotransferase protects against injury-induced osteoarthritis in mice
Shen, J., Wang, C., Ying, J., Xu, T., McAlinden, A. & O'Keefe, R. J., Sep 19 2019, In: JCI Insight. 4, 18, e128568.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
MicroRNA-138 Inhibits Osteogenic Differentiation and Mineralization of Human Dedifferentiated Chondrocytes by Regulating RhoC and the Actin Cytoskeleton
Zheng, H., Ramnaraign, D., Anderson, B. A., Tycksen, E., Nunley, R. & McAlinden, A., Feb 2019, In: JBMR Plus. 3, 2, e10071.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
MicroRNA-181a/b-1 over-expression enhances osteogenesis by modulating PTEN/PI3K/AKT signaling and mitochondrial metabolism
Zheng, H., Liu, J., Tycksen, E., Nunley, R. & McAlinden, A., Jun 2019, In: Bone. 123, p. 92-102 11 p.Research output: Contribution to journal › Article › peer-review
61 Scopus citations -
2018
Corrigendum to “Quantification of type II procollagen splice forms using alternative transcript-qPCR (AT-qPCR)” (Matrix Biol. 31(2012) (412-420)(S0945053X12000911)(10.1016/j.matbio.2012.08.002))
McAlinden, A., Shim, K. H., Wirthlin, L., Ravindran, S. & Hering, T. M., Jan 2018, In: Matrix Biology. 65, p. 119-120 2 p.Research output: Contribution to journal › Comment/debate
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MicroRNAs in orthopaedic research: Disease associations, potential therapeutic applications, and perspectives
McAlinden, A. & Im, G. I., Jan 2018, In: Journal of Orthopaedic Research. 36, 1, p. 33-51 19 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
2017
DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism
Shen, J., Wang, C., Li, D., Xu, T., Myers, J., Ashton, J. M., Wang, T., Zuscik, M. J., McAlinden, A. & O'Keefe, R. J., Jun 15 2017, In: JCI Insight. 2, 12, e93612.Research output: Contribution to journal › Article › peer-review
Open Access58 Scopus citations -
Emerging roles for long noncoding RNAs in skeletal biology and disease
Huynh, N. P. T., Anderson, B. A., Guilak, F. & McAlinden, A., Jan 2 2017, In: Connective Tissue Research. 58, 1, p. 116-141 26 p.Research output: Contribution to journal › Review article › peer-review
Open Access93 Scopus citations -
Inflammation and epigenetic regulation in osteoarthritis
Shen, J., Abu-Amer, Y., O’Keefe, R. J. & McAlinden, A., Jan 2 2017, In: Connective Tissue Research. 58, 1, p. 49-63 15 p.Research output: Contribution to journal › Review article › peer-review
Open Access184 Scopus citations -
miR-483 targets SMAD4 to suppress chondrogenic differentiation of human mesenchymal stem cells
Anderson, B. A. & McAlinden, A., Nov 2017, In: Journal of Orthopaedic Research. 35, 11, p. 2369-2377 9 p.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
Recent advances in epigenetic regulation of skeletal development, homeostasis and disease
McAlinden, A., Jan 2 2017, In: Connective Tissue Research. 58, 1, 1 p.Research output: Contribution to journal › Editorial
1 Scopus citations -
2015
Hypoxia-inducible factor 3-alpha expression is associated with the stable chondrocyte phenotype
Markway, B. D., Cho, H., Zilberman-Rudenko, J., Holden, P., McAlinden, A. & Johnstone, B., Nov 1 2015, In: Journal of Orthopaedic Research. 33, 11, p. 1561-1570 10 p.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
2014
Alternative splicing of type II procollagen: IIB or not IIB?
Mcalinden, A., Jun 2014, In: Connective Tissue Research. 55, 3, p. 165-176 12 p.Research output: Contribution to journal › Review article › peer-review
Open Access14 Scopus citations -
Changes in type II procollagen isoform expression during chondrogenesis by disruption of an alternative 5' splice site within Col2a1 exon 2
Hering, T. M., Wirthlin, L., Ravindran, S. & McAlinden, A., Jun 1 2014, In: Matrix Biology. 36, p. 51-63 13 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Characterization of a murine type IIB procollagen-specific antibody
Patra, D., DeLassus, E., McAlinden, A. & Sandell, L. J., Feb 2014, In: Matrix Biology. 34, p. 154-160 7 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Molecular properties and fibril ultrastructure of types II and XI collagens in cartilage of mice expressing exclusively the α1(IIA) collagen isoform
McAlinden, A., Traeger, G., Hansen, U., Weis, M. A., Ravindran, S., Wirthlin, L., Eyre, D. R. & Fernandes, R. J., Feb 2014, In: Matrix Biology. 34, p. 105-113 9 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
2013
Differentially Expressed MicroRNAs in Chondrocytes from Distinct Regions of Developing Human Cartilage
McAlinden, A., Varghese, N., Wirthlin, L. & Chang, L. W., Sep 9 2013, In: PloS one. 8, 9, e75012.Research output: Contribution to journal › Article › peer-review
Open Access47 Scopus citations -
Molecular insight into the association between cartilage regeneration and ear wound healing in genetic mouse models: Targeting new genes in regeneration
Rai, M. F., Schmidt, E. J., McAlinden, A., Cheverud, J. M. & Sandell, L. J., Nov 2013, In: G3: Genes, Genomes, Genetics. 3, 11, p. 1881-1891 11 p.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
2012
Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice
Bonar, S. L., Brydges, S. D., Mueller, J. L., McGeough, M. D., Pena, C., Chen, D., Grimston, S. K., Hickman-Brecks, C. L., Ravindran, S., McAlinden, A., Novack, D. V., Kastner, D. L., Civitelli, R., Hoffman, H. M. & Mbalaviele, G., Apr 27 2012, In: PloS one. 7, 4, e35979.Research output: Contribution to journal › Article › peer-review
Open Access99 Scopus citations -
Disruption of the developmentally-regulated Col2a1 pre-mRNA alternative splicing switch in a transgenic knock-in mouse model
Lewis, R., Ravindran, S., Wirthlin, L., Traeger, G., Fernandes, R. J. & McAlinden, A., Apr 2012, In: Matrix Biology. 31, 3, p. 214-226 13 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Quantification of type II procollagen splice forms using alternative transcript-qPCR (AT-qPCR)
McAlinden, A., Shim, K. H., Wirthlin, L., Ravindran, S. & Hering, T. M., Sep 2012, In: Matrix Biology. 31, 7-8, p. 412-420 9 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2011
Assessment of epiphyseal plate allograft viability and function after ex vivo storage in University of Wisconsin Solution
Ravindran, S., Boyer, M. I., Martens, E., Ntouvali, H. & McAlinden, A., Oct 1 2011, In: Journal of Pediatric Orthopaedics. 31, 7, p. 803-810 8 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Changes of chondrocyte expression profiles in human MSC aggregates in the presence of PEG microspheres and TGF-β3
Ravindran, S., Roam, J. L., Nguyen, P. K., Hering, T. M., Elbert, D. L. & McAlinden, A., Nov 2011, In: Biomaterials. 32, 33, p. 8436-8445 10 p.Research output: Contribution to journal › Article › peer-review
Open Access45 Scopus citations -
Effects of botulinum toxin-induced paralysis on postnatal development of the supraspinatus muscle
Das, R., Rich, J., Kim, H. M., McAlinden, A. & Thomopoulos, S., Feb 2011, In: Journal of Orthopaedic Research. 29, 2, p. 281-288 8 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
2009
Three-dimensional inverse Opal scaffolds for culture and differentiation of human mesenchymal stem cells
McAlinden, A., Choi, S. W., Xie, J., Du, Y., Ravindran, S., Delassus, E., Gotimer, A. & Xia, Y., Aug 1 2009, In: European Cells and Materials. 18, SUPPL. 1, 1 p.Research output: Contribution to journal › Article › peer-review
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2008
A novel tumor necrosis factor α-responsive CCAAT/enhancer binding protein site regulates expression of the cartilage-derived retinoic acid-sensitive protein gene in cartilage
Imamura, T., Imamura, C., McAlinden, A., Davies, S. R., Iwamoto, Y. & Sandell, L. J., May 2008, In: Arthritis and rheumatism. 58, 5, p. 1366-1376 11 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Expression of two novel alternatively spliced COL2A1 isoforms during chondrocyte differentiation
McAlinden, A., Johnstone, B., Kollar, J., Kazmi, N. & Hering, T. M., Apr 2008, In: Matrix Biology. 27, 3, p. 254-266 13 p.Research output: Contribution to journal › Article › peer-review
26 Scopus citations -
Missense and nonsense mutations in the alternatively-spliced exon 2 of COL2A1 cause the ocular variant of Stickler syndrome
McAlinden, A., Majava, M., Bishop, P. N., Perveen, R., Black, G. C. M., Pierpont, M. E., Ala-Kokko, L. & Männikkö, M., Jan 2008, In: Human mutation. 29, 1, p. 83-90 8 p.Research output: Contribution to journal › Article › peer-review
47 Scopus citations -
Upregulation of Runx2 and Osterix during in vitro chondrogenesis of human adipose-derived stromal cells
Rich, J. T., Rosová, I., Nolta, J. A., Myckatyn, T. M., Sandell, L. J. & McAlinden, A., Jul 18 2008, In: Biochemical and Biophysical Research Communications. 372, 1, p. 230-235 6 p.Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations -
2007
Mechanisms of Disease: Role of chondrocytes in the pathogenesis of osteoarthritis - Structure, chaos and senescence
Aigner, T., Söder, S., Gebhard, P. M., McAlinden, A. & Haag, J., Jul 2007, In: Nature Clinical Practice Rheumatology. 3, 7, p. 391-399 9 p.Research output: Contribution to journal › Review article › peer-review
212 Scopus citations -
Nuclear protein TIA-1 regulates COL2A1 alternative splicing and interacts with precursor mRNA and genomic DNA
McAlinden, A., Liang, L., Mukudai, Y., Imamura, T. & Sandell, L. J., Aug 17 2007, In: Journal of Biological Chemistry. 282, 33, p. 24444-24454 11 p.Research output: Contribution to journal › Article › peer-review
Open Access36 Scopus citations -
2005
Alternative splicing of type II procollagen exon 2 is regulated by the combination of a weak 5′ splice site and an adjacent intronic stem-loop cis element
McAlinden, A., Havlioglu, N., Liang, L., Davies, S. R. & Sandell, L. J., Sep 23 2005, In: Journal of Biological Chemistry. 280, 38, p. 32700-32711 12 p.Research output: Contribution to journal › Article › peer-review
Open Access39 Scopus citations -
2004
Quantification of mRNA expression levels in articular chondrocytes with PCR technologies.
McAlinden, A., Haag, J., Bau, B., Gebhard, P. M. & Aigner, T., 2004, In: Methods in Molecular Medicine. 100, p. 79-100 22 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Regulation of Protein Diversity by Alternative Pre-mRNA Splicing with Specific Focus on Chondrogenesis
McAlinden, A., Havlioglu, N. & Sandell, L. J., Mar 2004, In: Birth Defects Research Part C - Embryo Today: Reviews. 72, 1, p. 51-68 18 p.Research output: Contribution to journal › Review article › peer-review
10 Scopus citations -
2003
α-Helical Coiled-coil Oligomerization Domains Are Almost Ubiquitous in the Collagen Superfamily
McAlinden, A., Smith, T. A., Sandell, L. J., Ficheux, D., Parry, D. A. D. & Hulmes, D. J. S., Oct 24 2003, In: Journal of Biological Chemistry. 278, 43, p. 42200-42207 8 p.Research output: Contribution to journal › Article › peer-review
Open Access75 Scopus citations -
2002
Expression of type II procollagens during development of the human intervertebral disc
McAlinden, A., Zhu, Y. & Sandell, L. J., Nov 2002, In: Biochemical Society transactions. 30, 6, p. 831-838 8 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations