Ashutosh Kumar

2025

Conserved and Unique Mitochondrial Target Sequence of TRPV4 Can Independently Regulate Mitochondrial Functions

Acharya, T. K., Mahapatra, P., Kumar, S., Dubey, N. K., Rajalaxmi, S., Ghosh, A., Kumar, A. & Goswami, C., Apr 2025, In: Proteins: Structure, Function and Bioinformatics. 93, 4, p. 908-919 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2024

Mechanosensing in Metabolism

Tranter, J. D., Kumar, A., Nair, V. K. & Sah, R., Jan 2024, In: Comprehensive Physiology. 14, 1, p. 5269-5290 22 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Missense Mutations in Myc Box I Influence Nucleocytoplasmic Transport to Promote Leukemogenesis

Arthur, N. B. J., Christensen, K. A., Mannino, K., Ruzinova, M. B., Kumar, A., Gruszczynska, A., Day, R. B., Erdmann-Gilmore, P., Mi, Y., Sprung, R., York, C. R., Townsend, R. R., Spencer, D. H., Sykes, S. M. & Ferraro, F., Aug 15 2024, In: Clinical Cancer Research. 30, 16, p. 3622-3639 18 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2023

Adipose-targeted SWELL1 deletion exacerbates obesity- And age-related nonalcoholic fatty liver disease

Gunasekar, S. K., Heebink, J., Carpenter, D. H., Kumar, A., Xie, L., Zhang, H., Schilling, J. D. & Sah, R., Mar 8 2023, In: JCI Insight. 8, 5, e154940.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2022

Cytochrome C interacts with the pathogenic mutational hotspot region of TRPV4 and forms complexes that differ in mutation and metal ion-sensitive manner

Das, R., Kumar, A., Dalai, R. & Goswami, C., Jun 30 2022, In: Biochemical and Biophysical Research Communications. 611, p. 172-178 7 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes

Gunasekar, S. K., Xie, L., Kumar, A., Hong, J., Chheda, P. R., Kang, C., Kern, D. M., My-Ta, C., Maurer, J., Heebink, J., Gerber, E. E., Grzesik, W. J., Elliot-Hudson, M., Zhang, Y., Key, P., Kulkarni, C. A., Beals, J. W., Smith, G. I., Samuel, I. & Smith, J. K. & 10 others, Nau, P., Imai, Y., Sheldon, R. D., Taylor, E. B., Lerner, D. J., Norris, A. W., Klein, S., Brohawn, S. G., Kerns, R. & Sah, R., Dec 2022, In: Nature communications. 13, 1, 784.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

TRPV4 acts as a mitochondrial Ca²⁺-importer and regulates mitochondrial temperature and metabolism

Kanta Acharya, T., Kumar, A., Kumar Majhi, R., Kumar, S., Chakraborty, R., Tiwari, A., Smalla, K. H., Liu, X., Chang, Y. T., Gundelfinger, E. D. & Goswami, C., Nov 2022, In: Mitochondrion. 67, p. 38-58 21 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

TRPV4 interacts with MFN2 and facilitates endoplasmic reticulum-mitochondrial contact points for Ca²⁺-buffering

Acharya, T. K., Kumar, A., Kumar, S. & Goswami, C., Dec 1 2022, In: Life Sciences. 310, 121112.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

2021

Modified tamarind kernel polysaccharide-based matrix alters neuro-keratinocyte cross-talk and serves as a suitable scaffold for skin tissue engineering

Choudhury, P., Chawla, S., Agarwal, S., Singh, A., Nayak, A., Kumar, A., Maji, P. K., Goswami, C. & Goswami, L., Feb 2021, In: Materials Science and Engineering C. 121, 111779.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

The swell1-lrrc8 complex regulates endothelial akt-enos signaling and vascular function

Alghanem, A. F., Abello, J., Maurer, J. M., Kumar, A., Ta, C., Gunasekar, S. K., Fatima, U., Kang, C., Xie, L., Adeola, O., Riker, M., Elliot-Hudson, M., Minerath, R. A., Grueter, C. E., Mullins, R. F., Stratman, A. N. & Sah, R., Feb 2021, In: eLife. 10, p. 1 1 p., e61313.

Research output: Contribution to journal › Article › peer-review

Open Access

38 Scopus citations

TRPM8 channel inhibitor-encapsulated hydrogel as a tunable surface for bone tissue engineering

Acharya, T. K., Kumar, S., Tiwari, N., Ghosh, A., Tiwari, A., Pal, S., Majhi, R. K., Kumar, A., Das, R., Singh, A., Maji, P. K., Chattopadhyay, N., Goswami, L. & Goswami, C., Dec 2021, In: Scientific reports. 11, 1, 3730.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

2020

Differential expression and localization of TRPV channels in the mature sperm of Anas platyrhynchos

Majhi, R. K., Kumar, A., Giri, S. C. & Goswami, C., Nov 2020, In: Reproduction in Domestic Animals. 55, 11, p. 1619-1628 10 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Swell1 regulates skeletal muscle cell size, intracellular signalling, adiposity and glucose metabolism

Kumar, A., Xie, L., Ta, C. M., Hinton, A. J., Gunasekar, S. K., Minerath, R. A., Shen, K., Maurer, J. M., Grueter, C. E., Abel, E. D., Meyer, G. & Sah, R., Sep 2020, In: eLife. 9, p. 1-59 59 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

2018

Hydroxyethyl methacrylate grafted carboxy methyl tamarind (CMT-g-HEMA) polysaccharide based matrix as a suitable scaffold for skin tissue engineering

Choudhury, P., Kumar, S., Singh, A., Kumar, A., Kaur, N., Sanyasi, S., Chawla, S., Goswami, C. & Goswami, L., Jun 1 2018, In: Carbohydrate Polymers. 189, p. 87-98 12 p.

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia

Kang, C., Xie, L., Gunasekar, S. K., Mishra, A., Zhang, Y., Pai, S., Gao, Y., Kumar, A., Norris, A. W., Stephens, S. B. & Sah, R., Dec 1 2018, In: Nature communications. 9, 1, 367.

Research output: Contribution to journal › Article › peer-review

Open Access

75 Scopus citations

2017

Preferential selection of Arginine at the lipid-water-interface of TRPV1 during vertebrate evolution correlates with its snorkeling behaviour and cholesterol interaction

Saha, S., Ghosh, A., Tiwari, N., Kumar, A., Kumar, A. & Goswami, C., Dec 1 2017, In: Scientific reports. 7, 1, 16808.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

2016

Light and electron microscopic study of mature spermatozoa from White Pekin duck (Anas platyrhynchos): An ultrastructural and molecular analysis

Majhi, R. K., Kumar, A., Yadav, M., Kumar, P., Maity, A., Giri, S. C. & Goswami, C., Mar 1 2016, In: Andrology. 4, 2, p. 232-244 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

TRPV4 is endogenously expressed in vertebrate spermatozoa and regulates intracellular calcium in human sperm

Kumar, A., Majhi, R. K., Swain, N., Giri, S. C., Kar, S., Samanta, L. & Goswami, C., May 13 2016, In: Biochemical and Biophysical Research Communications. 473, 4, p. 781-788 8 p.

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

2015

Expression of temperature-sensitive ion channel TRPM8 in spermcells correlates with vertebrate evolution

Majhi, R. K., Saha, S., Kumar, A., Ghosh, A., Swain, N., Goswami, L., Mohapatra, P., Maity, A., Sahoo, V. K., Kumar, A. & Goswami, C., 2015, In: PeerJ. 2015, 10, e1310.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

Influence of membrane cholesterol in the molecular evolution and functional regulation of TRPV4

Kumari, S., Kumar, A., Sardar, P., Yadav, M., Majhi, R. K., Kumar, A. & Goswami, C., Jan 2 2015, In: Biochemical and Biophysical Research Communications. 456, 1, p. 312-319 8 p.

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

2014

A carboxy methyl tamarind polysaccharide matrix for adhesion and growth of osteoclast-precursor cells

Sanyasi, S., Kumar, A., Goswami, C., Bandyopadhyay, A. & Goswami, L., 2014, In: Carbohydrate Polymers. 101, 1, p. 1033-1042 10 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Induction of apoptosis by Fe(salen)Cl through caspase-dependent pathway specifically in tumor cells

Pradhan, N., Pratheek, B. M., Garai, A., Kumar, A., Meena, V. S., Ghosh, S., Singh, S., Kumari, S., Chandrashekar, T. K., Goswami, C., Chattopadhyay, S., Kar, S. & Maiti, P. K., Oct 1 2014, In: Cell Biology International. 38, 10, p. 1118-1131 14 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

2013

Importance of TRP channels in pain: Implications for stress

Kumar, A., Goswami, L. & Goswami, C., Jan 1 2013, In: Frontiers in Bioscience - Scholar. 5 S, 1, p. 19-38 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Thermosensitive ion channel TRPV1 is endogenously expressed in the sperm of a fresh water teleost fish (Labeo rohita) and regulates sperm motility

Majhi, R. K., Kumar, A., Yadav, M., Swain, N., Kumari, S., Saha, A., Pradhan, A., Goswami, L., Saha, S., Samanta, L., Maity, A., Nayak, T. K., Chattopadhyay, S., Rajakuberan, C., Kumar, A. & Goswami, C., 2013, In: Channels. 7, 6, a12.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

Ashutosh Kumar

Research output

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