Willing to Mentor

    Available to Mentor:

    Health Professions (Medical, OT, PT, Dental, Audiology, etc.) Students, PhD/MSTP Students, Post-Baccalaureate Students, Postdocs, Residents and Fellows, Undergraduate Students

    • 1174
      Citations
    20102024

    Research activity per year

    Personal profile

    Research interests

    The central research goal of our lab is to identify the molecular underpinnings of adverse maternal fetal cardio-metabolic outcomes from exposure to altered sex hormone milieu and endocrine disrupting chemicals in-utero.

    We are focusing on elucidating the mechanisms by which the perinatal environment can modulate biological processes in the offspring by integrating gestational physiology in a large animal model with cellular and molecular biology. Knowledge gained through these studies will help identify strategies targeted toward prevention and treatment such adverse outcomes.

    Cardiovascular disease (CVD) remains the leading cause of death worldwide, with a prevalence rate of 49.2% increasing with age in males and females. Despite significant advances in identifying CVD risk factors and their therapeutics, the morbidity and mortality from CVD remain high. Substantial evidence from human, animal, and epidemiological studies indicate that early life insults in-utero adversely program the cardiometabolic system, thereby predisposing to CVD later in life. Moreover, the underlying molecular mechanisms and sex-specific impact of CVD-related pathological cardiac remodeling and associated morbidity and mortality are not well understood. Currently we are addressing the sex specific impact of such in-utero insults on the cardio metabolic system in the offspring utilizing a sheep model of gestational androgen excess.

    Mentoring

    I am willing to mentor in the both basic science and clinical research in the field of maternal-fetal, cardiovascular and endocrine science. 

    Available to Mentor:

    • Undergraduate Students
    • Post-Baccalaureate Students
    • PhD/MSTP Students
    • Health Professions Students
    • Postdocs
    • Residents and Fellows

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