• 132 Citations
20122020

Research output per year

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Personal profile

Research interests

I am interested in the diagnosis and management of dysregulated complement activation in immune-mediated kidney diseases including transplant rejection. I have recently shown that complement receptor 1 expressed in the kidney is a potent regulator of complement activation. Also, recent discovery of the novel intracellular complement pathway in kidney cells based on complement C3 is rather intriguing. I am involved in deciphering how this system functions normally and in disease. Over the past decade, we have also identified genetic variants in complement proteins in patients with two prominent kidney diseases, atypical hemolytic uremic syndrome and C3 glomerulopathy. I am specifically interested in variant analysis and in devising simpler functional assays for analysis of the putative mutants. This will facilitate the identification of the phenotype/genotype correlations in cohorts of patients with renal diseases in which complement activation plays a key role in pathogenesis and direct the patient to appropriate therapy.

Areas of Clinical Interest

Kidney transplantation, recurrent glomerulonephritis, chronic kidney disease and fluid and electrolyte disorders.

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Research Output

  • 132 Citations
  • 6 Article
  • 4 Review article
  • The complement system in COVID-19: Friend and foe?

    Java, A., Apicelli, A. J., Kathryn Liszewski, M., Coler-Reilly, A., Atkinson, J. P., Kim, A. H. J. & Kulkarni, H. S., Aug 6 2020, In : JCI Insight. 5, 15, e140711.

    Research output: Contribution to journalArticle

    Open Access
  • 5 Scopus citations

    A Multimodality Approach to Assessing Factor I Genetic Variants in Atypical Hemolytic Uremic Syndrome

    Java, A., Pozzi, N., Love-Gregory, L. D., Heusel, J. W., Sung, Y. J., Hu, Z., Bertram, P., Liszewski, M. K., Cline, L. M., Ren, Z. & Atkinson, J. P., Jul 2019, In : Kidney International Reports. 4, 7, p. 1007-1017 11 p.

    Research output: Contribution to journalArticle

    Open Access
    1 Scopus citations

    Complement Dysregulation and Disease: Insights from Contemporary Genetics

    Liszewski, M. K., Java, A., Schramm, E. C. & Atkinson, J. P., Jan 24 2017, In : Annual Review of Pathology: Mechanisms of Disease. 12, p. 25-52 28 p.

    Research output: Contribution to journalArticle

  • 33 Scopus citations

    A familial C3GN secondary to defective C3 regulation by complement receptor 1 and complement factor H

    Chauvet, S., Roumenina, L. T., Bruneau, S., Marinozzi, M. C., Rybkine, T., Schramm, E. C., Java, A., Atkinson, J. P., Aldigier, J. C., Bridoux, F., Touchard, G. & Fremeaux-Bacchi, V., Jun 2016, In : Journal of the American Society of Nephrology. 27, 6, p. 1665-1677 13 p.

    Research output: Contribution to journalArticle

    Open Access
  • 21 Scopus citations