• 1890 Citations

Research output per year

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Personal profile

Research interests

My group is evaluating the role of autophagy and cell death in cytokine responses in pre-clinical models of sepsis.

Areas of Clinical Interest

Immunocompromised hosts, viral infections, emerging infections

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Research Output

Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes

Wang, Y. T., Zaitsev, K., Lu, Q., Li, S., Schaiff, W. T., Kim, K. W., Droit, L., Wilen, C. B., Desai, C., Balce, D. R., Orchard, R. C., Orvedahl, A., Park, S., Kreamalmeyer, D., Handley, S. A., Pfeifer, J. D., Baldridge, M. T., Artyomov, M. N., Stallings, C. L. & Virgin, S., Feb 1 2020, In : Nature microbiology. 5, 2, p. 272-281 10 p.

Research output: Contribution to journalLetter

  • 1 Scopus citations

    Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock

    Orvedahl, A., McAllaster, M. R., Sansone, A., Dunlap, B. F., Desai, C., Wang, Y. T., Balce, D. R., Luke, C. J., Lee, S., Orchard, R. C., Artyomov, M. N., Handley, S. A., Doench, J. G., Silverman, G. A. & Virgin, H. W., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 33, p. 16497-16506 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • 4 Scopus citations

    Viral complementation of immunodeficiency confers protection against enteric pathogens via interferon-λ

    Ingle, H., Lee, S., Ai, T., Orvedahl, A., Rodgers, R., Zhao, G., Sullender, M., Peterson, S. T., Locke, M., Liu, T. C., Yokoyama, C. C., Sharp, B., Schultz-Cherry, S., Miner, J. J. & Baldridge, M. T., Jul 1 2019, In : Nature microbiology. 4, 7, p. 1120-1128 9 p.

    Research output: Contribution to journalLetter

  • 18 Scopus citations

    Successful treatment of fulminant neonatal enteroviral myocarditis in monochorionic diamniotic twins with cardiopulmonary support, intravenous immunoglobulin and pocapavir

    Amdani, S. M., Kim, H. S., Orvedahl, A., John, A. O., Said, A. & Simpson, K., Jan 1 2018, In : BMJ Case Reports. 2018, 224133.

    Research output: Contribution to journalArticle

  • 5 Scopus citations
    1 Scopus citations