• 27139 Citations
1985 …2020

Research output per year

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Personal profile

Research interests

For the past twelve years Anne has been investigating the mechanism(s) by which the E4 isoform of apolipoprotein E (apoE) is a risk factor for Alzheimer's disease (AD). Her multidisciplinary approach, utilizing biochemical and cell biological experiments coupled with analysis of in vivo transgenic mouse models of AD, has been instrumental in defining an important role for apoE in the metabolism of amyloid-b (Abeta), the protein that accumulates and forms plaques in the AD brain. Over the past ten years, her interests have expanded into the AD biomarker field, with publications describing CSF and in vivo amyloid imaging measures as candidate biomarkers of preclinical and early stage AD. Anne is a co-investigator on the biomarkers portion of a large, long-standing Program Project through the Washington University ADRC investigating brain and cognitive health during healthy aging and dementia. She is also the Principal Investigator of the biomarkers section of a Program Project (Adult Children Study) designed to identify antecedent biomarkers of AD (i.e., biomarkers to detect AD prior to clinical symptoms), and the Biomarker Core Leader for the ADRC.

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Research Output

Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer's Disease

Dominantly Inherited Alzheimer Network (DIAN) & PREVENT-AD Research Group, 2020, (Accepted/In press) In : Biological Psychiatry.

Research output: Contribution to journalArticle

  • 1 Scopus citations

    A novel sensitive assay for detection of a biomarker of pericyte injury in cerebrospinal fluid

    Sweeney, M. D., Sagare, A. P., Pachicano, M., Harrington, M. G., Joe, E., Chui, H. C., Schneider, L. S., Montagne, A., Ringman, J. M., Fagan, A. M., Morris, J. C., Pa, J., Nation, D. A., Toga, A. W. & Zlokovic, B. V., Jun 1 2020, In : Alzheimer's and Dementia. 16, 6, p. 821-830 10 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

    Montagne, A., Nation, D. A., Sagare, A. P., Barisano, G., Sweeney, M. D., Chakhoyan, A., Pachicano, M., Joe, E., Nelson, A. R., D’Orazio, L. M., Buennagel, D. P., Harrington, M. G., Benzinger, T. L. S., Fagan, A. M., Ringman, J. M., Schneider, L. S., Morris, J. C., Reiman, E. M., Caselli, R. J., Chui, H. C. & 7 others, Tcw, J., Chen, Y., Pa, J., Conti, P. S., Law, M., Toga, A. W. & Zlokovic, B. V., May 7 2020, In : Nature. 581, 7806, p. 71-76 6 p.

    Research output: Contribution to journalArticle

  • 30 Scopus citations

    A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease

    the Dominantly Inherited Alzheimer Network, Mar 1 2020, In : Nature medicine. 26, 3, p. 398-407 10 p.

    Research output: Contribution to journalArticle

  • 18 Scopus citations

    Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN)

    Dominantly Inherited Alzheimer Network, Jan 1 2020, In : Alzheimer's and Dementia. 16, 1, p. 219-228 10 p.

    Research output: Contribution to journalArticle

    Open Access