Research output per year
Research output per year
Personal profile
Research interests
Dr. Cross' main interest involves lymphocyte migration to the central nervous system (CNS) and cell-mediated factors underlying demyelination and axon injury, including cytokines, chemokines and free radicals. Dr. Cross employs a mouse model of relapsing/remitting inflammatory CNS demyelination (experimental allergic encephalomyelitis) in these studies. Using information gained through all of these studies, our goal is to modulate the pathogenic lymphocytes in the mouse model, and eventually in humans with MS, to prevent CNS injury. The Cross laboratory is also interested in the role of B lymphocytes in MS, and is near completion of a clinical trial using B cell depletion in MS patients who have not responded optimally to standard therapies alone.
Clinical interests
, neuromyelitis optica, transverse myelitis, CADASIL, CNS vasculitis, experimental autoimmune encephalomyelitis, autoimmune demyelination, lymphocyte-endothelial cell adhesions.
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Collaborations and top research areas from the last five years
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Development of an LC-MS/MS Method to Measure Sphingolipids in CSF from Patients with Multiple SclerosisS
Perez-Paramo, Y. X., Dufield, D., Veeramachaneni, R., Parkhurst, E., Harp, C., Ramesh, A., Winger, R. C., Cross, A. H., Gelfand, J. M., Bar-Or, A., Rodney Mathews, W. & Anania, V. G., Mar 1 2024, In: Molecular pharmacology. 105, 3, p. 121-130 10 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Diffusion basis spectrum imaging and diffusion tensor imaging predict persistent black hole formation in multiple sclerosis
Wooliscroft, L., Salter, A., Adusumilli, G., Levasseur, V. A., Sun, P., Lancia, S., Perantie, D. C., Trinkaus, K., Naismith, R. T., Song, S. K. & Cross, A. H., Apr 2024, In: Multiple Sclerosis and Related Disorders. 84, 105494.Research output: Contribution to journal › Article › peer-review
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Emerging Cerebrospinal Fluid Biomarkers of Disease Activity and Progression in Multiple Sclerosis
Cross, A. H., Gelfand, J. M., Thebault, S., Bennett, J. L., Von Büdingen, H. C., Cameron, B., Carruthers, R., Edwards, K., Fallis, R., Gerstein, R., Giacomini, P. S., Greenberg, B., Hafler, D. A., Ionete, C., Kaunzner, U. W., Kodama, L., Lock, C., Longbrake, E. E., Musch, B. & Pardo, G. & 13 others, , Apr 8 2024, In: JAMA Neurology. 81, 4, p. 373-383 11 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Exploring the association between weight loss-inducing medications and multiple sclerosis: insights from the FDA adverse event reporting system database
Shirani, A., Cross, A. H. & Stuve, O., Jan 1 2024, In: Therapeutic Advances in Neurological Disorders. 17Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Functional outcomes of diets in multiple sclerosis (FOOD for MS): Protocol for a parallel arm randomized feeding trial for low glycemic load and calorie restriction
Martin, K., Cofield, S. S., Cross, A. H., Goss, A. M., Raji, C. A., Rinker, J. R., Wu, G. F., Blair, J., Fuchs, A., Ghezzi, L., Green, K., Pace, F., Pastori, G., Taylor, M. G., Piccio, L. & Wingo, B. C., Aug 2024, In: Contemporary Clinical Trials. 143, 107584.Research output: Contribution to journal › Article › peer-review