Ann Gronowski

Oree M Carroll and Lillian B Ladenson Professor of Clinical Chemistry in Pathology and Immunology, Professor of Pathology and Immunology, Co-Division Chief - Division of Laboratory and Genomic Medicine, Professor of Obstetrics and Gynecology

    • 3711
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    1991 …2025

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    Research interests

    Our research focuses primarily on the laboratory diagnostics of endocrinology and reproductive physiology with a particular emphasis on maternal-fetal medicine. Our work has investigated the hormone hCG (human chorionic gonadotropin) and its variant forms. In particular, we are interested in the beta core fragment of hCG (hCGβcf) which is the predominant form of hCG in urine after five weeks of pregnancy. We have shown that high concentrations of this variant can interfere with certain pregnancy tests and cause false negative results. We have also been studying how hCG concentrations increase with age.

    Although hCG is best known for its production by the placenta, it is also produced in the pituitary gland in peri-and post-menopausal women. Our research has focused on ways to differentiate between pituitary and placental hCG. I am also active in the field of ethics in laboratory medicine. I have published several papers on ethics, professionalism, and error disclosure. 

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