Research output per year
Research output per year
Personal profile
Research interests
My research interest is developing new therapeutic agents for pancreatic cancer. The mammalian target of rapamycin (mTOR) is a downstream mediator in the phosphatidylinositol 3-kinase (PI3K) pathway that regulates cell proliferation, cell survival and angiogenesis in cancer. We hypothesize that combined blockade of the converging pathways can yield a better anti-tumor activity. Currently, we are in the process of examining the clinical benefit of double blockade with a phase I clinical study of the mTOR inhibitor and the EGFR inhibitor in recurrent/refractory malignancies. Furthermore, we are evaluating the potential predictive factors for treatment response and exploring the mechanism of treatment resistance.
Clinical interests
gastrointestinal cancer, pancreatic cancer
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Collaborations and top research areas from the last five years
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Body composition measurements and clinical outcomes in patients with resectable pancreatic adenocarcinoma – analysis from SWOG S1505
Sohal, D. P. S., Boutin, R. D., Lenchik, L., Kim, J., Beg, M. S., Wang-Gillam, A., Wade, J. L., Guthrie, K. A., Chiorean, E. G., Ahmad, S. A., Lowy, A. M., Philip, P. A. & Chang, V. T. S., Mar 2024, In: Journal of Gastrointestinal Surgery. 28, 3, p. 232-235 4 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Combined KRAS-MAPK pathway inhibitors and HER2-directed drug conjugate is efficacious in pancreatic cancer
Bulle, A., Liu, P., Seehra, K., Bansod, S., Chen, Y., Zahra, K., Somani, V., Khawar, I. A., Chen, H. P., Dodhiawala, P. B., Li, L., Geng, Y., Mo, C. K., Mahsl, J., Ding, L., Govindan, R., Davies, S., Mudd, J., Hawkins, W. & Fields, R. C. & 7 others, , Dec 2024, In: Nature communications. 15, 1, 2503.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
Klomp, J. A., Klomp, J. E., Stalnecker, C. A., Bryant, K. L., Edwards, A. C., Drizyte-Miller, K., Hibshman, P. S., Diehl, J. N., Lee, Y. S., Morales, A. J., Taylor, K. E., Peng, S., Tran, N. L., Herring, L. E., Prevatte, A. W., Barker, N. K., Hover, L. D., Hallin, J., Chowdhury, S. & Coker, O. & 13 others, , Jun 7 2024, In: Science (New York, N.Y.). 384, 6700, p. eadk0775Research output: Contribution to journal › Article › peer-review
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ERBB2 (HER2) amplifications and co-occurring KRAS alterations in the circulating cell-free DNA of pancreatic ductal adenocarcinoma patients and response to HER2 inhibition
Barzi, A., Weipert, C. M., Espenschied, C. R., Raymond, V. M., Wang-Gillam, A., Nezami, M. A., Gordon, E. J., Mahadevan, D. & Mody, K., 2024, In: Frontiers in Oncology. 14, 1339302.Research output: Contribution to journal › Article › peer-review
Open Access -
Intratumoral Cell Neighborhoods Coordinate Outcomes in Pancreatic Ductal Adenocarcinoma
Wattenberg, M. M., Colby, S., Garrido-Laguna, I., Xue, Y., Chang, R., Delman, D., Lee, J., Affolter, K., Mulvihill, S. J., Beg, M. S., Wang-Gillam, A., Wade, J. L., Guthrie, K. A., Chiorean, E. G., Ahmad, S. A., Lowy, A. M., Philip, P. A., Sohal, D. P. S. & Beatty, G. L., Jun 2024, In: Gastroenterology. 166, 6, p. 1114-1129 16 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations