Research output per year
Research output per year
Assistant Professor of Biochemistry and Molecular Biophysics
Research activity per year
My main research interests are the physical principles and molecular mechanisms determining biomolecular function. A particular focus are intrinsically disordered proteins (IDPs). At variance with the classical structurefunction paradigm that we are familiar with from 50 years of structural biology, IDPs lack a persistent structure but, nevertheless, participate in many biological processes such as transcription, translation and signal transduction. In my work, I combine fluorescence single-molecule spectroscopy with concepts from polymer physics to explain fundamental properties of IDPs. I am interested in expanding the scope of single-molecule and correlation methods to investigate the role of disordered proteins in vivo, especially within RNA granules, non-membrane bound organelles that play a key-role in the spatial and temporal regulation of RNA, and whose malfunctioning has been linked to infertilities, cancer, and neurodegenerative diseases. A long-term goal will be to bridge the gap between detailed molecular understanding and cellular and organismic processes.
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Review article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review