Andrea Bredemeyer

2023

CCL17 Protects Against Viral Myocarditis by Suppressing the Recruitment of Regulatory T Cells

Feng, G., Zhu, C., Lin, C-Y., Bredemeyer, A., Förster, I., Kreisel, D. & Lavine, K. J., 2023, In: Journal of the American Heart Association. 12, 4, e028442.

Research output: Contribution to journal › Article › peer-review

Open Access

Defining cardiac functional recovery in end-stage heart failure at single-cell resolution

Amrute, J. M., Lai, L., Ma, P., Koenig, A. L., Kamimoto, K., Bredemeyer, A., Shankar, T. S., Kuppe, C., Kadyrov, F. F., Schulte, L. J., Stoutenburg, D., Kopecky, B. J., Navankasattusas, S., Visker, J., Morris, S. A., Kramann, R., Leuschner, F., Mann, D. L., Drakos, S. G. & Lavine, K. J., Apr 2023, In: Nature Cardiovascular Research. 2, 4, p. 399-416 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2022

CCL17 Aggravates Myocardial Injury by Suppressing Recruitment of Regulatory T Cells

Feng, G., Bajpai, G., Ma, P., Koenig, A., Bredemeyer, A., Lokshina, I., Lai, L., Förster, I., Leuschner, F., Kreisel, D. & Lavine, K. J., Mar 8 2022, In: Circulation. 145, 10, p. 765-782 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Derivation of extra-embryonic and intra-embryonic macrophage lineages from human pluripotent stem cells

Bredemeyer, A. L., Amrute, J. M., Koenig, A. L., Idol, R. A., He, L., Luff, S. A., Dege, C., Leid, J. M., Schilling, J. D., Hinson, J. T., Dinauer, M. C., Sturgeon, C. M. & Lavine, K. J., Apr 2022, In: Development (Cambridge). 149, 8, dev200016.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood

Borcherding, N., Jia, W., Giwa, R., Field, R. L., Moley, J. R., Kopecky, B. J., Chan, M. M., Yang, B. Q., Sabio, J. M., Walker, E. C., Osorio, O., Bredemeyer, A. L., Pietka, T., Alexander-Brett, J., Morley, S. C., Artyomov, M. N., Abumrad, N. A., Schilling, J., Lavine, K., Crewe, C., & 1 othersBrestoff, J. R., Oct 4 2022, In: Cell metabolism. 34, 10, p. 1499-1513.e8

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

Donor Macrophages Modulate Rejection After Heart Transplantation

Kopecky, B. J., Dun, H., Amrute, J. M., Lin, C. Y., Bredemeyer, A. L., Terada, Y., Bayguinov, P. O., Koenig, A. L., Frye, C. C., Fitzpatrick, J. A. J., Kreisel, D. & Lavine, K. J., Aug 23 2022, In: Circulation. 146, 8, p. 623-638 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure

Koenig, A. L., Shchukina, I., Amrute, J., Andhey, P. S., Zaitsev, K., Lai, L., Bajpai, G., Bredemeyer, A., Smith, G., Jones, C., Terrebonne, E., Rentschler, S. L., Artyomov, M. N. & Lavine, K. J., Mar 2022, In: Nature Cardiovascular Research. 1, 3, p. 263-280 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

69 Scopus citations

2021

Resident cardiac macrophages mediate adaptive myocardial remodeling

Wong, N. R., Mohan, J., Kopecky, B. J., Guo, S., Du, L., Leid, J., Feng, G., Lokshina, I., Dmytrenko, O., Luehmann, H., Bajpai, G., Ewald, L., Bell, L., Patel, N., Bredemeyer, A., Weinheimer, C. J., Nigro, J. M., Kovacs, A., Morimoto, S., Bayguinov, P. O., & 10 othersFisher, M. R., Stump, W. T., Greenberg, M., Fitzpatrick, J. A. J., Epelman, S., Kreisel, D., Sah, R., Liu, Y., Hu, H. & Lavine, K. J., Sep 14 2021, In: Immunity. 54, 9, p. 2072-2088.e7

Research output: Contribution to journal › Article › peer-review

Open Access

63 Scopus citations

SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis

Bailey, A. L., Dmytrenko, O., Greenberg, L., Bredemeyer, A. L., Ma, P., Liu, J., Penna, V., Winkler, E. S., Sviben, S., Brooks, E., Nair, A. P., Heck, K. A., Rali, A. S., Simpson, L., Saririan, M., Hobohm, D., Stump, W. T., Fitzpatrick, J. A., Xie, X., Zhang, X., & 9 othersShi, P. Y., Hinson, J. T., Gi, W. T., Schmidt, C., Leuschner, F., Lin, C. Y., Diamond, M. S., Greenberg, M. J. & Lavine, K. J., Apr 2021, In: JACC: Basic to Translational Science. 6, 4, p. 331-345 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

98 Scopus citations

2019

Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation

Li, W., Feng, G., Gauthier, J. M., Lokshina, I., Higashikubo, R., Evans, S., Liu, X., Hassan, A., Tanaka, S., Cicka, M., Hsiao, H. M., Ruiz-Perez, D., Bredemeyer, A., Gross, R. W., Mann, D. L., Tyurina, Y. Y., Gelman, A. E., Kagan, V. E., Linkermann, A., Lavine, K. J., & 1 othersKreisel, D., Jun 3 2019, In: Journal of Clinical Investigation. 129, 6, p. 2293-2304 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

263 Scopus citations

Tissue Resident CCR2- and CCR2+ Cardiac Macrophages Differentially Orchestrate Monocyte Recruitment and Fate Specification Following Myocardial Injury

Bajpai, G., Bredemeyer, A., Li, W., Zaitsev, K., Koenig, A. L., Lokshina, I., Mohan, J., Ivey, B., Hsiao, H. M., Weinheimer, C., Kovacs, A., Epelman, S., Artyomov, M., Kreisel, D. & Lavine, K. J., Jan 18 2019, In: Circulation research. 124, 2, p. 263-278 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

333 Scopus citations

XLF and H2AX function in series to promote replication fork stability

Chen, B. R., Quinet, A., Byrum, A. K., Jackson, J., Berti, M., Thangavel, S., Bredemeyer, A. L., Hindi, I., Mosammaparast, N., Tyler, J. K., Vindigni, A. & Sleckman, B. P., 2019, In: Journal of Cell Biology. 218, 7, p. 2113-2123 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

2018

High-Throughput Screening Approach for Identifying Compounds That Inhibit Nonhomologous End Joining

Bredemeyer, A. L., Edwards, B. S., Haynes, M. K., Morales, A. J., Wang, Y., Ursu, O., Waller, A., Sklar, L. A. & Sleckman, B. P., Aug 1 2018, In: SLAS Discovery. 23, 7, p. 624-633 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining

Hung, P. J., Johnson, B., Chen, B. R., Byrum, A. K., Bredemeyer, A. L., Yewdell, W. T., Johnson, T. E., Lee, B. J., Deivasigamani, S., Hindi, I., Amatya, P., Gross, M. L., Paull, T. T., Pisapia, D. J., Chaudhuri, J., Petrini, J. J. H., Mosammaparast, N., Amarasinghe, G. K., Zha, S., Tyler, J. K., & 1 othersSleckman, B. P., Jul 19 2018, In: Molecular cell. 71, 2, p. 332-342.e8

Research output: Contribution to journal › Article › peer-review

Open Access

66 Scopus citations

The human heart contains distinct macrophage subsets with divergent origins and functions

Bajpai, G., Schneider, C., Wong, N., Bredemeyer, A., Hulsmans, M., Nahrendorf, M., Epelman, S., Kreisel, D., Liu, Y., Itoh, A., Shankar, T. S., Selzman, C. H., Drakos, S. G. & Lavine, K. J., Aug 1 2018, In: Nature medicine. 24, 8, p. 1234-1245 12 p.

Research output: Contribution to journal › Article › peer-review

350 Scopus citations

2017

Deficiency of XLF and PAXX prevents DNA double-strand break repair by non-homologous end joining in lymphocytes

Hung, P. J., Chen, B. R., George, R., Liberman, C., Morales, A. J., Colon-Ortiz, P., Tyler, J. K., Sleckman, B. P. & Bredemeyer, A. L., Feb 1 2017, In: Cell Cycle. 16, 3, p. 286-295 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

Pediatric and adult dilated cardiomyopathy represent distinct pathological entities

Patel, M. D., Mohan, J., Schneider, C., Bajpai, G., Purevjav, E., Canter, C. E., Towbin, J., Bredemeyer, A. & Lavine, K. J., Jul 20 2017, In: JCI Insight. 2, 14, e94382.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

2016

Modeling altered T-cell development with induced pluripotent stem cells from patients with RAG1-dependent immune deficiencies

Brauer, P. M., Pessach, I. M., Clarke, E., Rowe, J. H., De Bruin, L. O., Lee, Y. N., Dominguez-Brauer, C., Comeau, A. M., Awong, G., Felgentreff, K., Zhang, Y. H., Bredemeyer, A., Al-Herz, W., Du, L., Ververs, F., Kennedy, M., Giliani, S., Keller, G., Sleckman, B. P., Schatz, D. G., & 3 othersBushman, F. D., Notarangelo, L. D. & Zúñiga-Pflücker, J. C., Aug 11 2016, In: Blood. 128, 6, p. 783-793 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

2015

DNA damage responses: Beyond double-strand break repair

Bredemeyer, A. L. & Sleckman, B. P., Jan 5 2015, In: Current Biology. 25, 1, p. R45-R46

Research output: Contribution to journal › Short survey › peer-review

Open Access

3 Scopus citations

2014

HCoDES Reveals Chromosomal DNA End Structures with Single-Nucleotide Resolution

Dorsett, Y., Zhou, Y., Tubbs, A. T., Chen, B. R., Purman, C., Lee, B. S., George, R., Bredemeyer, A. L., Zhao, J. Y., Sodergen, E., Weinstock, G. M., Han, N. D., Reyes, A., Oltz, E. M., Dorsett, D., Misulovin, Z., Payton, J. E. & Sleckman, B. P., Dec 18 2014, In: Molecular cell. 56, 6, p. 808-818 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

KAP-1 promotes resection of broken DNA ends not protected by γ-H2AX and 53BP1 in G₁-phase lymphocytes

Tubbs, A. T., Dorsett, Y., Chan, E., Helmink, B., Lee, B. S., Hung, P., George, R., Bredemeyer, A. L., Mittal, A., Pappu, R. V., Chowdhury, D., Mosammaparast, N., Krangel, M. S. & Sleckmana, B. P., 2014, In: Molecular and cellular biology. 34, 15, p. 2811-2821 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

β-Catenin induces T-cell transformation by promoting genomic instability

Dose, M., Emmanuel, A. O., Chaumeil, J., Zhang, J., Sun, T., Germar, K., Aghajani, K., Davis, E. M., Keerthivasan, S., Bredemeyer, A. L., Sleckman, B. P., Rosen, S. T., Skok, J. A., Le Beau, M. M., Georgopoulos, K. & Gounari, F., Jan 7 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 1, p. 391-396 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

53 Scopus citations

2013

Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination

Lee, B. S., Gapud, E. J., Zhang, S., Dorsett, Y., Bredemeyer, A., George, R., Callen, E., Daniel, J. A., Osipovich, O., Oltz, E. M., Bassing, C. H., Nussenzweig, A., Lees-Miller, S., Hammel, M., Chen, B. P. C. & Sleckman, B. P., 2013, In: Molecular and cellular biology. 33, 18, p. 3568-3579 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

2012

Recurrent hemizygous deletions in cancers may optimize proliferative potential

Solimini, N. L., Xu, Q., Mermel, C. H., Liang, A. C., Schlabach, M. R., Luo, J., Burrows, A. E., Anselmo, A. N., Bredemeyer, A. L., Li, M. Z., Beroukhim, R., Meyerson, M. & Elledge, S. J., Jul 6 2012, In: Science. 336, 6090, p. 104-109 6 p.

Research output: Contribution to journal › Article › peer-review

140 Scopus citations

2011

Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation

Gapud, E. J., Dorsett, Y., Yin, B., Callen, E., Bredemeyer, A., Mahowald, G. K., Omi, K. Q., Walker, L. M., Bednarski, J. J., McKinnon, P. J., Bassing, C. H., Nussenzweig, A. & Sleckmana, B. P., Feb 1 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 5, p. 2022-2027 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

55 Scopus citations

2010

A Genome-wide Camptothecin Sensitivity Screen Identifies a Mammalian MMS22L-NFKBIL2 Complex Required for Genomic Stability

O'Connell, B. C., Adamson, B., Lydeard, J. R., Sowa, M. E., Ciccia, A., Bredemeyer, A. L., Schlabach, M., Gygi, S. P., Elledge, S. J. & Harper, J. W., Nov 24 2010, In: Molecular cell. 40, 4, p. 645-657 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

94 Scopus citations

Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex

Reavie, L., Gatta, G. D., Crusio, K., Aranda-Orgilles, B., Buckley, S. M., Thompson, B., Lee, E., Gao, J., Bredemeyer, A. L., Helmink, B. A., Zavadil, J., Sleckman, B. P., Palomero, T., Ferrando, A. & Aifantis, I., Mar 2010, In: Nature immunology. 11, 3, p. 207-215 9 p.

Research output: Contribution to journal › Article › peer-review

94 Scopus citations

2009

Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis

Mahowald, G. K., Baron, J. M., Mahowald, M. A., Kulkarni, S., Bredemeyer, A. L., Bassing, C. H. & Sleckman, B. P., 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 43, p. 18339-18344 6 p.

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Formation of Dynamic γ-H2AX Domains along Broken DNA Strands Is Distinctly Regulated by ATM and MDC1 and Dependent upon H2AX Densities in Chromatin

Savic, V., Yin, B., Maas, N. L., Bredemeyer, A. L., Carpenter, A. C., Helmink, B. A., Yang-Iott, K. S., Sleckman, B. P. & Bassing, C. H., May 15 2009, In: Molecular cell. 34, 3, p. 298-310 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

150 Scopus citations

Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination

Yin, B., Savic, V., Juntilla, M. M., Bredemeyer, A. L., Yang-Iott, K. S., Helmink, B. A., Koretzky, G. A., Sleckman, B. P. & Bassing, C. H., Nov 23 2009, In: Journal of Experimental Medicine. 206, 12, p. 2625-2639 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

Intrathymic proliferation wave essential for Vα14⁺ natural killer T cell development depends on c-Myc

Dose, M., Sleckman, B. P., Han, J., Bredemeyer, A. L., Bendelac, A. & Gounari, F., May 26 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 21, p. 8641-8646 6 p.

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks

Helmink, B. A., Bredemeyer, A. L., Lee, B. S., Huang, C. Y., Sharma, G. G., Walker, L. M., Bednarski, J. J., Lee, W. L., Pandita, T. K., Bassing, C. H. & Sleckman, B. P., Mar 16 2009, In: Journal of Experimental Medicine. 206, 3, p. 669-679 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

74 Scopus citations

The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart

Ciccia, A., Bredemeyer, A. L., Sowa, M. E., Terret, M. E., Jallepalli, P. V., Harper, J. W. & Elledge, S. J., Oct 15 2009, In: Genes and Development. 23, 20, p. 2415-2425 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

157 Scopus citations

2008

Aberrant V(D)J recombination in ataxia telangiectasia mutated-deficient lymphocytes is dependent on nonhomologous DNA end joining

Bredemeyer, A. L., Huang, C. Y., Walker, L. M., Bassing, C. H. & Sleckman, B. P., Aug 15 2008, In: Journal of Immunology. 181, 4, p. 2620-2625 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes

Bredemeyer, A. L., Helmink, B. A., Innes, C. L., Calderon, B., McGinnis, L. M., Mahowald, G. K., Gapud, E. J., Walker, L. M., Collins, J. B., Weaver, B. K., Mandik-Nayak, L., Schreiber, R. D., Allen, P. M., May, M. J., Paules, R. S., Bassing, C. H. & Sleckman, B. P., Dec 11 2008, In: Nature. 456, 7223, p. 819-824 6 p.

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Dynamic regulation of c-Myc proto-oncogene expression during lymphocyte development revealed by a GFP-c-Myc knock-in mouse

Huang, C. Y., Bredemeyer, A. L., Walker, L. M., Bassing, C. H. & Sleckman, B. P., Feb 2008, In: European Journal of Immunology. 38, 2, p. 342-349 8 p.

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

2007

ATM Prevents the Persistence and Propagation of Chromosome Breaks in Lymphocytes

Callén, E., Jankovic, M., Difilippantonio, S., Daniel, J. A., Chen, H. T., Celeste, A., Pellegrini, M., McBride, K., Wangsa, D., Bredemeyer, A. L., Sleckman, B. P., Ried, T., Nussenzweig, M. & Nussenzweig, A., Jul 13 2007, In: Cell. 130, 1, p. 63-75 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

157 Scopus citations

SWI-SNF: Promoter of accessibility

Bredemeyer, A. L. & Sleckman, B. P., Aug 2007, In: Nature immunology. 8, 8, p. 795-796 2 p.

Research output: Contribution to journal › Article › peer-review

2006

ATM stabilizes DNA double-strand-break complexes during V(D)J recombination

Bredemeyer, A. L., Sharma, G. G., Huang, C. Y., Helmink, B. A., Walker, L. M., Khor, K. C., Nuskey, B., Sullivan, K. E., Pandita, T. K., Bassing, C. H. & Sleckman, B. P., Jul 27 2006, In: Nature. 442, 7101, p. 466-470 5 p.

Research output: Contribution to journal › Article › peer-review

317 Scopus citations

Proteasome activator PA200 is required for normal spermatogenesis

Khor, B., Bredemeyer, A. L., Huang, C. Y., Turnbull, I. R., Evans, R., Maggi, L. B., White, J. M., Walker, L. M., Carnes, K., Hess, R. A. & Sleckman, B. P., Apr 2006, In: Molecular and cellular biology. 26, 8, p. 2999-3007 9 p.

Research output: Contribution to journal › Article › peer-review

119 Scopus citations

2004

Regulation of T-cell receptor β-chain gene assembly by recombination signals: The beyond 12/23 restriction

Tillman, R. E., Wooley, A. L., Hughes, M. M., Khor, B. & Sleckman, B. P., Aug 2004, In: Immunological Reviews. 200, p. 36-43 8 p.

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

2003

Cutting edge: Targeting of Vβ to Dβ rearrangement by RSSs can be mediated by the V(D)J recombinase in the absence of additional lymphoid-specific factors

Tillman, R. E., Wooley, A. L., Khor, B., Wehrly, T. D., Little, C. A. & Sleckman, B. P., Jan 1 2003, In: Journal of Immunology. 170, 1, p. 5-9 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

2002

Restrictions limiting the generation of DNA double strand breaks during chromosomal V(D)J recombination

Tillman, R. E., Wooley, A. L., Hughes, M. M., Wehrly, T. D., Swat, W. & Sleckman, B. P., Feb 4 2002, In: Journal of Experimental Medicine. 195, 3, p. 309-316 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Andrea Bredemeyer

Research output

Search results