Amynah Pradhan

2024

Histone deacetylase inhibitor decreases hyperalgesia in a mouse model of alcohol withdrawal-induced hyperalgesia

Aguilar, J., De Carvalho, L. M., Chen, H., Condon, R., Lasek, A. W. & Pradhan, A. A., Mar 2024, In: Alcohol: Clinical and Experimental Research. 48, 3, p. 478-487 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Identification of 1,3,8-Triazaspiro[4.5]Decane-2,4-Dione Derivatives as a Novel δ Opioid Receptor-Selective Agonist Chemotype

Meqbil, Y. J., Aguilar, J., Blaine, A. T., Chen, L., Cassell, R. J., Pradhan, A. A. & van Rijn, R. M., Jun 1 2024, In: Journal of Pharmacology and Experimental Therapeutics. 389, 3, p. 301-309 9 p.

Research output: Contribution to journal › Article › peer-review

Regulation of headache response and transcriptomic network by the trigeminal ganglion clock

Han, C., Lim, J. Y., Koike, N., Kim, S. Y., Ono, K., Tran, C. K., Mangutov, E., Kim, E., Zhang, Y., Li, L., Pradhan, A. A., Yagita, K., Chen, Z., Yoo, S. H. & Burish, M. J., Feb 2024, In: Headache. 64, 2, p. 195-210 16 p.

Research output: Contribution to journal › Article › peer-review

2023

PACAP-PAC1 receptor inhibition is effective in opioid induced hyperalgesia and medication overuse headache models

Bertels, Z., Mangutov, E., Siegersma, K., Cropper, H. C., Tipton, A. & Pradhan, A. A., Feb 17 2023, In: iScience. 26, 2, 105950.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2022

Delta opioid receptors in Nav1.8 expressing peripheral neurons partially regulate the effect of delta agonist in models of migraine and opioid-induced hyperalgesia

Bertels, Z., Dripps, I. J., Shah, P., Moye, L. S., Tipton, A. F., Siegersma, K. & Pradhan, A. A., Aug 1 2022, In: Neurobiology of Pain. 12, 100099.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Migraine and peripheral pain models show differential alterations in neuronal complexity

Bertels, Z., Mangutov, E., Conway, C., Siegersma, K., Asif, S., Shah, P., Huck, N., Tawfik, V. L. & Pradhan, A. A., Jul 1 2022, In: Headache. 62, 7, p. 780-791 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

2021

Alternative splicing mechanisms underlying opioid-induced hyperalgesia

Zhang, P., Perez, O. C., Southey, B. R., Sweedler, J. V., Pradhan, A. A. & Rodriguez-Zas, S. L., Oct 2021, In: Genes. 12, 10, 1570.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

A non-convulsant delta-opioid receptor agonist, KNT-127, reduces cortical spreading depression and nitroglycerin-induced allodynia

Bertels, Z., Witkowski, W. D., Asif, S., Siegersma, K., van Rijn, R. M. & Pradhan, A. A., Jan 2021, In: Headache. 61, 1, p. 170-178 9 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Delta opioid receptor regulation of calcitonin gene-related peptide dynamics in the trigeminal complex

Moye, L. S., Siegersma, K., Dripps, I., Witkowski, W., Mangutov, E., Wang, D., Scherrer, G. & Pradhan, A. A., Aug 1 2021, In: Pain. 162, 8, p. 2297-2308 12 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Enhanced understanding of molecular interactions and function underlying pain processes through networks of transcript isoforms, genes, and gene families

Zhang, P., Southey, B. R., Sweedler, J. V., Pradhan, A. & Rodriguez-Zas, S. L., 2021, In: Advances and Applications in Bioinformatics and Chemistry. 14, p. 49-69 21 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Neuronal complexity is attenuated in preclinical models of migraine and restored by hdac6 inhibition

Bertels, Z., Singh, H., Dripps, I., Siegersma, K., Tipton, A. F., Witkowski, W., Sheets, Z., Shah, P., Conway, C., Mangutov, E., Ao, M., Petukhova, V., Karumudi, B., Petukhov, P. A., Baca, S. M., Rasenick, M. M. & Pradhan, A. A., Apr 2021, In: eLife. 10, e63076.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

2020

Acid-sensing ion channel 3 blockade inhibits durovascular and nitric oxide-mediated trigeminal pain

Holton, C. M., Strother, L. C., Dripps, I., Pradhan, A. A., Goadsby, P. J. & Holland, P. R., Jun 1 2020, In: British Journal of Pharmacology. 177, 11, p. 2478-2486 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Differential medication overuse risk of novel anti-migraine therapeutics

Saengjaroentham, C., Strother, L. C., Dripps, I., Jabir, M. R. S., Pradhan, A., Goadsby, P. J. & Holland, P. R., Sep 1 2020, In: Brain. 143, 9, p. 2681-2688 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

Forebrain delta opioid receptors regulate the response of delta agonist in models of migraine and opioid-induced hyperalgesia

Dripps, I. J., Bertels, Z., Moye, L. S., Tipton, A. F., Siegersma, K., Baca, S. M., Kieffer, B. L. & Pradhan, A. A., Dec 1 2020, In: Scientific reports. 10, 1, 17629.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

NOP receptor agonist attenuates nitroglycerin-induced migraine-like symptoms in mice

Targowska-Duda, K. M., Ozawa, A., Bertels, Z., Cippitelli, A., Marcus, J. L., Mielke-Maday, H. K., Zribi, G., Rainey, A. N., Kieffer, B. L., Pradhan, A. A. & Toll, L., Jun 15 2020, In: Neuropharmacology. 170, 108029.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

2019

Delta opioid receptor agonists are effective for multiple types of headache disorders

Moye, L. S., Tipton, A. F., Dripps, I., Sheets, Z., Crombie, A., Violin, J. D. & Pradhan, A. A., Apr 2019, In: Neuropharmacology. 148, p. 77-86 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

52 Scopus citations

Effect of Histone Deacetylase Inhibitor on Ethanol Withdrawal-Induced Hyperalgesia in Rats

Pradhan, A. A., Tipton, A. F., Zhang, H., Akbari, A. & Pandey, S. C., Aug 1 2019, In: International Journal of Neuropsychopharmacology. 22, 8, p. 523-527 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Opioid-Induced Hyperalgesia Is Associated with Dysregulation of Circadian Rhythm and Adaptive Immune Pathways in the Mouse Trigeminal Ganglia and Nucleus Accumbens

Zhang, P., Moye, L. S., Southey, B. R., Dripps, I., Sweedler, J. V., Pradhan, A. & Rodriguez-Zas, S. L., Dec 1 2019, In: Molecular Neurobiology. 56, 12, p. 7929-7949 21 p.

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

PACAP and other neuropeptide targets link chronic migraine and opioid-induced hyperalgesia in mouse models

Anapindi, K. D. B., Yang, N., Romanova, E. V., Rubakhin, S. S., Tipton, A., Dripps, I., Sheets, Z., Sweedler, J. V. & Pradhan, A. A., 2019, In: Molecular and Cellular Proteomics. 18, 12, p. 2447-2458 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

The development of a mouse model of mTBI-induced post-traumatic migraine, and identification of the delta opioid receptor as a novel therapeutic target

Moye, L. S., Novack, M. L., Tipton, A. F., Krishnan, H., Pandey, S. C. & Pradhan, A. A. A., Jan 1 2019, In: Cephalalgia. 39, 1, p. 77-90 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

2018

Gene network dysregulation in the trigeminal ganglia and nucleus accumbens of a model of chronic migraine-associated hyperalgesia

Jeong, H., Moye, L. S., Southey, B. R., Hernandez, A. G., Dripps, I., Romanova, E. V., Rubakhin, S. S., Sweedler, J. V., Pradhan, A. A. & Rodriguez-Zas, S. L., Dec 18 2018, In: Frontiers in Systems Neuroscience. 12, 63.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Soluble guanylyl cyclase is a critical regulator of migraine-associated pain

Ben Aissa, M., Tipton, A. F., Bertels, Z., Gandhi, R., Moye, L. S., Novack, M., Bennett, B. M., Wang, Y., Litosh, V., Lee, S. H., Gaisina, I. N., Thatcher, G. R. J. & Pradhan, A. A., Jul 1 2018, In: Cephalalgia. 38, 8, p. 1471-1484 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

Tolerance to high-internalizing δ opioid receptor agonist is critically mediated by arrestin 2

Vicente-Sanchez, A., Dripps, I. J., Tipton, A. F., Akbari, H., Akbari, A., Jutkiewicz, E. M. & Pradhan, A. A., Jul 2018, In: British Journal of Pharmacology. 175, 14, p. 3050-3059 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

2017

Animal model of chronic migraine-associated pain

Moye, L. S. & Pradhan, A. A. A., Jul 1 2017, In: Current Protocols in Neuroscience. 2017, p. 9.60.1-9.60.9

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

A PTEN-regulated checkpoint controls surface delivery of σ opioid receptors

Shiwarski, D. J., Tipton, A., Giraldo, M. D., Schmidt, B. F., Gold, M. S., Pradhan, A. A. & Puthenveedu, M. A., Apr 5 2017, In: Journal of Neuroscience. 37, 14, p. 3741-3752 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

2016

Agonist-specific recruitment of arrestin isoforms differentially modify delta opioid receptor function

Pradhan, A. A., Perroy, J., Walwyn, W. M., Smith, M. L., Vicente-Sanchez, A., Segura, L., Bana, A., Kieffer, B. L. & Evans, C. J., Mar 23 2016, In: Journal of Neuroscience. 36, 12, p. 3541-3551 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

55 Scopus citations

Neuroimmune Regulation of GABAergic Neurons Within the Ventral Tegmental Area during Withdrawal from Chronic Morphine

Taylor, A. M. W., Castonguay, A., Ghogha, A., Vayssiere, P., Pradhan, A. A. A., Xue, L., Mehrabani, S., Wu, J., Levitt, P., Olmstead, M. C., De Koninck, Y., Evans, C. J. & Cahill, C. M., Mar 1 2016, In: Neuropsychopharmacology. 41, 4, p. 949-959 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

86 Scopus citations

The effects of acute and preventive migraine therapies in a mouse model of chronic migraine

Tipton, A. F., Tarash, I., McGuire, B., Charles, A. & Pradhan, A. A., Oct 1 2016, In: Cephalalgia. 36, 11, p. 1048-1056 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

56 Scopus citations

2015

Anti-nociception mediated by a κ opioid receptor agonist is blocked by a δ receptor agonist

Taylor, A. M. W., Roberts, K. W., Pradhan, A. A., Akbari, H. A., Walwyn, W., Lutfy, K., Carroll, F. I., Cahill, C. M. & Evans, C. J., Jan 2015, In: British Journal of Pharmacology. 172, 2, p. 691-703 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Cell-autonomous regulation of mu-opioid receptor recycling by substance P

Bowman, S. L., Soohoo, A. L., Shiwarski, D. J., Schulz, S., Pradhan, A. A. & Puthenveedu, M. A., Mar 24 2015, In: Cell Reports. 10, 11, p. 1925-1936 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

In vivo techniques to investigate the internalization profi le of opioid receptors

Pradhan, A. A., Tawfik, V. L., Tipton, A. F. & Scherrer, G., 2015, In: Methods in Molecular Biology. 1230, p. 87-104 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

2014

Characterization of a novel model of chronic migraine

Pradhan, A. A., Smith, M. L., McGuire, B., Tarash, I., Evans, C. J. & Charles, A., Feb 2014, In: Pain. 155, 2, p. 269-274 6 p.

Research output: Contribution to journal › Article › peer-review

221 Scopus citations

δ-Opioid receptor agonists inhibit migraine-related hyperalgesia, aversive state and cortical spreading depression in mice

Pradhan, A. A., Smith, M. L., Zyuzin, J. & Charles, A., May 2014, In: British Journal of Pharmacology. 171, 9, p. 2375-2384 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

84 Scopus citations

2013

Chronic inflammatory injury results in increased coupling of delta opioid receptors to voltage-gated Ca²⁺ channels

Pradhan, A., Smith, M., McGuire, B., Evans, C. & Walwyn, W., Mar 4 2013, In: Molecular Pain. 9, 1, 8.

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Evaluation of cre recombinase delivery in mammalian cells using baculovirus infection

Erbs, E., Pradhan, A. A., Matifas, A., Kieffer, B. L. & Massotte, D., Jul 2013, In: Journal of Biotechnology. 166, 4, p. 182-186 5 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Select G-Protein-Coupled Receptors Modulate Agonist-Induced Signaling via a ROCK, LIMK, and β-Arrestin 1 Pathway

Mittal, N., Roberts, K., Pal, K., Bentolila, L. A., Fultz, E., Minasyan, A., Cahill, C., Pradhan, A., Conner, D., DeFea, K., Evans, C. & Walwyn, W., Nov 27 2013, In: Cell Reports. 5, 4, p. 1010-1021 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

45 Scopus citations

2011

Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking β-arrestin 2

Lam, H., Maga, M., Pradhan, A., Evans, C. J., Maidment, N. T., Hales, T. G. & Walwyn, W., Apr 12 2011, In: Molecular Pain. 7, 24.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

Sequential and opposing alterations of 5-HT _1A receptor function during withdrawal from chronic morphine

Lutz, P. E., Pradhan, A. A., Goeldner, C. & Kieffer, B. L., Nov 2011, In: European Neuropsychopharmacology. 21, 11, p. 835-840 6 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

2010

Ligand-directed trafficking of the δ-opioid receptor in vivo: Two paths toward analgesic tolerance

Pradhan, A. A. A., Walwyn, W., Nozaki, C., Filliol, D., Erbs, E., Matifas, A., Evans, C. & Kieffer, B. L., Dec 8 2010, In: Journal of Neuroscience. 30, 49, p. 16459-16468 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

119 Scopus citations

Modality of hyperalgesia tested, not type of nerve damage, predicts pharmacological sensitivity in rat models of neuropathic pain

Pradhan, A. A. A., Yu, X. H. & Laird, J. M. A., May 2010, In: European Journal of Pain. 14, 5, p. 503-509 7 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

2009

In vivo delta opioid receptor internalization controls behavioral effects of agonists

Pradhan, A. A. A., Becker, J. A. J., Scherrer, G., Tryoen-Toth, P., Filliol, D., Matifas, A., Massotte, D., Gavériaux-Ruff, C. & Kieffer, B. L., May 1 2009, In: PloS one. 4, 5, e5425.

Research output: Contribution to journal › Article › peer-review

Open Access

156 Scopus citations

Role of rat sensory neuron-specific receptor (rSNSR1) in inflammatory pain: Contribution of TRPV1 to SNSR signaling in the pain pathway

Ndong, C., Pradhan, A., Puma, C., Morello, J. P., Hoffert, C., Groblewski, T., O'Donnell, D. & Laird, J. M. A., May 2009, In: Pain. 143, 1-2, p. 130-137 8 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

2006

Chronic morphine administration results in tolerance to delta opioid receptor-mediated antinociception

Pradhan, A. A. A., Siau, C., Constantin, A. & Clarke, P. B. S., 2006, In: Neuroscience. 141, 2, p. 947-954 8 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

2005

Comparison between δ-opioid receptor functional response and autoradiographic labeling in rat brain and spinal cord

Ali Pradhan, A. A. & Clarke, P. B. S., Jan 24 2005, In: Journal of Comparative Neurology. 481, 4, p. 416-426 11 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Pharmacologically selective block of mu opioid antinociception by peptide nucleic acid antisense in absence of detectable ex vivo knockdown

Pradhan, A. A. A. & Clarke, P. B. S., Jan 4 2005, In: European Journal of Pharmacology. 506, 3, p. 229-236 8 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

2004

Morphine-induced changes in δ opioid receptor trafficking are linked to somatosensory processing in the rat spinal cord

Morinville, A., Cahill, C. M., Aibak, H., Rymar, V. V., Pradhan, A., Hoffert, C., Mennicken, F., Stroh, T., Sadikot, A. F., O'Donnell, D., Clarke, P. B. S., Collier, B., Henry, J. L., Vincent, J. P. & Beaudet, A., Jun 16 2004, In: Journal of Neuroscience. 24, 24, p. 5549-5559 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

68 Scopus citations

2003

Enhanced calcium signaling to bradykinin in airway smooth muscle from hyperresponsive inbred rats

Tao, F. C., Shah, S., Pradhan, A. A., Tolloczko, B. & Martin, J. G., Jan 1 2003, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 284, 1 28-1, p. L90-L99

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

2002

[¹²⁵I]Epibatidine-labelled nicotinic receptors in the extended striatum and cerebral cortex: Lack of association with serotonergic afferents

Pradhan, A. A. A., Cumming, P. & Clarke, P. B. S., Nov 8 2002, In: Brain Research. 954, 2, p. 227-236 10 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Evidence for sequence-dependent and reversible nonspecific effects of PS-capped antisense treatment after intracerebral administration

Boye, S. M., Pradhan, A. A. A., Grant, R. J. & Clarke, P. B. S., 2002, In: Antisense and Nucleic Acid Drug Development. 12, 2, p. 95-102 8 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

2000

Supraspinal antinociceptive response to [D-Pen^2,5]-enkephalin (DPDPE) is pharmacologically distinct from that to other δ-agonists in the rat

Fraser, G. L., Pradhan, A. A., Clarke, P. B. S. & Wahlestedt, C., 2000, In: Journal of Pharmacology and Experimental Therapeutics. 295, 3, p. 1135-1141 7 p.

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Amynah Pradhan

Research output

Search results