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Personal profile

Research interests

The goal of my research is to delineate the molecular mechanisms of beta cell death resulting in type 1 diabetes (T1DM) to discover novel beta cell preserving therapies for diabetic patients. My research has shown that pharmacologic preservation of cellular calcium homeostasis can prevent cytokine mediated beta cell death in vitro. Further studies are underway to determine if these compounds are protective in animal models of diabetes. I am also actively studying the role of beta cell driven sterile inflammation in insulitis and beta cell death. Recent studies indicate that the ER stress related protein thioredoxin interacting protein (TXNIP) may be a key molecular mediator of hyperglycemia induced islet inflammation and beta cell death. Studies are underway utilizing in vivo and in vitro TXNIP knock out models to delineate the role and mechanism of TXNIP in the development and progression of T1DM.

Areas of Clinical Interest

Pediatric endocrinology, diabetes in kids; Williams Syndrome; growth disorders

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Research Output

  • 514 Citations
  • 10 Article
  • 3 Review article
  • 1 Comment/debate
Open Access
  • 3 Scopus citations

    Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death

    Clark, A. L., Kanekura, K., Lavagnino, Z., Spears, L. D., Abreu, D., Mahadevan, J., Yagi, T., Semenkovich, C. F., Piston, D. W. & Urano, F., Dec 1 2017, In : Scientific reports. 7, 1, 5611.

    Research output: Contribution to journalArticle

    Open Access
  • 9 Scopus citations

    Endoplasmic reticulum stress in beta cells and autoimmune diabetes

    Clark, A. L. & Urano, F., Dec 1 2016, In : Current Opinion in Immunology. 43, p. 60-66 7 p.

    Research output: Contribution to journalReview article

  • 24 Scopus citations

    Hypercalcemia in Patients with Williams-Beuren Syndrome

    Sindhar, S., Lugo, M., Levin, M. D., Danback, J. R., Brink, B. D., Yu, E., Dietzen, D. J., Clark, A. L., Purgert, C. A., Waxler, J. L., Elder, R. W., Pober, B. R. & Kozel, B. A., Nov 1 2016, In : Journal of Pediatrics. 178, p. 254-260.e4

    Research output: Contribution to journalArticle

  • 17 Scopus citations

    Even silent hypoglycemia induces cardiac arrhythmias

    Clark, A. L., Best, C. J. & Fisher, S. J., May 2014, In : Diabetes. 63, 5, p. 1457-1459 3 p.

    Research output: Contribution to journalComment/debate

    Open Access
    15 Scopus citations