• 1003 Citations

Research output per year

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Personal profile

Research interests

Dr. Horani's main research interest focuses on airway epithelial cell pathogensis including primary ciliary dyskinesia (PCD), a genetic condition that results in impaired mucociliary clearance, causing progressive involvement of the respiratory tract characterized by recurrent infections of the lungs, middle ear, and paranasal sinuses. Dr. Horani is the recipient of multiple scientific awards related to his work in pediatric research. Working alongside members of a multidisciplinary team at Washington University in St. Louis, Dr. Horani's work in the laboratory examines the importance of different genes in the pathogenesis of primary ciliary dyskinesia and studies the function of several proteins in the assembly of motile cilia, a structure known to be defective in PCD.

Areas of Clinical Interest

Primary Ciliary Dyskinesia, Cystic Fibrosis, Asthma

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Research Output

Mutation of CFAP57, a protein required for the asymmetric targeting of a subset of inner dynein arms in Chlamydomonas, causes primary ciliary dyskinesia

Bustamante-Marin, X. M., Horani, A., Stoyanova, M., Charng, W. L., Bottier, M., Sears, P. R., Yin, W. N., Daniels, L. A., Bowen, H., Conrad, D. F., Knowles, M. R., Ostrowski, L. E., Zariwala, M. A. & Dutcher, S. K., Aug 7 2020, In : PLoS genetics. 16, 8, e1008691.

Research output: Contribution to journalArticle

Open Access
  • American Thoracic Society 2019 Pediatric Core Curriculum

    Moore, P. E., Boyer, D., Perkins, R., Katz, E. S., Castro-Codesal, M. L., MacLean, J. E., Akil, N., Esther, C. R., Kaslow, J., Lewis, T. C., Krone, K. A., Quizon, A., Simpson, R., Benscoter, D., Spielberg, D. R., Melicoff, E., Kuklinski, C. A., Blatter, J. A., Dy, J., Rettig, J. S. & 2 others, Horani, A. & Gross, J., Dec 1 2019, In : Pediatric Pulmonology. 54, 12, p. 1880-1894 15 p.

    Research output: Contribution to journalReview article

  • Frequenting sequencing: How genetics teaches US cilia biology

    Horani, A. & Brody, S. L., Oct 1 2019, In : American Journal of Respiratory Cell and Molecular Biology. 61, 4, p. 403-404 2 p.

    Research output: Contribution to journalEditorial

    Open Access
    1 Scopus citations

    Advances in the Genetics of Primary Ciliary Dyskinesia: Clinical Implications

    Horani, A. & Ferkol, T. W., Sep 2018, In : CHEST. 154, 3, p. 645-652 8 p.

    Research output: Contribution to journalReview article

  • 22 Scopus citations

    A liquid-like organelle at the root of motile ciliopathy

    Huizar, R. L., Lee, C., Boulgakov, A. A., Horani, A., Tu, F., Marcotte, E. M., Brody, S. L. & Wallingford, J. B., Dec 1 2018, In : eLife. 7

    Research output: Contribution to journalArticle

    Open Access
  • 12 Scopus citations