Research Output per year
Research Output per year
Personal profile
Research interests
Dr. Horani's main research interest focuses on airway epithelial cell pathogensis including primary ciliary dyskinesia (PCD), a genetic condition that results in impaired mucociliary clearance, causing progressive involvement of the respiratory tract characterized by recurrent infections of the lungs, middle ear, and paranasal sinuses. Dr. Horani is the recipient of multiple scientific awards related to his work in pediatric research. Working alongside members of a multidisciplinary team at Washington University in St. Louis, Dr. Horani's work in the laboratory examines the importance of different genes in the pathogenesis of primary ciliary dyskinesia and studies the function of several proteins in the assembly of motile cilia, a structure known to be defective in PCD.
Areas of Clinical Interest
Primary Ciliary Dyskinesia, Cystic Fibrosis, Asthma
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Research Output
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Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells
Hawkins, F. J., Suzuki, S., Beermann, M. L., Barillà, C., Wang, R., Villacorta-Martin, C., Berical, A., Jean, J. C., Le Suer, J., Matte, T., Simone-Roach, C., Tang, Y., Schlaeger, T. M., Crane, A. M., Matthias, N., Huang, S. X. L., Randell, S. H., Wu, J., Spence, J. R., Carraro, G. & 7 others, , 2020, (Accepted/In press) In: Cell Stem Cell.Research output: Contribution to journal › Article › peer-review
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Mutation of CFAP57, a protein required for the asymmetric targeting of a subset of inner dynein arms in Chlamydomonas, causes primary ciliary dyskinesia
Bustamante-Marin, X. M., Horani, A., Stoyanova, M., Charng, W. L., Bottier, M., Sears, P. R., Yin, W. N., Daniels, L. A., Bowen, H., Conrad, D. F., Knowles, M. R., Ostrowski, L. E., Zariwala, M. A. & Dutcher, S. K., Aug 7 2020, In: PLoS genetics. 16, 8, e1008691.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
American Thoracic Society 2019 Pediatric Core Curriculum
Moore, P. E., Boyer, D., Perkins, R., Katz, E. S., Castro-Codesal, M. L., MacLean, J. E., Akil, N., Esther, C. R., Kaslow, J., Lewis, T. C., Krone, K. A., Quizon, A., Simpson, R., Benscoter, D., Spielberg, D. R., Melicoff, E., Kuklinski, C. A., Blatter, J. A., Dy, J., Rettig, J. S. & 2 others, , Dec 1 2019, In: Pediatric Pulmonology. 54, 12, p. 1880-1894 15 p.Research output: Contribution to journal › Review article › peer-review
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Frequenting sequencing: How genetics teaches US cilia biology
Horani, A. & Brody, S. L., Oct 1 2019, In: American Journal of Respiratory Cell and Molecular Biology. 61, 4, p. 403-404 2 p.Research output: Contribution to journal › Editorial
Open Access1 Scopus citations -
Advances in the Genetics of Primary Ciliary Dyskinesia: Clinical Implications
Horani, A. & Ferkol, T. W., Sep 2018, In: CHEST. 154, 3, p. 645-652 8 p.Research output: Contribution to journal › Review article › peer-review
26 Scopus citations