Research output per year
Research output per year
Personal profile
Research interests
Dr. Horani's main research interest focuses on airway epithelial cell pathogensis including primary ciliary dyskinesia (PCD), a genetic condition that results in impaired mucociliary clearance, causing progressive involvement of the respiratory tract characterized by recurrent infections of the lungs, middle ear, and paranasal sinuses. Dr. Horani is the recipient of multiple scientific awards related to his work in pediatric research. Working alongside members of a multidisciplinary team at Washington University in St. Louis, Dr. Horani's work in the laboratory examines the importance of different genes in the pathogenesis of primary ciliary dyskinesia and studies the function of several proteins in the assembly of motile cilia, a structure known to be defective in PCD.
Clinical interests
Primary ciliary dyskinesia, cystic fibrosis, asthma
Mentoring
I am committed to reducing inequities in the scientific field, as well as the medical field by promoting a diverse environment within the lab. I
believe that medical education, and the experience aspiring scientists receive in the lab, are essential in promoting diversity within the scientific community as well as the general community as a whole.
Available to Mentor:
- PhD/MSTP Students
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Airway Disease Modeling with Gene-Edited Human Basal Cell Transplantation
Berical, A. C., Kiyokawa, H., Beermann, M. L., Wallman, D., Cherfane, G., Dunphy, V., Pan, J., Tilston-Lunel, A., Varelas, X., Horani, A., Brody, S. L., Kotton, D. N. & Hawkins, F. J., Jan 2025, In: American journal of respiratory and critical care medicine. 211, 1, p. 131-134 4 p.Research output: Contribution to journal › Letter › peer-review
2 Scopus citations -
Reply to Huang et al. Sowing Tailored Seeds: Gene-edited Basal Cells for Precision Regulation of Airway Phenotypes
Berical, A. C., Kiyokawa, H., Beermann, M. L., Wallman, D., Cherfane, G., Dunphy, V., Pan, J., Tilston-Lunel, A., Varelas, X., Horani, A., Brody, S. L., Kotton, D. N. & Hawkins, F. J., May 1 2025, In: American journal of respiratory and critical care medicine. 211, 5, p. 884 1 p.Research output: Contribution to journal › Letter › peer-review
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Undocking of an extensive ciliary network induces proteostasis and cell fate switching resulting in severe primary ciliary dyskinesia
Brody, S. L., Pan, J., Huang, T., Xu, J., Xu, H., Koenitizer, J. R., Brennan, S. K., Nanjundappa, R., Saba, T. G., Rumman, N., Berical, A., Hawkins, F. J., Wang, X., Zhang, R., Mahjoub, M. R., Horani, A. & Dutcher, S. K., Jan 29 2025, In: Science translational medicine. 17, 783, eadp5173.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Antigen stasis and airway nitrosative stress in human primary ciliary dyskinesia
Gaston, B., Smith, L. A., Davis, M. D., Saunders, J., Daniels, I., Horani, A., Brody, S. L., Giddings, O., Zhao, Y. & Marozkina, N., Apr 2024, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 326, 4, p. L468-L476Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules
Genomics England Research Consortium, Dodd, D. O., Mechaussier, S., Yeyati, P. L., McPhie, F., Anderson, J. R., Khoo, C. J., Shoemark, A., Gupta, D. K., Attard, T., Zariwala, M. A., Legendre, M., Bracht, D., Wallmeier, J., Gui, M., Fassad, M. R., Parry, D. A., Tennant, P. A., Meynert, A. & Wheway, G. & 64 others, , Apr 26 2024, In: Science. 384, 6694, eadf5489.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations