Research output per year
Research output per year
Personal profile
Research interests
Dr. Horani's main research interest focuses on airway epithelial cell pathogensis including primary ciliary dyskinesia (PCD), a genetic condition that results in impaired mucociliary clearance, causing progressive involvement of the respiratory tract characterized by recurrent infections of the lungs, middle ear, and paranasal sinuses. Dr. Horani is the recipient of multiple scientific awards related to his work in pediatric research. Working alongside members of a multidisciplinary team at Washington University in St. Louis, Dr. Horani's work in the laboratory examines the importance of different genes in the pathogenesis of primary ciliary dyskinesia and studies the function of several proteins in the assembly of motile cilia, a structure known to be defective in PCD.
Areas of Clinical Interest
Primary Ciliary Dyskinesia, Cystic Fibrosis, Asthma
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Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells
Hawkins, F. J., Suzuki, S., Beermann, M. L., Barillà, C., Wang, R., Villacorta-Martin, C., Berical, A., Jean, J. C., Le Suer, J., Matte, T., Simone-Roach, C., Tang, Y., Schlaeger, T. M., Crane, A. M., Matthias, N., Huang, S. X. L., Randell, S. H., Wu, J., Spence, J. R., Carraro, G. & 7 others, , Jan 7 2021, In: Cell Stem Cell. 28, 1, p. 79-95.e8Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Implementation of a screening tool for primary ciliary dyskinesia (PCD) in a pediatric otolaryngology clinic
Brennan, S. K., Molter, D., Menezes, M., Dunsky, K., Leonard, D., Lieu, J., Hirose, K., Hazan, G., Horani, A., Ferkol, T. & Brody, S. L., Mar 2021, In: International Journal of Pediatric Otorhinolaryngology. 142, 110586.Research output: Contribution to journal › Article › peer-review
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Understanding Primary Ciliary Dyskinesia and Other Ciliopathies
Horani, A. & Ferkol, T. W., Mar 2021, In: Journal of Pediatrics. 230, p. 15-22.e1Research output: Contribution to journal › Article › peer-review
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Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins
Lee, C., Cox, R. M., Papoulas, O., Horani, A., Drew, K., Devitt, C. C., Brody, S. L., Marcotte, E. M. & Wallingford, J. B., Dec 2020, In: eLife. 9, p. 1-23 23 p., e58662.Research output: Contribution to journal › Article › peer-review
Open Access -
Mutation of CFAP57, a protein required for the asymmetric targeting of a subset of inner dynein arms in Chlamydomonas, causes primary ciliary dyskinesia
Bustamante-Marin, X. M., Horani, A., Stoyanova, M., Charng, W. L., Bottier, M., Sears, P. R., Yin, W. N., Daniels, L. A., Bowen, H., Conrad, D. F., Knowles, M. R., Ostrowski, L. E., Zariwala, M. A. & Dutcher, S. K., Aug 7 2020, In: PLoS genetics. 16, 8, e1008691.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations