Research output per year
Research output per year
Personal profile
Research interests
Dr. Horani's main research interest focuses on airway epithelial cell pathogensis including primary ciliary dyskinesia (PCD), a genetic condition that results in impaired mucociliary clearance, causing progressive involvement of the respiratory tract characterized by recurrent infections of the lungs, middle ear, and paranasal sinuses. Dr. Horani is the recipient of multiple scientific awards related to his work in pediatric research. Working alongside members of a multidisciplinary team at Washington University in St. Louis, Dr. Horani's work in the laboratory examines the importance of different genes in the pathogenesis of primary ciliary dyskinesia and studies the function of several proteins in the assembly of motile cilia, a structure known to be defective in PCD.
Clinical interests
Primary Ciliary Dyskinesia, Cystic Fibrosis, Asthma
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Kif9 is an active kinesin motor required for ciliary beating and proximodistal patterning of motile axonemes
Konjikusic, M. J., Lee, C., Yue, Y., Shrestha, B. D., Nguimtsop, A. M., Horani, A., Brody, S., Prakash, V. N., Gray, R. S., Verhey, K. J. & Wallingford, J. B., Mar 1 2023, In: Journal of cell science. 136, 5Research output: Contribution to journal › Article › peer-review
Open Access -
Engineering rotating apical-out airway organoid for assessing respiratory cilia motility
Wijesekara, P., Yadav, P., Perkins, L. A., Stolz, D. B., Franks, J. M., Watkins, S. C., Reinoso Jacome, E., Brody, S. L., Horani, A., Xu, J., Barati Farimani, A. & Ren, X., Aug 19 2022, In: iScience. 25, 8, 104730.Research output: Contribution to journal › Article › peer-review
Open Access -
The Translational Landscape of SARS-CoV-2-infected Cells Reveals Suppression of Innate Immune Genes
Puray-Chavez, M., Lee, N., Tenneti, K., Wang, Y., Vuong, H. R., Liu, Y., Horani, A., Huang, T., Gunsten, S. P., Case, J. B., Yang, W., Diamond, M. S., Brody, S. L., Dougherty, J. & Kutluay, S. B., Jun 2022, In: mBio. 13, 3Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Variations in infection control practices suggest a need for guidelines in primary ciliary dyskinesia patient care
Caliskan, A. B., Horani, A., Manion, M. & Brody, S., Apr 2022, In: Pediatric Pulmonology. 57, 4, p. 1072-1075 4 p.Research output: Contribution to journal › Article › peer-review
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Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells
Hawkins, F. J., Suzuki, S., Beermann, M. L., Barillà, C., Wang, R., Villacorta-Martin, C., Berical, A., Jean, J. C., Le Suer, J., Matte, T., Simone-Roach, C., Tang, Y., Schlaeger, T. M., Crane, A. M., Matthias, N., Huang, S. X. L., Randell, S. H., Wu, J., Spence, J. R., Carraro, G., & 7 others, Jan 7 2021, In: Cell Stem Cell. 28, 1, p. 79-95.e8Research output: Contribution to journal › Article › peer-review
61 Scopus citations