Personal profile
Research interests
Professor Pathak`s research interests include mechanobiology of the cell, biomaterials, and interactions between cells and extracellular matrices. In particular, his research aims to understand how numerous parameters that define three-dimensional ECMs (e.g. stiffness, porosity, and fibrous microstructure) all interactively affect cell motility through a variety of sub-cellular mechanisms. His lab tackles this multi-variable problem through a multidisciplinary approach that includes fabrication of new matrix platforms, development of advanced measurement tools in cell biology, and construction of predictive computational models. Within this scheme, his current research program is organized around these broad topics:
Regulation of tumor cell invasion by matrix properties
Mechanical memory in cell migration
Epithelial cells in confined and heterogeneous environments
Single cell migration in mechanically diverse environments
Available to Mentor:
- PhD Students
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Collaborations and top research areas from the last five years
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The Nemp1–Nesprin complex mediates cellular responses to matrix mechanics
Ganguly, A., Zmuda, H., Abello, J., Illy, D., Walter, C., Tsatskis, Y., Thanintorn, N., Zhang, Y., Hakim, B. A., Hodzic, D., Stratman, A. N., Jurisicova, A., Pathak, A. & McNeill, H., Mar 3 2026, In: Proceedings of the National Academy of Sciences of the United States of America. 123, 9, e2521253123.Research output: Contribution to journal › Article › peer-review
Open Access -
Adipose stromal cells in the human rotator cuff are resistant to fibrotic microenvironmental cues
Kamm, D. R., Shaji, A., Bohnert, K. L., Keener, J. D., Pathak, A. & Meyer, G. A., Dec 1 2025, In: Journal of Physiology. 603, 23, p. 7567-7587 21 p.Research output: Contribution to journal › Article › peer-review
4 Link opens in a new tab Scopus citations -
Cadherin-1-mediated communication at the leader-follower boundary controls mouse breast tumor organoid collective migration
Morikis, V. A., Avila, D. B., DiMauro, A., Cao, Y., Hwang, P. Y., Pathak, A. & Longmore, G. D., Dec 23 2025, In: Cell Reports. 44, 12, 116631.Research output: Contribution to journal › Article › peer-review
Open Access -
Distinct roles of protrusions and collagen deformation in collective invasion of cancer cell types
Lee, Y. L., Longmore, G. D. & Pathak, A., May 6 2025, In: Biophysical Journal. 124, 9, p. 1506-1520 15 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Emergent depth-mechanosensing of epithelial collectives regulates cell clustering and dispersal on layered matrices
Yu, H. & Pathak, A., Sep 16 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 37, e2423875122.Research output: Contribution to journal › Article › peer-review
Open Access