Research output per year
Research output per year
Personal profile
Research interests
Professor Pathak`s research interests include mechanobiology of the cell, biomaterials, and interactions between cells and extracellular matrices. In particular, his research aims to understand how numerous parameters that define three-dimensional ECMs (e.g. stiffness, porosity, and fibrous microstructure) all interactively affect cell motility through a variety of sub-cellular mechanisms. His lab tackles this multi-variable problem through a multidisciplinary approach that includes fabrication of new matrix platforms, development of advanced measurement tools in cell biology, and construction of predictive computational models. Within this scheme, his current research program is organized around these broad topics:
Regulation of tumor cell invasion by matrix properties
Mechanical memory in cell migration
Epithelial cells in confined and heterogeneous environments
Single cell migration in mechanically diverse environments
Available to Mentor:
- PhD/MSTP Students
Fingerprint
Dive into the research topics where Amit Pathak is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
A Cdh3-β-catenin-laminin signaling axis in a subset of breast tumor leader cells control leader cell polarization and directional collective migration
Hwang, P. Y., Mathur, J., Cao, Y., Almeida, J., Ye, J., Morikis, V., Cornish, D., Clarke, M., Stewart-Wigglesworth, S., Pathak, A. & Longmore, G. D., Jan 9 2023, In: Developmental cell. 58, 1, p. 34-50.e9Research output: Contribution to journal › Article › peer-review
Open Access -
Cell-matrix interactions, force transmission, and mechanosensation
Walter, C., Zmuda, H., Almeida, J. A. & Pathak, A., Jan 1 2022, Cell Movement in Health and Disease. Elsevier, p. 129-147 19 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
-
Nucleoli in epithelial cell collectives respond to tumorigenic, spatial, and mechanical cues
Jaecker, F. F., Almeida, J. A., Krull, C. M. & Pathak, A., Sep 15 2022, In: Molecular biology of the cell. 33, 11, br19.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Dynamic self-reinforcement of gene expression determines acquisition of cellular mechanical memory
Price, C. C., Mathur, J., Boerckel, J. D., Pathak, A. & Shenoy, V. B., Nov 16 2021, In: Biophysical Journal. 120, 22, p. 5074-5089 16 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Control of adhesive ligand density for modulation of nucleus pulposus cell phenotype
Barcellona, M. N., Speer, J. E., Fearing, B. V., Jing, L., Pathak, A., Gupta, M. C., Buchowski, J. M., Kelly, M. & Setton, L. A., Aug 2020, In: Biomaterials. 250, 120057.Research output: Contribution to journal › Article › peer-review
22 Scopus citations