Personal profile
Research interests
Our research focuses on unraveling the molecular mechanisms underlying substrate specificity and degradation by AAA proteolytic machines and their associated adaptor proteins, utilizing structural biology, biochemistry, and cellular assays in both bacteria and human mitochondria.
Available to Mentor:
- PhD Students
Fingerprint
Dive into the research topics where Alireza Ghanbarpour is active. These topic labels come from the works of this person and are generated automatically. Together they form a unique fingerprint. Contact the Profiles team with questions.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
An open axial channel of the AAA ClpXP protease enhances degradation of specific classes of protein substrates
Lyu, Y., Bolstad, I., Davis, J. H., Sauer, R. T. & Ghanbarpour, A., Jan 2026, In: Protein Science. 35, 1, e70372.Research output: Contribution to journal › Article › peer-review
Open Access -
Bacterial immune activation via supramolecular assembly with phage triggers
Zhang, T., Lyu, Y., Beck, C. R., Iqbal, N., Barbosa, R., Ghanbarpour, A. & Laub, M. T., Mar 26 2026, In: Nature. 651, 8107, p. 1051-1059 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
An asymmetric nautilus-like HflK/C assembly controls FtsH proteolysis of membrane proteins
Ghanbarpour, A., Telusma, B., Powell, B. M., Zhang, J. J., Bolstad, I., Vargas, C., Keller, S., Baker, T. A., Sauer, R. T. & Davis, J. H., May 2 2025, In: EMBO Journal. 44, 9, p. 2501-2513 13 p., e2409334121.Research output: Contribution to journal › Article › peer-review
Open Access15 Link opens in a new tab Scopus citations -
Exploiting a rational β-strand insertion strategy and disulfide locking to mechanically manipulate domain-swapped protein structures
Ghanbarpour, A., Kenaya, N., Bingham, C., Turke, M., Pinger, C., Kemp, C., Studzinski, E., Vasileiou, C., Borhan, B. & Geiger, J. H., Oct 2 2025, In: Structure. 33, 10, p. 1739-1749.e3Research output: Contribution to journal › Article › peer-review
2 Link opens in a new tab Scopus citations -
Structural insights into the Pseudomonas aeruginosa ClpP1•ClpP2 heterocomplex and its interactions with the AAA+ ClpX unfoldase
Ghanbarpour, A., Zhang, J. J., Davis, J. H., Baker, T. A. & Sauer, R. T., Oct 2025, In: Protein Science. 34, 10, e70310.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Scopus citations