• 5594

Research activity per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

The ability of B cells to expand and differentiate into memory and plasma cells in response to antigenic stimulation underlies the success of most - if not all - vaccines currently in use. Despite this, and the fact that we have known about humoral immunity for centuries, we still do not have a thorough understanding of how the fate of responding B cell is determined, and how the longevity of the response is controlled. Such understanding will be key in our quest to develop vaccines that elicit broadly protective and durable immune responses. My lab is trying to address the following questions:

1) What are the cellular and molecular mechanisms that regulate memory B cell generation and maintenance?

2) What are the different subsets of human memory B cells? And how do they contribute to protection?

3) What are the rules for eliciting broadly neutralizing B cell responses against rapidly evolving pathogens, such as influenza viruses?


  • COVID-19

Available to Mentor:

  • PhD/MSTP Students


Dive into the research topics where Ali Ellebedy is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 1 Similar Profiles


Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
  • Author Correction: The persistence of memory: defining, engineering, and measuring vaccine durability (Nature Immunology, (2022), 23, 12, (1665-1668), 10.1038/s41590-022-01359-z)

    Palin, A. C., Alter, G., Crotty, S., Ellebedy, A. H., Lane, M. C., Lee, F. E. H., Locci, M., Malaspina, A., Mallia, C., McElrath, M. J., Pulendran, B., Singh, A. & D’Souza, M. P., Jan 2023, In: Nature immunology. 24, 1, p. 200 1 p.

    Research output: Contribution to journalComment/debate

    Open Access
  • Immunological imprinting: Understanding COVID-19

    Koutsakos, M. & Ellebedy, A. H., May 9 2023, In: Immunity. 56, 5, p. 909-913 5 p.

    Research output: Contribution to journalReview articlepeer-review

  • ‘Persistent germinal center responses: slow-growing trees bear the best fruits’

    Matz, H. C., McIntire, K. M. & Ellebedy, A. H., Aug 2023, In: Current Opinion in Immunology. 83, 102332.

    Research output: Contribution to journalReview articlepeer-review

  • Antibodies targeting the neuraminidase active site inhibit influenza H3N2 viruses with an S245N glycosylation site

    Stadlbauer, D., McMahon, M., Turner, H. L., Zhu, X., Wan, H., Carreño, J. M., O’Dell, G., Strohmeier, S., Khalil, Z., Luksza, M., van Bakel, H., Simon, V., Ellebedy, A. H., Wilson, I. A., Ward, A. B. & Krammer, F., Dec 2022, In: Nature communications. 13, 1, 7864.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • Defining the risk of SARS-CoV-2 variants on immune protection

    DeGrace, M. M., Ghedin, E., Frieman, M. B., Krammer, F., Grifoni, A., Alisoltani, A., Alter, G., Amara, R. R., Baric, R. S., Barouch, D. H., Bloom, J. D., Bloyet, L. M., Bonenfant, G., Boon, A. C. M., Boritz, E. A., Bratt, D. L., Bricker, T. L., Brown, L., Buchser, W. J., Carreño, J. M., & 110 othersCohen-Lavi, L., Darling, T. L., Davis-Gardner, M. E., Dearlove, B. L., Di, H., Dittmann, M., Doria-Rose, N. A., Douek, D. C., Drosten, C., Edara, V. V., Ellebedy, A., Fabrizio, T. P., Ferrari, G., Fischer, W. M., Florence, W. C., Fouchier, R. A. M., Franks, J., García-Sastre, A., Godzik, A., Gonzalez-Reiche, A. S., Gordon, A., Haagmans, B. L., Halfmann, P. J., Ho, D. D., Holbrook, M. R., Huang, Y., James, S. L., Jaroszewski, L., Jeevan, T., Johnson, R. M., Jones, T. C., Joshi, A., Kawaoka, Y., Kercher, L., Koopmans, M. P. G., Korber, B., Koren, E., Koup, R. A., LeGresley, E. B., Lemieux, J. E., Liebeskind, M. J., Liu, Z., Livingston, B., Logue, J. P., Luo, Y., McDermott, A. B., McElrath, M. J., Meliopoulos, V. A., Menachery, V. D., Montefiori, D. C., Mühlemann, B., Munster, V. J., Munt, J. E., Nair, M. S., Netzl, A., Niewiadomska, A. M., O’Dell, S., Pekosz, A., Perlman, S., Pontelli, M. C., Rockx, B., Rolland, M., Rothlauf, P. W., Sacharen, S., Scheuermann, R. H., Schmidt, S. D., Schotsaert, M., Schultz-Cherry, S., Seder, R. A., Sedova, M., Sette, A., Shabman, R. S., Shen, X., Shi, P. Y., Shukla, M., Simon, V., Stumpf, S., Sullivan, N. J., Thackray, L. B., Theiler, J., Thomas, P. G., Trifkovic, S., Türeli, S., Turner, S. A., Vakaki, M. A., van Bakel, H., VanBlargan, L. A., Vincent, L. R., Wallace, Z. S., Wang, L., Wang, M., Wang, P., Wang, W., Weaver, S. C., Webby, R. J., Weiss, C. D., Wentworth, D. E., Weston, S. M., Whelan, S. P. J., Whitener, B. M., Wilks, S. H., Xie, X., Ying, B., Yoon, H., Zhou, B., Hertz, T., Smith, D. J., Diamond, M. S., Post, D. J. & Suthar, M. S., May 26 2022, In: Nature. 605, 7911, p. 640-652 13 p.

    Research output: Contribution to journalReview articlepeer-review

    Open Access
    45 Scopus citations