Ali Ellebedy

Assistant Professor of Pathology and Immunology, Assistant Professor of Medicine, Assistant Professor of Molecular Microbiology

    • 1715 Citations
    20092020

    Research output per year

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    Personal profile

    Research interests

    The ability of B cells to expand and differentiate into memory and plasma cells in response to antigenic stimulation underlies the success of most - if not all - vaccines currently in use. Despite this, and the fact that we have known about humoral immunity for centuries, we still do not have a thorough understanding of how the fate of responding B cell is determined, and how the longevity of the response is controlled. Such understanding will be key in our quest to develop vaccines that elicit broadly protective and durable immune responses. My lab is trying to address the following questions: 1) What are the cellular and molecular mechanisms that regulate memory B cell generation and maintenance? 2) What are the different subsets of human memory B cells? And how do they contribute to protection? 3) What are the rules for eliciting broadly neutralizing B cell responses against rapidly evolving pathogens, such as influenza viruses?

    Keywords

    • COVID-19

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    Research Output

    Adjuvanted H5N1 influenza vaccine enhances both cross-reactive memory B cell and strain-specific naive B cell responses in humans

    Ellebedy, A. H., Nachbagauer, R., Jackson, K. J. L., Dai, Y. N., Han, J., Alsoussi, W. B., Davis, C. W., Stadlbauer, D., Rouphael, N., Chromikova, V., McCausland, M., Chang, C. Y., Cortese, M., Bower, M., Chennareddy, C., Schmitz, A. J., Zarnitsyna, V. I., Lai, L., Rajabhathor, A., Kazemian, C. & 8 others, Antia, R., Mulligan, M. J., Ward, A. B., Fremont, D. H., Boyd, S. D., Pulendran, B., Krammer, F. & Ahmed, R., Jul 28 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 30, p. 17957-17964 8 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    A potently neutralizing antibody protects mice against SARS-CoV-2 infection

    Alsoussi, W. B., Turner, J. S., Case, J. B., Zhao, H., Schmitz, A. J., Zhou, J. Q., Chen, R. E., Lei, T., Rizk, A. A., McIntire, K. M., Winkler, E. S., Fox, J. M., Kafai, N. M., Thackray, L. B., Hassan, A. O., Amanat, F., Krammer, F., Watson, C. T., Kleinstein, S. H., Fremont, D. H. & 2 others, Diamond, M. S. & Ellebedy, A. H., Aug 15 2020, In : Journal of Immunology. 205, 4, p. 915-922 8 p.

    Research output: Contribution to journalArticle

    Open Access
  • 5 Scopus citations

    A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies

    Hassan, A. O., Case, J. B., Winkler, E. S., Thackray, L., Kafai, N. M., Bailey, A. L., McCune, B. T., Fox, J. M., Chen, R. E., Alsoussi, W. B., Turner, J. S., Schmitz, A. J., Lei, T., Shrihari, S., Keeler, S. P., Fremont, D., Greco, S., McCray, P. B., Perlman, S., Holtzman, M. J. & 2 others, Ellebedy, A. & Diamond, M. S., Jan 1 2020, (Accepted/In press) In : Cell.

    Research output: Contribution to journalArticle

    Open Access
  • 29 Scopus citations

    Harnessing Activin A Adjuvanticity to Promote Antibody Responses to BG505 HIV Envelope Trimers

    Carnathan, D. G., Kaushik, K., Ellebedy, A. H., Enemuo, C. A., Gebru, E. H., Dhadvai, P., Rasheed, M. A. U., Pauthner, M. G., Ozorowski, G., Ahmed, R., Burton, D. R., Ward, A. B., Silvestri, G., Crotty, S. & Locci, M., Jun 16 2020, In : Frontiers in immunology. 11, 1213.

    Research output: Contribution to journalArticle

    Open Access
  • Immune checkpoint modulation enhances HIV-1 antibody induction

    Bradley, T., Kuraoka, M., Yeh, C. H., Tian, M., Chen, H., Cain, D. W., Chen, X., Cheng, C., Ellebedy, A. H., Parks, R., Barr, M., Sutherland, L. L., Scearce, R. M., Bowman, C. M., Bouton-Verville, H., Santra, S., Wiehe, K., Lewis, M. G., Ogbe, A., Borrow, P. & 10 others, Montefiori, D., Bonsignori, M., Anthony Moody, M., Verkoczy, L., Saunders, K. O., Ahmed, R., Mascola, J. R., Kelsoe, G., Alt, F. W. & Haynes, B. F., Dec 1 2020, In : Nature communications. 11, 1, 948.

    Research output: Contribution to journalArticle

    Open Access
  • 5 Scopus citations