Ali Ellebedy

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Ali Ellebedy

Associate Professor of Pathology and Immunology, Associate Professor of Medicine, Associate Professor of Molecular Microbiology

    Willing to Mentor

    Available to Mentor:

    PhD/MSTP Students

    • 5594
      Citations
    20092023

    Research activity per year

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    Personal profile

    Research interests

    The ability of B cells to expand and differentiate into memory and plasma cells in response to antigenic stimulation underlies the success of most - if not all - vaccines currently in use. Despite this, and the fact that we have known about humoral immunity for centuries, we still do not have a thorough understanding of how the fate of responding B cell is determined, and how the longevity of the response is controlled. Such understanding will be key in our quest to develop vaccines that elicit broadly protective and durable immune responses. My lab is trying to address the following questions:

    1) What are the cellular and molecular mechanisms that regulate memory B cell generation and maintenance?

    2) What are the different subsets of human memory B cells? And how do they contribute to protection?

    3) What are the rules for eliciting broadly neutralizing B cell responses against rapidly evolving pathogens, such as influenza viruses?

    Keywords

    • COVID-19

    Available to Mentor:

    • PhD/MSTP Students

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    • Author Correction: The persistence of memory: defining, engineering, and measuring vaccine durability (Nature Immunology, (2022), 23, 12, (1665-1668), 10.1038/s41590-022-01359-z)

      Palin, A. C., Alter, G., Crotty, S., Ellebedy, A. H., Lane, M. C., Lee, F. E. H., Locci, M., Malaspina, A., Mallia, C., McElrath, M. J., Pulendran, B., Singh, A. & D’Souza, M. P., Jan 2023, In: Nature immunology. 24, 1, p. 200 1 p.

      Research output: Contribution to journal › Comment/debate

      Open Access

    • Immunological imprinting: Understanding COVID-19

      Koutsakos, M. & Ellebedy, A. H., May 9 2023, In: Immunity. 56, 5, p. 909-913 5 p.

      Research output: Contribution to journal › Review article › peer-review

    • ‘Persistent germinal center responses: slow-growing trees bear the best fruits’

      Matz, H. C., McIntire, K. M. & Ellebedy, A. H., Aug 2023, In: Current Opinion in Immunology. 83, 102332.

      Research output: Contribution to journal › Review article › peer-review

    • Antibodies targeting the neuraminidase active site inhibit influenza H3N2 viruses with an S245N glycosylation site

      Stadlbauer, D., McMahon, M., Turner, H. L., Zhu, X., Wan, H., Carreño, J. M., O’Dell, G., Strohmeier, S., Khalil, Z., Luksza, M., van Bakel, H., Simon, V., Ellebedy, A. H., Wilson, I. A., Ward, A. B. & Krammer, F., Dec 2022, In: Nature communications. 13, 1, 7864.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • Defining the risk of SARS-CoV-2 variants on immune protection

      DeGrace, M. M., Ghedin, E., Frieman, M. B., Krammer, F., Grifoni, A., Alisoltani, A., Alter, G., Amara, R. R., Baric, R. S., Barouch, D. H., Bloom, J. D., Bloyet, L. M., Bonenfant, G., Boon, A. C. M., Boritz, E. A., Bratt, D. L., Bricker, T. L., Brown, L., Buchser, W. J., Carreño, J. M., & 110 othersCohen-Lavi, L., Darling, T. L., Davis-Gardner, M. E., Dearlove, B. L., Di, H., Dittmann, M., Doria-Rose, N. A., Douek, D. C., Drosten, C., Edara, V. V., Ellebedy, A., Fabrizio, T. P., Ferrari, G., Fischer, W. M., Florence, W. C., Fouchier, R. A. M., Franks, J., García-Sastre, A., Godzik, A., Gonzalez-Reiche, A. S., Gordon, A., Haagmans, B. L., Halfmann, P. J., Ho, D. D., Holbrook, M. R., Huang, Y., James, S. L., Jaroszewski, L., Jeevan, T., Johnson, R. M., Jones, T. C., Joshi, A., Kawaoka, Y., Kercher, L., Koopmans, M. P. G., Korber, B., Koren, E., Koup, R. A., LeGresley, E. B., Lemieux, J. E., Liebeskind, M. J., Liu, Z., Livingston, B., Logue, J. P., Luo, Y., McDermott, A. B., McElrath, M. J., Meliopoulos, V. A., Menachery, V. D., Montefiori, D. C., Mühlemann, B., Munster, V. J., Munt, J. E., Nair, M. S., Netzl, A., Niewiadomska, A. M., O’Dell, S., Pekosz, A., Perlman, S., Pontelli, M. C., Rockx, B., Rolland, M., Rothlauf, P. W., Sacharen, S., Scheuermann, R. H., Schmidt, S. D., Schotsaert, M., Schultz-Cherry, S., Seder, R. A., Sedova, M., Sette, A., Shabman, R. S., Shen, X., Shi, P. Y., Shukla, M., Simon, V., Stumpf, S., Sullivan, N. J., Thackray, L. B., Theiler, J., Thomas, P. G., Trifkovic, S., Türeli, S., Turner, S. A., Vakaki, M. A., van Bakel, H., VanBlargan, L. A., Vincent, L. R., Wallace, Z. S., Wang, L., Wang, M., Wang, P., Wang, W., Weaver, S. C., Webby, R. J., Weiss, C. D., Wentworth, D. E., Weston, S. M., Whelan, S. P. J., Whitener, B. M., Wilks, S. H., Xie, X., Ying, B., Yoon, H., Zhou, B., Hertz, T., Smith, D. J., Diamond, M. S., Post, D. J. & Suthar, M. S., May 26 2022, In: Nature. 605, 7911, p. 640-652 13 p.

      Research output: Contribution to journal › Review article › peer-review

      Open Access
      45 Scopus citations
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