Alexander Stegh

2024

Multimodal neuro-nanotechnology: Challenging the existing paradigm in glioblastoma therapy

Kudruk, S., Forsyth, C. M., Dion, M. Z., Hedlund Orbeck, J. K., Luo, J., Klein, R., Kim, A., Heimberger, A. B., Mirkin, C. A., Stegh, A. H. & Artzi, N., 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 8, e2306973121.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2021

A first-in-human phase 0 clinical study of RNA interference-based spherical nucleic acids in patients with recurrent glioblastoma

Kumthekar, P., Ko, C. H., Paunesku, T., Dixit, K., Sonabend, A. M., Bloch, O., Tate, M., Schwartz, M., Zuckerman, L., Lezon, R., Lukas, R. V., Jovanovic, B., McCortney, K., Colman, H., Chen, S., Lai, B., Antipova, O., Deng, J., Li, L. & Tommasini-Ghelfi, S. & 17 others, Hurley, L. A., Unruh, D., Sharma, N. V., Kandpal, M., Kouri, F. M., Davuluri, R. V., Brat, D. J., Muzzio, M., Glass, M., Vijayakumar, V., Heidel, J., Giles, F. J., Adams, A. K., James, C. D., Woloschak, G. E., Horbinski, C. & Stegh, A. H., Mar 10 2021, In: Science translational medicine. 13, 584, eabb3945.

Research output: Contribution to journal › Article › peer-review

Open Access

151 Scopus citations

2019

Cancer-associated mutation and beyond: The emerging biology of isocitrate dehydrogenases in human disease

Tommasini-Ghelfi, S., Murnan, K., Kouri, F. M., Mahajan, A. S., May, J. L. & Stegh, A. H., 2019, In: Science Advances. 5, 5, aaw4543.

Research output: Contribution to journal › Article › peer-review

Open Access

96 Scopus citations

IDH3α regulates one-carbon metabolism in glioblastoma

May, J. L., Kouri, F. M., Hurley, L. A., Liu, J., Tommasini-Ghelfi, S., Ji, Y., Gao, P., Calvert, A. E., Lee, A., Chandel, N. S., Davuluri, R. V., Horbinski, C. M., Locasale, J. W. & Stegh, A. H., 2019, In: Science Advances. 5, 1, eaat0456.

Research output: Contribution to journal › Article › peer-review

Open Access

53 Scopus citations

2017

Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation

Calvert, A. E., Chalastanis, A., Wu, Y., Hurley, L. A., Kouri, F. M., Bi, Y., Kachman, M., May, J. L., Bartom, E., Hua, Y., Mishra, R. K., Schiltz, G. E., Dubrovskyi, O., Mazar, A. P., Peter, M. E., Zheng, H., James, C. D., Burant, C. F., Chandel, N. S. & Davuluri, R. V. & 2 others, Horbinski, C. & Stegh, A. H., May 30 2017, In: Cell Reports. 19, 9, p. 1858-1873 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

152 Scopus citations

Dual bioluminescence and near-infrared fluorescence monitoring to evaluate spherical nucleic acid nanoconjugate activity in vivo

Sita, T. L., Kouri, F. M., Hurley, L. A., Merkel, T. J., Chalastanis, A., May, J. L., Ghelfi, S. T., Cole, L. E., Cayton, T. C., Barnaby, S. N., Sprangers, A. J., Savalia, N., James, C. D., Lee, A., Mirkin, C. A. & Stegh, A. H., Apr 18 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 16, p. 4129-4134 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

Internalized CD44s splice isoform attenuates EGFR degradation by targeting Rab7A

Wang, W., Zhang, H., Liu, S., Kim, C. K., Xu, Y., Hurley, L. A., Nishikawa, R., Nagane, M., Hu, B., Stegh, A. H., Cheng, S. Y. & Cheng, C., Aug 1 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 31, p. 8366-8371 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

2016

Inhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth

Hashizume, R., Zhang, A., Mueller, S., Prados, M. D., Lulla, R. R., Goldman, S., Saratsis, A. M., Mazar, A. P., Stegh, A. H., Cheng, S. Y., Horbinski, C., Haas-Kogan, D. A., Sarkaria, J. N., Waldman, T. & James, C. D., Nov 1 2016, In: Neuro-oncology. 18, 11, p. 1519-1528 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

101 Scopus citations

2015

MiR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma

Kouri, F. M., Hurley, L. A., Daniel, W. L., Day, E. S., Hua, Y., Hao, L., Peng, C. Y., Merkel, T. J., Queisser, M. A., Ritner, C., Zhang, H., David James, C., Sznajder, J. I., Chin, L., Giljohann, D. A., Kessler, J. A., Peter, M. E., Mirkin, C. A. & Stegh, A. H., 2015, In: Genes and Development. 29, 7, p. 732-745 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

182 Scopus citations

miRNA-182 and the regulation of the glioblastoma phenotype - toward miRNA-based precision therapeutics

Kouri, F. M., Ritner, C. & Stegh, A. H., Jan 1 2015, In: Cell Cycle. 14, 24, p. 3794-3800 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

Ribozyme-Spherical Nucleic Acids

Rouge, J. L., Sita, T. L., Hao, L., Kouri, F. M., Briley, W. E., Stegh, A. H. & Mirkin, C. A., Aug 14 2015, In: Journal of the American Chemical Society. 137, 33, p. 10528-10531 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

53 Scopus citations

Therapeutic applications of spherical nucleic acids

Barnaby, S. N., Sita, T. L., Petrosko, S. H., Stegh, A. H. & Mirkin, C. A., 2015, In: Cancer treatment and research. 166, p. 23-50 28 p.

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

2014

Bcl2L13 is a ceramide synthase inhibitor in glioblastoma

Jensen, S. A., Calvert, A. E., Volpert, G., Kouri, F. M., Hurley, L. A., Luciano, J. P., Wu, Y., Chalastanis, A., Futerman, A. H. & Stegh, A. H., Apr 15 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 15, p. 5682-5687 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

82 Scopus citations

HOIL-1L functions as the PKCζ ubiquitin ligase to promote lung tumor growth

Queisser, M. A., Dada, L. A., Deiss-Yehiely, N., Angulo, M., Zhou, G., Kouri, F. M., Knab, L. M., Liu, J., Stegh, A. H., DeCamp, M. M., Budinger, G. R. S., Chandel, N. S., Ciechanover, A., Iwai, K. & Sznajder, J. I., Sep 15 2014, In: American journal of respiratory and critical care medicine. 190, 6, p. 688-698 11 p.

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

NT113, A pan-ERBB inhibitor with high brain penetrance, inhibits the growth of glioblastoma xenografts with EGFR amplification

Yoshida, Y., Ozawa, T., Yao, T. W., Shen, W., Brown, D., Parsa, A. T., Raizer, J. J., Cheng, S. Y., Stegh, A. H., Mazar, A. P., Giles, F. J., Sarkaria, J. N., Butowski, N., Nicolaides, T. & James, C. D., Dec 1 2014, In: Molecular Cancer Therapeutics. 13, 12, p. 2919-2929 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

2013

Spherical nucleic acid nanoparticle conjugates as an RNAi-based therapy for glioblastoma

Jensen, S. A., Day, E. S., Ko, C. H., Hurley, L. A., Luciano, J. P., Kouri, F. M., Merkel, T. J., Luthi, A. C., Patel, P. C., Cutler, J. I., Daniel, W. L., Scott, A. W., Rotz, M. W., Meade, T. J., Giljohann, D. A., Mirkin, C. A. & Stegh, A. H., Oct 30 2013, In: Science translational medicine. 5, 209, 209ra152.

Research output: Contribution to journal › Article › peer-review

Open Access

490 Scopus citations

2011

SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression

Ding, Z., Wu, C. J., Chu, G. C., Xiao, Y., Ho, D., Zhang, J., Perry, S. R., Labrot, E. S., Wu, X., Lis, R., Hoshida, Y., Hiller, D., Hu, B., Jiang, S., Zheng, H., Stegh, A. H., Scott, K. L., Signoretti, S., Bardeesy, N. & Wang, Y. A. & 8 others, Hill, D. E., Golub, T. R., Stampfer, M. J., Wong, W. H., Loda, M., Mucci, L., Chin, L. & Depinho, R. A., Feb 10 2011, In: Nature. 470, 7333, p. 269-276 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

424 Scopus citations

2010

Glioma oncoprotein Bc12L12 inhibits the p53 tumor suppressor

Stegh, A. H., Brennan, C., Mahoney, J. A., Forloney, K. L., Jenq, H. T., Luciano, J. P., Protopopov, A., Chin, L. & DePinho, R. A., Oct 1 2010, In: Genes and Development. 24, 19, p. 2194-2204 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

77 Scopus citations

2008

Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma

Stegh, A. H., Kesari, S., Mahoney, J. E., Jenq, H. T., Forloney, K. L., Protopopov, A., Louis, D. N., Chin, L. & DePinho, R. A., Aug 5 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 31, p. 10703-10708 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

137 Scopus citations

2007

Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma

Stegh, A. H., Kim, H., Bachoo, R. M., Forloney, K. L., Zhang, J., Schulze, H., Park, K., Hannon, G. J., Yuan, J., Louis, D. N., DePinho, R. A. & Chin, L., Jan 1 2007, In: Genes and Development. 21, 1, p. 98-111 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

132 Scopus citations

Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies

Stommel, J. M., Kimmelman, A. C., Ying, H., Nabioullin, R., Ponugoti, A. H., Wiedemeyer, R., Stegh, A. H., Bradner, J. E., Ligon, K. L., Brennan, C., Chin, L. & DePinho, R. A., Oct 12 2007, In: Science. 318, 5848, p. 287-290 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

784 Scopus citations

2002

DEDD regulates degradation of intermediate filaments during apoptosis

Lee, J. C., Schickling, O., Stegh, A. H., Oshima, R. G., Dinsdale, D., Cohen, G. M. & Peter, M. E., Sep 16 2002, In: Journal of Cell Biology. 158, 6, p. 1051-1066 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

74 Scopus citations

Inactivation of caspase-8 on mitochondria of Bcl-X_L-expressing MCF7-Fas cells role for the bifunctional apoptosis regulator protein

Stegh, A. H., Barnhart, B. C., Volkland, J., Algeciras-Schimnich, A., Ke, N., Reed, J. C. & Peter, M. E., Feb 8 2002, In: Journal of Biological Chemistry. 277, 6, p. 4351-4360 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

105 Scopus citations

2001

Apoptosis and caspases

Stegh, A. H. & Peter, M. E., 2001, In: Cardiology clinics. 19, 1, p. 13-29 17 p.

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Nuclear localization of DEDD leads to caspase-6 activation through its death effector domain and inhibition of RNA polymerase I dependent transcription

Schickling, O., Stegh, A. H., Byrd, J. & Peter, M. E., 2001, In: Cell Death and Differentiation. 8, 12, p. 1157-1168 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

55 Scopus citations

2000

Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor- mediated apoptosis

Stegh, A. H., Herrmann, H., Lampel, S., Weisenberger, D., Andrä, K., Seper, M., Wiche, G., Krammer, P. H. & Peter, M. E., Aug 2000, In: Molecular and cellular biology. 20, 15, p. 5665-5679 15 p.

Research output: Contribution to journal › Article › peer-review

140 Scopus citations

1998

DEDD, a novel death effector domain-containing protein, targeted to the nucleolus

Stegh, A. H., Schickling, O., Ehret, A., Scaffidi, C., Peterhänsel, C., Hofmann, T. G., Grummt, I., Krammer, P. H. & Peter, M. E., Oct 15 1998, In: EMBO Journal. 17, 20, p. 5974-5986 13 p.

Research output: Contribution to journal › Article › peer-review

115 Scopus citations

Alexander Stegh

Research output

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