Alexander Kozlov

Kozlov, A. G., Cheng, X., Zhang, H., Shinn, M. K., Weiland, E., Nguyen, B., Shkel, I. A., Zytkiewicz, E., Finkelstein, I. J., Record, M. T. & Lohman, T. M., May 15 2022, In: Journal of Molecular Biology. 434, 9, 167562.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

2021

Allosteric effects of SSB C-Terminal tail on assembly of E. coli RecOR proteins

Shinn, M. K., Kozlov, A. G. & Lohman, T. M., Feb 26 2021, In: Nucleic acids research. 49, 4, p. 1987-2004 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Probing E. coli SSB protein-DNA topology by reversing DNA backbone polarity

Kozlov, A. G. & Lohman, T. M., Apr 20 2021, In: Biophysical Journal. 120, 8, p. 1522-1533 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2020

Comparative Analysis of CPI-Motif Regulation of Biochemical Functions of Actin Capping Protein

McConnell, P., Mekel, M., Kozlov, A. G., Mooren, O. L., Lohman, T. M. & Cooper, J. A., Mar 24 2020, In: Biochemistry. 59, 11, p. 1202-1215 14 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Development of a single-stranded DNA-binding protein fluorescent fusion toolbox

Dubiel, K., Henry, C., Spenkelink, L. M., Kozlov, A. G., Wood, E. A., Jergic, S., Dixon, N. E., van Oijen, A. M., Cox, M. M., Lohman, T. M., Sandler, S. J. & Keck, J. L., 2020, In: Nucleic acids research. 48, 11, p. 6053-6067 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2019

Are the intrinsically disordered linkers involved in SSB binding to accessory proteins?

Shinn, M. K., Kozlov, A. G., Nguyen, B., Bujalowski, W. M. & Lohman, T. M., Sep 19 2019, In: Nucleic acids research. 47, 16, p. 8581-8594 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

Protein Environment and DNA Orientation Affect Protein-Induced Cy3 Fluorescence Enhancement

Nguyen, B., Ciuba, M. A., Kozlov, A. G., Levitus, M. & Lohman, T. M., Jul 9 2019, In: Biophysical Journal. 117, 1, p. 66-73 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Regulation of Nearest-Neighbor Cooperative Binding of E. coli SSB Protein to DNA

Kozlov, A. G., Shinn, M. K. & Lohman, T. M., Dec 3 2019, In: Biophysical Journal. 117, 11, p. 2120-2140 21 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Structural Mechanisms of Cooperative DNA Binding by Bacterial Single-Stranded DNA-Binding Proteins

Dubiel, K., Myers, A. R., Kozlov, A. G., Yang, O., Zhang, J., Ha, T., Lohman, T. M. & Keck, J. L., Jan 18 2019, In: Journal of Molecular Biology. 431, 2, p. 178-195 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

UvrD helicase activation by MutL involves rotation of its 2B subdomain

Ordabayev, Y. A., Nguyen, B., Kozlov, A. G., Jia, H. & Lohman, T. M., Aug 13 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 33, p. 16320-16325 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

2018

Allosteric Coupling of CARMIL and V-1 Binding to Capping Protein Revealed by Hydrogen-Deuterium Exchange

Johnson, B., McConnell, P., Kozlov, A. G., Mekel, M., Lohman, T. M., Gross, M. L., Amarasinghe, G. K. & Cooper, J. A., May 29 2018, In: Cell Reports. 23, 9, p. 2795-2804 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

2017

Glutamate promotes SSB protein–protein Interactions via intrinsically disordered regions

Kozlov, A. G., Shinn, M. K., Weiland, E. A. & Lohman, T. M., Sep 1 2017, In: Journal of Molecular Biology. 429, 18, p. 2790-2801 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

2016

Chemo-mechanical pushing of proteins along single-stranded DNA

Sokoloski, J. E., Kozlov, A. G., Galletto, R. & Lohman, T. M., May 31 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 22, p. 6194-6199 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

Is a fully wrapped SSB-DNA complex essential for Escherichia coli survival?

Waldman, V. M., Weiland, E., Kozlov, A. G. & Lohman, T. M., May 19 2016, In: Nucleic acids research. 44, 9, p. 4317-4329 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2015

Intrinsically disordered C-terminal tails of E. coli single-stranded DNA binding protein regulate cooperative binding to single-stranded DNA

Kozlov, A. G., Weiland, E., Mittal, A., Waldman, V., Antony, E., Fazio, N., Pappu, R. V. & Lohman, T. M., Feb 27 2015, In: Journal of Molecular Biology. 427, 4, p. 763-774 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

78 Scopus citations

Structural dynamics of E. Coli singlestranded DNA binding protein reveal DNA wrapping and unwrapping pathways

Suksombat, S., Khafizov, R., Kozlov, A. G., Lohman, T. M. & Chemla, Y. R., Aug 25 2015, In: eLife. 4, AUGUST2015, e08193.

Research output: Contribution to journal › Article › peer-review

Open Access

74 Scopus citations

2014

Ultrafast redistribution of E. coli SSB along Long single-stranded DNA via intersegment transfer

Lee, K. S., Marciel, A. B., Kozlov, A. G., Schroeder, C. M., Lohman, T. M. & Ha, T., Jun 26 2014, In: Journal of Molecular Biology. 426, 13, p. 2413-2421 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

2013

Multiple C-terminal tails within a single E coli SSB homotetramer coordinate DNA replication and repair

Antony, E., Weiland, E., Yuan, Q., Manhart, C. M., Nguyen, B., Kozlov, A. G., McHenry, C. S. & Lohman, T. M., Nov 29 2013, In: Journal of Molecular Biology. 425, 23, p. 4802-4819 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

52 Scopus citations

2012

Plasmodium falciparum SSB tetramer binds single-stranded DNA only in a fully wrapped mode

Antony, E., Kozlov, A. G., Nguyen, B. & Lohman, T. M., Jul 20 2012, In: Journal of Molecular Biology. 420, 4-5, p. 284-295 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Single-molecule views of protein movement on single-stranded DNA

Ha, T., Kozlov, A. G. & Lohman, T. M., Jun 9 2012, In: Annual Review of Biophysics. 41, 1, p. 295-319 25 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

109 Scopus citations

SSB binding to ssDNA using isothermal titration calorimetry

Kozlov, A. G. & Lohman, T. M., 2012, Single-Stranded DNA Binding Proteins: Methods and Protocols. Humana Press Inc., p. 37-54 18 p. (Methods in Molecular Biology; vol. 922).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

9 Scopus citations

SSB-DNA binding monitored by fluorescence intensity and anisotropy

Kozlov, A. G., Galletto, R. & Lohman, T. M., 2012, Single-Stranded DNA Binding Proteins: Methods and Protocols. Humana Press Inc., p. 55-83 29 p. (Methods in Molecular Biology; vol. 922).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

33 Scopus citations

2011

E. coli SSB tetramer binds the first and second molecules of (dT) ₃₅ with heat capacities of opposite sign

Kozlov, A. G. & Lohman, T. M., Nov 2011, In: Biophysical Chemistry. 159, 1, p. 48-57 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Erratum: SSB functions as a sliding platform that migrates on DNA via reptation (Cell (2011) 146 (222-232))

Zhou, R., Kozlov, A. G., Roy, R., Zhang, J., Korolev, S., Lohman, T. M. & Ha, T., Aug 5 2011, In: Cell. 146, 3, p. 485 1 p.

Research output: Contribution to journal › Comment/debate

Open Access

1 Scopus citations

SSB functions as a sliding platform that migrates on DNA via reptation

Zhou, R., Kozlov, A. G., Roy, R., Zhang, J., Korolev, S., Lohman, T. M. & Ha, T., Jul 22 2011, In: Cell. 146, 2, p. 222-232 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

160 Scopus citations

2010

Binding of the dimeric Deinococcus radiodurans single-stranded DNA binding protein to single-stranded DNA

Kozlov, A. G., Eggington, J. M., Cox, M. M. & Lohman, T. M., Sep 28 2010, In: Biochemistry. 49, 38, p. 8266-8275 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Binding specificity of escherichia coli single-stranded DNA binding protein for the χ subunit of DNA pol III holoenzyme and PriA helicase

Kozlov, A. G., Jezewska, M. J., Bujalowski, W. & Lohman, T. M., May 4 2010, In: Biochemistry. 49, 17, p. 3555-3566 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

58 Scopus citations

Regulation of single-stranded DNA binding by the C termini of Escherichia coli single-stranded DNA-binding (SSB) protein

Kozlov, A. G., Cox, M. M. & Lohman, T. M., May 28 2010, In: Journal of Biological Chemistry. 285, 22, p. 17246-17252 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

78 Scopus citations

2009

Erratum: SSB protein diffusion on single-stranded DNA stimulates RecA filament formation (Nature (2009) 461 (1092-1097))

Roy, R., Kozlov, A. G., Lohman, T. M. & Ha, T., Dec 17 2009, In: Nature. 462, 7275, p. 944 1 p.

Research output: Contribution to journal › Comment/debate

Open Access

SSB protein diffusion on single-stranded DNA stimulates RecA filament formation

Roy, R., Kozlov, A. G., Lohman, T. M. & Ha, T., Oct 22 2009, In: Nature. 461, 7267, p. 1092-1097 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

226 Scopus citations

2008

SSB as an organizer/mobilizer of genome maintenance complexes

Shereda, R. D., Kozlov, A. G., Lohman, T. M., Cox, M. M. & Keck, J. L., Sep 2008, In: Critical Reviews in Biochemistry and Molecular Biology. 43, 5, p. 289-318 30 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

443 Scopus citations

2007

Dynamic Structural Rearrangements Between DNA Binding Modes of E. coli SSB Protein

Roy, R., Kozlov, A. G., Lohman, T. M. & Ha, T., Jun 22 2007, In: Journal of Molecular Biology. 369, 5, p. 1244-1257 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

125 Scopus citations

2006

Effects of monovalent anions on a temperature-dependent heat capacity change for Escherichia coli SSB tetramer binding to single-stranded DNA

Kozlov, A. G. & Lohman, T. M., Apr 25 2006, In: Biochemistry. 45, 16, p. 5190-5205 16 p.

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Microsecond Dynamics of Protein-DNA Interactions: Direct Observation of the Wrapping/Unwrapping Kinetics of Single-stranded DNA around the E. coli SSB Tetramer

Kuznetsov, S. V., Kozlov, A. G., Lohman, T. M. & Ansari, A., May 26 2006, In: Journal of Molecular Biology. 359, 1, p. 55-65 11 p.

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Polar destabilization of DNA duplexes with single-stranded overhangs by the Deinococcus radiodurans SSB protein

Eggington, J. M., Kozlov, A. G., Cox, M. M. & Lohman, T. M., Dec 5 2006, In: Biochemistry. 45, 48, p. 14490-14502 13 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Saccharomyces cerevisiae replication protein A binds to single-stranded DNA in multiple salt-dependent modes

Kumaran, S., Kozlov, A. G. & Lohman, T. M., Oct 3 2006, In: Biochemistry. 45, 39, p. 11958-11973 16 p.

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

2004

The C-terminal domain of full-length E. coli SSB is disordered even when bound to DNA

Savvides, S. N., Raghunathan, S., Fütterer, K., Kozlov, A. G., Lohman, T. M. & Waksman, G., Jul 2004, In: Protein Science. 13, 7, p. 1942-1947 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

121 Scopus citations

2002

Concentration-induced denaturation of DNA in salt-free solutions

Davydova, O. V., Kozlov, A. G. & Kargov, S. I., Oct 1 2002, In: Russian Journal of Physical Chemistry A. 76, 10, p. 1676-1679 4 p.

Research output: Contribution to journal › Article › peer-review

Concentration-induced denaturing of DNA in salt-free solutions

Davydova, O. V., Kozlov, A. G. & Kargov, S. I., Jan 1 2002, In: Zhurnal Fizicheskoj Khimii. 76, 10, p. 1847-1851 5 p.

Research output: Contribution to journal › Article › peer-review

Kinetic mechanism of direct transfer of Escherichia coli SSB tetramers between single-stranded DNA molecules

Kozlov, A. G. & Lohman, T. M., Oct 1 2002, In: Biochemistry. 41, 39, p. 11611-11627 17 p.

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Stopped-flow studies of the kinetics of single-stranded DNA binding and wrapping around the Escherichia coli SSB tetramer

Kozlov, A. G. & Lohman, T. M., May 14 2002, In: Biochemistry. 41, 19, p. 6032-6044 13 p.

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

2000

Large contribution of coupled protonation equilibria to the observed enthalpy and heat capacity changes for ssDNA binding to Escherichia coli SSB protein

Kozlov, A. G. & Lohman, T. M., 2000, In: Proteins: Structure, Function and Genetics. 41, SUPPL. 4, p. 8-22 15 p.

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Structure of the DNA binding domain of E. coli SSB bound to ssDNA

Raghunathan, S., Kozlov, A. G., Lohman, T. M. & Waksman, G., Aug 2000, In: Nature Structural Biology. 7, 8, p. 648-652 5 p.

Research output: Contribution to journal › Article › peer-review

392 Scopus citations

Thermodynamic analysis of interactions between denaturants and protein surface exposed on unfolding: Interpretation of urea and guanidinium chloride m-values and their correlation with changes in accessible surface area (ASA) using preferential interaction coefficients and the local-bulk domain model

Kozlov, A. G. & Lohman, T. M., 2000, In: Proteins: Structure, Function and Genetics. 41, SUPPL. 4, p. 72-85 14 p.

Research output: Contribution to journal › Article › peer-review

139 Scopus citations

1999

Adenine base unstacking dominates the observed enthalpy and heat capacity changes for the Escherichia coli SSB tetramer binding to single- stranded oligoadenylates

Kozlov, A. G. & Lohman, T. M., Jun 1 1999, In: Biochemistry. 38, 22, p. 7388-7397 10 p.

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

1998

Calorimetric studies of E. coli SSB protein-single-stranded DNA interactions. Effects of monovalent salts on binding enthalpy

Kozlov, A. G. & Lohman, T. M., May 22 1998, In: Journal of Molecular Biology. 278, 5, p. 999-1014 16 p.

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

1997

Interaction of silver ions with polyguanylic acid in isoionic solutions without support electrolyte

Kargov, S. I., Kozlov, A. G. & Davydova, O. V., 1997, In: Zhurnal Fizicheskoi Khimii. 71, 8, p. 1510-1513 4 p.

Research output: Contribution to journal › Article › peer-review

Alexander Kozlov

Research output

Search results