Alessandro Vindigni

2025

Genetic buffering mechanisms in SNF2-family translocases

Agashe, S. & Vindigni, A., 2025, (Accepted/In press) In: Trends in Genetics.

Research output: Contribution to journal › Short survey › peer-review

Open Access

2024

A RAD18-UBC13-PALB2-RNF168 axis mediates replication fork recovery in BRCA1-deficient cancer cells

Cybulla, E., Wallace, S., Meroni, A., Jackson, J., Agashe, S., Tennakoon, M., Limbu, M., Quinet, A., Lomonosova, E., Noia, H., Tirman, S., Wood, M., Lemacon, D., Fuh, K., Zou, L. & Vindigni, A., Aug 27 2024, In: Nucleic acids research. 52, 15, p. 8861-8879 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

DNA combing versus DNA spreading and the separation of sister chromatids

Meroni, A., Wells, S. E., Fonseca, C., Chaudhuri, A. R., Caldecott, K. W. & Vindigni, A., 2024, In: Journal of Cell Biology. 223, 4, e202305082.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Nucleolytic processing of abasic sites underlies PARP inhibitor hypersensitivity in ALC1-deficient BRCA mutant cancer cells

Ramakrishnan, N., Weaver, T. M., Aubuchon, L. N., Woldegerima, A., Just, T., Song, K., Vindigni, A., Freudenthal, B. D. & Verma, P., Dec 2024, In: Nature communications. 15, 1, 6343.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated replication stress

Fingerman, D. F., O’Leary, D. R., Hansen, A. R., Tran, T., Harris, B. R., DeWeerd, R. A., Hayer, K. E., Fan, J., Chen, E., Tennakoon, M., Meroni, A., Szeto, J. H., Devenport, J., LaVigne, D., Weitzman, M. D., Shalem, O., Bednarski, J., Vindigni, A., Zhao, X. & Green, A. M., Aug 1 2024, In: EMBO Journal. 43, 15, p. 3240-3255 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2023

ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms

Leung, W., Simoneau, A., Saxena, S., Jackson, J., Patel, P. S., Limbu, M., Vindigni, A. & Zou, L., Jul 25 2023, In: Cell Reports. 42, 7, 112792.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Leveraging the replication stress response to optimize cancer therapy

Cybulla, E. & Vindigni, A., Jan 2023, In: Nature Reviews Cancer. 23, 1, p. 6-24 19 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

45 Scopus citations

RAD51 bypasses the CMG helicase to promote replication fork reversal

Liu, W., Saito, Y., Jackson, J., Bhowmick, R., Kanemaki, M. T., Vindigni, A. & Cortez, D., Apr 28 2023, In: Science. 380, 6643, p. 382-387 6 p.

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Rapid profiling of DNA replication dynamics using mass spectrometry–based analysis of nascent DNA

Ashour, M. E., Byrum, A. K., Meroni, A., Xia, J., Singh, S., Galletto, R., Rosenberg, S. M., Vindigni, A. & Mosammaparast, N., Apr 3 2023, In: Journal of Cell Biology. 222, 4, e202207121.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2022

A RADAR method to measure DNA topoisomerase covalent complexes

Meroni, A. & Vindigni, A., Jan 2022, Helicase Enzymes Part A. Trakselis, M. A. (ed.). Academic Press Inc., p. 369-381 13 p. (Methods in Enzymology; vol. 672).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Open Access

1 Scopus citations

GAS6/AXL Inhibition Enhances Ovarian Cancer Sensitivity to Chemotherapy and PARP Inhibition through Increased DNA Damage and Enhanced Replication Stress

Mullen, M. M., Lomonosova, E., Toboni, M. D., Oplt, A., Cybulla, E., Blachut, B., Zhao, P., Noia, H., Wilke, D., Rankin, E. B., Kuroki, L. M., Hagemann, A. R., Hagemann, I. S., McCourt, C. K., Thaker, P. H., Mutch, D. G., Powell, M. A., Mosammaparast, N., Vindigni, A. & Fuh, K., Feb 2022, In: Molecular Cancer Research. 20, 2, p. 265-279 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors

Meroni, A., Grosser, J., Agashe, S., Ramakrishnan, N., Jackson, J., Verma, P., Baranello, L. & Vindigni, A., 2022, In: Science Advances. 8, 49, abq0648.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Profilin-1 regulates DNA replication forks in a context-dependent fashion by interacting with SNF2H and BOD1L

Zhu, C., Iwase, M., Li, Z., Wang, F., Quinet, A., Vindigni, A. & Shao, J., Dec 2022, In: Nature communications. 13, 1, 6531.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Studying Single-Stranded DNA Gaps at Replication Intermediates by Electron Microscopy

Jackson, J. & Vindigni, A., 2022, Methods in Molecular Biology. Humana Press Inc., p. 81-103 23 p. (Methods in Molecular Biology; vol. 2444).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Open Access

4 Scopus citations

2021

Aberrant RNA methylation triggers recruitment of an alkylation repair complex

Tsao, N., Brickner, J. R., Rodell, R., Ganguly, A., Wood, M., Oyeniran, C., Ahmad, T., Sun, H., Bacolla, A., Zhang, L., Lukinović, V., Soll, J. M., Townley, B. A., Casanova, A. G., Tainer, J. A., He, C., Vindigni, A., Reynoird, N. & Mosammaparast, N., Oct 21 2021, In: Molecular cell. 81, 20, p. 4228-4242.e8

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

CARM1 regulates replication fork speed and stress response by stimulating PARP1

Genois, M. M., Gagné, J. P., Yasuhara, T., Jackson, J., Saxena, S., Langelier, M. F., Ahel, I., Bedford, M. T., Pascal, J. M., Vindigni, A., Poirier, G. G. & Zou, L., Feb 18 2021, In: Molecular cell. 81, 4, p. 784-800.e8

Research output: Contribution to journal › Article › peer-review

Open Access

71 Scopus citations

Entinostat, a selective HDAC1/2 inhibitor, potentiates the effects of olaparib in homologous recombination proficient ovarian cancer

Gupta, V. G., Hirst, J., Petersen, S., Roby, K. F., Kusch, M., Zhou, H., Clive, M. L., Jewell, A., Pathak, H. B., Godwin, A. K., Wilson, A. J., Crispens, M. A., Cybulla, E., Vindigni, A., Fuh, K. C. & Khabele, D., Jul 2021, In: Gynecologic oncology. 162, 1, p. 163-172 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Lamin A/C recruits ssDNA protective proteins RPA and RAD51 to stalled replication forks to maintain fork stability

Graziano, S., Coll-Bonfill, N., Teodoro-Castro, B., Kuppa, S., Jackson, J., Shashkova, E., Mahajan, U., Vindigni, A., Antony, E. & Gonzalo, S., Nov 1 2021, In: Journal of Biological Chemistry. 297, 5, 101301.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

PRIMPOL ready, set, reprime!

Tirman, S., Cybulla, E., Quinet, A., Meroni, A. & Vindigni, A., 2021, In: Critical Reviews in Biochemistry and Molecular Biology. 56, 1, p. 17-30 14 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

26 Scopus citations

RADX prevents genome instability by confining replication fork reversal to stalled forks

Krishnamoorthy, A., Jackson, J., Mohamed, T., Adolph, M., Vindigni, A. & Cortez, D., Jul 15 2021, In: Molecular cell. 81, 14, p. 3007-3017.e5

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

Telomere erosion in human pluripotent stem cells leads to atr-mediated mitotic catastrophe

Vessoni, A. T., Zhang, T., Quinet, A., Jeong, H. C., Munroe, M., Wood, M., Tedone, E., Vindigni, A., Shay, J. W., Greenberg, R. A. & Batista, L. F. Z., 2021, In: Journal of Cell Biology. 220, 6, e202011014.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells

Tirman, S., Quinet, A., Wood, M., Meroni, A., Cybulla, E., Jackson, J., Pegoraro, S., Simoneau, A., Zou, L. & Vindigni, A., Oct 7 2021, In: Molecular cell. 81, 19, p. 4026-4040.e8

Research output: Contribution to journal › Article › peer-review

Open Access

107 Scopus citations

To skip or not to skip: choosing repriming to tolerate DNA damage

Quinet, A., Tirman, S., Cybulla, E., Meroni, A. & Vindigni, A., Feb 18 2021, In: Molecular cell. 81, 4, p. 649-658 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

60 Scopus citations

2020

Homologous recombination deficiency real-time clinical assays, ready or not?

Fuh, K., Mullen, M., Blachut, B., Stover, E., Konstantinopoulos, P., Liu, J., Matulonis, U., Khabele, D., Mosammaparast, N. & Vindigni, A., Dec 2020, In: Gynecologic oncology. 159, 3, p. 877-886 10 p.

Research output: Contribution to journal › Review article › peer-review

46 Scopus citations

Inhibition of the translesion synthesis polymerase REV1 exploits replication gaps as a cancer vulnerability

Nayak, S., Calvo, J. A., Cong, K., Peng, M., Berthiaume, E., Jackson, J., Zaino, A. M., Vindigni, A., Hadden, M. K. & Cantor, S. B., Jun 2020, In: Science Advances. 6, 24, eaaz7808.

Research output: Contribution to journal › Article › peer-review

Open Access

81 Scopus citations

ISG15 fast-tracks DNA replication

Meroni, A. & Vindigni, A., Aug 3 2020, In: The Journal of cell biology. 219, 8

Research output: Contribution to journal › Comment/debate

Open Access

2 Scopus citations

PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells

Quinet, A., Tirman, S., Jackson, J., Šviković, S., Lemaçon, D., Carvajal-Maldonado, D., González-Acosta, D., Vessoni, A. T., Cybulla, E., Wood, M., Tavis, S., Batista, L. F. Z., Méndez, J., Sale, J. E. & Vindigni, A., Feb 6 2020, In: Molecular cell. 77, 3, p. 461-474.e9

Research output: Contribution to journal › Article › peer-review

Open Access

163 Scopus citations

TDP-43 dysfunction results in R-loop accumulation and DNA replication defects

Wood, M., Quinet, A., Lin, Y. L., Davis, A. A., Pasero, P., Ayala, Y. M. & Vindigni, A., Oct 2020, In: Journal of cell science. 133, 20, jcs244129.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

The multifunctional protein PACS-1 is required for HDAC2- and HDAC3-dependent chromatin maturation and genomic stability

Mani, C., Tripathi, K., Luan, S., Clark, D. W., Andrews, J. F., Vindigni, A., Thomas, G. & Palle, K., Mar 19 2020, In: Oncogene. 39, 12, p. 2583-2596 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

2019

Ca²⁺-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection

Li, S., Lavagnino, Z., Lemacon, D., Kong, L., Ustione, A., Ng, X., Zhang, Y., Wang, Y., Zheng, B., Piwnica-Worms, H., Vindigni, A., Piston, D. W. & You, Z., Jun 20 2019, In: Molecular cell. 74, 6, p. 1123-1137.e6

Research output: Contribution to journal › Article › peer-review

Open Access

63 Scopus citations

Defining and Modulating ‘BRCAness’

Byrum, A. K., Vindigni, A. & Mosammaparast, N., Sep 2019, In: Trends in Cell Biology. 29, 9, p. 740-751 12 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

121 Scopus citations

Mitotic regulators TPX2 and Aurora A protect DNA forks during replication stress by counteracting 53BP1 function

Byrum, A. K., Carvajal-Maldonado, D., Mudge, M. C., Valle-Garcia, D., Majid, M. C., Patel, R., Sowa, M. E., Gygi, S. P., Wade Harper, J., Shi, Y., Vindigni, A. & Mosammaparast, N., Feb 1 2019, In: Journal of Cell Biology. 218, 2, p. 422-432 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing

Carvajal-Maldonado, D., Byrum, A. K., Jackson, J., Wessel, S., Lemaçon, D., Guitton-Sert, L., Quinet, A., Tirman, S., Graziano, S., Masson, J. Y., Cortez, D., Gonzalo, S., Mosammaparast, N. & Vindigni, A., Feb 20 2019, In: Nucleic acids research. 47, 3, p. 1294-1310 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

XLF and H2AX function in series to promote replication fork stability

Chen, B. R., Quinet, A., Byrum, A. K., Jackson, J., Berti, M., Thangavel, S., Bredemeyer, A. L., Hindi, I., Mosammaparast, N., Tyler, J. K., Vindigni, A. & Sleckman, B. P., 2019, In: Journal of Cell Biology. 218, 7, p. 2113-2123 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2018

A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin

Kreienkamp, R., Graziano, S., Coll-Bonfill, N., Bedia-Diaz, G., Cybulla, E., Vindigni, A., Dorsett, D., Kubben, N., Batista, L. F. Z. & Gonzalo, S., Feb 20 2018, In: Cell Reports. 22, 8, p. 2006-2015 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

92 Scopus citations

Superfast DNA replication causes damage in cancer cells

Quinet, A. & Vindigni, A., Jul 12 2018, In: Nature. 559, 7713, CM15859876.

Research output: Contribution to journal › Short survey › peer-review

Open Access

13 Scopus citations

2017

A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair

Brickner, J. R., Soll, J. M., Lombardi, P. M., Vågbø, C. B., Mudge, M. C., Oyeniran, C., Rabe, R., Jackson, J., Sullender, M. E., Blazosky, E., Byrum, A. K., Zhao, Y., Corbett, M. A., Gécz, J., Field, M., Vindigni, A., Slupphaug, G., Wolberger, C. & Mosammaparast, N., Nov 16 2017, In: Nature. 551, 7680, p. 389-393 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

74 Scopus citations

Break-induced replication promotes formation of lethal joint molecules dissolved by Srs2

Elango, R., Sheng, Z., Jackson, J., Decata, J., Ibrahim, Y., Pham, N. T., Liang, D. H., Sakofsky, C. J., Vindigni, A., Lobachev, K. S., Ira, G. & Malkova, A., Dec 1 2017, In: Nature communications. 8, 1, 1790.

Research output: Contribution to journal › Article › peer-review

Open Access

49 Scopus citations

Combining electron microscopy with single molecule DNA fiber approaches to study DNA replication dynamics

Vindigni, A. & Lopes, M., Jun 2017, In: Biophysical Chemistry. 225, p. 3-9 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

DNA Fiber Analysis: Mind the Gap!

Quinet, A., Carvajal-Maldonado, D., Lemacon, D. & Vindigni, A., 2017, Methods in Enzymology. Academic Press Inc., p. 55-82 28 p. (Methods in Enzymology; vol. 591).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

151 Scopus citations

Human ribonuclease H1 resolves R-loops and thereby enables progression of the DNA replication fork

Parajuli, S., Teasley, D. C., Murali, B., Jackson, J., Vindigni, A. & Stewart, S. A., Sep 15 2017, In: Journal of Biological Chemistry. 292, 37, p. 15216-15224 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

Lemaçon, D., Jackson, J., Quinet, A., Brickner, J. R., Li, S., Yazinski, S., You, Z., Ira, G., Zou, L., Mosammaparast, N. & Vindigni, A., Dec 1 2017, In: Nature communications. 8, 1, 860.

Research output: Contribution to journal › Article › peer-review

Open Access

303 Scopus citations

Nucleases Acting at Stalled Forks: How to Reboot the Replication Program with a Few Shortcuts

Pasero, P. & Vindigni, A., Nov 27 2017, In: Annual Review of Genetics. 51, p. 477-499 23 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

85 Scopus citations

Replication Fork Reversal: Players and Guardians

Quinet, A., Lemaçon, D. & Vindigni, A., Dec 7 2017, In: Molecular cell. 68, 5, p. 830-833 4 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

200 Scopus citations

Special issue: “At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy”

Vindigni, A., Jun 2017, In: Biophysical Chemistry. 225, p. 1-2 2 p.

Research output: Contribution to journal › Editorial

2016

Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by topo-isomerase I inhibitors

Yamamoto, K., Wang, J., Sprinzen, L., Xu, J., Haddock, C. J., Li, C., Lee, B. J., Loredan, D. G., Jiang, W., Vindigni, A., Wang, D., Rabadan, R. & Zha, S., Jun 15 2016, In: eLife. 5, JUN2016, e14709.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

Replication stress: Getting back on track

Berti, M. & Vindigni, A., Feb 3 2016, In: Nature Structural and Molecular Biology. 23, 2, p. 103-109 7 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

189 Scopus citations

Structural and biochemical characterization of an RNA/DNA binding motif in the N-terminal domain of RecQ4 helicases

Marino, F., Mojumdar, A., Zucchelli, C., Bhardwaj, A., Buratti, E., Vindigni, A., Musco, G. & Onesti, S., Feb 18 2016, In: Scientific reports. 6, 21501.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

The architectural chromatin factor high mobility group A1 enhancesdna Ligase IV activity influencingdna repair

Pellarin, I., Arnoldo, L., Costantini, S., Pegoraro, S., Ros, G., Penzo, C., Triolo, G., Demarchi, F., Sgarra, R., Vindigni, A. & Manfioletti, G., Oct 2016, In: PloS one. 11, 10, e0164258.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Topoisomerase IIβ mediates the resistance of glioblastoma stem cells to replication stress-inducing drugs

Kenig, S., Faoro, V., Bourkoula, E., Podergajs, N., Ius, T., Vindigni, M., Skrap, M., Lah, T., Cesselli, D., Storici, P. & Vindigni, A., Jul 26 2016, In: Cancer Cell International. 16, 1, 58.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Alessandro Vindigni

Research output

Search results