Research output per year
Research output per year
Personal profile
Research interests
My research focus aims to understand how gene-regulatory elements control gene expression in mammals, as it relates to the genetic basis of development, evolution and disease. To study the function of enhancers, my approach includes three key components.
First, I will identify putative enhancers from comprehensive genomic datasets and GWAS data. Secondly, the in vivo function of these enhancer candidates will be characterized using a combination of mouse genetics and functional genomics techniques. In the final phase, by integrating this functional information, I will use enhancers as tools to manipulate phenotype, such as altering morphology and developing new therapeutic approaches.
Available to Mentor:
- Undergraduate Students
- Post-Baccalaureate Students
- PhD Students
- Postdocs
- Residents and Fellows
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Collaborations and top research areas from the last five years
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Implantation of engineered adipocytes suppresses tumor progression in cancer models
Nguyen, H. P., An, K., Ito, Y., Kharbikar, B. N., Sheng, R., Paredes, B., Murray, E., Pham, K., Bruck, M., Zhou, X., Biellak, C., Ushiki, A., Nobuhara, M., Fong, S. L., Bernards, D. A., Lynce, F., Dillon, D. A., Magbanua, M. J. M., Huppert, L. A. & Hammerlindl, H. & 8 others, , Dec 2025, In: Nature Biotechnology. 43, 12, p. 1979-1995 17 p.Research output: Contribution to journal › Article › peer-review
Open Access38 Link opens in a new tab Scopus citations -
Deciphering the impact of genomic variation on function
UM1HG011969, UM1HG011966, Single Cell, QTL/Statgen, Phenotypic Impact and Function, Neuro, Noncoding Variants, MPRA, iPSC, Impact on Diverse Populations, Immune, Imaging, Evolution, Enumerating Variants, Defining and Systematizing Function, CRISPR, Coding Variants, Cellular Programs and Networks, Cardiometabolic & Standards and Pipelines & 61 others, , Sep 5 2024, In: Nature. 633, 8028, p. 47-57 11 p.Research output: Contribution to journal › Article › peer-review
Open Access63 Link opens in a new tab Scopus citations -
Deletion of Pax1 scoliosis-associated regulatory elements leads to a female-biased tail abnormality
Ushiki, A., Sheng, R. R., Zhang, Y., Zhao, J., Nobuhara, M., Murray, E., Ruan, X., Rios, J. J., Wise, C. A. & Ahituv, N., Mar 26 2024, In: Cell Reports. 43, 3, 113907.Research output: Contribution to journal › Article › peer-review
Open Access8 Link opens in a new tab Scopus citations -
Deletion of CTCF sites in the SHH locus alters enhancer–promoter interactions and leads to acheiropodia
University of Washington Center for Mendelian Genomics, Ushiki, A., Zhang, Y., Xiong, C., Zhao, J., Georgakopoulos-Soares, I., Kane, L., Jamieson, K., Bamshad, M. J., Nickerson, D. A., Shen, Y., Lettice, L. A., Silveira-Lucas, E. L., Petit, F. & Ahituv, N., Dec 1 2021, In: Nature communications. 12, 1, 2282.Research output: Contribution to journal › Article › peer-review
Open Access42 Link opens in a new tab Scopus citations -
Genomic characterization of the adolescent idiopathic scoliosis-associated transcriptome and regulome
Makki, N., Zhao, J., Liu, Z., Eckalbar, W. L., Ushiki, A., Khanshour, A. M., Wu, J., Rios, J., Gray, R. S., Wise, C. A. & Ahituv, N., Nov 15 2020, In: Human molecular genetics. 29, 22, p. 3606-3615 10 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Link opens in a new tab Scopus citations