Research output per year
Research output per year
Research output
- 24 Article
- 24 results
Search results
-
2025
Two cardinal features of ALS, reduced STMN2 and pathogenic TDP-43, synergize to accelerate motor decline in mice
Krus, K. L., Benitez, A. M., Strickland, A., Milbrandt, J., Bloom, A. J. & DiAntonio, A., Feb 2025, In: Experimental Neurology. 384, 115068.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients
Bloom, A. J., Mao, X., Strickland, A., Sasaki, Y., Milbrandt, J. & DiAntonio, A., Dec 2022, In: Molecular neurodegeneration. 17, 1, 1.Research output: Contribution to journal › Article › peer-review
Open Access42 Scopus citations -
Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy
Krus, K. L., Strickland, A., Yamada, Y., Devault, L., Schmidt, R. E., Bloom, A. J., Milbrandt, J. & DiAntonio, A., Jun 28 2022, In: Cell Reports. 39, 13, 111001.Research output: Contribution to journal › Article › peer-review
Open Access44 Scopus citations -
2021
Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss
Wu, T., Zhu, J., Strickland, A., Ko, K. W., Sasaki, Y., Dingwall, C. B., Yamada, Y., Figley, M. D., Mao, X., Neiner, A., Bloom, A. J., DiAntonio, A. & Milbrandt, J., Oct 19 2021, In: Cell Reports. 37, 3, 109872.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
2019
Mouse strain-specific acute respiratory effects of nicotine unrelated to nicotine metabolism
Bloom, A. J., Sep 2 2019, In: Toxicology Mechanisms and Methods. 29, 7, p. 542-548 7 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Nicotine oxidation by genetic variants of CYP2B6 and in human brain microsomes
Bloom, A. J., Wang, P. F. & Kharasch, E. D., Apr 2019, In: Pharmacology Research and Perspectives. 7, 2, e00468.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Strain-specific altered nicotine metabolism in 3,3′-diindolylmethane (DIM) exposed mice
Bloom, A. J., Upadhyaya, P. & Kharasch, E. D., May 1 2019, In: Biopharmaceutics and Drug Disposition. 40, 5-6, p. 188-194 7 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
2018
CYP2A6 metabolism in the development of smoking behaviors in young adults
Olfson, E., Bloom, J., Bertelsen, S., Budde, J. P., Breslau, N., Brooks, A., Culverhouse, R., Chan, G., Chen, L. S., Chorlian, D., Dick, D. M., Edenberg, H. J., Hartz, S., Hatsukami, D., Hesselbrock, V. M., Johnson, E. O., Kramer, J. R., Kuperman, S., Meyers, J. L. & Nurnberger, J. & 8 others, , Jan 2018, In: Addiction Biology. 23, 1, p. 437-447 11 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain
Teitelbaum, A. M., Murphy, S. E., Akk, G., Baker, T. B., Germann, A., Von Weymarn, L. B., Bierut, L. J., Goate, A., Kharasch, E. D. & Bloom, A. J., Jan 1 2018, In: Pharmacogenomics Journal. 18, 1, p. 136-143 8 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
2014
Beyond cigarettes per day: A genome-wide association study of the biomarker carbon monoxide
Bloom, A. J., Hartz, S. M., Baker, T. B., Chen, L. S., Piper, M. E., Fox, L., Martinez, M., Hatsukami, D., Johnson, E. O., Laurie, C. C., Saccone, N. L., Goate, A. & Bierut, L. J., Sep 1 2014, In: Annals of the American Thoracic Society. 11, 7, p. 1003-1010 8 p.Research output: Contribution to journal › Article › peer-review
Open Access33 Scopus citations -
Pharmacotherapy effects on smoking cessation vary with nicotine metabolism gene (CYP2A6)
Chen, L. S., Bloom, A. J., Baker, T. B., Smith, S. S., Piper, M. E., Martinez, M., Saccone, N., Hatsukami, D., Goate, A. & Bierut, L., Jan 2014, In: Addiction. 109, 1, p. 128-137 10 p.Research output: Contribution to journal › Article › peer-review
Open Access83 Scopus citations -
Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms
Bloom, A. J., Baker, T. B., Chen, L. S., Breslau, N., Hatsukami, D., Bierut, L. J. & Goate, A., Jan 2014, In: Human molecular genetics. 23, 2, p. 555-561 7 p.Research output: Contribution to journal › Article › peer-review
Open Access30 Scopus citations -
2013
A compensatory effect upon splicing results in normal function of the CYP2A6*14 allele
Bloom, A. J., Harari, O., Martinez, M., Zhang, X., McDonald, S. A., Murphy, S. E. & Goate, A., Mar 2013, In: Pharmacogenetics and Genomics. 23, 3, p. 107-116 10 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
CYP2B6 non-coding variation associated with smoking cessation is also associated with differences in allelic expression, splicing, and nicotine metabolism independent of common amino-acid changes
Bloom, A. J., Martinez, M., Chen, L. S., Bierut, L. J., Murphy, S. E. & Goate, A., Nov 15 2013, In: PloS one. 8, 11, e79700.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption
Bloom, A. J., Murphy, S. E., Martinez, M., Von Weymarn, L. B., Bierut, L. J. & Goate, A., Feb 2013, In: Pharmacogenetics and Genomics. 23, 2, p. 62-68 7 p.Research output: Contribution to journal › Article › peer-review
Open Access30 Scopus citations -
The contribution of common UGT2B10 and CYP2A6 alleles to variation in nicotine glucuronidation among european americans
Bloom, A. J., Von Weymarn, L. B., Martinez, M., Bierut, L. J., Goate, A. & Murphy, S. E., Dec 2013, In: Pharmacogenetics and Genomics. 23, 12, p. 706-716 11 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
2012
Use of a predictive model derived from in vivo endophenotype measurements to demonstrate associations with a complex locus, CYP2A6
Bloom, A. J., Harari, O., Martinez, M., Madden, P. A. F., Martin, N. G., Montgomery, G. W., Rice, J. P., Murphy, S. E., Bierut, L. J. & Goate, A., Jul 2012, In: Human molecular genetics. 21, 13, p. 3050-3062 13 p., dds114.Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations -
2011
Phr1 is required for proper retinocollicular targeting of nasal-dorsal retinal ganglion cells
Vo, B. Q., Bloom, A. J. & Culican, S. M., Mar 2011, In: Visual Neuroscience. 28, 2, p. 175-181 7 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans
Bloom, J., Hinrichs, A. L., Wang, J. C., Von Weymarn, L. B., Kharasch, E. D., Bierut, L. J., Goate, A. & Murphy, S. E., Jul 2011, In: Pharmacogenetics and Genomics. 21, 7, p. 403-416 14 p.Research output: Contribution to journal › Article › peer-review
Open Access76 Scopus citations -
2009
Phr1 regulates retinogeniculate targeting independent of activity and ephrin-A signalling
Culican, S. M., Bloom, A. J., Weiner, J. A. & DiAntonio, A., Jun 22 2009, In: Molecular and Cellular Neuroscience. 41, 3, p. 304-312 9 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
2007
The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons
Bloom, A. J., Miller, B. R., Sanes, J. R. & DiAntonio, A., Oct 15 2007, In: Genes and Development. 21, 20, p. 2593-2606 14 p.Research output: Contribution to journal › Article › peer-review
Open Access111 Scopus citations -
1999
Identification of residues in the monocyte chemotactic protein-1 that contact the MCP-1 receptor, CCR2
Hemmerich, S., Paavola, C., Bloom, A., Bhakta, S., Freedman, R., Grunberger, D., Krstenansky, J., Lee, S., McCarley, D., Mulkins, M., Wong, B., Pease, J., Mizoue, L., Mirzadegan, T., Polsky, I., Thompson, K., Handel, T. M. & Jarnagin, K., Oct 5 1999, In: Biochemistry. 38, 40, p. 13013-13025 13 p.Research output: Contribution to journal › Article › peer-review
148 Scopus citations -
Identification of surface residues of the monocyte chemotactic protein 1 that affect signaling through the receptor CCR2
Jarnagin, K., Grunberger, D., Mulkins, M., Wong, B., Hemmerich, S., Paavola, C., Bloom, A., Bhakta, S., Diehl, F., Freedman, R., McCarley, D., Polsky, I., Ping-Tsou, A., Kosaka, A. & Handel, T. M., Dec 7 1999, In: Biochemistry. 38, 49, p. 16167-16177 11 p.Research output: Contribution to journal › Article › peer-review
99 Scopus citations -
1998
Monomeric monocyte chemoattractant protein-1 (MCP-1) binds and activates the MCP-1 receptor CCR2B
Paavola, C. D., Hemmerich, S., Grunberger, D., Polsky, I., Bloom, A., Freedman, R., Mulkins, M., Bhakta, S., McCarley, D., Wiesent, L., Wong, B., Jarnagin, K. & Handelt, T. M., Dec 11 1998, In: Journal of Biological Chemistry. 273, 50, p. 33157-33165 9 p.Research output: Contribution to journal › Article › peer-review
Open Access182 Scopus citations