• 290
    Citations
20122024

Research activity per year

Personal profile

Research interests

Overview: Cancer develops through accumulation of DNA mutations and structural aberrations collectively known as genome instability. Genome damage in adult-onset malignancies can be traced to exogenous carcinogens or simply the process of aging. However, pediatric cancers do not arise as a result of aging or exogenous genotoxic agents. We are interested in the etiology of genome instability in pediatric cancers and the resulting genome-protective responses, also called DNA damage responses, that are activated. Our long-term goal is to identify factors within DNA damage response signaling pathways that represent therapeutic vulnerabilities in order to develop new treatment options for children with cancer. Our current investigations are centered around two etiologies of endogenous DNA damage in leukemia: (1) APOBEC3 enzymes, DNA cytosine deaminases that are expressed at high levels in acute myeloid leukemia, and (2) MLL (KMT2A) gene rearrangements that drive infant acute lymphoblastic leukemia. Projects: 1. Functional whole-genome knock out screen to evaluate synthetic lethality with APOBEC3A expression in leukemia. 2. Impact of APOBEC3A on DNA replication. 3. DNA damage responses elicited by MLL gene rearrangements in infant leukemia. 4. Impact of APOBEC3 enzymes on normal and malignant hematopoiesis.

Mentoring

The Green Lab strives to have an environment of scientific productivity, collegiality, congeniality, collaboration, and fun! We are proud to be home to a diverse group of trainees from varied scientific, geographic, ethnic, and social backgrounds. We believe that diversity improves us as a group and welcome others who feel the same. We aim to promote diversity and look forward to recruiting lab members from backgrounds that are underrepresented in science. In the Green Lab, we celebrate differences and learn from one another. 

Available to Mentor:

  • PhD/MSTP Students

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