Willing to Mentor

    Available to Mentor:

    PhD/MSTP Students

    • Source: Scopus
    1989 …2022

    Research activity per year

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    Personal profile

    Research interests

    I investigate the molecular mechanisms that control the formation, function, and maintenance of neural circuits in development and disease. My lab combines genetic, molecular, neuroanatomical, and electrophysiological studies in both mouse, iPSC-derived human neurons, and Drosophila to identify pathways required for the development and maintenance of axons and synapses. I have extensive experience in imaging, genetic manipulation, cell biology, and in conducting large-scale genetic screens to elucidate the underlying biologic pathways that contribute to neuronal circuit formation and maintenance. We have recently identified SARM1 as the central executioner driving the degeneration of diseased axons, elucidated its function as an NAD+ consuming enzyme, and developed candidate therapeutics for the treatment of neurodegeneration. We are currently studying axon-glial interactions, neuroimmune activation, and axon survival pathways in order to dissect the molecular mechanisms driving axonal degeneration in the injured and diseased nervous system and to identify novel disease modifying therapies. 

    Mentoring

    I take mentoring very seriously. My overarching goal is to work with each trainee to get them where they want to go. As part of that, I emphasize learning how to think like a scientist, how to write in a clear and cogent manner, and how to give talks that both enlighten and entertain. My expectations are high for both my trainees and myself as that is how great science gets done. I am proud to report that I have been awarded the “Outstanding Faculty Mentor Award” by the postdoctoral society of Washington University School of Medicine as well as the “Outstanding Faculty Mentor Award” by the graduate student senate at Washington University. 

    Available to Mentor:

    • PhD/MSTP Students

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