• 10362 Citations
1989 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

I investigate the molecular mechanisms that control the formation, function, and maintenance of neural circuits in development and disease. My lab combines genetic, molecular, neuroanatomical, and electrophysiological studies in both Drosophila and mouse to identify pathways required for the development and maintenance of axons and synapses. I have extensive experience in imaging, genetic manipulation, cell biology, and in conducting large-scale genetic screens with Drosophila as a means of elucidating the underlying biologic pathways that contribute to neuronal circuit formation and maintenance. We have recently identified a role for the DLK/JNK kinase pathway in driving the degeneration of injured axons. We are currently combining large-scale genetic screens in the fly with functional analysis in the mouse to dissect the molecular mechanisms driving axonal degeneration in the injured and diseased nervous system.

Fingerprint Dive into the research topics where Aaron DiAntonio is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 8 Similar Profiles

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output

cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons

Sasaki, Y., Engber, T. M., Hughes, R. O., Figley, M. D., Wu, T., Bosanac, T., Devraj, R., Milbrandt, J., Krauss, R. & DiAntonio, A., Jul 2020, In : Experimental Neurology. 329, 113252.

Research output: Contribution to journalArticle

  • 3 Scopus citations

    DLK Activation Synergizes with Mitochondrial Dysfunction to Downregulate Axon Survival Factors and Promote SARM1-Dependent Axon Degeneration

    Summers, D. W., Frey, E., Walker, L. J., Milbrandt, J. & DiAntonio, A., Feb 1 2020, In : Molecular Neurobiology. 57, 2, p. 1146-1158 13 p.

    Research output: Contribution to journalArticle

  • 6 Scopus citations

    Domain-centric database to uncover structure of minimally characterized viral genomes

    Bramley, J. C., Yenkin, A. L., Zaydman, M. A., DiAntonio, A., Milbrandt, J. D. & Buchser, W. J., Dec 1 2020, In : Scientific data. 7, 1, 202.

    Research output: Contribution to journalArticle

    Open Access
  • Models of axon degeneration in Drosophila larvae

    Brace, E. J. & DiAntonio, A., 2020, Methods in Molecular Biology. Humana Press Inc., p. 311-320 10 p. (Methods in Molecular Biology; vol. 2143).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration

    Ko, K. W., Milbrandt, J. & DiAntonio, A., Jun 2020, In : Journal of Cell Biology. 219, 8 August, e201912047.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations