Section of Molecular Oncology & Developmental Therapeutics

2025

A Phase II Open-Label, Randomized Clinical Trial of Atezolizumab with or without Human Recombinant IL-7 (CYT107) in Advanced Urothelial Cancer

Sweis, R. F., Chatta, G. S., Jain, R. K., Moon, H., Delacroix, S. E., Fang, A., D'Amico, L., Kask, A. S., Cheever, M. A., Fling, S., Sharon, E., Lacroix, A., Kaiser, J. C., Pachynski, R. K. & Yu, E. Y., Jan 15 2025, In: Clinical Cancer Research. 31, 2, p. 299-307 9 p.

Research output: Contribution to journal › Article › peer-review

Integration of Clinical Trial Development in Hematology-Oncology Fellowship Training

Auberle, C., Wu, N., Dipersio, J. F., Waqar, S. N. & Ratner, L., Jan 1 2025, In: Academic medicine : journal of the Association of American Medical Colleges. 100, 1, p. 38-41 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Phase I trial of ATR inhibitor elimusertib with FOLFIRI in advanced or metastatic gastrointestinal malignancies (ETCTN 10406)

Krishnamurthy, A., Wang, H., Rhee, J. C., Davar, D., Moy, R. H., Ratner, L., Christner, S. M., Holleran, J. L., Deppas, J., Sclafani, C., Schmitz, J. C., Gore, S., Chu, E., Bakkenist, C. J., Beumer, J. H. & Villaruz, L. C., Dec 2025, In: Cancer Chemotherapy and Pharmacology. 95, 1, 27.

Research output: Contribution to journal › Article › peer-review

2024

Adjuvant Trastuzumab Emtansine Versus Paclitaxel Plus Trastuzumab for Stage i Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: 5-Year Results and Correlative Analyses from ATEMPT

Consortium of the TBCRC Translational Investigators, Nov 1 2024, In: Journal of Clinical Oncology. 42, 31, p. 3652-3665 14 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

A macrophage-cell model of HIV latency reveals the unusual importance of the bromodomain axis

Kisaka, J. K., Rauch, D., Griffith, M. & Kyei, G. B., Dec 2024, In: Virology Journal. 21, 1, 80.

Research output: Contribution to journal › Article › peer-review

Open Access

An HTLV-1 envelope mRNA vaccine is immunogenic and protective in New Zealand rabbits

Tu, J. J., King, E., Maksimova, V., Smith, S., Macias, R., Cheng, X., Vegesna, T., Yu, L., Ratner, L., Green, P. L., Niewiesk, S., Richner, J. M. & Panfil, A. R., Feb 2024, In: Journal of virology. 98, 2

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis

PDXNET Consortium, Jul 1 2024, In: Cancer research. 84, 13, p. 2060-2072 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

A Phase 1/2 multicenter trial of DKN-01 as monotherapy or in combination with docetaxel for the treatment of metastatic castration-resistant prostate cancer (mCRPC)

Wise, D. R., Pachynski, R. K., Denmeade, S. R., Aggarwal, R. R., Deng, J., Febles, V. A., Balar, A. V., Economides, M. P., Loomis, C., Selvaraj, S., Haas, M., Kagey, M. H., Newman, W., Baum, J., Troxel, A. B., Griglun, S., Leis, D., Yang, N., Aranchiy, V. & Machado, S. & 12 others, Waalkes, E., Gargano, G., Soamchand, N., Puranik, A., Chattopadhyay, P., Fedal, E., Deng, F. M., Ren, Q., Chiriboga, L., Melamed, J., Sirard, C. A. & Wong, K. K., 2024, (Accepted/In press) In: Prostate Cancer and Prostatic Diseases.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

A Proposal for the Comprehensive Care of Men on Androgen Deprivation Therapy: Recommendations from the Multidisciplinary Prostate Cancer 360 Working Group

Crawford, E. D., Garnick, M. B., Eckel, R. H., Miner, M. M., Freedland, S. J., Pachynski, R. K., Wassersug, R. J., Rosenberg, M. T., Walker, L. M., Fairman, C., Curley, T., Crosby, M., Lin, P. H. & Hafron, J. M., Jan 1 2024, In: Urology Practice. 11, 1, p. 18-29 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

ARID2 mutations may relay a distinct subset of cutaneous melanoma patients with different outcomes

Akinjiyan, F. A., Nassief, G., Phillipps, J., Adeyelu, T., Elliott, A., Abdulla, F., Zhou, A. Y., Souroullas, G., Kim, K. B., Vanderwalde, A., Park, S. J. & Ansstas, G., Dec 2024, In: Scientific reports. 14, 1, 3444.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Assessment of the safety of nivolumab in people living with HIV with advanced cancer on antiretroviral therapy: the AIDS Malignancy Consortium 095 Study

Rajdev, L., Jackie Wang, C. C., Joshi, H., Lensing, S., Lee, J., Ramos, J. C., Baiocchi, R., Ratner, L., Rubinstein, P. G., Ambinder, R., Henry, D., Streicher, H., Little, R. F., Chiao, E., Dittmer, D. P., Einstein, M. H., Cesarman, E., Mitsuyasu, R. & Sparano, J. A., Mar 15 2024, In: Cancer. 130, 6, p. 985-994 10 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

BCAR4 Expression as a Predictive Biomarker for Endocrine Therapy Resistance in Breast Cancer

Liao, M., Webster, J., Coonrod, E. M., Weilbaecher, K. N., Maher, C. A. & White, N. M., Jun 2024, In: Clinical breast cancer. 24, 4, p. 368-375.e2

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Beyond Average: a-Particle Distribution and Dose Heterogeneity in Bone Metastatic Prostate Cancer

Benabdallah, N., Lu, P., Abou, D. S., Zhang, H., Ulmert, D., Hobbs, R. F., Gay, H. A., Simons, B. W., Saeed, M. A., Rogers, B. E., Jha, A. K., Tai, Y. C., Malone, C. D., Ippolito, J. E., Michalski, J., Jennings, J. W., Baumann, B. C., Pachynski, R. K. & Thorek, D. L. J., Feb 10 2024, In: Journal of Nuclear Medicine. 65, 2, p. 245-251 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Body composition measurements and clinical outcomes in patients with resectable pancreatic adenocarcinoma – analysis from SWOG S1505

Sohal, D. P. S., Boutin, R. D., Lenchik, L., Kim, J., Beg, M. S., Wang-Gillam, A., Wade, J. L., Guthrie, K. A., Chiorean, E. G., Ahmad, S. A., Lowy, A. M., Philip, P. A. & Chang, V. T. S., Mar 2024, In: Journal of Gastrointestinal Surgery. 28, 3, p. 232-235 4 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Chemokine Receptor 2 Targeted PET/CT Imaging Distant Metastases in Pancreatic Ductal Adenocarcinoma

Zhang, X., Detering, L., Heo, G. S., Sultan, D., Luehmann, H., Li, L., Somani, V., Lesser, J., Tao, J., Kang, L. I., Li, A., Lahad, D., Rho, S., Ruzinova, M. B., DeNardo, D. G., Dehdashti, F., Lim, K. H. & Liu, Y., Jan 12 2024, In: ACS Pharmacology and Translational Science. 7, 1, p. 285-293 9 p.

Research output: Contribution to journal › Article › peer-review

Chemotherapy and the Extra-Tumor Immune Microenvironment: EXTRA-TIME

Phan, T. G., Weilbaecher, K., Aft, R., Croucher, P. I. & Chaffer, C. L., Apr 1 2024, In: Cancer discovery. 14, 4, p. 643-647 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Combined KRAS-MAPK pathway inhibitors and HER2-directed drug conjugate is efficacious in pancreatic cancer

Bulle, A., Liu, P., Seehra, K., Bansod, S., Chen, Y., Zahra, K., Somani, V., Khawar, I. A., Chen, H. P., Dodhiawala, P. B., Li, L., Geng, Y., Mo, C. K., Mahsl, J., Ding, L., Govindan, R., Davies, S., Mudd, J., Hawkins, W. G. & Fields, R. C. & 7 others, DeNardo, D. G., Knoerzer, D., Held, J. M., Grierson, P. M., Wang-Gillam, A., Ruzinova, M. B. & Lim, K. H., Dec 2024, In: Nature communications. 15, 1, 2503.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers

Klomp, J. A., Klomp, J. E., Stalnecker, C. A., Bryant, K. L., Edwards, A. C., Drizyte-Miller, K., Hibshman, P. S., Diehl, J. N., Lee, Y. S., Morales, A. J., Taylor, K. E., Peng, S., Tran, N. L., Herring, L. E., Prevatte, A. W., Barker, N. K., Hover, L. D., Hallin, J., Chowdhury, S. & Coker, O. & 13 others, Lee, H. M., Goodwin, C. M., Gautam, P., Olson, P., Christensen, J. G., Shen, J. P., Kopetz, S., Graves, L. M., Lim, K. H., Wang-Gillam, A., Wennerberg, K., Cox, A. D. & Der, C. J., Jun 7 2024, In: Science (New York, N.Y.). 384, 6700, p. eadk0775

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer

Fowle-Grider, R., Rowles, J. L., Shen, I., Wang, Y., Schwaiger-Haber, M., Dunham, A. J., Jayachandran, K., Inkman, M., Zahner, M., Naser, F. J., Jackstadt, M. M., Spalding, J. L., Chiang, S., McCommis, K. S., Dolle, R. E., Kramer, E. T., Zimmerman, S. M., Souroullas, G. P., Finck, B. N. & Shriver, L. P. & 4 others, Kaufman, C. K., Schwarz, J. K., Zhang, J. & Patti, G. J., Dec 19 2024, In: Nature. 636, 8043, p. 737-744 8 p., 211.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages

Iglesia, M. D., Jayasinghe, R. G., Chen, S., Terekhanova, N. V., Herndon, J. M., Storrs, E., Karpova, A., Zhou, D. C., Naser Al Deen, N., Shinkle, A. T., Lu, R. J. H., Caravan, W., Houston, A., Zhao, Y., Sato, K., Lal, P., Street, C., Martins Rodrigues, F., Southard-Smith, A. N. & Targino da Costa, A. L. N. & 40 others, Zhu, H., Mo, C. K., Crowson, L., Fulton, R. S., Wyczalkowski, M. A., Fronick, C. C., Fulton, L. A., Sun, H., Davies, S. R., Appelbaum, E. L., Chasnoff, S. E., Carmody, M., Brooks, C., Liu, R., Wendl, M. C., Oh, C., Bender, D., Cruchaga, C., Harari, O., Bredemeyer, A., Lavine, K., Bose, R., Margenthaler, J., Held, J. M., Achilefu, S., Ademuyiwa, F., Aft, R., Ma, C., Colditz, G. A., Ju, T., Oh, S. T., Fitzpatrick, J., Hwang, E. S., Shoghi, K. I., Chheda, M. G., Veis, D. J., Chen, F., Fields, R. C., Gillanders, W. E. & Ding, L., Nov 2024, In: Nature Cancer. 5, 11, p. 1713-1736 24 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

ERBB2 (HER2) amplifications and co-occurring KRAS alterations in the circulating cell-free DNA of pancreatic ductal adenocarcinoma patients and response to HER2 inhibition

Barzi, A., Weipert, C. M., Espenschied, C. R., Raymond, V. M., Wang-Gillam, A., Nezami, M. A., Gordon, E. J., Mahadevan, D. & Mody, K., 2024, In: Frontiers in Oncology. 14, 1339302.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Evaluating Immune Checkpoint Blockade in Metastatic Castration-Resistant Prostate Cancers with Deleterious CDK12 Alterations in the Phase 2 IMPACT Trial

Nguyen, C. B., Reimers, M. A., Perera, C., Abida, W., Chou, J., Feng, F. Y., Antonarakis, E. S., McKay, R. R., Pachynski, R. K., Zhang, J., Reichert, Z. R., Palmbos, P. L., Caram, M. E. V., Vaishampayan, U. N., Heath, E. I., Hopkins, A. C., Cieslik, M. P., Wu, Y. M., Robinson, D. R. & Baladandayuthapani, V. & 2 others, Chinnaiyan, A. M. & Alva, A. S., Aug 1 2024, In: Clinical Cancer Research. 30, 15, p. 3200-3210 11 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Evaluation of Copanlisib in Combination with Eribulin in Triple-negative Breast Cancer Patient-derived Xenograft Models

Guo, Z., Luo, J., Jay Mashl, R., Hoog, J., Maiti, P., Fettig, N., Davies, S. R., Aft, R., Held, J. M., Govindan, R., Ding, L., Li, S., von Morze, C., Wulf, G. M., Shoghi, K. I. & Ma, C. X., Jun 2024, In: Cancer research communications. 4, 6, p. 1430-1440 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

High dimensional analyses reveal IL-15 enhances activation of Sipuleucel-T lymphocyte subsets and reverses immunoresistance

Saeed, M. A., Peng, B., Kim, K., Rawat, K., Kuehm, L. M., Siegel, Z. R., Borkowski, A., Habib, N., Van Tine, B., Sheikh, N., Tuyen, V., Thorek, D. L. J., Fehniger, T. A. & Pachynski, R. K., May 1 2024, In: Cancer immunology research. 12, 5

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

HTLV-1 infected T cells cause bone loss via small extracellular vesicles

Pokhrel, N. K., Panfil, A. R., Habib, H., Seeniraj, S., Joseph, A., Rauch, D., Cox, L., Sprung, R., Gilmore, P. E., Zhang, Q., Townsend, R. R., Yu, L., Yilmaz, A. S., Aurora, R., Park, W., Ratner, L., Weilbaecher, K. N. & Veis, D. J., Oct 2024, In: Journal of Extracellular Vesicles. 13, 10, e12516.

Research output: Contribution to journal › Article › peer-review

Open Access

MyPathway Human Epidermal Growth Factor Receptor 2 Basket Study: Pertuzumab 1 Trastuzumab Treatment of a Tissue-Agnostic Cohort of Patients With Human Epidermal Growth Factor Receptor 2–Altered Advanced Solid Tumors

Sweeney, C. J., Hainsworth, J. D., Bose, R., Burris, H. A., Kurzrock, R., Swanton, C., Friedman, C. F., Spigel, D. R., Szado, T., Schulze, K., Price, R., Malato, J., Lo, A. A., Levy, J., Wang, Y., Yu, W. & Meric-Bernstam, F., Jan 20 2024, In: Journal of Clinical Oncology. 42, 3, p. 258-265 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Nivolumab plus relatlimab and nivolumab plus ipilimumab for patients with advanced renal cell carcinoma: results from the open-label, randomised, phase II FRACTION-RCC trial

Choueiri, T. K., Kuzel, T. M., Tykodi, S. S., Verzoni, E., Kluger, H., Nair, S., Perets, R., George, S., Gurney, H., Pachynski, R. K., Folefac, E., Castonguay, V., Lee, C. H., Vaishampayan, U., Miller, W. H., Bhagavatheeswaran, P., Wang, Y., Gupta, S., DeSilva, H. & Lee, C. W. & 2 others, Escudier, B. & Motzer, R. J., Dec 2024, In: ESMO Open. 9, 12, 104073.

Research output: Contribution to journal › Article › peer-review

Open Access

O-GlcNAcylation of MITF regulates its activity and CDK4/6 inhibitor resistance in breast cancer

Zhang, Y., Zhou, S., Kai, Y., Zhang, Y. Q., Peng, C., Li, Z., mughal, M. J., Julie, B., Zheng, X., Ma, J., Ma, C. X., Shen, M., Hall, M. D., Li, S. & Zhu, W., Dec 2024, In: Nature communications. 15, 1, 5597.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Remission of longstanding metastatic paraganglioma in a patient after use of zoledronic acid

Schutte, J., Mardani, M., Weilbaecher, K., Prasad, V., Chrisinger, J. S. A. & Trikalinos, N. A., Nov 28 2024, In: BMJ Case Reports. 17, 11, e262628.

Research output: Contribution to journal › Article › peer-review

Resistance to abemaciclib is associated with increased metastatic potential and lysosomal protein deregulation in breast cancer cells

Scheidemann, E. R., Demas, D. M., Hou, C., Ma, J., He, W., Sharma, G., Schultz, E., Weilbaecher, K. N. & Shajahan-Haq, A. N., Feb 2024, In: Molecular Carcinogenesis. 63, 2, p. 209-223 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Safety Evaluations of Rapamycin Perfluorocarbon Nanoparticles in Ovarian Tumor-Bearing Mice

Zhou, Q., Harding, J. C., Fan, P., Spasojevic, I., Kovacs, A., Akk, A., Mitchell, A., Springer, L. E., Gaut, J. P., Rauch, D., Wickline, S. A., Pham, C., Fuh, K. & Pan, H., Nov 2024, In: Nanomaterials. 14, 21, 1752.

Research output: Contribution to journal › Article › peer-review

Open Access

Stat3-mediated Atg7 expression regulates anti-tumor immunity in mouse melanoma

Zimmerman, S. M., Suh, E., Smith, S. R. & Souroullas, G. P., Nov 2024, In: Cancer Immunology, Immunotherapy. 73, 11, 218.

Research output: Contribution to journal › Article › peer-review

Open Access

Stromal reprogramming overcomes resistance to RAS-MAPK inhibition to improve pancreas cancer responses to cytotoxic and immune therapy

Liu, X., Baer, J. M., Stone, M. L., Knolhoff, B. L., Hogg, G. D., Turner, M. C., Kao, Y. L., Weinstein, A. G., Ahmad, F., Chen, J., Schmidt, A. D., Klomp, J. A., Coho, H., Coho, K. S., Coma, S., Pachter, J. A., Bryant, K. L., Kang, L. I., Lim, K. H. & Beatty, G. L. & 1 others, DeNardo, D. G., Oct 23 2024, In: Science translational medicine. 16, 770, eado2402.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

The Cell Cycle: a Key to Unlock EZH2-targeted Therapy Resistance

Paolini, R. L. & Souroullas, G. P., Jun 1 2024, In: Cancer discovery. 14, 6, p. 903-905 3 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

The New Proposed U.S. Preventive Services Task Force Recommendation on Breast Cancer Screening for Women in Their 40s

Lee, M. V., Garrett, H. V., Weilbaecher, K., Toriola, A. & Bennett, D. L., Sep 1 2024, In: Annals of internal medicine. 177, 9, p. 1292-1293 2 p.

Research output: Contribution to journal › Article › peer-review

The TRIM4 E3 ubiquitin ligase degrades TPL2 and is modulated by oncogenic KRAS

Bansod, S., Dodhiawala, P. B., Geng, Y., Bulle, A., Liu, P., Li, L., Townsend, R., Grierson, P. M., Held, J. M., Adhikari, H. & Lim, K. H., Sep 24 2024, In: Cell Reports. 43, 9, 114667.

Research output: Contribution to journal › Article › peer-review

Open Access

Three- and Seven-month Prostate-specific Antigen Levels as Prognostic Markers for Overall Survival in Metastatic Hormone-sensitive Prostate Cancer: Results from SWOG S1216, a Phase 3 Randomized Trial of Androgen Deprivation Plus Orteronel or Bicalutamide

Parikh, M., Tangen, C., Hussain, M. H. A., Gupta, S., Callis, S., Jo, Y., Harzstark, A., Paller, C. J., George, S., Zibelman, M. R., Cheng, H. H., Maughan, B. L., Zhang, J., Pachynski, R. K., Bryce, A. H., Lin, D. W., Quinn, D. I., Lerner, S. P., Thompson, I. M. & Dorff, T. B. & 2 others, Lara, P. N. & Agarwal, N., Oct 1 2024, In: European Urology Oncology. 7, 5, p. 1097-1104 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Tumour evolution and microenvironment interactions in 2D and 3D space

Mo, C. K., Liu, J., Chen, S., Storrs, E., Targino da Costa, A. L. N., Houston, A., Wendl, M. C., Jayasinghe, R. G., Iglesia, M. D., Ma, C., Herndon, J. M., Southard-Smith, A. N., Liu, X., Mudd, J., Karpova, A., Shinkle, A., Goedegebuure, S. P., Abdelzaher, A. T. M. A., Bo, P. & Fulghum, L. & 26 others, Livingston, S., Balaban, M., Hill, A., Ippolito, J. E., Thorsson, V., Held, J. M., Hagemann, I. S., Kim, E. H., Bayguinov, P. O., Kim, A. H., Mullen, M. M., Shoghi, K. I., Ju, T., Reimers, M. A., Weimholt, C., Kang, L. I., Puram, S. V., Veis, D. J., Pachynski, R., Fuh, K. C., Chheda, M. G., Gillanders, W. E., Fields, R. C., Raphael, B. J., Chen, F. & Ding, L., Oct 31 2024, In: Nature. 634, 8036, p. 1178-1186 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

2023

A phase II study of palbociclib plus letrozole plus trastuzumab as neoadjuvant treatment for clinical stages II and III ER+ HER2+ breast cancer (PALTAN)

Ademuyiwa, F. O., Northfelt, D. W., O’Connor, T., Levine, E., Luo, J., Tao, Y., Hoog, J., Laury, M. L., Summa, T., Hammerschmidt, T., Guo, Z., Frith, A., Weilbaecher, K., Opyrchal, M., Aft, R., Clifton, K., Suresh, R., Bagegni, N., Hagemann, I. S. & Iglesia, M. D. & 1 others, Ma, C. X., Dec 2023, In: npj Breast Cancer. 9, 1, 1.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

A Pilot Study of Paricalcitol plus Nanoliposomal Irinotecan and 5-FU/LV in Advanced Pancreatic Cancer Patients after Progression on Gemcitabine-Based Therapy

Grierson, P. M., Suresh, R., Tan, B., Pedersen, K. S., Amin, M., Park, H., Trikalinos, N. A., Liu, J., Boice, N., Brown, A., Bansod, S., Wang-Gillam, A. & Lim, K. H., 2023, In: Clinical Cancer Research. 29, 23, p. 4733-4739 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Breast Cancer Mutations HER2^V777L and PIK3CA^H1047R Activate the p21–CDK4/6–Cyclin D1 Axis to Drive Tumorigenesis and Drug Resistance

Cheng, X., Sun, Y., Highkin, M., Vemalapally, N., Jin, X., Zhou, B., Prior, J. L., Tipton, A. R., Li, S., Iliuk, A., Achilefu, S., Hagemann, I. S., Edwards, J. R. & Bose, R., Sep 2023, In: Cancer research. 83, 17, p. 2839-2857 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Brentuximab vedotin with AVD for stage II–IV HIV-related Hodgkin lymphoma (AMC 085): phase 2 results from an open-label, single arm, multicentre phase 1/2 trial

AIDS Malignancy Consortium, Lymphoma Study Association, Rubinstein, P. G., Moore, P. C., Bimali, M., Lee, J. Y., Rudek, M. A., Chadburn, A., Ratner, L., Henry, D. H., Cesarman, E., DeMarco, C. E., Costagliola, D., Taoufik, Y., Ramos, J. C., Sharon, E., Reid, E. G., Ambinder, R. F., Mitsuyasu, R. & Mounier, N. & 9 others, Besson, C., Noy, A., Barta, S. K., Hamdan, A., Boué, F., Delobel, P., Galicier, L., Coppo, P. & Ghesquières, H., Aug 2023, In: The Lancet Haematology. 10, 8, p. e624-e632

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Chemerin triggers migration of a CD8 T cell subset with natural killer cell functions

Ballet, R., LaJevic, M., Huskey-Mullin, N., Roach, R., Brulois, K., Huang, Y., Saeed, M. A., Dang, H. X., Pachynski, R. K., Wilson, E., Butcher, E. C. & Zabel, B. A., Oct 4 2023, In: Molecular Therapy. 31, 10, p. 2887-2900 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Clinical characteristics and outcomes of infection with human T-lymphotropic virus in a non-endemic area: a single institution study

Gang, M., Gao, F., Poondru, S., Thomas, T. & Ratner, L., 2023, In: Frontiers in Microbiology. 14, 1187697.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Combining the Tyrosine Kinase Inhibitor Cabozantinib and the mTORC1/2 Inhibitor Sapanisertib Blocks ERK Pathway Activity and Suppresses Tumor Growth in Renal Cell Carcinoma

Wu, Y., Chen, S., Yang, X., Sato, K., Lal, P., Wang, Y., Shinkle, A. T., Wendl, M. C., Primeau, T. M., Zhao, Y., Gould, A., Sun, H., Mudd, J. L., Hoog, J., Mashl, R. J., Wyczalkowski, M. A., Mo, C. K., Liu, R., Herndon, J. M. & Davies, S. R. & 19 others, Liu, D., Ding, X., Evrard, Y. A., Welm, B. E., Lum, D., Koh, M. Y., Welm, A. L., Chuang, J. H., Moscow, J. A., Meric-Bernstam, F., Govindan, R., Li, S., Hsieh, J., Fields, R. C., Lim, K. H., Ma, C. X., Zhang, H., Ding, L. & Chen, F., Dec 15 2023, In: Cancer research. 183, 24, p. 4161-4178 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Diagnostic Performance and Safety of ¹⁸F-rhPSMA-7.3 Positron Emission Tomography in Men With Suspected Prostate Cancer Recurrence: Results From a Phase 3, Prospective, Multicenter Study (SPOTLIGHT)

Jani, A. B., Ravizzini, G. C., Gartrell, B. A., Siegel, B. A., Twardowski, P., Saltzstein, D., Fleming, M. T., Chau, A., Davis, P., Chapin, B. F., Schuster, D. M., Allaf, M., Avery, R. J., Avril, N., Barker, H., Belkoff, L., Bostrom, P., Cher, M. L., Chisholm, D. & Covington, M. F. & 29 others, Cox, I., Esposito, G., Gardiner, P., Gauden, D., Helfand, B., Hermsen, R., Josephson, D., Kay, M., Koontz, B. F., Kostakoglu, L., Kuo, P., Lavely, W., Liem, I. H., Lokuta, M., Lowentritt, B., Michalski, J., Miller, M. P., Mourtzikos, K., Pachynski, R., Penny, R., Piert, M., Purysko, A., Rais-Bahrami, S., Savir-Baruch, B., Somford, R., Tewari, A., Uchio, E., Yoo, D. & Zukotynski, K., Aug 1 2023, In: Journal of Urology. 210, 2, p. 299-311 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

Effect of a MUC5AC Antibody (NPC-1C) Administered with Second-Line Gemcitabine and Nab-Paclitaxel on the Survival of Patients with Advanced Pancreatic Ductal Adenocarcinoma: A Randomized Clinical Trial

Huffman, B. M., Basu Mallick, A., Horick, N. K., Wang-Gillam, A., Hosein, P. J., Morse, M. A., Beg, M. S., Murphy, J. E., Mavroukakis, S., Zaki, A., Schlechter, B. L., Sanoff, H., Manz, C., Wolpin, B. M., Arlen, P., Lacy, J. & Cleary, J. M., Jan 5 2023, In: JAMA Network Open. 6, 1, p. E2249720

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Endothelial cells are a key target of IFN-g during response to combined PD-1/CTLA-4 ICB treatment in a mouse model of bladder cancer

Freshour, S. L., Chen, T. H. P., Fisk, B., Shen, H., Mosior, M., Skidmore, Z. L., Fronick, C., Bolzenius, J. K., Griffith, O. L., Arora, V. K. & Griffith, M., Oct 20 2023, In: iScience. 26, 10, 107937.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Engineered nucleus-free mesenchymal stem cells (MSCs) for the targeted delivery of therapeutics to disease site

Schwartz, Z., Zhao, P., Wang, A., Zhao, G., Zeng, W., Wang, Y., Luu, H. H., Haydon, R. C., He, T. C., Reid, R. R. & Strelzow, J., Mar 2023, In: Genes and Diseases. 10, 2, p. 310-312 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma

Wu, Y., Terekhanova, N. V., Caravan, W., Naser Al Deen, N., Lal, P., Chen, S., Mo, C. K., Cao, S., Li, Y., Karpova, A., Liu, R., Zhao, Y., Shinkle, A., Strunilin, I., Weimholt, C., Sato, K., Yao, L., Serasanambati, M., Yang, X. & Wyczalkowski, M. & 22 others, Zhu, H., Zhou, D. C., Jayasinghe, R. G., Mendez, D., Wendl, M. C., Clark, D., Newton, C., Ruan, Y., Reimers, M. A., Pachynski, R. K., Kinsinger, C., Jewell, S., Chan, D. W., Zhang, H., Chaudhuri, A. A., Chheda, M. G., Humphreys, B. D., Mesri, M., Rodriguez, H., Hsieh, J. J., Ding, L. & Chen, F., Dec 2023, In: Nature communications. 14, 1, 1681.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Section of Molecular Oncology & Developmental Therapeutics

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