Section of Computational Biology

Search results

  • 2014

    Comprehensive molecular characterization of gastric adenocarcinoma

    Cancer Genome Atlas Research Network, Sep 11 2014, In: Nature. 513, 7517, p. 202-209 8 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    4765 Scopus citations
  • Comprehensive molecular profiling of lung adenocarcinoma: The cancer genome atlas research network

    Collisson, E. A., Campbell, J. D., Brooks, A. N., Berger, A. H., Lee, W., Chmielecki, J., Beer, D. G., Cope, L., Creighton, C. J., Danilova, L., Ding, L., Getz, G., Hammerman, P. S., Hayes, D. N., Hernandez, B., Herman, J. G., Heymach, J. V., Jurisica, I., Kucherlapati, R. & Kwiatkowski, D. & 290 others, Ladanyi, M., Robertson, G., Schultz, N., Shen, R., Sinha, R., Sougnez, C., Tsao, M. S., Travis, W. D., Weinstein, J. N., Wigle, D. A., Wilkerson, M. D., Chu, A., Cherniack, A. D., Hadjipanayis, A., Rosenberg, M., Weisenberger, D. J., Laird, P. W., Radenbaugh, A., Ma, S., Stuart, J. M., Byers, L. A., Baylin, S. B., Govindan, R., Meyerson, M., Gabriel, S. B., Cibulskis, K., Kim, J., Stewart, C., Lichtenstein, L., Lander, E. S., Lawrence, M. S., Getz, E., Fulton, R., Fulton, L. L., McLellan, M. D., Wilson, R. K., Ye, K., Fronick, C. C., Maher, C. A., Miller, C. A., Wendl, M. C., Cabanski, C., Mardis, E., Wheeler, D., Balasundaram, M., Butterfield, Y. S. N., Carlsen, R., Chuah, E., Dhalla, N., Guin, R., Hirst, C., Lee, D., Li, H. I., Mayo, M., Moore, R. A., Mungall, A. J., Schein, J. E., Sipahimalani, P., Tam, A., Varhol, R., Robertson, A. G., Wye, N., Thiessen, N., Holt, R. A., Jones, S. J. M., Marra, M. A., Imielinski, M., Onofrio, R. C., Hodis, E., Zack, T., Helman, E., Pedamallu, C. S., Mesirov, J., Saksena, G., Schumacher, S. E., Carter, S. L., Garraway, L., Beroukhim, R., Lee, S., Mahadeshwar, H. S., Pantazi, A., Protopopov, A., Ren, X., Seth, S., Song, X., Tang, J., Yang, L., Zhang, J., Chen, P. C., Parfenov, M., Xu, A. W., Santoso, N., Chin, L., Park, P. J., Hoadley, K. A., Auman, J. T., Meng, S., Shi, Y., Buda, E., Waring, S., Veluvolu, U., Tan, D., Mieczkowski, P. A., Jones, C. D., Simons, J. V., Soloway, M. G., Bodenheimer, T., Jefferys, S. R., Roach, J., Hoyle, A. P., Wu, J., Balu, S., Singh, D., Prins, J. F., Marron, J. S., Parker, J. S., Perou, C. M., Liu, J., Maglinte, D. T., Lai, P. H., Bootwalla, M. S., Van Den Berg, D. J., Triche, T., Cho, J., DiCara, D., Heiman, D., Lin, P., Mallard, W., Voet, D., Zhang, H., Zou, L., Noble, M. S., Gehlenborg, N., Thorvaldsdottir, H., Nazaire, M. D., Robinson, J., Aksoy, B. A., Ciriello, G., Taylor, B. S., Dresdner, G., Gao, J., Gross, B., Seshan, V. E., Reva, B., Sumer, S. O., Weinhold, N., Sander, C., Ng, S., Zhu, J., Benz, C. C., Yau, C., Haussler, D., Spellman, P. T., Kimes, P. K., Broom, B. M., Wang, J., Lu, Y., Ng, P. K. S., Diao, L., Liu, W., Amos, C. I., Akbani, R., Mills, G. B., Curley, E., Paulauskis, J., Lau, K., Morris, S., Shelton, T., Mallery, D., Gardner, J., Penny, R., Saller, C., Tarvin, K., Richards, W. G., Cerfolio, R., Bryant, A., Raymond, D. P., Pennell, N. A., Farver, C., Czerwinski, C., Huelsenbeck-Dill, L., Iacocca, M., Petrelli, N., Rabeno, B., Brown, J., Bauer, T., Dolzhanskiy, C. O., Potapova, O., Rotin, D., Voronina, O., Nemirovich-Danchenko, E., Fedosenko, K. V., Gal, A., Behera, M., Ramalingam, S. S., Sica, G., Flieder, D., Boyd, J., Weaver, J. E., Kohl, B., Thinh, D. H. Q., Sandusky, G., Juhl, H., Duhig, E., Illei, P., Gabrielson, E., Shin, J., Lee, B., Rogers, K., Trusty, D., Brock, M. V., Williamson, C., Burks, E., Rieger-Christ, K., Holway, A., Sullivan, T., Asiedu, M. K., Kosari, F., Rekhtman, N., Zakowski, M., Rusch, V. W., Zippile, P., Suh, J., Pass, H., Goparaju, C., Owusu-Sarpong, Y., Bartlett, J. M. S., Kodeeswaran, S., Parfitt, J., Sekhon, H., Albert, M., Eckman, J., Myers, J. B., Morrison, C., Gaudioso, C., Borgia, J. A., Bonomi, P., Pool, M., Liptay, M. J., Moiseenko, F., Zaytseva, I., Dienemann, H., Meister, M., Schnabel, P. A., Muley, T. R., Peifer, M., Gomez-Fernandez, C., Herbert, L., Egea, S., Huang, M., Thorne, L. B., Boice, L., Salazar, A. H., Funkhouser, W. K., Rathmell, W. K., Dhir, R., Yousem, S. A., Dacic, S., Schneider, F., Siegfried, J. M., Hajek, R., Watson, M. A., McDonald, S., Meyers, B., Clarke, B., Yang, I. A., Fong, K. M., Hunter, L., Windsor, M., Bowman, R. V., Peters, S., Letovanec, I., Khan, K. Z., Jensen, M. A., Snyder, E. E., Srinivasan, D., Kahn, A. B., Baboud, J., Pot, D. A., Shaw, K. R. M., Sheth, M., Davidsen, T., Demchok, J. A., Yang, L., Wang, Z., Tarnuzzer, R., Zenklusen, J. C., Ozenberger, B. A., Sofia, H. J. & Cheney, R., 2014, In: Nature. 511, 7511, p. 543-550 8 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    4122 Scopus citations
  • Discovery of rosavirus 2, a novel variant of a rodent-associated picornavirus, in children from The Gambia

    Lim, E. S., Cao, S., Holtz, L. R., Antonio, M., Stine, O. C. & Wang, D., Apr 2014, In: Virology. 454-455, 1, p. 25-33 9 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    15 Scopus citations
  • Expanding the computational toolbox for mining cancer genomes

    Ding, L., Wendl, M. C., McMichael, J. F. & Raphael, B. J., Aug 2014, In: Nature Reviews Genetics. 15, 8, p. 556-570 15 p.

    Research output: Contribution to journalReview articlepeer-review

    Open Access
    144 Scopus citations
  • Open Access
    377 Scopus citations
  • Geographic variation in the eukaryotic virome of human diarrhea

    Holtz, L. R., Cao, S., Zhao, G., Bauer, I. K., Denno, D. M., Klein, E. J., Antonio, M., Stine, O. C., Snelling, T. L., Kirkwood, C. D. & Wang, D., Nov 1 2014, In: Virology. 468, p. 556-564 9 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    63 Scopus citations
  • High Frequency Strand Slippage Mutations in CTCF in MSI-Positive Endometrial Cancers

    Zighelboim, I., Mutch, D. G., Knapp, A., Ding, L., Xie, M., Cohn, D. E. & Goodfellow, P. J., Jan 2014, In: Human mutation. 35, 1, p. 63-65 3 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    25 Scopus citations
  • Human genomic regions with exceptionally high levels of population differentiation identified from 911 whole-genome sequences

    Colonna, V., Ayub, Q., Chen, Y., Pagani, L., Luisi, P., Pybus, M., Garrison, E., Xue, Y., Tyler-Smith, C., Abecasis, G. R., Auton, A., Brooks, L. D., Depristo, M. A., Durbin, R. M., Handsaker, R. E., Kang, H. M., Marth, G. T., McVean, G., Altshuler, D. M. & Durbin, R. M. & 685 others, Abecasis, G. R., Bentley, D. R., Chakravarti, A., Clark, A. G., Donnelly, P., Eichler, E. E., Flicek, P., Gabriel, S. B., Gibbs, R. A., Green, E. D., Hurles, M. E., Knoppers, B. M., Korbel, J. O., Lander, E. S., Lee, C., Lehrach, H., Mardis, E. R., Marth, G. T., McVean, G. A., Nickerson, D. A., Schmidt, J. P., Sherry, S. T., Wang, J., Wilson, R. K., Gibbs, R. A., Dinh, H., Kovar, C., Lee, S., Lewis, L., Muzny, D., Reid, J., Wang, M., Wang, J., Fang, X., Guo, X., Jian, M., Jiang, H., Jin, X., Li, G., Li, J., Li, Y., Li, Z., Liu, X., Lu, Y., Ma, X., Su, Z., Tai, S., Tang, M., Wang, B., Wang, G., Wu, H., Wu, R., Yin, Y., Zhang, W., Zhao, J., Zhao, M., Zheng, X., Zhou, Y., Lander, E. S., Altshuler, D. M., Gabriel, S. B., Gupta, N., Flicek, P., Clarke, L., Leinonen, R., Smith, R. E., Zheng-Bradley, X., Bentley, D. R., Grocock, R., Humphray, S., James, T., Kingsbury, Z., Lehrach, H., Sudbrak, R., Albrecht, M. W., Amstislavskiy, V. S., Borodina, T. A., Lienhard, M., Mertes, F., Sultan, M., Timmermann, B., Yaspo, M. L., Sherry, S. T., McVean, G. A., Mardis, E. R., Wilson, R. K., Fulton, L., Fulton, R., Weinstock, G. M., Durbin, R. M., Balasubramaniam, S., Burton, J., Danecek, P., Keane, T. M., Kolb-Kokocinski, A., McCarthy, S., Stalker, J., Quail, M., Schmidt, J. P., Davies, C. J., Gollub, J., Webster, T., Wong, B., Zhan, Y., Auton, A., Gibbs, R. A., Yu, F., Bainbridge, M., Challis, D., Evani, U. S., Lu, J., Muzny, D., Nagaswamy, U., Reid, J., Sabo, A., Wang, Y., Yu, J., Wang, J., Coin, L. J., Fang, L., Guo, X., Jin, X., Li, G., Li, Q., Li, Y., Li, Z., Lin, H., Liu, B., Luo, R., Qin, N., Shao, H., Wang, B., Xie, Y., Ye, C., Yu, C., Zhang, F., Zheng, H., Zhu, H., Marth, G. T., Garrison, E. P., Kural, D., Lee, W. P., Leong, W. F., Ward, A. N., Wu, J., Zhang, M., Lee, C., Griffin, L., Hsieh, C. H., Mills, R. E., Shi, X., von Grotthuss, M., Zhang, C., Daly, M. J., Depristo, M. A., Altshuler, D. M., Banks, E., Bhatia, G., Carneiro, M. O., Del Angel, G., Gabriel, S. B., Genovese, G., Gupta, N., Handsaker, R. E., Hartl, C., Lander, E. S., McCarroll, S. A., Nemesh, J. C., Poplin, R. E., Schaffner, S. F., Shakir, K., Yoon, S. C., Lihm, J., Makarov, V., Jin, H., Kim, W., Kim, K. C., Korbel, J. O., Rausch, T., Flicek, P., Beal, K., Clarke, L., Cunningham, F., Herrero, J., McLaren, W. M., Ritchie, G. R., Smith, R. E., Zheng-Bradley, X., Clark, A. G., Gottipati, S., Keinan, A., Rodriguez-Flores, J. L., Sabeti, P. C., Grossman, S. R., Tabrizi, S., Tariyal, R., Cooper, D. N., Ball, E. V., Stenson, P. D., Bentley, D. R., Barnes, B., Bauer, M., Cheetham, R., Cox, T., Eberle, M., Humphray, S., Kahn, S., Murray, L., Peden, J., Shaw, R., Ye, K., Batzer, M. A., Konkel, M. K., Walker, J. A., Macarthur, D. G., Lek, M., Sudbrak, R., Amstislavskiy, V. S., Herwig, R., Shriver, M. D., Bustamante, C. D., Byrnes, J. K., De La Vega, F. M., Gravel, S., Kenny, E. E., Kidd, J. M., Lacroute, P., Maples, B. K., Moreno-Estrada, A., Zakharia, F., Halperin, E., Baran, Y., Craig, D. W., Christoforides, A., Homer, N., Izatt, T., Kurdoglu, A. A., Sinari, S. A., Squire, K., Sherry, S. T., Xiao, C., Sebat, J., Bafna, V., Ye, K., Burchard, E. G., Hernandez, R. D., Gignoux, C. R., Haussler, D., Katzman, S. J., Kent, W. J., Howie, B., Ruiz-Linares, A., Dermitzakis, E. T., Lappalainen, T., Devine, S. E., Liu, X., Maroo, A., Tallon, L. J., Rosenfeld, J. A., Michelson, L. P., Anderson, P., Angius, A., Bigham, A., Blackwell, T., Busonero, F., Cucca, F., Fuchsberger, C., Jones, C., Li, Y., Lyons, R., Maschio, A., Porcu, E., Reinier, F., Sanna, S., Schlessinger, D., Sidore, C., Tan, A., Trost, M. K., Awadalla, P., Hodgkinson, A., Lunter, G., McVean, G. A., Marchini, J. L., Myers, S., Churchhouse, C., Delaneau, O., Gupta-Hinch, A., Iqbal, Z., Mathieson, I., Rimmer, A., Xifara, D. K., Oleksyk, T. K., Fu, Y., Liu, X., Xiong, M., Jorde, L., Witherspoon, D., Xing, J., Browning, B. L., Alkan, C., Hajirasouliha, I., Hormozdiari, F., Ko, A., Sudmant, P. H., Mardis, E. R., Chen, K., Chinwalla, A., Ding, L., Dooling, D., Koboldt, D. C., McLellan, M. D., Wallis, J. W., Wendl, M. C., Zhang, Q., Durbin, R. M., Hurles, M. E., Tyler-Smith, C., Albers, C. A., Ayub, Q., Balasubramaniam, S., Chen, Y., Coffey, A. J., Colonna, V., Danecek, P., Huang, N., Jostins, L., Keane, T. M., Li, H., McCarthy, S., Scally, A., Stalker, J., Walter, K., Xue, Y., Zhang, Y., Gerstein, M. B., Abyzov, A., Balasubramanian, S., Chen, J., Clarke, D., Fu, Y., Habegger, L., Harmanci, A. O., Jin, M., Khurana, E., Mu, X. J., Sisu, C., Li, Y., Luo, R., Zhu, H., Lee, C., Griffin, L., Hsieh, C. H., Mills, R. E., Shi, X., von Grotthuss, M., Zhang, C., Marth, G. T., Garrison, E. P., Kural, D., Lee, W. P., Ward, A. N., Wu, J., Zhang, M., McCarroll, S. A., Altshuler, D. M., Banks, E., Del Angel, G., Genovese, G., Handsaker, R. E., Hartl, C., Nemesh, J. C., Shakir, K., Yoon, S. C., Lihm, J., Makarov, V., Degenhardt, J., Flicek, P., Clarke, L., Smith, R. E., Zheng-Bradley, X., Korbel, J. O., Rausch, T., Stütz, A. M., Bentley, D. R., Barnes, B., Cheetham, R., Eberle, M., Humphray, S., Kahn, S., Murray, L., Shaw, R., Ye, K., Batzer, M. A., Konkel, M. K., Walker, J. A., Lacroute, P., Craig, D. W., Homer, N., Church, D., Xiao, C., Sebat, J., Bafna, V., Michaelson, J. J., Ye, K., Devine, S. E., Liu, X., Maroo, A., Tallon, L. J., Lunter, G., McVean, G. A., Iqbal, Z., Witherspoon, D., Xing, J., Eichler, E. E., Alkan, C., Hajirasouliha, I., Hormozdiari, F., Ko, A., Sudmant, P. H., Chen, K., Chinwalla, A., Ding, L., McLellan, M. D., Wallis, J. W., Hurles, M. E., Blackburne, B., Li, H., Lindsay, S. J., Ning, Z., Scally, A., Walter, K., Zhang, Y., Gerstein, M. B., Abyzov, A., Chen, J., Clarke, D., Khurana, E., Mu, X. J., Sisu, C., Gibbs, R. A., Yu, F., Bainbridge, M., Challis, D., Evani, U. S., Kovar, C., Lewis, L., Lu, J., Muzny, D., Nagaswamy, U., Reid, J., Sabo, A., Yu, J., Guo, X., Li, Y., Wu, R., Marth, G. T., Garrison, E. P., Leong, W. F., Ward, A. N., Del Angel, G., Depristo, M. A., Gabriel, S. B., Gupta, N., Hartl, C., Poplin, R. E., Clark, A. G., Rodriguez-Flores, J. L., Flicek, P., Clarke, L., Smith, R. E., Zheng-Bradley, X., Macarthur, D. G., Bustamante, C. D., Gravel, S., Craig, D. W., Christoforides, A., Homer, N., Izatt, T., Sherry, S. T., Xiao, C., Dermitzakis, E., Abecasis, G. R., Kang, H. M., McVean, G. A., Mardis, E. R., Dooling, D., Fulton, L., Fulton, R., Koboldt, D. C., Durbin, R. M., Balasubramaniam, S., Keane, T. M., McCarthy, S., Stalker, J., Gerstein, M. B., Balasubramanian, S., Habegger, L., Garrison, E. P., Gibbs, R. A., Bainbridge, M., Muzny, D., Yu, F., Yu, J., Del Angel, G., Handsaker, R. E., Makarov, V., Rodriguez-Flores, J. L., Jin, H., Kim, W., Kim, K. C., Flicek, P., Beal, K., Clarke, L., Cunningham, F., Herrero, J., McLaren, W. M., Ritchie, G. R., Zheng-Bradley, X., Tabrizi, S., Macarthur, D. G., Lek, M., Bustamante, C. D., De La Vega, F. M., Craig, D. W., Kurdoglu, A. A., Lappalainen, T., Rosenfeld, J. A., Michelson, L. P., Awadalla, P., Hodgkinson, A., McVean, G. A., Chen, K., Tyler-Smith, C., Chen, Y., Colonna, V., Frankish, A., Harrow, J., Xue, Y., Gerstein, M. B., Abyzov, A., Balasubramanian, S., Chen, J., Clarke, D., Fu, Y., Harmanci, A. O., Jin, M., Khurana, E., Mu, X. J., Sisu, C., Gibbs, R. A., Kovar, C., Kalra, D., Hale, W., Fowler, G., Muzny, D., Reid, J., Wang, J., Guo, X., Li, G., Li, Y., Zheng, X., Altshuler, D. M., Flicek, P., Clarke, L., Barker, J., Kelman, G., Kulesha, E., Leinonen, R., McLaren, W. M., Radhakrishnan, R., Roa, A., Smirnov, D., Smith, R. E., Streeter, I., Toneva, I., Vaughan, B., Zheng-Bradley, X., Bentley, D. R., Cox, T., Humphray, S., Kahn, S., Sudbrak, R., Albrecht, M. W., Lienhard, M., Craig, D. W., Izatt, T., Kurdoglu, A. A., Sherry, S. T., Ananiev, V., Belaia, Z., Beloslyudtsev, D., Bouk, N., Chen, C., Church, D., Cohen, R., Cook, C., Garner, J., Hefferon, T., Kimelman, M., Liu, C., Lopez, J., Meric, P., O'sullivan, C., Ostapchuk, Y., Ponomarov, S., Schneider, V., Shekhtman, E., Sirotkin, K., Slotta, D., Xiao, C., Zhang, H., Haussler, D., Abecasis, G. R., McVean, G. A., Alkan, C., Ko, A., Dooling, D., Durbin, R. M., Balasubramaniam, S., Keane, T. M., McCarthy, S., Stalker, J., Chakravarti, A., Abecasis, G. R., Barnes, K. C., Beiswanger, C., Burchard, E., Bustamante, C. D., Cai, H., Cao, H., Durbin, R. M., Gharani, N., Gibbs, R. A., Gignoux, C. R., Gravel, S., Henn, B., Jones, D., Jorde, L., Kaye, J. S., Keinan, A., Kent, A., Kerasidou, A., Li, Y., Mathias, R., McVean, G., Moreno-Estrada, A., Ossorio, P. N., Parker, M., Reich, D., Rotimi, C. N., Royal, C. D., Sandoval, K., Su, Y., Sudbrak, R., Tian, Z., Timmermann, B., Tishkoff, S., Toji, L. H., Tyler-Smith, C., Via, M., Wang, Y., Yang, H., Yang, L., Zhu, J., Bodmer, W., Bedoya, G., Ruiz-Linares, A., Ming, C. Z., Yang, G., You, C. J., Peltonen, L., Garcia-Montero, A., Orfao, A., Dutil, J., Martinez-Cruzado, J. C., Oleksyk, T. K., Brooks, L. D., Felsenfeld, A. L., McEwen, J. E., Clemm, N. C., Duncanson, A., Dunn, M., Green, E. D., Guyer, M. S. & Peterson, J. L., Jun 30 2014, In: Genome biology. 15, 6, R88.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    59 Scopus citations
  • Integrated analysis of germline and somatic variants in ovarian cancer

    Kanchi, K. L., Johnson, K. J., Lu, C., McLellan, M. D., Leiserson, M. D. M., Wendl, M. C., Zhang, Q., Koboldt, D. C., Xie, M., Kandoth, C., McMichael, J. F., Wyczalkowski, M. A., Larson, D. E., Schmidt, H. K., Miller, C. A., Fulton, R. S., Spellman, P. T., Mardis, E. R., Druley, T. E. & Graubert, T. A. & 4 others, Goodfellow, P. J., Raphael, B. J., Wilson, R. K. & Ding, L., Jan 22 2014, In: Nature communications. 5, 3156.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    234 Scopus citations
  • Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel

    Delaneau, O., Marchini, J., McVeanh, G. A., Donnelly, P., Lunter, G., Marchini, J. L., Myers, S., Gupta-Hinch, A., Iqbal, Z., Mathieson, I., Rimmer, A., Xifara, D. K., Kerasidou, A., Churchhouse, C., Altshuler, D. M., Gabriel, S. B., Lander, E. S., Gupta, N., Daly, M. J. & DePristo, M. A. & 363 others, Banks, E., Bhatia, G., Carneiro, M. O., Del Angel, G., Genovese, G., Handsaker, R. E., Hartl, C., McCarroll, S. A., Nemesh, J. C., Poplin, R. E., Schaffner, S. F., Shakir, K., Sabeti, P. C., Grossman, S. R., Tabrizi, S., Tariyal, R., Li, H., Reich, D., Durbin, R. M., Hurles, M. E., Balasubramaniam, S., Burton, J., Danecek, P., Keane, T. M., Kolb-Kokocinski, A., McCarthy, S., Stalker, J., Quail, M., Ayub, Q., Chen, Y., Coffey, A. J., Colonna, V., Huang, N., Jostins, L., Scally, A., Walter, K., Xue, Y., Zhang, Y., Blackburne, B., Lindsay, S. J., Ning, Z., Frankish, A., Harrow, J., Chris, T. S., Abecasis, G. R., Kang, H. M., Anderson, P., Blackwell, T., Busonero, F., Fuchsberger, C., Jun, G., Maschio, A., Porcu, E., Sidore, C., Tan, A., Trost, M. K., Bentley, D. R., Grocock, R., Humphray, S., James, T., Kingsbury, Z., Bauer, M., Cheetham, R. K., Cox, T., Eberle, M., Murray, L., Shaw, R., Chakravarti, A., Clark, A. G., Keinan, A., Rodriguez-Flores, J. L., De LaVega, F. M., Degenhardt, J., Eichler, E. E., Flicek, P., Clarke, L., Leinonen, R., Smith, R. E., Zheng-Bradley, X., Beal, K., Cunningham, F., Herrero, J., McLaren, W. M., Ritchie, G. R. S., Barker, J., Kelman, G., Kulesha, E., Radhakrishnan, R., Roa, A., Smirnov, D., Streeter, I., Toneva, I., Gibbs, R. A., Dinh, H., Kovar, C., Lee, S., Lewis, L., Muzny, D., Reid, J., Wang, M., Yu, F., Bainbridge, M., Challis, D., Evani, U. S., Lu, J., Nagaswamy, U., Sabo, A., Wang, Y., Yu, J., Fowler, G., Hale, W., Kalra, D., Green, E. D., Knoppers, B. M., Korbel, J. O., Rausch, T., Sttz, A. M., Lee, C., Griffin, L., Hsieh, C. H., Mills, R. E., Von Grotthuss, M., Zhang, C., Shi, X., Lehrach, H., Sudbrak, R., Amstislavskiy, V. S., Lienhard, M., Mertes, F., Sultan, M., Timmermann, B., Yaspo, M. L., Herwig, S. R., Mardis, E. R., Wilson, R. K., Fulton, L., Fulton, R., Weinstock, G. M., Chinwalla, A., Ding, L., Dooling, D., Koboldt, D. C., McLellan, M. D., Wallis, J. W., Wendl, M. C., Zhang, Q., Marth, G. T., Garrison, E. P., Kural, D., Lee, W. P., Leong, W. F., Ward, A. N., Wu, J., Zhang, M., Nickerson, D. A., Alkan, C., Hormozdiari, F., Ko, A., Sudmant, P. H., Schmidt, J. P., Davies, C. J., Gollub, J., Webster, T., Wong, B., Zhan, Y., Sherry, S. 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G., Lek, M., Shriver, M. D., Bustamante, C. D., Gravel, S., Kenny, E. E., Kidd, J. M., Lacroute, P., Maples, B. K., Moreno-Estrada, A., Zakharia, F., Henn, B., Sandoval, K., Byrnes, J. K., Halperin, E., Baran, Y., Craig, D. W., Christoforides, A., Izatt, T., Kurdoglu, A. A., Sinari, S. A., Homer, N., Squire, K., Sebat, J., Bafna, V., Ye, K., Burchard, E. G., Hernandez, R. D., Gignoux, C. R., Haussler, D., Katzman, S. J., Kent, W. J., Howie, B., Ruiz-Linares, A., Dermitzakis, E. T., Lappalainen, T., Devine, S. E., Liu, X., Maroo, A., Tallon, L. J., Rosenfeld, J. A., Michelson, L. P., Angius, A., Cucca, F., Sanna, S., Bigham, A., Jones, C., Reinier, F., Li, Y., Lyons, R., Schlessinger, D., Awadalla, P., Hodgkinson, A., Oleksyk, T. K., Martinez-Cruzado, J. C., Fu, Y., Liu, X., Xiong, M., Jorde, L., Witherspoon, D., Xing, J., Browning, B. L., Hajirasouliha, I., Chen, K., Albers, C. A., Gerstein, M. B., Abyzov, A., Chen, J., Fu, Y., Habegger, L., Harmanci, A. O., Mu, X. J., Sisu, C., Balasubramanian, S., Jin, M., Khurana, E., Clarke, D., Michaelson, J. J., OSullivan, C., Barnes, K. C., Gharani, N., Toji, L. H., Gerry, N., Kaye, J. S., Kent, A., Mathias, R., Ossorio, P. N., Parker, M., Rotimi, C. N., Royal, C. D., Tishkoff, S., Via, M., Bodmer, W., Bedoya, G., Yang, G., You, C. J., Garcia-Montero, A., Orfao, A., Dutil, J., Brooks, L. D., Felsenfeld, A. L., McEwen, J. E., Clemm, N. C., Guyer, M. S., Peterson, J. L., Duncanson, A., Dunn, M. & Peltonen, L., Jun 13 2014, In: Nature communications. 5, 3934.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    287 Scopus citations
  • MSIsensor: Microsatellite instability detection using paired tumor-normal sequence data

    Niu, B., Ye, K., Zhang, Q., Lu, C., Xie, M., McLellan, M. D., Wendl, M. C. & Ding, L., Apr 1 2014, In: Bioinformatics. 30, 7, p. 1015-1016 2 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    532 Scopus citations
  • Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin

    The Cancer Genome Atlas Research Network, Aug 14 2014, In: Cell. 158, 4, p. 929-944 16 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    1125 Scopus citations
  • Predicting structure and stability for RNA complexes with intermolecular loop - Loop base-pairing

    Cao, S., Xu, X. & Chen, S. J., Jun 2014, In: RNA. 20, 6, p. 835-845 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    18 Scopus citations
  • Proteogenomic characterization of human colon and rectal cancer

    Zhang, B., Wang, J., Wang, X., Zhu, J., Liu, Q., Shi, Z., Chambers, M. C., Zimmerman, L. J., Shaddox, K. F., Kim, S., Davies, S. R., Wang, S., Wang, P., Kinsinger, C. R., Rivers, R. C., Rodriguez, H., Townsend, R. R., Ellis, M. J. C., Carr, S. A. & Tabb, D. L. & 44 others, Coffey, R. J., Slebos, R. J. C., Liebler, D. C., Gillette, M. A., Klauser, K. R., Kuhn, E., Mani, D. R., Mertins, P., Ketchum, K. A., Paulovich, A. G., Whiteaker, J. R., Edwards, N. J., McGarvey, P. B., Madhavan, S., Chan, D., Pandey, A., Shih, I. M., Zhang, H., Zhang, Z., Zhu, H., Whiteley, G. A., Skates, S. J., White, F. M., Levine, D. A., Boja, E. S., Hiltke, T., Mesri, M., Shaw, K. M., Stein, S. E., Fenyo, D., Liu, T., McDermott, J. E., Payne, S. H., Rodland, K. D., Smith, R. D., Rudnick, P., Snyder, M., Zhao, Y., Chen, X., Ransohoff, D. F., Hoofnagle, A. N., Sanders, M. E., Wang, Y. & Ding, L., Sep 18 2014, In: Nature. 513, 7518, p. 382-387 6 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    1071 Scopus citations
  • Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma

    Chen, X., Bahrami, A., Pappo, A., Easton, J., Dalton, J., Hedlund, E., Ellison, D., Shurtleff, S., Wu, G., Wei, L., Parker, M., Rusch, M., Nagahawatte, P., Wu, J., Mao, S., Boggs, K., Mulder, H., Yergeau, D., Lu, C. & Ding, L. & 11 others, Edmonson, M., Qu, C., Wang, J., Li, Y., Navid, F., Daw, N. C., Mardis, E. R., Wilson, R. K., Downing, J. R., Zhang, J. & Dyer, M. A., Oct 4 2014, In: Cell Reports. 7, 1, p. 104-112 9 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    541 Scopus citations
  • Re-sequencing Expands Our Understanding of the Phenotypic Impact of Variants at GWAS Loci

    Service, S. K., Teslovich, T. M., Fuchsberger, C., Ramensky, V., Yajnik, P., Koboldt, D. C., Larson, D. E., Zhang, Q., Lin, L., Welch, R., Ding, L., McLellan, M. D., O'Laughlin, M., Fronick, C., Fulton, L. L., Magrini, V., Swift, A., Elliott, P., Jarvelin, M. R. & Kaakinen, M. & 14 others, McCarthy, M. I., Peltonen, L., Pouta, A., Bonnycastle, L. L., Collins, F. S., Narisu, N., Stringham, H. M., Tuomilehto, J., Ripatti, S., Fulton, R. S., Sabatti, C., Wilson, R. K., Boehnke, M. & Freimer, N. B., Jan 2014, In: PLoS genetics. 10, 1, e1004147.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    46 Scopus citations
  • SciClone: Inferring Clonal Architecture and Tracking the Spatial and Temporal Patterns of Tumor Evolution

    Miller, C. A., White, B. S., Dees, N. D., Griffith, M., Welch, J. S., Griffith, O. L., Vij, R., Tomasson, M. H., Graubert, T. A., Walter, M. J., Ellis, M. J., Schierding, W., DiPersio, J. F., Ley, T. J., Mardis, E. R., Wilson, R. K. & Ding, L., Aug 7 2014, In: PLoS computational biology. 10, 8, e1003665.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    337 Scopus citations
  • Simple and accurate methods for quantifying deformation, disruption, and development in biological tissues

    Boyle, J. J., Kume, M., Wyczalkowski, M. A., Taber, L. A., Pless, R. B., Xia, Y., Genin, G. M. & Thomopoulos, S., Nov 6 2014, In: Journal of the Royal Society Interface. 11, 100, 0685.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    28 Scopus citations
  • Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia

    Roberts, K. G., Li, Y., Payne-Turner, D., Harvey, R. C., Yang, Y. L., Pei, D., McCastlain, K., Ding, L., Lu, C., Song, G., Ma, J., Becksfort, J., Rusch, M., Chen, S. C., Easton, J., Cheng, J., Boggs, K., Santiago-Morales, N., Iacobucci, I. & Fulton, R. S. & 54 others, Wen, J., Valentine, M., Cheng, C., Paugh, S. W., Devidas, M., Chen, I. M., Reshmi, S., Smith, A., Hedlund, E., Gupta, P., Nagahawatte, P., Wu, G., Chen, X., Yergeau, D., Vadodaria, B., Mulder, H., Winick, N. J., Larsen, E. C., Carroll, W. L., Heerema, N. A., Carroll, A. J., Grayson, G., Tasian, S. K., Moore, A. S., Keller, F., Frei-Jones, M., Whitlock, J. A., Raetz, E. A., White, D. L., Hughes, T. P., Guidry Auvil, J. M., Smith, M. A., Marcucci, G., Bloomfield, C. D., Mrózek, K., Kohlschmidt, J., Stock, W., Kornblau, S. M., Konopleva, M., Paietta, E., Pui, C. H., Jeha, S., Relling, M. V., Evans, W. E., Gerhard, D. S., Gastier-Foster, J. M., Mardis, E., Wilson, R. K., Loh, M. L., Downing, J. R., Hunger, S. P., Willman, C. L., Zhang, J. & Mullighan, C. G., Sep 11 2014, In: New England Journal of Medicine. 371, 11, p. 1005-1015 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    1092 Scopus citations
  • The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma

    Wu, G., Diaz, A. K., Paugh, B. S., Rankin, S. L., Ju, B., Li, Y., Zhu, X., Qu, C., Chen, X., Zhang, J., Easton, J., Edmonson, M., Ma, X., Lu, C., Nagahawatte, P., Hedlund, E., Rusch, M., Pounds, S., Lin, T. & Onar-Thomas, A. & 27 others, Huether, R., Kriwacki, R., Parker, M., Gupta, P., Becksfort, J., Wei, L., Mulder, H. L., Boggs, K., Vadodaria, B., Yergeau, D., Russell, J. C., Ochoa, K., Fulton, R. S., Fulton, L. L., Jones, C., Boop, F. A., Broniscer, A., Wetmore, C., Gajjar, A., Ding, L., Mardis, E. R., Wilson, R. K., Taylor, M. R., Downing, J. R., Ellison, D. W., Zhang, J. & Baker, S. J., May 2014, In: Nature Genetics. 46, 5, p. 444-450 7 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    796 Scopus citations
  • The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes

    Huether, R., Dong, L., Chen, X., Wu, G., Parker, M., Wei, L., Ma, J., Edmonson, M. N., Hedlund, E. K., Rusch, M. C., Shurtleff, S. A., Mulder, H. L., Boggs, K., Vadordaria, B., Cheng, J., Yergeau, D., Song, G., Becksfort, J., Lemmon, G. & Weber, C. & 19 others, Cai, Z., Dang, J., Walsh, M., Gedman, A. L., Faber, Z., Easton, J., Gruber, T., Kriwacki, R. W., Partridge, J. F., Ding, L., Wilson, R. K., Mardis, E. R., Mullighan, C. G., Gilbertson, R. J., Baker, S. J., Zambetti, G., Ellison, D. W., Zhang, J. & Downing, J. R., Apr 8 2014, In: Nature communications. 5, 3630.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    311 Scopus citations
  • TIGRA: A targeted iterative graph routing assembler for breakpoint assembly

    Chen, K., Chen, L., Fan, X., Wallis, J., Ding, L. & Weinstock, G., Feb 2014, In: Genome research. 24, 2, p. 310-317 8 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    65 Scopus citations
  • 2013

    Activating HER2 mutations in HER2 gene amplification negative breast cancer

    Bose, R., Kavuri, S. M., Searleman, A. C., Shen, W., Shen, D., Koboldt, D. C., Monsey, J., Goel, N., Aronson, A. B., Li, S., Ma, C. X., Ding, L., Mardis, E. R. & Ellis, M. J., 2013, In: Cancer discovery. 3, 2, p. 224-237 14 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    674 Scopus citations
  • Advances for studying clonal evolution in cancer

    Ding, L., Raphael, B. J., Chen, F. & Wendl, M. C., Nov 1 2013, In: Cancer Letters. 340, 2, p. 212-219 8 p.

    Research output: Contribution to journalReview articlepeer-review

    Open Access
    55 Scopus citations
  • BreakTrans: Uncovering the genomic architecture of gene fusions

    Chen, K., Navin, N. E., Wang, Y., Schmidt, H. K., Wallis, J. W., Niu, B., Fan, X., Zhao, H., McLellan, M. D., Hoadley, K. A., Mardis, E. R., Ley, T. J., Perou, C. M., Wilson, R. K. & Ding, L., Aug 23 2013, In: Genome biology. 14, 8, R87.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    20 Scopus citations
  • Clonal diversity of recurrently mutated genes in myelodysplastic syndromes

    Walter, M. J., Shen, D., Shao, J., Ding, L., White, B., Kandoth, C., Miller, C. A., Niu, B., McLellan, M. D., Dees, N. D., Fulton, R., Elliot, K., Heath, S., Grillot, M., Westervelt, P., Link, D. C., DiPersio, J. F., Mardis, E., Ley, T. J. & Wilson, R. K. & 1 others, Graubert, T. A., Jun 2013, In: Leukemia. 27, 6, p. 1275-1282 8 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    244 Scopus citations
  • Comprehensive identification of mutational cancer driver genes across 12 tumor types

    Tamborero, D., Gonzalez-Perez, A., Perez-Llamas, C., Deu-Pons, J., Kandoth, C., Reimand, J., Lawrence, M. S., Getz, G., Bader, G. D., Ding, L. & Lopez-Bigas, N., 2013, In: Scientific reports. 3, 2650.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    388 Scopus citations
  • Computational and experimental study of the mechanics of embryonic wound healing

    Wyczalkowski, M. A., Varner, V. D. & Taber, L. A., Dec 2013, In: Journal of the Mechanical Behavior of Biomedical Materials. 28, p. 125-146 22 p.

    Research output: Contribution to journalArticlepeer-review

    14 Scopus citations
  • Computational approaches to identify functional genetic variants in cancer genomes

    Gonzalez-Perez, A., Mustonen, V., Reva, B., Ritchie, G. R. S., Creixell, P., Karchin, R., Vazquez, M., Fink, J. L., Kassahn, K. S., Pearson, J. V., Bader, G. D., Boutros, P. C., Muthuswamy, L., Ouellette, B. F. F., Reimand, J., Linding, R., Shibata, T., Valencia, A., Butler, A. & Dronov, S. & 8 others, Flicek, P., Shannon, N. B., Carter, H., Li, D., Sander, C., Stuart, J. M., Stein, L. D. & Lopez-Bigas, N., Aug 2013, In: Nature Methods. 10, 8, p. 723-729 7 p.

    Research output: Contribution to journalReview articlepeer-review

    134 Scopus citations
  • Coverage theories for metagenomic DNA sequencing based on a generalization of Stevens' theorem

    Wendl, M. C., Kota, K., Weinstock, G. M. & Mitreva, M., Nov 2013, In: Journal of Mathematical Biology. 67, 5, p. 1141-1161 21 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    22 Scopus citations
  • DGIdb: Mining the druggable genome

    Griffith, M., Griffith, O. L., Coffman, A. C., Weible, J. V., Mcmichael, J. F., Spies, N. C., Koval, J., Das, I., Callaway, M. B., Eldred, J. M., Miller, C. A., Subramanian, J., Govindan, R., Kumar, R. D., Bose, R., Ding, L., Walker, J. R., Larson, D. E., Dooling, D. J. & Smith, S. M. & 3 others, Ley, T. J., Mardis, E. R. & Wilson, R. K., Dec 2013, In: Nature Methods. 10, 12, p. 1209-1210 2 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    384 Scopus citations
  • Differences that matter in cancer genomics

    Ding, L. & Wendl, M. C., Oct 2013, In: Nature Biotechnology. 31, 10, p. 892-893 2 p.

    Research output: Contribution to journalComment/debate

    3 Scopus citations
  • Endocrine-Therapy-Resistant ESR1 Variants Revealed by Genomic Characterization of Breast-Cancer-Derived Xenografts

    Li, S., Shen, D., Shao, J., Crowder, R., Liu, W., Prat, A., He, X., Liu, S., Hoog, J., Lu, C., Ding, L., Griffith, O. L., Miller, C., Larson, D., Fulton, R. S., Harrison, M., Mooney, T., McMichael, J. F., Luo, J. & Tao, Y. & 35 others, Goncalves, R., Schlosberg, C., Hiken, J. F., Saied, L., Sanchez, C., Giuntoli, T., Bumb, C., Cooper, C., Kitchens, R. T., Lin, A., Phommaly, C., Davies, S. R., Zhang, J., Kavuri, M. S., McEachern, D., Dong, Y. Y., Ma, C., Pluard, T., Naughton, M., Bose, R., Suresh, R., McDowell, R., Michel, L., Aft, R., Gillanders, W., DeSchryver, K., Wilson, R. K., Wang, S., Mills, G. B., Gonzalez-Angulo, A., Edwards, J. R., Maher, C., Perou, C. M., Mardis, E. R. & Ellis, M. J., Sep 26 2013, In: Cell Reports. 4, 6, p. 1116-1130 15 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    505 Scopus citations
  • Erratum: Differences that matter in cancer genomics (Nature Biotechnology (2013) 31 (892-893) DOI:10.1038/nbt.2715)

    Ding, L. & Wendl, M. C., Dec 1 2013, In: Nature Biotechnology. 31, 12, 1 p.

    Research output: Contribution to journalComment/debate

  • ERRATUM: Comprehensive identification of mutational cancer driver genes across 12 tumor types (Scientific Reports (2013) 3:2650 doi: 10.1038/srep02650)

    Tamborero, D., Gonzalez-Perez, A., Perez-Llamas, C., Deu-Pons, J., Kandoth, C., Reimand, J., Lawrence, M. S., Getz, G., Bader, G. D., Ding, L. & Lopez-Bigas, N., Oct 11 2013, In: Scientific reports. 3, 2952.

    Research output: Contribution to journalComment/debate

    Open Access
    3 Scopus citations
  • Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

    Ley, T. J., Miller, C., Ding, L., Raphael, B. J., Mungall, A. J., Robertson, G., Hoadley, K., Triche, T. J., Laird, P. W., Baty, J. D., Fulton, L. L., Fulton, R., Heath, S. E., Kalicki-Veizer, J., Kandoth, C., Klco, J. M., Koboldt, D. C., Kanchi, K. L., Kulkarni, S. & Lamprecht, T. L. & 119 others, Larson, D. E., Lin, G., Lu, C., McLellan, M. D., McMichael, J. F., Payton, J., Schmidt, H., Spencer, D. H., Tomasson, M. H., Wallis, J. W., Wartman, L. D., Watson, M. A., Welch, J., Wendl, M. C., Ally, A., Balasundaram, M., Birol, I., Butterfield, Y., Chiu, R., Chu, A., Chuah, E., Chun, H. J., Corbett, R., Dhalla, N., Guin, R., He, A., Hirst, C., Hirst, M., Holt, R. A., Jones, S., Karsan, A., Lee, D., Li, H. I., Marra, M. A., Mayo, M., Moore, R. A., Mungall, K., Parker, J., Pleasance, E., Plettner, P., Schein, J., Stoll, D., Swanson, L., Tam, A., Thiessen, N., Varhol, R., Wye, N., Zhao, Y., Gabriel, S., Getz, G., Sougnez, C., Zou, L., Leiserson, M. D. M., Vandin, F., Wu, H. T., Applebaum, F., Baylin, S. B., Akbani, R., Broom, B. M., Chen, K., Motter, T. C., Nguyen, K., Weinstein, J. N., Zhang, N., Ferguson, M. L., Adams, C., Black, A., Bowen, J., Gastier-Foster, J., Grossman, T., Lichtenberg, T., Wise, L., Davidsen, T., Demchok, J. A., Mills Shaw, K. R., Sheth, M., Sofia, H. J., Yang, L., Downing, J. R., Eley, G., Alonso, S., Ayala, B., Baboud, J., Backus, M., Barletta, S. P., Berton, D. L., Chu, A. L., Girshik, S., Jensen, M. A., Kahn, A., Kothiyal, P., Nicholls, M. C., Pihl, T. D., Pot, D. A., Raman, R., Sanbhadti, R. N., Snyder, E. E., Srinivasan, D., Walton, J., Wan, Y., Wang, Z., Issa, J. P. J., Beau, M. L., Carroll, M., Kantarjian, H., Kornblau, S., Bootwalla, M. S., Lai, P. H., Shen, H., Van Den Berg, D. J., Weisenberger, D. J., Link, D. C., Walter, M. J., Ozenberger, B. A., Mardis, E. R., Westervelt, P., Graubert, T. A., DiPersio, J. F. & Wilson, R. K., May 30 2013, In: New England Journal of Medicine. 368, 22, p. 2059-2074 16 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    3830 Scopus citations
  • Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif

    Hamilton, M. P., Rajapakshe, K., Hartig, S. M., Reva, B., McLellan, M. D., Kandoth, C., Ding, L., Zack, T. I., Gunaratne, P. H., Wheeler, D. A., Coarfa, C. & McGuire, S. E., 2013, In: Nature communications. 4, 2730.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    96 Scopus citations
  • Identification of Novel Viruses Using VirusHunter -- an Automated Data Analysis Pipeline

    Zhao, G., Krishnamurthy, S., Cai, Z., Popov, V. L., Travassos da Rosa, A. P., Guzman, H., Cao, S., Virgin, H. W., Tesh, R. B. & Wang, D., Oct 22 2013, In: PloS one. 8, 10, e78470.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    63 Scopus citations
  • Integrated genomic characterization of endometrial carcinoma

    Getz, G., Gabriel, S. B., Cibulskis, K., Lander, E., Sivachenko, A., Sougnez, C., Lawrence, M., Kandoth, C., Dooling, D., Fulton, R., Fulton, L., Kalicki-Veizer, J., McLellan, M. D., O'Laughlin, M., Schmidt, H., Wilson, R. K., Ye, K., Li, D., Ally, A. & Balasundaram, M. & 256 others, Birol, I., Butterfield, Y. S. N., Carlsen, R., Carter, C., Chu, A., Chuah, E., Chun, H. J. E., Dhalla, N., Guin, R., Hirst, C., Holt, R. A., Jones, S. J. M., Lee, D., Li, H. I., Marra, M. A., Mayo, M., Moore, R. A., Mungall, A. J., Plettner, P., Schein, J. E., Sipahimalani, P., Tam, A., Varhol, R. J., Gordon Robertson, A., Cherniack, A. D., Pashtan, I., Saksena, G., Onofrio, R. C., Schumacher, S. E., Tabak, B., Carter, S. L., Hernandez, B., Gentry, J., Salvesen, H. B., Ardlie, K., Winckler, W., Beroukhim, R., Meyerson, M., Hadjipanayis, A., Lee, S., Mahadeshwar, H. S., Park, P., Protopopov, A., Ren, X., Seth, S., Song, X., Tang, J., Xi, R., Yang, L., Dong, Z., Kucherlapati, R., Chin, L., Zhang, J., Todd Auman, J., Balu, S., Bodenheimer, T., Buda, E., Neil Hayes, D., Hoyle, A. P., Jefferys, S. R., Jones, C. D., Meng, S., Mieczkowski, P. A., Mose, L. E., Parker, J. S., Perou, C. M., Roach, J., Yan, S., Simons, J. V., Soloway, M. G., Tan, D., Topal, M. D., Waring, S., Wu, J., Hoadley, K. A., Baylin, S. B., Bootwalla, M. S., Lai, P. H., Triche, T. J., Van Den Berg, D. J., Weisenberger, D. J., Laird, P. W., Shen, H., Cho, J., Dicara, D., Frazer, S., Heiman, D., Jing, R., Lin, P., Mallard, W., Stojanov, P., Voet, D., Zhang, H., Zou, L., Noble, M., Reynolds, S. M., Shmulevich, I., Arman Aksoy, B., Antipin, Y., Ciriello, G., Dresdner, G., Gao, J., Gross, B., Jacobsen, A., Ladanyi, M., Reva, B., Sander, C., Sinha, R., Onur Sumer, S., Taylor, B. S., Cerami, E., Weinhold, N., Schultz, N., Shen, R., Benz, S., Goldstein, T., Haussler, D., Ng, S., Szeto, C., Stuart, J., Benz, C. C., Yau, C., Zhang, W., Annala, M., Broom, B. M., Casasent, T. D., Ju, Z., Liang, H., Liu, G., Lu, Y., Unruh, A. K., Wakefield, C., Weinstein, J. N., Zhang, N., Liu, Y., Broaddus, R., Akbani, R., Mills, G. B., Adams, C., Barr, T., Black, A. D., Bowen, J., Deardurff, J., Frick, J., Gastier-Foster, J. M., Grossman, T., Harper, H. A., Hart-Kothari, M., Helsel, C., Hobensack, A., Kuck, H., Kneile, K., Leraas, K. M., Lichtenberg, T. M., McAllister, C., Pyatt, R. E., Ramirez, N. C., Tabler, T. R., Vanhoose, N., White, P., Wise, L., Zmuda, E., Barnabas, N., Berry-Green, C., Blanc, V., Boice, L., Button, M., Farkas, A., Green, A., MacKenzie, J., Nicholson, D., Kalloger, S. E., Blake Gilks, C., Karlan, B. Y., Lester, J., Orsulic, S., Borowsky, M., Cadungog, M., Czerwinski, C., Huelsenbeck-Dill, L., Iacocca, M., Petrelli, N., Rabeno, B., Witkin, G., Nemirovich-Danchenko, E., Potapova, O., Rotin, D., Berchuck, A., Birrer, M., Disaia, P., Monovich, L., Curley, E., Gardner, J., Mallery, D., Penny, R., Dowdy, S. C., Winterhoff, B., Dao, L., Gostout, B., Meuter, A., Teoman, A., Dao, F., Olvera, N., Bogomolniy, F., Garg, K., Soslow, R. A., Abramov, M., Bartlett, J. M. S., Kodeeswaran, S., Parfitt, J., Moiseenko, F., Clarke, B. A., Goodman, M. T., Carney, M. E., Matsuno, R. K., Fisher, J., Huang, M., Kimryn Rathmell, W., Thorne, L., Van Le, L., Dhir, R., Edwards, R., Elishaev, E., Zorn, K., Goodfellow, P. J., Mutch, D., Kahn, A. B., Bell, D. W., Pollock, P. M., Wang, C., Wheeler, D., Shinbrot, E., Gordon Robertson, A., Ding, L., Blake Gilks, C., Mardis, E. R., Ayala, B., Chu, A. L., Jensen, M. A., Kothiyal, P., Pihl, T. D., Pontius, J., Pot, D. A., Snyder, E. E., Srinivasan, D., Mills Shaw, K. R., Sheth, M., Davidsen, T., Eley, G., Ferguson, M. L., Yang, L., Guyer, M. S., Ozenberger, B. A., Sofia, H. J., Gordon Robertson, A. & Levine, D. A., 2013, In: Nature. 497, 7447, p. 67-73 7 p.

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    3830 Scopus citations
  • Integrative annotation of variants from 1092 humans: Application to cancer genomics

    1000 Genomes Project Consortium, Oct 4 2013, In: Science. 342, 6154, 1235587.

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    286 Scopus citations
  • Mutational landscape and significance across 12 major cancer types

    Kandoth, C., McLellan, M. D., Vandin, F., Ye, K., Niu, B., Lu, C., Xie, M., Zhang, Q., McMichael, J. F., Wyczalkowski, M. A., Leiserson, M. D. M., Miller, C. A., Welch, J. S., Walter, M. J., Wendl, M. C., Ley, T. J., Wilson, R. K., Raphael, B. J. & Ding, L., 2013, In: Nature. 502, 7471, p. 333-339 7 p.

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    3354 Scopus citations
  • Retrotransposition of gene transcripts leads to structural variation in mammalian genomes

    Ewing, A. D., Ballinger, T. J., Earl, D., Harris, C. C., Ding, L., Wilson, R. K. & Haussler, D., Mar 13 2013, In: Genome biology. 14, 3, R22.

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    89 Scopus citations
  • Somatic neurofibromatosis type 1 (NF1) inactivation characterizes NF1-associated pilocytic astrocytoma

    Gutmann, D. H., McLellan, M. D., Hussain, I., Wallis, J. W., Fulton, L. L., Fulton, R. S., Magrini, V., Demeter, R., Wylie, T., Kandoth, C., Leonard, J. R., Guha, A., Miller, C. A., Ding, L. & Mardis, E. R., Mar 2013, In: Genome research. 23, 3, p. 431-439 9 p.

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  • Targeting Oxidative Stress in Embryonal Rhabdomyosarcoma

    Chen, X., Stewart, E., Shelat, A. A., Qu, C., Bahrami, A., Hatley, M., Wu, G., Bradley, C., McEvoy, J., Pappo, A., Spunt, S., Valentine, M. B., Valentine, V., Krafcik, F., Lang, W. H., Wierdl, M., Tsurkan, L., Tolleman, V., Federico, S. M. & Morton, C. & 26 others, Lu, C., Ding, L., Easton, J., Rusch, M., Nagahawatte, P., Wang, J., Parker, M., Wei, L., Hedlund, E., Finkelstein, D., Edmonson, M., Shurtleff, S., Boggs, K., Mulder, H., Yergeau, D., Skapek, S., Hawkins, D. S., Ramirez, N., Potter, P. M., Sandoval, J. A., Davidoff, A. M., Mardis, E. R., Wilson, R. K., Zhang, J., Downing, J. R. & Dyer, M. A., Dec 9 2013, In: Cancer Cell. 24, 6, p. 710-724 15 p.

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    241 Scopus citations
  • The cancer genome atlas pan-cancer analysis project

    Weinstein, J. N., Collisson, E. A., Mills, G. B., Shaw, K. R. M., Ozenberger, B. A., Ellrott, K., Sander, C., Stuart, J. M., Chang, K., Creighton, C. J., Davis, C., Donehower, L., Drummond, J., Wheeler, D., Ally, A., Balasundaram, M., Birol, I., Butterfield, Y. S. N., Chu, A. & Chuah, E. & 316 others, Chun, H. J. E., Dhalla, N., Guin, R., Hirst, M., Hirst, C., Holt, R. A., Jones, S. J. M., Lee, D., Li, H. I., Marra, M. A., Mayo, M., Moore, R. A., Mungall, A. J., Robertson, A. G., Schein, J. E., Sipahimalani, P., Tam, A., Thiessen, N., Varhol, R. J., Beroukhim, R., Bhatt, A. S., Brooks, A. N., Cherniack, A. D., Freeman, S. S., Gabriel, S. B., Helman, E., Jung, J., Meyerson, M., Ojesina, A. I., Pedamallu, C. S., Saksena, G., Schumacher, S. E., Tabak, B., Zack, T., Lander, E. S., Bristow, C. A., Hadjipanayis, A., Haseley, P., Kucherlapati, R., Lee, S., Lee, E., Luquette, L. J., Mahadeshwar, H. S., Pantazi, A., Parfenov, M., Park, P. J., Protopopov, A., Ren, X., Santoso, N., Seidman, J., Seth, S., Song, X., Tang, J., Xi, R., Xu, A. W., Yang, L., Zeng, D., Auman, J. T., Balu, S., Buda, E., Fan, C., Hoadley, K. A., Jones, C. D., Meng, S., Mieczkowski, P. A., Parker, J. S., Perou, C. M., Roach, J., Shi, Y., Silva, G. O., Tan, D., Veluvolu, U., Waring, S., Wilkerson, M. D., Wu, J., Zhao, W., Bodenheimer, T., Hayes, D. N., Hoyle, A. P., Jeffreys, S. R., Mose, L. E., Simons, J. V., Soloway, M. G., Baylin, S. B., Berman, B. P., Bootwalla, M. S., Danilova, L., Herman, J. G., Hinoue, T., Laird, P. W., Rhie, S. K., Shen, H., Triche, T., Weisenberger, D. J., Carter, S. L., Cibulskis, K., Chin, L., Zhang, J., Sougnez, C., Wang, M., Getz, G., Dinh, H., Doddapaneni, H. V., Gibbs, R., Gunaratne, P., Han, Y., Kalra, D., Kovar, C., Lewis, L., Morgan, M., Morton, D., Muzny, D., Reid, J., Xi, L., Cho, J., Dicara, D., Frazer, S., Gehlenborg, N., Heiman, D. I., Kim, J., Lawrence, M. S., Lin, P., Liu, Y., Noble, M. S., Stojanov, P., Voet, D., Zhang, H., Zou, L., Stewart, C., Bernard, B., Bressler, R., Eakin, A., Iype, L., Knijnenburg, T., Kramer, R., Kreisberg, R., Leinonen, K., Lin, J., Liu, Y., Miller, M., Reynolds, S. M., Rovira, H., Shmulevich, I., Thorsson, V., Yang, D., Zhang, W., Amin, S., Wu, C. J., Wu, C. C., Akbani, R., Aldape, K., Baggerly, K. A., Broom, B., Casasent, T. D., Cleland, J., Dodda, D., Edgerton, M., Han, L., Herbrich, S. M., Ju, Z., Kim, H., Lerner, S., Li, J., Liang, H., Liu, W., Lorenzi, P. L., Lu, Y., Melott, J., Nguyen, L., Su, X., Verhaak, R., Wang, W., Wong, A., Yang, Y., Yao, J., Yao, R., Yoshihara, K., Yuan, Y., Yung, A. K., Zhang, N., Zheng, S., Ryan, M., Kane, D. W., Aksoy, B. A., Ciriello, G., Dresdner, G., Gao, J., Gross, B., Jacobsen, A., Kahles, A., Ladanyi, M., Lee, W., Lehmann, K. V., Miller, M. L., Ramirez, R., Rätsch, G., Reva, B., Schultz, N., Senbabaoglu, Y., Shen, R., Sinha, R., Sumer, S. O., Sun, Y., Taylor, B. S., Weinhold, N., Fei, S., Spellman, P., Benz, C., Carlin, D., Cline, M., Craft, B., Goldman, M., Haussler, D., Ma, S., Ng, S., Paull, E., Radenbaugh, A., Salama, S., Sokolov, A., Swatloski, T., Uzunangelov, V., Waltman, P., Yau, C., Zhu, J., Hamilton, S. R., Abbott, S., Abbott, R., Dees, N. D., Delehaunty, K., Ding, L., Dooling, D. J., Eldred, J. M., Fronick, C. C., Fulton, R., Fulton, L. L., Kalicki-Veizer, J., Kanchi, K. L., Kandoth, C., Koboldt, D. C., Larson, D. E., Ley, T. J., Lin, L., Lu, C., Magrini, V. J., Mardis, E. R., McLellan, M. D., McMichael, J. F., Miller, C. A., O'Laughlin, M., Pohl, C., Schmidt, H., Smith, S. M., Walker, J., Wallis, J. W., Wendl, M. C., Wilson, R. K., Wylie, T., Zhang, Q., Burton, R., Jensen, M. A., Kahn, A., Pihl, T., Pot, D., Wan, Y., Levine, D. A., Black, A. D., Bowen, J., Frick, J., Gastier-Foster, J. M., Harper, H. A., Helsel, C., Leraas, K. M., Lichtenberg, T. M., McAllister, C., Ramirez, N. C., Sharpe, S., Wise, L., Zmuda, E., Chanock, S. J., Davidsen, T., Demchok, J. A., Eley, G., Felau, I., Sheth, M., Sofia, H., Staudt, L., Tarnuzzer, R., Wang, Z., Yang, L., Zhang, J., Omberg, L., Margolin, A., Raphael, B. J., Vandin, F., Wu, H. T., Leiserson, M. D. M., Benz, S. C., Vaske, C. J., Noushmehr, H., Wolf, D., Veer, L. V. T., Anastassiou, D., Yang, T. H. O., Lopez-Bigas, N., Gonzalez-Perez, A., Tamborero, D., Xia, Z., Li, W., Cho, D. Y., Przytycka, T., Hamilton, M., McGuire, S., Nelander, S., Johansson, P., Jörnsten, R. & Kling, T., Oct 1 2013, In: Nature Genetics. 45, 10, p. 1113-1120 8 p.

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    5378 Scopus citations
  • The genomic landscape of hypodiploid acute lymphoblastic leukemia

    Holmfeldt, L., Wei, L., Diaz-Flores, E., Walsh, M., Zhang, J., Ding, L., Payne-Turner, D., Churchman, M., Andersson, A., Chen, S. C., Mccastlain, K., Becksfort, J., Ma, J., Wu, G., Patel, S. N., Heatley, S. L., Phillips, L. A., Song, G., Easton, J. & Parker, M. & 43 others, Chen, X., Rusch, M., Boggs, K., Vadodaria, B., Hedlund, E., Drenberg, C., Baker, S., Pei, D., Cheng, C., Huether, R., Lu, C., Fulton, R. S., Fulton, L. L., Tabib, Y., Dooling, D. J., Ochoa, K., Minden, M., Lewis, I. D., To, L. B., Marlton, P., Roberts, A. W., Raca, G., Stock, W., Neale, G., Drexler, H. G., Dickins, R. A., Ellison, D. W., Shurtleff, S. A., Pui, C. H., Ribeiro, R. C., Devidas, M., Carroll, A. J., Heerema, N. A., Wood, B., Borowitz, M. J., Gastier-Foster, J. M., Raimondi, S. C., Mardis, E. R., Wilson, R. K., Downing, J. R., Hunger, S. P., Loh, M. L. & Mullighan, C. G., Mar 2013, In: Nature Genetics. 45, 3, p. 242-252 11 p.

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    533 Scopus citations
  • The somatic genomic landscape of glioblastoma

    TCGA Research Network, Oct 10 2013, In: Cell. 155, 2, p. 462 1 p.

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    3596 Scopus citations
  • Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas

    Zhang, J., Wu, G., Miller, C. P., Tatevossian, R. G., Dalton, J. D., Tang, B., Orisme, W., Punchihewa, C., Parker, M., Qaddoumi, I., Boop, F. A., Lu, C., Kandoth, C., Ding, L., Lee, R., Huether, R., Chen, X., Hedlund, E., Nagahawatte, P. & Rusch, M. & 28 others, Boggs, K., Cheng, J., Becksfort, J., Ma, J., Song, G., Li, Y., Wei, L., Wang, J., Shurtleff, S., Easton, J., Zhao, D., Fulton, R. S., Fulton, L. L., Dooling, D. J., Vadodaria, B., Mulder, H. L., Tang, C., Ochoa, K., Mullighan, C. G., Gajjar, A., Kriwacki, R., Sheer, D., Gilbertson, R. J., Mardis, E. R., Wilson, R. K., Downing, J. R., Baker, S. J. & Ellison, D. W., Jun 2013, In: Nature Genetics. 45, 6, p. 602-612 11 p.

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    670 Scopus citations
  • 2012

    A domain-based model for predicting large and complex pseudoknotted structures

    Cao, S. & Chen, S. J., Feb 2012, In: RNA Biology. 9, 2, p. 201-212 12 p.

    Research output: Contribution to journalArticlepeer-review

    5 Scopus citations
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