Precision Radiotheranostics Translation Center (PRTC)

2009

Synthesis and biological evaluation of novel carbon-11 labeled pyridyl ethers: candidate ligands for in vivo imaging of α4β2 nicotinic acetylcholine receptors (α4β2-nAChRs) in the brain with positron emission tomography

Gao, Y., Ravert, H. T., Kuwabara, H., Xiao, Y., Endres, C. J., Hilton, J., Holt, D. P., Kumar, A., Alexander, M., Wong, D. F., Dannals, R. F. & Horti, A. G., Jul 1 2009, In: Bioorganic and Medicinal Chemistry. 17, 13, p. 4367-4377 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Synthesis and characterization of the copper(ii) complexes of new N ₂S₂-donor macrocyclic ligands: Synthesis and in vivo evaluation of the ⁶⁴Cu complexes

Papini, G., Alidori, S., Lewis, J. S., Reichert, D. E., Pellei, M., Lobbia, G. G., Biddlecombe, G. B., Anderson, C. J. & Santini, C., 2009, In: Dalton Transactions. 1, p. 177-184 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Synthesis and in vitro and in vivo evaluation of ¹⁸F-labeled positron emission tomography (PET) ligands for imaging the vesicular acetylcholine transporter

Tu, Z., Efange, S. M. N., Xu, J., Li, S., Jones, L. A., Parsons, S. M. & Mach, R. H., Mar 12 2009, In: Journal of Medicinal Chemistry. 52, 5, p. 1358-1369 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6

Chu, W., Rothfuss, J., Chu, Y., Zhou, D. & Mach, R. H., Apr 23 2009, In: Journal of Medicinal Chemistry. 52, 8, p. 2188-2191 4 p.

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Synthesis of 1-stannacyclopent-3-enes and their pyrolysis to stannylenes

Zhou, D., Reiche, C., Nag, M., Soderquist, J. A. & Gaspar, P. P., Apr 27 2009, In: Organometallics. 28, 8, p. 2595-2608 14 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

TH‐D‐213A‐02: An Improved Iterative Thresholding Approach for 3D PET Tumor Delineation: Phantom Study

lu, W., li, H., Yang, F., Yang, D., Laforest, R., Thorstad, W. & Low, D., Jun 2009, In: Medical physics. 36, 6, p. 2820-2821 2 p.

Research output: Contribution to journal › Article › peer-review

TH‐D‐213A‐04: Application of Supervised Spectral Clustering for PET Tumor Delineation: A Phantom Study

Yang, F., Li, H., Yang, D., Laforest, R., Thorstad, W., Low, D. & Lu, W., Jun 2009, In: Medical physics. 36, 6, 1 p.

Research output: Contribution to journal › Article › peer-review

2008

Accurate event-driven motion compensation in high-resolution PET incorporating scattered and random events

Rahmim, A., Dinelle, K., Cheng, J. C., Shilov, M. A., Segars, W. P., Lidstone, S. C., Blinder, S., Rousset, O. G., Vajihollahi, H., Tsui, B. M. W., Wong, D. F. & Sossi, V., Aug 2008, In: IEEE Transactions on Medical Imaging. 27, 8, p. 1018-1033 16 p., 4446612.

Research output: Contribution to journal › Article › peer-review

135 Scopus citations

A feasibility study of a prototype PET insert device to convert a general-purpose animal PET scanner to higher resolution

Wu, H., Pal, D., O'Sullivan, J. A. & Tai, Y. C., Jan 1 2008, In: Journal of Nuclear Medicine. 49, 1, p. 79-87 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Anhydride-functionalized fullerene: a versatile precursor for fullerene-based materials

Heo, G. S. & Moon, B., Sep 15 2008, In: Tetrahedron Letters. 49, 38, p. 5540-5543 4 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

An imaging comparison of ⁶⁴Cu-ATSM and ⁶⁰Cu-ATSM in cancer of the uterine cervix

Lewis, J. S., Laforest, R., Dehdashti, F., Grigsby, P. W., Welch, M. J. & Siegel, B. A., Jul 1 2008, In: Journal of Nuclear Medicine. 49, 7, p. 1177-1182 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

172 Scopus citations

A novel PET tumor delineation method based on adaptive region-growing and dual-front active contours

Li, H., Thorstad, W. L., Biehl, K. J., Laforest, R., Su, Y., Shoghi, K. I., Donnelly, E. D., Low, D. A. & Lu, W., 2008, In: Medical physics. 35, 8, p. 3711-3721 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

104 Scopus citations

Assessing tumor hypoxia in cervical cancer by PET with ⁶⁰Cu- labeled diacetyl-bis(N⁴-methylthiosemicarbazone)

Dehdashti, F., Grigsby, P. W., Lewis, J. S., Laforest, R., Siegel, B. A. & Welch, M. J., Feb 1 2008, In: Journal of Nuclear Medicine. 49, 2, p. 201-205 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

204 Scopus citations

Bayesian hierarchical modeling of receptor occupancy in PET trials

Vandenhende, F., Renard, D., Nie, Y., Kumar, A., Miller, J., Tauscher, J., Witcher, J., Zhou, Y. & Wong, D. F., Mar 2008, In: Journal of Biopharmaceutical Statistics. 18, 2, p. 256-272 17 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Blood levels and DA transporter occupancy of orally administered methylphenidate in juvenile rhesus monkeys measured by high resolution PET

Wilcox, K. M., Zhou, Y., Wong, D. F., Alexander, M., Rahmim, A., Hilton, J. & Weed, M. R., Dec 2008, In: Synapse. 62, 12, p. 950-952 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Design and implementation of an automated partial volume correction in PET: Application to dopamine receptor quantification in the normal human striatum

Rousset, O. G., Collins, D. L., Rahmim, A. & Wong, D. F., Jul 1 2008, In: Journal of Nuclear Medicine. 49, 7, p. 1097-1106 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

87 Scopus citations

Discovery of (-)-7-methyl-2-exo-[3′-(6-[¹⁸F]nuoropyridin- 2-yl)-5′-pyridinyl]-7-azabicyclo[2.2.1]heptane, a radiolabeled antagonist for cerebral nicotinic acetylcholine receptor (α4β2-nAChR) with optimal positron emission tomography imaging properties

Gao, Y., Kuwabara, H., Spivak, C. E., Xiao, Y., Kellar, K., Ravert, H. T., Kumar, A., Alexander, M., Hilton, J., Wong, D. F., Dannals, R. F. & Horti, A. G., Aug 14 2008, In: Journal of Medicinal Chemistry. 51, 15, p. 4751-4764 14 p.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Evaluation of a bromine-76-labeled progestin 16α,17α-dioxolane for breast tumor imaging and radiotherapy: in vivo biodistribution and metabolic stability studies

Zhou, D., Sharp, T. L., Fettig, N. M., Lee, H., Lewis, J. S., Katzenellenbogen, J. A. & Welch, M. J., Aug 2008, In: Nuclear Medicine and Biology. 35, 6, p. 655-663 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Image quality with non-standard nuclides in PET

Laforest, R. & Liu, X., Jun 2008, In: Quarterly Journal of Nuclear Medicine and Molecular Imaging. 52, 2, p. 151-158 8 p.

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Imaging in drug discovery, preclinical, and early clinical development.

Wong, D. F., Jun 2008, In: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 49, 6, p. 26N-28N

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): Implications to manganese-induced parkinsonism

Guilarte, T. R., Burton, N. C., McGlothan, J. L., Verina, T., Zhou, Y., Alexander, M., Pham, L., Griswold, M., Wong, D. F., Syversen, T. & Schneider, J. S., Dec 2008, In: Journal of Neurochemistry. 107, 5, p. 1236-1247 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

141 Scopus citations

In vivo imaging of cancer biomarkers using activatable molecular probes

Elias, D. R., Thorek, D. L. J., Chen, A. K., Czupryna, J. & Tsourkas, A., 2008, In: Cancer Biomarkers. 4, 6, p. 287-305 19 p.

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

In vivo measurement of cell proliferation in canine brain tumor using C-11-labeled FMAU and PET

Conti, P. S., Bading, J. R., Mouton, P. P., Links, J. M., Alauddin, M. M., Fissekis, J. D., Ravert, H. T., Hilton, J., Wong, D. F. & Anderson, J. H., Jan 2008, In: Nuclear Medicine and Biology. 35, 1, p. 131-141 11 p.

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Longitudinal cerebral blood flow and amyloid deposition: An emerging pattern?

Sojkova, J., Beason-Held, L., Zhou, Y., An, Y., Kraut, M. A., Ye, W., Ferrucci, L., Mathis, C. A., Klunk, W. E., Wong, D. F. & Resnick, S. M., Sep 1 2008, In: Journal of Nuclear Medicine. 49, 9, p. 1465-1471 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

57 Scopus citations

Mechanisms of dopaminergic and serotonergic neurotransmission in Tourette syndrome: Clues from an in vivo neurochemistry study with PET

Wong, D. F., Brašić, J. R., Singer, H. S., Schretlen, D. J., Kuwabara, H., Zhou, Y., Nandi, A., Maris, M. A., Alexander, M., Ye, W., Rousset, O., Kumar, A., Szabo, Z., Gjedde, A. & Grace, A. A., May 2008, In: Neuropsychopharmacology. 33, 6, p. 1239-1251 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

210 Scopus citations

Micro insert: A prototype full-ring PET device for improving the image resolution of a small-animal PET scanner

Wu, H., Pal, D., Tae, Y. S., O'Sullivan, J. A. & Tai, Y. C., Oct 1 2008, In: Journal of Nuclear Medicine. 49, 10, p. 1668-1676 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

45 Scopus citations

Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis

Nahrendorf, M., Zhang, H., Hembrador, S., Panizzi, P., Sosnovik, D. E., Aikawa, E., Libby, P., Swirski, F. K. & Weissleder, R., Jan 2008, In: Circulation. 117, 3, p. 379-387 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

504 Scopus citations

New pansomatostatin ligands and their chelated versions: Affinity profile, agonist activity, internalization, and tumor targeting

Ginj, M., Zhang, H., Eisenwiener, K. P., Wild, D., Schulz, S., Rink, H., Cescato, R., Reubi, J. C. & Maecke, H. R., Apr 1 2008, In: Clinical Cancer Research. 14, 7, p. 2019-2027 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

68 Scopus citations

New synthesis and evaluation of enantiomers of 7-methyl-2-exo-(3′-iodo-5′-pyridinyl)-7-azabicyclo[2.2.1]heptane as stereoselective ligands for PET imaging of nicotinic acetylcholine receptors

Gao, Y., Horti, A. G., Kuwabara, H., Ravert, H. T., Holt, D. P., Kumar, A., Alexander, M., Wong, D. F. & Dannals, R. F., Dec 1 2008, In: Bioorganic and Medicinal Chemistry Letters. 18, 23, p. 6168-6170 3 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Persistent cognitive and dopamine transporter deficits in abstinent methamphetamine users

McCann, U. D., Kuwabara, H., Kumar, A., Palermo, M., Abbey, R., Brasic, J., Ye, W., Alexander, M., Dannals, R. F., Wong, D. F. & Ricaurte, G. A., Feb 2008, In: Synapse. 62, 2, p. 91-100 10 p.

Research output: Contribution to journal › Article › peer-review

171 Scopus citations

Radiation dosimetry of N-([¹¹C]methyl)benperidol as determined by whole-body PET imaging of primates

Antenor-Dorsey, J. A. V., Laforest, R., Moerlein, S. M., Videen, T. O. & Perlmutter, J. S., Apr 2008, In: European Journal of Nuclear Medicine and Molecular Imaging. 35, 4, p. 771-778 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Size, charge and concentration dependent uptake of iron oxide particles by non-phagocytic cells

Thorek, D. L. J. & Tsourkas, A., Sep 2008, In: Biomaterials. 29, 26, p. 3583-3590 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

330 Scopus citations

Striatal and extrastriatal D ₂/D ₃-receptor-binding properties of ziprasidone: A positron emission tomography study with [ ¹⁸F]fallypride and [ ¹¹C]raclopride (D ₂/D ₃-receptor occupancy of ziprasidone)

Vernaleken, I., Fellows, C., Janouschek, H., Bröcheler, A., Veselinovic, T., Landvogt, C., Boy, C., Buchholz, H. G., Spreckelmeyer, K., Bartenstein, P., Cumming, P., Hiemke, C., Rösch, F., Schäfer, W., Wong, D. F. & Gründer, G., Dec 2008, In: Journal of Clinical Psychopharmacology. 28, 6, p. 608-617 10 p.

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

SU‐GG‐J‐03: 3D Pathology Validation for Head‐And‐Neck Tumor Segmentation in PET/CT/MRI Images

lu, W., li, H., Lewis, J., Thorstad, W., Low, D., Laforest, R., Nussenbaum, B., Zhu, J., Parikh, P., wu, B. & Biehl, K., Jun 2008, In: Medical physics. 35, 6, p. 2679 1 p.

Research output: Contribution to journal › Article › peer-review

Synthesis, characterization, and antimalarial activity of novel Schiff-base-phenol and naphthalene-amine ligands

Harpstrite, S. E., Collins, S. D., Oksman, A., Goldberg, D. E. & Sharma, V., 2008, In: Medicinal Chemistry. 4, 4, p. 392-395 4 p.

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Synthesis of dinitro-substituted furans, thiophenes, and azoles

Katritzky, A. R., Vakulenko, A. V., Sivapackiam, J., Draghici, B. & Damavarapu, R., Mar 3 2008, In: Synthesis. 5, p. 699-706 8 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

System matrix modelling of externally tracked motion

Rahmim, A., Cheng, J. C., Dinelle, K., Shilov, M., Segars, W. P., Rousset, O. G., Tsui, B. M. W., Wong, D. F. & Sossi, V., Jun 2008, In: Nuclear Medicine Communications. 29, 6, p. 574-581 8 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Time course of alterations in myocardial glucose utilization in the Zucker diabetic fatty rat with correlation to gene expression of glucose transporters: A small-animal PET investigation

Shoghi, K. I., Gropler, R. J., Sharp, T., Herrero, P., Fettig, N., Su, Y., Mitra, M. S., Kovacs, A., Finck, B. N. & Welch, M. J., Aug 1 2008, In: Journal of Nuclear Medicine. 49, 8, p. 1320-1327 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

57 Scopus citations

Virtual-pinhole PET

Tai, Y. C., Wu, H., Pal, D. & O'Sullivan, J. A., Mar 1 2008, In: Journal of Nuclear Medicine. 49, 3, p. 471-479 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

93 Scopus citations

VMAT2 and dopamine neuron loss in a primate model of Parkinson's disease

Chen, M. K., Kuwabara, H., Zhou, Y., Adams, R. J., Brašić, J. R., McGlothan, J. L., Verina, T., Burton, N. C., Alexander, M., Kumar, A., Wong, D. F. & Guilarte, T. R., Apr 2008, In: Journal of Neurochemistry. 105, 1, p. 78-90 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

111 Scopus citations

Wavelet denoising in voxel-based parametric estimation of small animal PET images: A systematic evaluation of spatial constraints and noise reduction algorithms

Su, Y. & Shoghi, K. I., Nov 7 2008, In: Physics in medicine and biology. 53, 21, p. 5899-5915 17 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

2007

¹⁸F-fluoroacetate: A potential acetate analog for prostate tumor imaging - In vivo evaluation of ¹⁸F-fluoroacetate versus ¹¹C-acetate

Ponde, D. E., Dence, C. S., Oyama, N., Kim, J., Tai, Y. C., Laforest, R., Siegel, B. A. & Welch, M. J., Mar 1 2007, In: Journal of Nuclear Medicine. 48, 3, p. 420-428 9 p.

Research output: Contribution to journal › Article › peer-review

130 Scopus citations

2D linear and iterative reconstruction algorithms for a PET-insert scanner

Pal, D., O'Sullivan, J. A., Wu, H., Janecek, M. & Tai, Y. C., Jul 21 2007, In: Physics in medicine and biology. 52, 14, p. 4293-4310 18 p., 018.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Adaptive brachytherapy treatment planning for cervical cancer using FDG-PET

Lin, L. L., Mutic, S., Low, D. A., LaForest, R., Vicic, M., Zoberi, I., Miller, T. R. & Grigsby, P. W., Jan 1 2007, In: International Journal of Radiation Oncology Biology Physics. 67, 1, p. 91-96 6 p.

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Advances in the quantification of [11C]raclopride dynamic PET with amphetamine challenges

Zhou, Y., Weed, M. R., Chen, M. K., Rahmim, A., Ye, W., Brasic, J. R., Alexander, M., Crabb, A. H., McGlothan, J. L., Ali, F., Guilarte, T. R. & Wong, D. F., Nov 13 2007, In: Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1, p. PO01-06M

Research output: Contribution to journal › Article › peer-review

A partial volume correction-based approach for detection of receptor/transporter distribution in the human brain: Initial application to [11C]raclopride PET scans

Kuwabara, H., Kumar, A., Rousset, O., Ye, W., Brasic, J., Alexander, M. & Wong, D. F., Nov 13 2007, In: Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1, p. PP07-01U

Research output: Contribution to journal › Article › peer-review

Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals?

Antunes, P., Ginj, M., Zhang, H., Waser, B., Baum, R. P., Reubi, J. C. & Maecke, H., Jul 2007, In: European Journal of Nuclear Medicine and Molecular Imaging. 34, 7, p. 982-993 12 p.

Research output: Contribution to journal › Article › peer-review

340 Scopus citations

A retro-Diels Alder route to tetramethyldisilene Me₂Si= SiMe₂ revisited: Flow pyrolysis of 1,1,2,2-Tetramethyl-1,2-disilacyclohex-4-ene

Zhou, D., Nag, M., Russel, A. L., Read, D., Rohrs, H. W., Gross, M. L. & Gaspar, P. P., Jan 2007, In: Silicon Chemistry. 3, 3-4, p. 117-122 6 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Association of amphetamine-induced striatal dopamine release and cortisol responses to psychological stress

Wand, G. S., Oswald, L. M., McCaul, M. E., Wong, D. F., Johnson, E., Zhou, Y., Kuwabara, H. & Kumar, A., Nov 2007, In: Neuropsychopharmacology. 32, 11, p. 2310-2320 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

129 Scopus citations

Comparing IV amphetamine-induced 11C raclopride displacement between HRRT and GE advance PET: Implications for high resolution/sensitivity on dopmaine release measures

Wong, D. F., Rousset, O., Rahmim, A., Kumar, A., Kuwabara, H., Nandi, A., Zhou, Y., McCaul, B. & Wand, G., Nov 13 2007, In: Journal of Cerebral Blood Flow and Metabolism. 27, SUPPL. 1, p. PO03-05U

Research output: Contribution to journal › Article › peer-review

Precision Radiotheranostics Translation Center (PRTC)

Research output

Search results