• The integration and dissemination of heterogeneous data, information and knowledge resources.
• Computational approaches to the interpretation of bio-molecular, image and clinical phenotypes to inform precision medicine.
• The acceleration of clinical and translational research through the systematic management of study protocols, data resources and analytical pipelines.
• The creation of learning healthcare systems in which cyclical evidence generation and application becomes integral to care delivery.
• The use of ubiquitous computing and sensing technologies capable of facilitating population health monitoring and intervention strategies.
• Methodological and technical approaches to enable and enhance research reproducibility and rigor.

I² is led by Philip R.O. Payne, PhD, FACMI, FAMIA, and draws upon a multi-disciplinary team of faculty investigators, technical staff and trainees that are fully integrated with the departments and institutes comprising the SOM and partnering academic units from throughout WashU. The institute provides for a crosscutting community of practice that enhances and extends the academic and operational strengths of WashU and leverages the unique living laboratory afforded by the WashU, BJC HealthCare, and the Cortex Innovation Community.