Institute for Informatics, Data Science and Biostatistics (I2DB)

2016

Drug repurposing hypothesis generation using the "RE:fine drugs" system

Regan, K., Moosavinasab, S., Payne, P. & Lin, S., Dec 11 2016, In: Journal of Visualized Experiments. 2016, 118, e54948.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Efficacy and safety of deflazacort vs prednisone and placebo for Duchenne muscular dystrophy

Griggs, R. C., Miller, J. P., Greenberg, C. R., Fehlings, D. L., Pestronk, A., Mendell, J. R., Moxley, R. T., King, W., Kissel, J. T., Cwik, V., Vanasse, M., Florence, J. M., Pandya, S., Dubow, J. S. & Meyer, J. M., Nov 15 2016, In: Neurology. 87, 20, p. 2123-2131 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

125 Scopus citations

Electronic health record-based assessment of cardiovascular health: The stroke prevention in healthcare delivery environments (SPHERE) study

Foraker, R. E., Shoben, A. B., Kelley, M. M., Lai, A. M., Lopetegui, M. A., Jackson, R. D., Langan, M. A. & Payne, P. R. O., Dec 1 2016, In: Preventive Medicine Reports. 4, p. 303-308 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Examining the joint effect of disability, health behaviors, and comorbidity on mortality in MS

Salter, A., Tyry, T., Wang, G., Fox, R. J., Cutter, G. & Marrie, R. A., Oct 1 2016, In: Neurology: Clinical Practice. 6, 5, p. 397-408 12 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Exploring the feasibility and acceptability of sensor monitoring of gait and falls in the homes of persons with multiple sclerosis

Newland, P., Wagner, J. M., Salter, A., Thomas, F. P., Skubic, M. & Rantz, M., Sep 1 2016, In: Gait and Posture. 49, p. 277-282 6 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Expression of TIA1 and PAX5 in Classical Hodgkin Lymphoma at Initial Diagnosis May Predict Clinical Outcome

Nguyen, T. D. T., Frater, J. L., Klein, J., Chen, L., Bartlett, N. L., Foyil, K. V. & Kreisel, F. H., Jul 1 2016, In: Applied Immunohistochemistry and Molecular Morphology. 24, 6, p. 383-391 9 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Folate-conjugated immunoglobulin targets melanoma tumor cells for NK cell effector functions

Skinner, C. C., McMichael, E. L., Jaime-Ramirez, A. C., Abrams, Z. B., Lee, R. J. & Carson, W. E., Aug 1 2016, In: Melanoma Research. 26, 4, p. 329-337 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Genetic association of left ventricular mass assessed by M-mode and two-dimensional echocardiography

Barve, R. A., Gu, C. C., Yang, W., Chu, J., Dávila-Román, V. G. & De Las Fuentes, L., Jan 1 2016, In: Journal of Hypertension. 34, 1, p. 88-96 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Pattaro, C., Teumer, A., Gorski, M., Chu, A. Y., Li, M., Mijatovic, V., Garnaas, M., Tin, A., Sorice, R., Li, Y., Taliun, D., Olden, M., Foster, M., Yang, Q., Chen, M. H., Pers, T. H., Johnson, A. D., Ko, Y. A., Fuchsberger, C. & Tayo, B. & 678 others, Nalls, M., Feitosa, M. F., Isaacs, A., Dehghan, A., D'Adamo, P., Adeyemo, A., Dieffenbach, A. K., Zonderman, A. B., Nolte, I. M., Van Der Most, P. J., Wright, A. F., Shuldiner, A. R., Morrison, A. C., Hofman, A., Smith, A. V., Dreisbach, A. W., Franke, A., Uitterlinden, A. G., Metspalu, A., Tonjes, A., Lupo, A., Robino, A., Johansson, Å., Demirkan, A., Kollerits, B., Freedman, B. I., Ponte, B., Oostra, B. A., Paulweber, B., Krämer, B. K., Mitchell, B. D., Buckley, B. M., Peralta, C. A., Hayward, C., Helmer, C., Rotimi, C. N., Shaffer, C. M., Müller, C., Sala, C., Van Duijn, C. M., Saint-Pierre, A., Ackermann, D., Shriner, D., Ruggiero, D., Toniolo, D., Lu, Y., Cusi, D., Czamara, D., Ellinghaus, D., Siscovick, D. S., Ruderfer, D., Gieger, C., Grallert, H., Rochtchina, E., Atkinson, E. J., Holliday, E. G., Boerwinkle, E., Salvi, E., Bottinger, E. P., Murgia, F., Rivadeneira, F., Ernst, F., Kronenberg, F., Hu, F. B., Navis, G. J., Curhan, G. C., Ehret, G. B., Homuth, G., Coassin, S., Thun, G. A., Pistis, G., Gambaro, G., Malerba, G., Montgomery, G. W., Eiriksdottir, G., Jacobs, G., Li, G., Wichmann, H. E., Campbell, H., Schmidt, H., Wallaschofski, H., Völzke, H., Brenner, H., Kroemer, H. K., Kramer, H., Lin, H., Leach, I. M., Ford, I., Guessous, I., Rudan, I., Prokopenko, I., Borecki, I., Heid, I. M., Kolcic, I., Persico, I., Jukema, J. W., Wilson, J. F., Felix, J. F., Divers, J., Lambert, J. C., Stafford, J. M., Gaspoz, J. M., Smith, J. A., Faul, J. D., Wang, J. J., Ding, J., Hirschhorn, J. N., Attia, J., Whitfield, J. B., Chalmers, J., Viikari, J., Coresh, J., Denny, J. C., Karjalainen, J., Fernandes, J. K., Endlich, K., Butterbach, K., Keene, K. L., Lohman, K., Portas, L., Launer, L. J., Lyytikäinen, L. P., Yengo, L., Franke, L., Ferrucci, L., Rose, L. M., Kedenko, L., Rao, M., Struchalin, M., Kleber, M. E., Cavalieri, M., Haun, M., Cornelis, M. C., Ciullo, M., Pirastu, M., De Andrade, M., McEvoy, M. A., Woodward, M., Adam, M., Cocca, M., Nauck, M., Imboden, M., Waldenberger, M., Pruijm, M., Metzger, M., Stumvoll, M., Evans, M. K., Sale, M. M., Kähönen, M., Boban, M., Bochud, M., Rheinberger, M., Verweij, N., Bouatia-Naji, N., Martin, N. G., Hastie, N., Probst-Hensch, N., Soranzo, N., Devuyst, O., Raitakari, O., Gottesman, O., Franco, O. H., Polasek, O., Gasparini, P., Munroe, P. B., Ridker, P. M., Mitchell, P., Muntner, P., Meisinger, C., Smit, J. H., Abecasis, G. R., Adair, L. S., Alexander, M., Altshuler, D., Amin, N., Arking, D. E., Arora, P., Aulchenko, Y., Bakker, S. J. L., Bandinelli, S., Barroso, I., Beckmann, J. S., Beilby, J. P., Bergman, R. N., Bergmann, S., Bis, J. C., Boehnke, M., Bonnycastle, L. L., Bornstein, S. R., Bots, M. L., Bragg-Gresham, J. L., Brand, S. M., Brand, E., Braund, P. S., Brown, M. J., Burton, P. R., Casas, J. P., Caulfield, M. J., Chakravarti, A., Chambers, J. C., Chandak, G. R., Chang, Y. P. C., Charchar, F. J., Chaturvedi, N., Cho, Y. S., Clarke, R., Collins, F. S., Collins, R., Connell, J. M., Cooper, J. A., Cooper, M. N., Cooper, R. S., Corsi, A. M., Dörr, M., Dahgam, S., Danesh, J., Smith, G. D., Day, I. N. M., Deloukas, P., Denniff, M., Dominiczak, A. F., Dong, Y., Doumatey, A., Elliott, P., Elosua, R., Erdmann, J., Eyheramendy, S., Farrall, M., Fava, C., Forrester, T., Fowkes, F. G. R., Fox, E. R., Frayling, T. M., Galan, P., Ganesh, S. K., Garcia, M., Gaunt, T. R., Glazer, N. L., Go, M. J., Goel, A., Grässler, J., Grobbee, D. E., Groop, L., Guarrera, S., Guo, X., Hadley, D., Hamsten, A., Han, B. G., Hardy, R., Hartikainen, A. L., Heath, S., Heckbert, S. R., Hedblad, B., Hercberg, S., Hernandez, D., Hicks, A. A., Hilton, G., Hingorani, A. D., Hoffman Bolton, J. A., Hopewell, J. C., Howard, P., Humphries, S. E., Hunt, S. C., Hveem, K., Ikram, M. A., Islam, M., Iwai, N., Jarvelin, M. R., Jackson, A. U., Jafar, T. H., Janipalli, C. S., Johnson, T., Kathiresan, S., Khaw, K. T., Kim, H. L., Kinra, S., Kita, Y., Kivimaki, M., Kooner, J. S., Kumar, M. J. K., Kuh, D., Kulkarni, S. R., Kumari, M., Kuusisto, J., Kuznetsova, T., Laakso, M., Laan, M., Laitinen, J., Lakatta, E. G., Langefeld, C. D., Larson, M. G., Lathrop, M., Lawlor, D. A., Lawrence, R. W., Lee, J. Y., Lee, N. R., Levy, D., Li, Y., Longstreth, W. T., Luan, J., Lucas, G., Ludwig, B., Mangino, M., Mani, K. R., Marmot, M. G., Mattace-Raso, F. U. S., Matullo, G., McArdle, W. L., McKenzie, C. A., Meitinger, T., Melander, O., Meneton, P., Meschia, J. F., Miki, T., Milaneschi, Y., Mohlke, K. L., Mooser, V., Morken, M. A., Morris, R. W., Mosley, T. H., Najjar, S., Narisu, N., Newton-Cheh, C., Nguyen, K. D. H., Nilsson, P., Nyberg, F., O'Donnell, C. J., Ogihara, T., Ohkubo, T., Okamura, T., Ong, R. T. H., Ongen, H., Onland-Moret, N. C., O'Reilly, P. F., Org, E., Orru, M., Palmas, W., Palmen, J., Palmer, L. J., Palmer, N. D., Parker, A. N., Peden, J. F., Peltonen, L., Perola, M., Pihur, V., Platou, C. G. P., Plump, A., Prabhakaran, D., Psaty, B. M., Raffel, L. J., Rao, D. C., Rasheed, A., Ricceri, F., Rice, K. M., Rosengren, A., Rotter, J. I., Rudock, M. E., Sõber, S., Salako, T., Saleheen, D., Salomaa, V., Samani, N. J., Schwartz, S. M., Schwarz, P. E. H., Scott, L. J., Scott, J., Scuteri, A., Sehmi, J. S., Seielstad, M., Seshadri, S., Sharma, P., Shaw-Hawkins, S., Shi, G., Shrine, N. R. G., Sijbrands, E. J. G., Sim, X., Singleton, A., Sjögren, M., Smith, N. L., Artigas, M. S., Spector, T. D., Staessen, J. A., Stancakova, A., Steinle, N. I., Strachan, D. P., Stringham, H. M., Sun, Y. V., Swift, A. J., Tabara, Y., Tai, E. S., Talmud, P. J., Taylor, A., Terzic, J., Thelle, D. S., Tobin, M. D., Tomaszewski, M., Tripathy, V., Tuomilehto, J., Tzoulaki, I., Uda, M., Ueshima, H., Uiterwaal, C. S. P. M., Umemura, S., Van Der Harst, P., Van Der Schouw, Y. T., Van Gilst, W. H., Vartiainen, E., Vasan, R. S., Veldre, G., Verwoert, G. C., Viigimaa, M., Vinay, D. G., Vineis, P., Voight, B. F., Vollenweider, P., Wagenknecht, L. E., Wain, L. V., Wang, X., Wang, T. J., Wareham, N. J., Watkins, H., Weder, A. B., Whincup, P. H., Wiggins, K. L., Witteman, J. C. M., Wong, A., Wu, Y., Yajnik, C. S., Yao, J., Young, J. H., Zelenika, D., Zhai, G., Zhang, W., Zhang, F., Zhao, J. H., Zhu, H., Zhu, X., Zitting, P., Zukowska-Szczechowska, E., Okada, Y., Wu, J. Y., Gu, D., Takeuchi, F., Takahashi, A., Maeda, S., Tsunoda, T., Chen, P., Lim, S. C., Wong, T. Y., Liu, J., Young, T. L., Aung, T., Teo, Y. Y., Kim, Y. J., Kang, D., Chen, C. H., Tsai, F. J., Chang, L. C., Fann, S. J. C., Mei, H., Hixson, J. E., Chen, S., Katsuya, T., Isono, M., Albrecht, E., Yamamoto, K., Kubo, M., Nakamura, Y., Kamatani, N., Kato, N., He, J., Chen, Y. T., Tanaka, T., Reilly, M. P., Schunkert, H., Assimes, T. L., Hall, A., Hengstenberg, C., König, I. R., Laaksonen, R., McPherson, R., Thompson, J. R., Thorsteinsdottir, U., Ziegler, A., Absher, D., Chen, L., Cupples, L. A., Halperin, E., Li, M., Musunuru, K., Preuss, M., Schillert, A., Thorleifsson, G., Wells, G. A., Holm, H., Roberts, R., Stewart, A. F. R., Fortmann, S., Go, A., Hlatky, M., Iribarren, C., Knowles, J., Myers, R., Quertermous, T., Sidney, S., Risch, N., Tang, H., Blankenberg, S., Schnabel, R., Sinning, C., Lackner, K. J., Tiret, L., Nicaud, V., Cambien, F., Bickel, C., Rupprecht, H. J., Perret, C., Proust, C., Münzel, T. F., Barbalic, M., Chen, I. Y. D., Demissie-Banjaw, S., Folsom, A., Lumley, T., Marciante, K., Taylor, K. D., Volcik, K., Gretarsdottir, S., Gulcher, J. R., Kong, A., Stefansson, K., Thorgeirsson, G., Andersen, K., Fischer, M., Grosshennig, A., Linsel-Nitschke, P., Stark, K., Schreiber, S., Aherrahrou, Z., Bruse, P., Doering, A., Klopp, N., Diemert, P., Loley, C., Medack, A., Nahrstedt, J., Peters, A., Wagner, A. K., Willenborg, C., Böhm, B. O., Dobnig, H., Grammer, T. B., Hoffmann, M. M., Meinitzer, A., Winkelmann, B. R., Pilz, S., Renner, W., Scharnagl, H., Stojakovic, T., Tomaschitz, A., Winkler, K., Guiducci, C., Burtt, N., Gabriel, S. B., Dandona, S., Jarinova, O., Qu, L., Wilensky, R., Matthai, W., Hakonarson, H. H., Devaney, J., Burnett, M. S., Pichard, A. D., Kent, K. M., Satler, L., Lindsay, J. M., Waksman, R., Knouff, C. W., Waterworth, D. M., Walker, M. C., Epstein, S. E., Rader, D. J., Nelson, C. P., Wright, B. J., Balmforth, A. J., Ball, S. G., Loehr, L. R., Rosamond, W. D., Benjamin, E., Haritunians, T., Couper, D., Murabito, J., Wang, Y. A., Stricker, B. H., Chang, P. P., Willerson, J. T., Felix, S. B., Watzinger, N., Aragam, J., Zweiker, R., Lind, L., Rodeheffer, R. J., Greiser, K. H., Deckers, J. W., Stritzke, J., Ingelsson, E., Kullo, I., Haerting, J., Reffelmann, T., Redfield, M. M., Werdan, K., Mitchell, G. F., Arnett, D. K., Gottdiener, J. S., Blettner, M., Friedrich, N., Kovacs, P., Wild, P. S., Froguel, P., Rettig, R., Mägi, R., Biffar, R., Schmidt, R., Middelberg, R. P. S., Carroll, R. J., Penninx, B. W., Scott, R. J., Katz, R., Sedaghat, S., Wild, S. H., Kardia, S. L. R., Ulivi, S., Hwang, S. J., Enroth, S., Kloiber, S., Trompet, S., Stengel, B., Hancock, S. J., Turner, S. T., Rosas, S. E., Stracke, S., Harris, T. B., Zeller, T., Zemunik, T., Lehtimäki, T., Illig, T., Aspelund, T., Nikopensius, T., Esko, T., Tanaka, T., Gyllensten, U., Völker, U., Emilsson, V., Vitart, V., Aalto, V., Gudnason, V., Chouraki, V., Chen, W. M., Igl, W., März, W., Koenig, W., Lieb, W., Loos, R. J. F., Liu, Y., Snieder, H., Pramstaller, P. P., Parsa, A., O'Connell, J. R., Susztak, K., Hamet, P., Tremblay, J., De Boer, I. H., Böger, C. A., Goessling, W., Chasman, D. I., Köttgen, A., Kao, W. H. L. & Fox, C. S., Jan 21 2016, In: Nature communications. 7, 10023.

Research output: Contribution to journal › Article › peer-review

Open Access

384 Scopus citations

Genetics and population analysis: Estimating and testing high-dimensional mediation effects in epigenetic studies

Zhang, H., Zheng, Y., Zhang, Z., Gao, T., Joyce, B., Yoon, G., Zhang, W., Schwartz, J., Just, A., Colicino, E., Vokonas, P., Zhao, L., Lv, J., Baccarelli, A., Hou, L. & Liu, L., Oct 15 2016, In: Bioinformatics. 32, 20, p. 3150-3154 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

104 Scopus citations

Genetic Susceptibility to Lipid Levels and Lipid Change over Time and Risk of Incident Hyperlipidemia in Chinese Populations

Lu, X., Huang, J., Mo, Z., He, J., Wang, L., Yang, X., Tan, A., Chen, S., Chen, J., Charles Gu, C., Chen, J., Li, Y., Zhao, L., Li, H., Hao, Y., Li, J., Hixson, J. E., Li, Y., Cheng, M. & Liu, X. & 18 others, Cao, J., Liu, F., Huang, C., Shen, C., Shen, J., Yu, L., Xu, L., Mu, J., Wu, X., Ji, X., Guo, D., Zhou, Z., Yang, Z., Wang, R., Yang, J., Yan, W., Peng, X. & Gu, D., Feb 1 2016, In: Circulation: Cardiovascular Genetics. 9, 1, p. 37-44 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

51 Scopus citations

Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference

Wen, W., Kato, N., Hwang, J. Y., Guo, X., Tabara, Y., Li, H., Dorajoo, R., Yang, X., Tsai, F. J., Li, S., Wu, Y., Wu, T., Kim, S., Guo, X., Liang, J., Shungin, D., Adair, L. S., Akiyama, K., Allison, M. & Cai, Q. & 56 others, Chang, L. C., Chen, C. H., Chen, Y. T., Cho, Y. S., Choi, B. Y., Gao, Y., Go, M. J., Gu, D., Han, B. G., He, M., Hixson, J. E., Hu, Y., Huang, T., Isono, M., Jung, K. J., Kang, D., Kim, Y. J., Kita, Y., Lee, J., Lee, N. R., Lee, J., Wang, Y., Liu, J. J., Long, J., Moon, S., Nakamura, Y., Nakatochi, M., Ohnaka, K., Rao, D., Shi, J., Sull, J. W., Tan, A., Ueshima, H., Wu, C., Xiang, Y. B., Yamamoto, K., Yao, J., Ye, X., Yokota, M., Zhang, X., Zheng, Y., Qi, L., Rotter, J. I., Jee, S. H., Lin, D., Mohlke, K. L., He, J., Mo, Z., Wu, J. Y., Tai, E. S., Lin, X., Miki, T., Kim, B. J., Takeuchi, F., Zheng, W. & Shu, X. O., Jan 20 2016, In: Scientific reports. 6, 17958.

Research output: Contribution to journal › Article › peer-review

Open Access

54 Scopus citations

Genome-wide association studies suggest sex-specific loci associated with abdominal and visceral fat

Sung, Y. J., Pérusse, L., Sarzynski, M. A., Fornage, M., Sidney, S., Sternfeld, B., Rice, T., Terry, J. G., Jacobs, D. R., Katzmarzyk, P., Curran, J. E., Jeffrey Carr, J., Blangero, J., Ghosh, S., Després, J. P., Rankinen, T., Rao, D. C. & Bouchard, C., Apr 1 2016, In: International Journal of Obesity. 40, 4, p. 662-674 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

75 Scopus citations

Genome-Wide Gene-Sodium Interaction Analyses on Blood Pressure: The Genetic Epidemiology Network of Salt-Sensitivity Study

Li, C., He, J., Chen, J., Zhao, J., Gu, D., Hixson, J. E., Rao, D. C., Jaquish, C. E., Gu, C. C., Chen, J., Huang, J., Chen, S. & Kelly, T. N., Aug 1 2016, In: Hypertension. 68, 2, p. 348-355 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

Kilpeläinen, T. O., Carli, J. F. M., Skowronski, A. A., Sun, Q., Kriebel, J., Feitosa, M. F., Hedman, Å. K., Drong, A. W., Hayes, J. E., Zhao, J., Pers, T. H., Schick, U., Grarup, N., Kutalik, Z., Trompet, S., Mangino, M., Kristiansson, K., Beekman, M., Lyytikäinen, L. P. & Eriksson, J. & 157 others, Henneman, P., Lahti, J., Tanaka, T., Luan, J., Fabiola Del, G. M., Pasko, D., Renström, F., Willems, S. M., Mahajan, A., Rose, L. M., Guo, X., Liu, Y., Kleber, M. E., Pérusse, L., Gaunt, T., Ahluwalia, T. S., Ju Sung, Y., Ramos, Y. F., Amin, N., Amuzu, A., Barroso, I., Bellis, C., Blangero, J., Buckley, B. M., Böhringer, S., I Chen, Y. D., De Craen, A. J. N., Crosslin, D. R., Dale, C. E., Dastani, Z., Day, F. R., Deelen, J., Delgado, G. E., Demirkan, A., Finucane, F. M., Ford, I., Garcia, M. E., Gieger, C., Gustafsson, S., Hallmans, G., Hankinson, S. E., Havulinna, A. S., Herder, C., Hernandez, D., Hicks, A. A., Hunter, D. J., Illig, T., Ingelsson, E., Ioan-Facsinay, A., Jansson, J. O., Jenny, N. S., Jørgensen, M. E., Jørgensen, T., Karlsson, M., Koenig, W., Kraft, P., Kwekkeboom, J., Laatikainen, T., Ladwig, K. H., Leduc, C. A., Lowe, G., Lu, Y., Marques-Vidal, P., Meisinger, C., Menni, C., Morris, A. P., Myers, R. H., Männistö, S., Nalls, M. A., Paternoster, L., Peters, A., Pradhan, A. D., Rankinen, T., Rasmussen-Torvik, L. J., Rathmann, W., Rice, T. K., Brent Richards, J., Ridker, P. M., Sattar, N., Savage, D. B., Söderberg, S., Timpson, N. J., Vandenput, L., Van Heemst, D., Uh, H. W., Vohl, M. C., Walker, M., Wichmann, H. E., Widén, E., Wood, A. R., Yao, J., Zeller, T., Zhang, Y., Meulenbelt, I., Kloppenburg, M., Astrup, A., Sørensen, T. I. A., Sarzynski, M. A., Rao, D. C., Jousilahti, P., Vartiainen, E., Hofman, A., Rivadeneira, F., Uitterlinden, A. G., Kajantie, E., Osmond, C., Palotie, A., Eriksson, J. G., Heliövaara, M., Knekt, P. B., Koskinen, S., Jula, A., Perola, M., Huupponen, R. K., Viikari, J. S., Kähönen, M., Lehtimäki, T., Raitakari, O. T., Mellström, D., Lorentzon, M., Casas, J. P., Bandinelli, S., März, W., Isaacs, A., Van Dijk, K. W., Van Duijn, C. M., Harris, T. B., Bouchard, C., Allison, M. A., Chasman, D. I., Ohlsson, C., Lind, L., Scott, R. A., Langenberg, C., Wareham, N. J., Ferrucci, L., Frayling, T. M., Pramstaller, P. P., Borecki, I. B., Waterworth, D. M., Bergmann, S., Waeber, G., Vollenweider, P., Vestergaard, H., Hansen, T., Pedersen, O., Hu, F. B., Eline Slagboom, P., Grallert, H., Spector, T. D., Jukema, J. W., Klein, R. J., Schadt, E. E., Franks, P. W., Lindgren, C. M., Leibel, R. L. & Loos, R. J. F., Feb 1 2016, In: Nature communications. 7, 10494.

Research output: Contribution to journal › Article › peer-review

Open Access

143 Scopus citations

Global microRNA profiling for diagnostic appraisal of melanocytic Spitz tumors

Latchana, N., Regan, K., Howard, J. H., Aldrink, J. H., Ranalli, M. A., Peters, S. B., Zhang, X., Gru, A., Payne, P. R. O., Suarez-Kelly, L. P. & Carson, W. E., Oct 1 2016, In: Journal of Surgical Research. 205, 2, p. 350-358 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Health insurance affects the use of disease-modifying therapy in multiple sclerosis

Wang, G., Marrie, R. A., Salter, A. R., Fox, R., Cofield, S. S., Tyry, T. & Cutter, G. R., Jul 26 2016, In: Neurology. 87, 4, p. 365-374 10 p.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Health insurance trajectories and long-term survival after heart transplantation

Tumin, D., Foraker, R. E., Smith, S., Tobias, J. D. & Hayes, D., Sep 1 2016, In: Circulation: Cardiovascular Quality and Outcomes. 9, 5, p. 576-584 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1

Harrison, J. S., Cornett, E. M., Goldfarb, D., Darosa, P. A., Li, Z. M., Yan, F., Dickson, B. M., Guo, A. H., Cantu, D. V., Kaustov, L., Brown, P. J., Arrowsmith, C. H., Erie, D. A., Major, M. B., Klevit, R. E., Krajewski, K., Kuhlman, B., Strahl, B. D. & Rothbart, S. B., Sep 6 2016, In: eLife. 5, Se, e17101.

Research output: Contribution to journal › Article › peer-review

Open Access

102 Scopus citations

High-fidelity analysis of perioperative QTc prolongation

Duma, A., Pal, S., Helsten, D., Stein, P. K., Miller, J. P. & Nagele, P., Feb 1 2016, In: Anesthesia and analgesia. 122, 2, p. 439-448 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Human epithelial NA⁺ channel missense variants identified in the GenSalt study alter channel activity

Ray, E. C., Chen, J., Kelly, T. N., He, J., Hamm, L. L., Gu, D., Shimmin, L. C., Hixson, J. E., Rao, D. C., Sheng, S. & Kleyman, T. R., 2016, In: American Journal of Physiology - Renal Physiology. 311, 5, p. F908-F914

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Identification and characterization of MCM3 as a kelch-like ECH-associated protein 1 (KEAP1) substrate

Mulvaney, K. M., Matson, J. P., Siesser, P. F., Tamir, T. Y., Goldfarb, D., Jacobs, T. M., Cloer, E. W., Harrison, J. S., Vaziri, C., Cook, J. G. & Major, M. B., Nov 4 2016, In: Journal of Biological Chemistry. 291, 45, p. 23719-23733 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

67 Scopus citations

Imaging and cerebrospinal fluid biomarkers in early preclinical alzheimer disease

Vlassenko, A. G., McCue, L., Jasielec, M. S., Su, Y., Gordon, B. A., Xiong, C., Holtzman, D. M., Benzinger, T. L. S., Morris, J. C. & Fagan, A. M., Sep 1 2016, In: Annals of neurology. 80, 3, p. 379-387 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

78 Scopus citations

Impact of structured rounding tools on time allocation during multidisciplinary rounds: An observational study

Abraham, J., Kannampallil, T. G., Patel, V. L., Patel, B. & Almoosa, K. F., Jul 1 2016, In: JMIR Human Factors. 3, 2, e29.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Insurance status by region at the time of heart transplantation: Implications for survival

Foraker, R. E., Tumin, D., Smith, S., Tobias, J. D. & Hayes, D., Dec 1 2016, In: Journal of Heart and Lung Transplantation. 35, 12, p. 1480-1486 7 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Integrative analysis of somatic mutations and transcriptomic data to functionally stratify breast cancer patients

Zhang, J., Abrams, Z., Parvin, J. D. & Huang, K., Aug 22 2016, In: BMC genomics. 17, 513.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Joint frailty models for zero-inflated recurrent events in the presence of a terminal event

Liu, L., Huang, X., Yaroshinsky, A. & Cormier, J. N., Mar 1 2016, In: Biometrics. 72, 1, p. 204-214 11 p.

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Longitudinal relationships among biomarkers for Alzheimer disease in the Adult Children Study

Xiong, C., Jasielec, M. S., Weng, H., Fagan, A. M., Benzinger, T. L. S., Head, D., Hassenstab, J., Grant, E., Sutphen, C. L., Buckles, V., Moulder, K. L. & Morris, J. C., Apr 19 2016, In: Neurology. 86, 16, p. 1499-1506 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

MicroRNA profiling of patient plasma for clinical trials using bioinformatics and biostatistical approaches

Markowitz, J., Abrams, Z., Jacob, N. K., Zhang, X., Hassani, J. N., Latchana, N., Wei, L., Regan, K. E., Brooks, T. R., Uppati, S. R., Levine, K. M., Bekaii-Saab, T., Kendra, K. L., Lesinski, G. B., Howard, J. H., Olencki, T., Payne, P. R. & Carson, W. E., Sep 29 2016, In: OncoTargets and Therapy. 9, p. 5931-5941 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

MSAcquisitionSimulator: Data-dependent acquisition simulator for LC-MS shotgun proteomics

Goldfarb, D., Wang, W. & Major, M. B., Apr 15 2016, In: Bioinformatics. 32, 8, p. 1269-1271 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers

Murakami, K., Günesdogan, U., Zylicz, J. J., Tang, W. W. C., Sengupta, R., Kobayashi, T., Kim, S., Butler, R., Dietmann, S. & Surani, M. A., Jan 21 2016, In: Nature. 529, 7586, p. 403-407 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

135 Scopus citations

Neurological manifestations of autosomal dominant familial Alzheimer's disease: a comparison of the published literature with the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS)

Dominantly Inherited Alzheimer Network (DIAN), Dec 1 2016, In: The Lancet Neurology. 15, 13, p. 1317-1325 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

85 Scopus citations

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Lu, Y., Day, F. R., Gustafsson, S., Buchkovich, M. L., Na, J., Bataille, V., Cousminer, D. L., Dastani, Z., Drong, A. W., Esko, T., Evans, D. M., Falchi, M., Feitosa, M. F., Ferreira, T., Hedman, Å. K., Haring, R., Hysi, P. G., Iles, M. M., Justice, A. E. & Kanoni, S. & 239 others, Lagou, V., Li, R., Li, X., Locke, A., Lu, C., Mägi, R., Perry, J. R. B., Pers, T. H., Qi, Q., Sanna, M., Schmidt, E. M., Scott, W. R., Shungin, D., Teumer, A., Vinkhuyzen, A. A. E., Walker, R. W., Westra, H. J., Zhang, M., Zhang, W., Zhao, J. H., Zhu, Z., Afzal, U., Ahluwalia, T. S., Bakker, S. J. L., Bellis, C., Bonnefond, A., Borodulin, K., Buchman, A. S., Cederholm, T., Choh, A. C., Choi, H. J., Curran, J. E., De Groot, L. C. P. G. M., De Jager, P. L., Dhonukshe-Rutten, R. A. M., Enneman, A. W., Eury, E., Evans, D. S., Forsen, T., Friedrich, N., Fumeron, F., Garcia, M. E., Gärtner, S., Han, B. G., Havulinna, A. S., Hayward, C., Hernandez, D., Hillege, H., Ittermann, T., Kent, J. W., Kolcic, I., Laatikainen, T., Lahti, J., Leach, I. M., Lee, C. G., Lee, J. Y., Liu, T., Liu, Y., Lobbens, S., Loh, M., Lyytikaïnen, L. P., Medina-Gomez, C., Michaëlsson, K., Nalls, M. A., Nielson, C. M., Oozageer, L., Pascoe, L., Paternoster, L., Polašek, O., Ripatti, S., Sarzynski, M. A., Shin, C. S., Naranäiä, N. S., Spira, D., Srikanth, P., Steinhagen-Thiessen, E., Sung, Y. J., Swart, K. M. A., Taittonen, L., Tanaka, T., Tikkanen, E., Van Der Velde, N., Van Schoor, N. M., Verweij, N., Wright, A. F., Yu, L., Zmuda, J. M., Eklund, N., Forrester, T., Grarup, N., Jackson, A. U., Kristiansson, K., Kuulasmaa, T., Kuusisto, J., Lichtner, P., Luan, J., Mahajan, A., Männistö, S., Palmer, C. D., Ried, J. S., Scott, R. A., Stancáková, A., Wagner, P. J., Demirkan, A., Döring, A., Gudnason, V., Kiel, D. P., Kühnel, B., Mangino, M., McKnight, B., Menni, C., O'Connell, J. R., Oostra, B. A., Shuldiner, A. R., Song, K., Vandenput, L., Van Duijn, C. M., Vollenweider, P., White, C. C., Boehnke, M., Boettcher, Y., Cooper, R. S., Forouhi, N. G., Gieger, C., Grallert, H., Hingorani, A., Jørgensen, T., Jousilahti, P., Kivimaki, M., Kumari, M., Laakso, M., Langenberg, C., Linneberg, A., Luke, A., McKenzie, C. A., Palotie, A., Pedersen, O., Peters, A., Strauch, K., Tayo, B. O., Wareham, N. J., Bennett, D. A., Bertram, L., Blangero, J., Blüher, M., Bouchard, C., Campbell, H., Cho, N. H., Cummings, S. R., Czerwinski, S. A., Demuth, I., Eckardt, R., Eriksson, J. G., Ferrucci, L., Franco, O. H., Froguel, P., Gansevoort, R. T., Hansen, T., Harris, T. B., Hastie, N., Heliövaara, M., Hofman, A., Jordan, J. M., Jula, A., Kähönen, M., Kajantie, E., Knekt, P. B., Koskinen, S., Kovacs, P., Lehtimäki, T., Lind, L., Liu, Y., Orwoll, E. S., Osmond, C., Perola, M., Pérusse, L., Raitakari, O. T., Rankinen, T., Rao, D. C., Rice, T. K., Rivadeneira, F., Rudan, I., Salomaa, V., Sørensen, T. I. A., Stumvoll, M., Tönjes, A., Towne, B., Tranah, G. J., Tremblay, A., Uitterlinden, A. G., Van Der Harst, P., Vartiainen, E., Viikari, J. S., Vitart, V., Vohl, M. C., Völzke, H., Walker, M., Wallaschofski, H., Wild, S., Wilson, J. F., Yengo, L., Bishop, D. T., Borecki, I. B., Chambers, J. C., Cupples, L. A., Dehghan, A., Deloukas, P., Fatemifar, G., Fox, C., Furey, T. S., Franke, L., Han, J., Hunter, D. J., Karjalainen, J., Karpe, F., Kaplan, R. C., Kooner, J. S., McCarthy, M. I., Murabito, J. M., Morris, A. P., Bishop, J. A. N., North, K. E., Ohlsson, C., Ong, K. K., Prokopenko, I., Richards, J. B., Schadt, E. E., Spector, T. D., Widén, E., Willer, C. J., Yang, J., Ingelsson, E., Mohlke, K. L., Hirschhorn, J. N., Pospisilik, J. A., Zillikens, M. C., Lindgren, C., Kilpelaïnen, T. O. & Loos, R. J. F., Feb 1 2016, In: Nature communications. 7, 10495.

Research output: Contribution to journal › Article › peer-review

Open Access

216 Scopus citations

No survival benefit to gaining private health insurance coverage for post-lung transplant care in adults with cystic fibrosis

Tumin, D., Foraker, R. E., Tobias, J. D. & Hayes, D., Mar 1 2016, In: Clinical Transplantation. 30, 3, p. 320-327 8 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Particulate air pollution exposure and expression of viral and human MicroRNAs in blood: The beijing truck driver air pollution study

Hou, L., Barupal, J., Zhang, W., Zheng, Y., Liu, L., Zhang, X., Dou, C., McCracken, J. P., Díaz, A., Motta, V., Sanchez-Guerra, M., Wolf, K. R., Bertazzi, P. A., Schwartz, J. D., Wang, S. & Baccarelli, A. A., Mar 2016, In: Environmental Health Perspectives. 124, 3, p. 344-350 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study

Chatterjee, P., Lim, W. L. F., Shui, G., Gupta, V. B., James, I., Fagan, A. M., Xiong, C., Sohrabi, H. R., Taddei, K., Brown, B. M., Benzinger, T., Masters, C., Snowden, S. G., Wenk, M. R., Bateman, R. J., Morris, J. C. & Martins, R. N., Feb 2 2016, In: Journal of Alzheimer's Disease. 50, 3, p. 887-894 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

Post Hoc Analyses of ApoE Genotype-Defined Subgroups in Clinical Trials

Kennedy, R. E., Cutter, G. R., Wang, G. & Schneider, L. S., Feb 22 2016, In: Journal of Alzheimer's Disease. 50, 4, p. 1205-1215 11 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Prospective changes in global DNA methylation and cancer incidence and mortality

Joyce, B. T., Gao, T., Zheng, Y., Liu, L., Zhang, W., Dai, Q., Shrubsole, M. J., Hibler, E. A., Cristofanilli, M., Zhang, H., Yang, H., Vokonas, P., Cantone, L., Schwartz, J., Baccarelli, A. & Hou, L., Aug 9 2016, In: British Journal of Cancer. 115, 4, p. 465-472 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

Quantitative Amyloid imaging in autosomal Dominant Alzheimer's disease: Results from the DIAN study group

Su, Y., Blazey, T. M., Owen, C. J., Christensen, J. J., Friedrichsen, K., Joseph-Mathurin, N., Wang, Q., Hornbeck, R. C., Ances, B. M., Snyder, A. Z., Cash, L. A., Koeppe, R. A., Klunk, W. E., Galasko, D., Brickman, A. M., McDade, E., Ringman, J. M., Thompson, P. M., Saykin, A. J. & Ghetti, B. & 16 others, Sperling, R. A., Johnson, K. A., Salloway, S. P., Schofield, P. R., Masters, C. L., Villemagne, V. L., Fox, N. C., Förster, S., Chen, K., Reiman, E. M., Xiong, C., Marcus, D. S., Weiner, M. W., Morris, J. C., Bateman, R. J. & Benzinger, T. L. S., Mar 2016, In: PloS one. 11, 3, e0152082.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

Quantitative computed tomography classification of lung nodules: initial comparison of 2- and 3-dimensional analysis

Gierada, D. S., Politte, D. G., Zheng, J., Schechtman, K. B., Whiting, B. R., Smith, K. E., Crabtree, T., Kreisel, D., Krupnick, A. S., Patterson, G. A., Puri, V. & Meyers, B. F., Jul 1 2016, In: Journal of computer assisted tomography. 40, 4, p. 589-595 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans

Olfson, E., Saccone, N. L., Johnson, E. O., Chen, L. S., Culverhouse, R., Doheny, K., Foltz, S. M., Fox, L., Gogarten, S. M., Hartz, S., Hetrick, K., Laurie, C. C., Marosy, B., Amin, N., Arnett, D., Barr, R. G., Bartz, T. M., Bertelsen, S., Borecki, I. B. & Brown, M. R. & 33 others, Chasman, D. I., Van Duijn, C. M., Feitosa, M. F., Fox, E. R., Franceschini, N., Franco, O. H., Grove, M. L., Guo, X., Hofman, A., Kardia, S. L. R., Morrison, A. C., Musani, S. K., Psaty, B. M., Rao, D. C., Reiner, A. P., Rice, K., Ridker, P. M., Rose, L. M., Schick, U. M., Schwander, K., Uitterlinden, A. G., Vojinovic, D., Wang, J. C., Ware, E. B., Wilson, G., Yao, J., Zhao, W., Breslau, N., Hatsukami, D., Stitzel, J. A., Rice, J., Goate, A. & Bierut, L. J., May 1 2016, In: Molecular Psychiatry. 21, 5, p. 601-607 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

'RE:fine drugs': an interactive dashboard to access drug repurposing opportunities

Moosavinasab, S., Patterson, J., Strouse, R., Rastegar-Mojarad, M., Regan, K., Payne, P. R. O., Huang, Y. & Lin, S. M., 2016, In: Database : the journal of biological databases and curation. 2016

Research output: Contribution to journal › Article › peer-review

Open Access

47 Scopus citations

Relationship between symptom change, relapse activity and disability progression in multiple sclerosis

Liu, Y., Morgan, C., Hornung, L., Tyry, T., Salter, A. R., Agashivala, N., Belletti, D. A., Kim, E., Fox, R. J., Cofield, S. S. & Cutter, G. R., Mar 15 2016, In: Journal of the Neurological Sciences. 362, p. 121-126 6 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Rethinking the role and impact of health information technology: Informatics as an interventional discipline

Payne, P. R. O., Lussier, Y., Foraker, R. E. & Embi, P. J., 2016, In: BMC Medical Informatics and Decision Making. 16, 1, 40.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Risk Factors for Incident Hospitalized Heart Failure with Preserved Versus Reduced Ejection Fraction in a Multiracial Cohort of Postmenopausal Women

Eaton, C. B., Pettinger, M., Rossouw, J., Martin, L. W., Foraker, R., Quddus, A., Liu, S., Wampler, N. S., Hank Wu, W. C., Manson, J. E., Margolis, K., Johnson, K. C., Allison, M., Corbie-Smith, G., Rosamond, W., Breathett, K. & Klein, L., Oct 1 2016, In: Circulation: Heart Failure. 9, 10, e002883.

Research output: Contribution to journal › Article › peer-review

Open Access

147 Scopus citations

Simultaneous paralogue knockout using a CRISPR-concatemer in mouse small intestinal organoids

Andersson-Rolf, A., Merenda, A., Mustata, R. C., Li, T., Dietmann, S. & Koo, B. K., Dec 15 2016, In: Developmental Biology. 420, 2, p. 271-277 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Stem cell function and stress response are controlled by protein synthesis

Blanco, S., Bandiera, R., Popis, M., Hussain, S., Lombard, P., Aleksic, J., Sajini, A., Tanna, H., Cortés-Garrido, R., Gkatza, N., Dietmann, S. & Frye, M., Jun 15 2016, In: Nature. 534, 7607, p. 335-340 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

314 Scopus citations

Symptomatic management of multiple sclerosis-associated tremor among participants in the NARCOMS registry

Meador, W., Salter, A. R. & Rinker, J. R., May 1 2016, In: International Journal of MS Care. 18, 3, p. 147-153 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Temporal biological variability in dendritic cells and regulatory T cells in peripheral blood of healthy adults

Kitcharoensakkul, M., Bacharier, L. B., Yin-Declue, H., Boomer, J. S., Burgdorf, D., Wilson, B., Schechtman, K. & Castro, M., Apr 1 2016, In: Journal of Immunological Methods. 431, p. 63-65 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Testing moderation in network meta-analysis with individual participant data

Dagne, G. A., Brown, C. H., Howe, G., Kellam, S. G. & Liu, L., Jul 10 2016, In: Statistics in medicine. 35, 15, p. 2485-2502 18 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Institute for Informatics, Data Science and Biostatistics (I2DB)

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